N-hydroxy-7-(2-naphthylthio) heptanomide inhibits retinal and choroidal angiogenesis

Molecular Pharmaceutics

Volumn 6, Issue 2, 2009, Pages 513-519

  Kim, Jeong Hun ^a   Kim, Jin Hyoung ^a   Oh, Meeyeon ^b   Yu, Young Suk ^a   Kim, Kyu Won ^b   Kwon, Ho Jeong ^a,b  

^a Yonsei University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

A hydroxy 7 (2 naphthylthio) heptanomide; Anti angiogenesis; Choroidal neovascularization; Histone deacetylase inhibitor; Retinal neovascularization

Indexed keywords

HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; N HYDROXY 7 (2 NAPHTHYLTHIO)HEPTANOMIDE; PROTEIN P21; TUBULIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VORINOSTAT;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG MECHANISM; FEMALE; FLUORESCENCE ANGIOGRAPHY; HUMAN; HUMAN CELL; MOUSE; NEWBORN; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA NEOVASCULARIZATION; SUBRETINAL NEOVASCULARIZATION;

ANIMALS; BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; CHOROIDAL NEOVASCULARIZATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENDOTHELIUM, VASCULAR; FEMALE; FLUORESCEIN ANGIOGRAPHY; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; IN SITU NICK-END LABELING; MICE; MICE, INBRED C57BL; NAPHTHALENES; RETINAL NEOVASCULARIZATION; UMBILICAL VEINS;

EID: 64649086747     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp800178b     Document Type: Article

References (30)

1. Folkman, J. Angiogenesis. Annu. Rev. Med. 2006, 57, 1-18.
2. Aiello, L. P. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 1994, 331, 1480-1487.
3. Risau, W. Mechanisms of angiogenesis. Nature 1997, 386, 671674.
4. Adamis, A. P.; Shima, D. T. The role of vascular endothelial growth factor in ocular health and disease. Retina 2005, 25, 111118.
5. Roth, A. M. Retinal vascular development in premature infants. Am. J. Ophthalmol. 1977, 84, 636-640.
6. Chen, J.; Smith, L. E. Retinopathy of prematurity. Angiogenesis 2007, 10, 133-140.
7. Smith, L. E. Oxygen-induced retinopathy in the mouse. Invest. Ophthalmol. Vis. Sci. 1994, 35, 101-111.
8. Pierce, E. A.; Foley, E. D.; Smith, L. E. Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity. Arch. Ophthalmol. 1996, 114, 1219-1228.
9. Macular Photocoagulation Group. Argon laser photocoagulation for neovascular maculopathy. Five-year results from randomized clinical trials. Macular Photocoagulation Study Group. Arch. Ophthalmol. 1991, 109, 1109-1114.
10. Miller, H.; Miller, B.; Ryan, S. J. The role of retinal pigment epithelium in the involution of subretinal neovascularization. Invest. Ophthalmol. Vis. Sci. 1986, 27, 1644-1652.
11. Grunstein, M. Histone acetylation in chromatin structure and transcription. Nature 1997, 389, 349-352.
12. Taunton, J.; Hassig, C. A.; Schreiber, S. L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 1996, 272, 408-411.
13. Hassig, C. A. Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell 1997, 89, 341-347.
14. Kim, M. S. Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat. Med. 2001, 7, 437443.
15. Richon, V. M. Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 5705-5708.
16. Mann, B. S. FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma. Oncologist. 2007, 12, 1247-1252.
17. Kim, D. H. Anti-tumor activity of N-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor. Biochem. Biophys. Res. Commun. 2007, 356, 233-238.
18. Haggarty, S. J. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 4389-4394.
19. Zhang, Y. HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J. 2003, 22, 1168-1179.
20. Matsuyama, A. In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J. 2002, 21, 68206831.
21. Han, J. W. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer. Res. 2000, 60, 6068-6074.
22. Archer, S. Y. p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 6791-6796.
23. Park, J. K. Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3-kinase inhibition in the human cervical cancer cell-line. Cancer Res. Treat. 2006, 38, 112-117.
24. Xiao, H.; Hasegawa, T.; Isobe, K. Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells. J. Cell. Biochem. 1999, 73, 291-302.
25. Kim, J. H. Homoisoflavanone inhibits retinal neovascularization through cell cycle arrest with decrease of cdc2 expression. Biochem. Biophys. Res. Commun. 2007, 362, 848-852.
26. Kim, J. H.; et al. Deguelin inhibits retinal neovascularization by down-regulation of HIF-1alpha in oxygen-induced retinopathy. J. Cell. Mol. Med. 2008 [Epub ahead of print].
27. Kim, J. H. Antiangiogenic effect of deguelin on choroidal neovascularization. J. Pharmacol. Exp. Ther. 2008, 324, 643647.
28. Sasakawa, Y. Antitumor efficacy of FK228, a novel histone deacetylase inhibitor, depends on the effect on expression of angiogenesis factors. Biochem. Pharmacol. 2003, 66, 897-906.
29. Deroanne, C. F. Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene 2002, 21, 427-436.
30. Min, J. K. Receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) increases vascular permeability: impaired permeability and angiogenesis in eNOS-deficient mice. Blood 2007, 109, 14951502.