Mutation of tyrosine 190 to alanine eliminates the inactivation of cytochrome P450 2B1 by peroxynitrite

Chemical Research in Toxicology

Volumn 16, Issue 2, 2003, Pages 129-136

  Lin, Hsia lien ^a   Kent, Ute M ^a   Zhang, Haoming ^b   Waskell, Lucy ^b   Hollenberg, Paul F ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ALANINE; CYTOCHROME P450 2B1; PEROXYNITRITE; RECOMBINANT ENZYME; TYROSINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME INACTIVATION; ESCHERICHIA COLI; HYDROGEN BOND; MASS SPECTROMETRY; NITRATION; NONHUMAN;

ALANINE; AMINO ACID SUBSTITUTION; CATALYSIS; CYTOCHROME P-450 CYP2B1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; MODELS, MOLECULAR; NITRIC OXIDE; PEROXYNITROUS ACID; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY; TYROSINE;

ESCHERICHIA COLI;

EID: 0037330482     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx020040b     Document Type: Article

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