Loss of the metal binding properties of metallothionein induced by hydrogen peroxide and free radicals

Toxicology

Volumn 120, Issue 1, 1997, Pages 37-46

  Jimenez I ^a   Gotteland, M ^a   Zarzuelo, A ^b   Uauy, R ^a   Speisky, H ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

Free radicals; Hydrogen peroxide; Metal binding; Metallothionein; Thiol oxidation

Indexed keywords

2,2' AZOBIS(2 AMIDINOPROPANE); CADMIUM 109; CATALASE; DEFEROXAMINE; DEFEROXAMINE MESYLATE; FREE RADICAL; HYDROGEN PEROXIDE; IRON; METALLOTHIONEIN; SUPEROXIDE DISMUTASE;

ARTICLE; METAL BINDING; OXIDATION; PRIORITY JOURNAL;

AMIDINES; CADMIUM RADIOISOTOPES; DITHIOTHREITOL; FREE RADICALS; HYDROGEN PEROXIDE; METALLOTHIONEIN; OXIDANTS; PROTEIN BINDING; SULFHYDRYL COMPOUNDS; XANTHINE; XANTHINE OXIDASE; XANTHINES;

EID: 0343376129     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(97)03638-X     Document Type: Article

References (28)

1. Abel, J. and Ruiter, N. (1989) Inhibition of hydroxyl-radical generated DNA degradation by metallothionein. Toxicol. Lett. 47, 191-196.
2. Bakka, A., Johnsen, A.S., Endresen, L. and Rugstad, H.E. (1982) Radioresistance in cells with high content of metallothionein. Experientia 38, 381-383.
3. Bray, T.M. and Bettger, W.J. (1990) The physiological role of zinc as an antioxidant. Free Radic. Biol. Med. 8, 281-291.
4. Bremner, I. (1987) Interactions between metallothionein and trace metals. Prog. Food Nutr. Sci. 11, 1-37.
5. 4)-induce hepatotoxicity by zinc: role of metallothionein. Toxicol. Appl. Pharmacol. 51, 107-116.
6. Coppen, D.E., Richardson, D.E. and Cousins, R.J. (1988) Zinc supression of free radicals induce in cultures of rats hepatocytes by iron, tert-butyl hydroperoxide, and 3-methylindole. Proc. Soc. Exp. Biol. Med. 189, 100-109.
7. Cousins, R.J. (1985) Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiol. Rev. 65(2), 238-309.
8. Eaton, D.L. and Toal, B.F. (1982) Evaluation of the Cd/ hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol. Appl. Pharmacol. 66, 134-142.
9. Fliss, H. and Ménard, M. (1992) Oxidant-induced mobilization of zinc from metallothionein. Arch. Biochem. Biophys. 293(1), 195-199.
10. Freedman, J.H. and Peisach, J. (1989) Resistence of cultured hepatoma cells to copper toxicity. Purification and characterization of the hepatoma metallothionein. Biochim. Biophys. Acta 992, 145-154.
11. Goering, P.L. and Klassen, C.D. (1984) Zinc-induced tolerance to cadmium hepatotoxicity. Toxicol. Appl. Pharmacol. 74, 299-307.
12. Greenstock, C.L., Jinot, C.P., Whitehouse, R.P. and Sargent, M.D. (1987) DNA radiation damage and its modification by metallothionein. Free. Radic. Res. Commun. 2, 233-239.
13. Hartmann, H.J., Gärtner, A. and Wesser, U. (1985) Neutrophile-generated oxidants cleave metallothionein and induce Zn/Cd/Cu release. Clin. Chim. Acta 152, 95-103.
14. Hidalgo, J., Campany, L., Borras, M., Garvey, J.S. and Armario, A. (1988) Metallothionein response to stress in rats: role in free radical scavenging. Am. J. Physiol. 255, E: 518-2410.
15. Kägi, J. H. R. (1991) Overview of metallothionein. In: J.F. Riordan and B.L. Vallee (Eds), Methods in Enzymology, Vol. 205, Academic Press, San Diego, Ca., pp. 613-630.
16. Kägi, J. H. R, Hunziker, P. and Vasäk, M. (1990) Metallothionein: biochemistry and spatial structure. In: H. Tomita (Ed), Trace Elements in Clinical Medicine, Springer-Verlag, Tokyo, pp. 395-403.
17. 2+ and NO to form products with a g = 2.039 ESR signal. Biochem. Biophys. Res. Comm. 196(2), 632-635.
18. Lazo, J.S. and Pitt, B.R. (1995) Metallothioneins and cell death by anticancer drugs. Annu. Rev. Pharmacol. Toxicol. 35, 635-653.
19. Lehman-McKeeman, L.D., Andrews, G.K. and Klassen, C.D. (1988) Mechanisms of regulation of rat hepatic metallothionein-I and metallothionein-II levels following administration of zinc. Toxicol. Appl. Pharmacol. 92, 1-9.
20. Leyshon-Sørland, K., Mørkrid, L. and Rugstad, H.E. (1993) Metallothionein: a protein conferring resistance in vitro to tumor necrosis factor. Cancer. Res. 53, 4874-4880.
21. Li, T.Y., Kraker, A.J., Shaw, C.F. III. and Petering, D.H. (1980) Ligand substitution reactions of metallothioneins with EDTA and apo-carbonic anhydrase. Proc. Natl. Acad. Sci. USA 77, 6334-6338.
22. Mello-Filho, A.C., Chubatsu, L.S. and Meneghine, R. (1988) V79 Chinese hamster cells rendered to high cadmium concentration also became resistant to oxidative stress. Biochem. J. 256, 475-47934.
23. Renan, M.J. and Dowman, P.I. (1989) Increased resistance of tumor cells exposed to metallothinein-inducing agents. Radiat. Res. 120, 442-455.
24. Sato, M. and Bremner, I. (1993) Oxygen free radicals and metallothionein. Free Radic. Biol. Med. 14, 325-337.
25. Satoh, M., Naganuma, A. and Imura, N. (1988) Involvement of cardiac metallothionein in prevention of adriamicin induce lipid peroxidation in the heart. Toxicology 53, 231-237.
26. Templeton, D.M. and Cherian, M.G. (1991) Toxicological significance of metallothionein. In: J.F. Riordan and B.L. Vallee (Eds), Methods in Enzymology, Vol. 205, Academic Press, San Diego, Ca, pp. 11-35.
27. Thomas, J.P., Bachowski, G.L. and Girotti, A.W. (1986) Inhibition of cell membrane lipid peroxidation by cadmium and zinc-metallothionein. Biochim. Biophys. Acta 884, 448-461.
28. Thornalley, P.J. and Vasäk, M. (1985) Possible role for metallothionein in protection against radiation-induce oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochim. Biophys. Acta. 827, 36-44.