Homoisoflavanone inhibits retinal neovascularization through cell cycle arrest with decrease of cdc2 expression

Biochemical and Biophysical Research Communications

Volumn 362, Issue 4, 2007, Pages 848-852

  Kim, Jeong Hun ^a,b   Kim, Ki Hyun ^c   Kim, Jin Hyoung ^d   Yu, Young Suk ^a,b   Kim, Young Myeong ^e   Kim, Kyu Won ^d   Kwon, Ho Jeong ^c  

^a Seoul National University   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c Seoul National University   (South Korea)

^d Tumor Microenvironment Global Core Research Center   (South Korea)

^e Kangwon National University   (South Korea)

Author keywords

cdc2; Cell cycle arrest; Homoisoflavanone; p21WAF1; Retinal neovascularization

Indexed keywords

CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR 1; HOMOISOFLAVONE DERIVATIVE; NATURAL PRODUCT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLINDNESS; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CREMASTRA APPENDICULATA; DIABETIC RETINOPATHY; DRUG CYTOTOXICITY; DRUG EXPOSURE; HUMAN; HUMAN CELL; MEDICINAL PLANT; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA MACULA AGE RELATED DEGENERATION; RETINA NEOVASCULARIZATION; RETROLENTAL FIBROPLASIA; VISUAL IMPAIRMENT;

ANIMALS; CDC2 PROTEIN KINASE; CELL CYCLE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMANS; INFANT, NEWBORN; ISOFLAVONES; MICE; MICE, INBRED C57BL; RETINAL NEOVASCULARIZATION; RETINOPATHY OF PREMATURITY;

CREMASTRA APPENDICULATA;

EID: 34548548894     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.08.100     Document Type: Article

References (13)

1. Folkman J. Angiogenesis. Annu. Rev. Med. 57 (2006) 1-18
2. Aiello L.P., Avery R.L., Arrigg P.G., Keyt B.A., Jampel H.D., Shah S.T., Pasquale L.R., Thieme H., Iwamoto M.A., Park J.E., Nguyen H.V., Aiello L.M., Ferrara N., and King G.L. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331 (1994) 1480-1487
3. Silverman W.A. Retrolental Fibrofibroplasia: A Modern Parable (1980), Grune & Stratton, New York, USA
4. Roth A.M. Retinal vascular development in premature infants. Am. J. Ophthalmol. 84 (1977) 636-640
5. Chen J., and Smith L.E. Retinopathy of prematurity. Angiogenesis 10 (2007) 133-140
6. Smith L.E., Wesolowski E., McLellan A., Kostyk S.K., D'Amato R., Sullivan R., and D'Amore P.A. Oxygen-induced retinopathy in the mouse. Invest. Ophthalmol. Vis. Sci. 35 (1994) 101-111
7. Shim J.S., Kim J.H., Lee J., Kim S.N., and Kwon H.J. Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata. Planta Med. 70 (2004) 171-173
8. Zhang D., Kaufman P.L., Gao G., Saunders R.A., and Ma J.X. Intravitreal injection of plasminogen kringle 5, an endogenous angiogenic inhibitor, arrests retinal neovascularization in rats. Diabetologia 44 (2001) 757-765
9. Chae S.W., Sohn J.H., Shin H.S., and Park Y.E. Expression of cyclooxygenase-2 protein in gastric carcinogenesis. Cancer Res. Treat. 34 (2002) 252-257
10. Wang S., Wu Z., Sorenson C.M., Lawler J., and Sheibani N. Thrombospondin-1-deficient mice exhibit increased vascular density during retinal vascular development and are less sensitive to hyperoxia-mediated vessel obliteration. Dev. Dyn. 228 (2003) 630-642
11. J.H. Kim, J.H. Kim, Y.S. Yu, B.H. Min, K.W. Kim, The role of clusterin in retinal development and in free radical damage, Br. J. Ophthalmol. in press.
12. Taylor W.R., DePrimo S.E., Agarwal A., Agarwal M.L., Schönthal A.H., Katula K.S., and Stark G.R. Mechanisms of G2 arrest in response to overexpression of p53. Mol. Biol. Cell. 10 (1999) 3607-3622
13. CIP1/WAF1. J. Pharmacol. Exp. Ther. 318 (2006) 142-151