Regulation of phosphoinositide 3-kinase γ protein kinase activity in vitro and in COS-7 cells

Signal Transduction

Volumn 1, Issue 1-2, 2001, Pages 79-85

  Bondev, Andrey ^a   Bondeva, Tzvetanka ^a   Wetzker, Reinhard ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

G ; MEK1; p101; PI3K; Protein phosphorylation

Indexed keywords

EID: 0012615833     PISSN: 16154053     EISSN: None     Source Type: Journal    
DOI: 10.1002/1615-4061(200111)1:1/2<79::aid-sita79>3.0.co;2-0     Document Type: Article

References (17)

1. Wymann, M. P., Pirola, L. (1998) Structure and function of phosphoinositide 3-kinases. Biochim. Biophys. Acta 1436: 127-50.
2. Carpenter, C. L., Cantley, L. C. (1996) Phosphoinositide 3-kinase and the regulation of cell growth. Biochim. Biophys. Acta 1288: M11-6.
3. Cantley, L., Pawson, T. (2001) Cell regulation. Curr. Opin. Cell. Biol. 13: 121-4.
4. Dhand, R., Hiles, I., Panayotou, G., Roche, S., Fry, M. J., Gout, I., Totty, N. F., Truong, O., Vicendo, P., Yonezawa, K., Kasuga, H., Courtneidge, S., Waterfield, M. (1994) PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. EMBO J. 13: 522-33.
5. Vanhaesebroeck, B., Higashi, K., Raven, C., Welham, M., Anderson, S., Brennan, P., Ward, S. G., Waterfield, M. D. (1999) Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo. EMBO J. 18: 1292-302.
6. Lam, K., Carpenter, C. L., Ruderman, N. B., Friel, J. C., Kelly, K. L. (1994) The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin. J. Biol. Chem. 269: 20648-52.
7. Stoyanova, S., Bulgarelli-Leva, G., Kirsch, C., Hanck, T., Klinger, R., Wetzker, R., Wymann, M. P. (1997) Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin. Biochem. J. 324: 489-95.
8. Vanhaesebroeck, B., Welham, M. J., Kotani, K., Stein, R., Warne, P. H., Zvelebil, M. J., Higashi, K., Volinia, S., Downward, J., Waterfield, M. D. (1997) P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc. Natl. Acad. Sci. USA 94: 4330-5.
9. Bondev, A., Rubio, I., Wetzker, R. (1999) Differential regulation of lipid and protein kinase activities of phosphoinositide 3-kinase gamma in vitro. Biol. Chem. 380: 1337-40.
10. Bondeva, T., Pirola, L., Bulgarelli-Leva, G., Rubio, I., Wetzker, R., Wymann, M. P. (1998) Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK. Science 282: 293-6.
11. Pirola, L., Bulgarelli-Leva, G., Van Obberghen, E., Wymann, M. P. (2001) Activation loop sequences confer substrate specificity to phosphoinositide 3-Kinase alpha: Functions of lipid-kinase deficient PI3Kα in signaling. J. Biol. Chem. in press.
12. Maier, U., Babich, A., Nurnberg, B. (1999) Roles of non-catalytic subunits in Gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma. J. Biol. Chem. 274: 29311-7.
13. Maier, U., Babich, A., Macrez, N., Leopoldt, D., Gierschik, P., Illenberger, D., Nurnberg, B. (2000) Gbeta 5gamma2 is a highly selective activator of phospholipid-dependent enzymes. J. Biol. Chem. 275: 13746-54.
14. Kozasa, T., Gilman, A. G. (1995) Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha12 and inhibition of adenylyl cyclase by alpha z. J. Biol. Chem. 270: 1734-41.
15. Lopez-Ilasaca, M., Crespo, P., Pellici, P. G., Gutkind, J. S., Wetzker, R. (1997) Linkage of G protein-coupled receptors to the MARK signaling pathway through PI 3-kinase gamma. Science 275: 394-7.
16. Chan, T. O., Rittenhouse, S. E., Tsichlis, P. N. (1999) AKT/ PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Ann. Rev. Biochem. 68: 965-1014.
17. Franke, T. F., Kaplan, D. R., Cantley, L. C., Toker, A. (1997) Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275: 665-668.