Deguelin inhibits retinal neovascularization by down-regulation of HIF-1α in oxygen-induced retinopathy

Journal of Cellular and Molecular Medicine

Volumn 12, Issue 6A, 2008, Pages 2407-2415

  Kim, J H ^a   Yu, Y S ^a   Shin, J Y ^a   Lee, H Y ^b   Kim, K W ^c  

^a Seoul National University Hospital   (South Korea)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c Seoul National University   (South Korea)

Author keywords

Deguelin; HIF 1 ; Oxygen induced retinopathy; Retinal neovascularization

Indexed keywords

EID: 57149144673     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00243.x     Document Type: Article

References (22)

1. Folkman J. Angiogenesis. Annu Rev Med. 2006 57 : 1 18.
2. Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE, Nguyen HV, Aiello LM, Ferrara N, King GL. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med. 1994 331 : 1480 7.
3. Silverman WA. Retrolental Fibrofibropla-sia: A Modern Parable, New York : Grune & Stratton 1980 : 37 42.
4. Roth AM. Retinal vascular development in premature infants. Am J Ophthalmol. 1977 84 : 636 40.
5. Chen J, Smith LE. Retinopathy of Prematurity. Angiogenesis. 2007 10 : 133 40.
6. Smith LE, Wesolowski E, McLellan A, Kostyk SK, D'Amato R, Sullivan R, D'Amore PA. Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci. 1994 35 : 101 11.
7. Gerhäuser C, Mar W, Lee SK, Suh N, Luo Y, Kosmeder J, Luyengi L, Fong HH, Kinghorn AD, Moriarty RM, Mehta RG, Constantinou A, Monn RC, Pezzuto JM. Rotenoids mediatepotent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase. Nat Med. 1995 1 : 260 6.
8. Fang N, Casida JE. Anticancer action of cubé insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities. Proc Natl Acad Sci USA 1998 95 : 3380 4.
9. Gerhauser C, Lee SK, Kosmeder JW, Moriarty RM, Hamel E, Mehta RG, Moon RC, Pezzuto JM. Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent. Cancer Res. 1997 57 : 3429 35.
10. nd., Sun S, Pezzuto JM, Lotan R, Hong WK, Lee HY. Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in pre-malignant human bronchial epithelial cells. J Natl Cancer Inst. 2003 95 : 291 302.
11. Lee HY. Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells. Biochem Pharmacol. 2004 68 : 1119 24.
12. Lee HY, Suh YA, Kosmeder JW, Pezzuto JM, Hong WK, Kurie JM. Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells. Clin Cancer Res. 2004 10 : 1074 9.
13. Lee HY, Oh SH, Woo JK, Kim WY, Van Pelt CS, Price RE, Cody D, Tran H, Pezzuto JM, Moriarty RM, Hong WK. Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis. J Natl Cancer Inst. 2005 97 : 1695 9.
14. Oh SH, Woo JK, Yazici YD, Myers JN, Kim WY, Jin Q, Hong SS, Park HJ, Suh YG, Kim KW, Hong WK, Lee HY. Structural basis for depletion of heat shock protein 90 client proteins by deguelin. J Natl Cancer Inst. 2007 99 : 949 61.
15. Oh SH, Woo JK, Jin Q, Kang HJ, Jeong JW, Kim KW, Hong WK, Lee HY. Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha. Int J Cancer. 2008 122 : 5 14.
16. Zhang D, Kaufman PL, Gao G, Saunders RA, Ma JX. Intravitreal injection of plasminogen kringle 5, an endogenous angiogenic inhibitor, arrests retinal neovascularization in rats. Diabetologia. 2001 44 : 757 65.
17. Bae MK, Ahn MY, Jeong JW, Bae MH, Lee YM, Bae SK, Park JW, Kim KR, Kim KW. Jab1 interacts directly with HIF-1alpha and regulates its stability. J Biol Chem. 2002 277 : 9 12.
18. Wang S, Wu Z, Sorenson CM, Lawler J, Sheibani N. Thrombospondin-1- deficient mice exhibit increased vascular density during retinal vascular development and are less sensitive to hyperoxia-mediated vessel obliteration. Dev Dyn. 2003 228 : 630 42.
19. Kim JH, Kim JH, Yu YS, Min BH, Kim KW. The role of clusterin in retinal development and in free radical damage. Br J Ophthalmol. 2007 91 : 1541 6.
20. Connolly SE, Hores TA, Smith LE, D'Amore PA. Characterization of vascular development in the mouse retina. Microvasc Res. 1988 36 : 275 90.
21. Chan-Ling T, Gock B, Stone J. The effect of oxygen on vasoformative cell division. Evidence that 'physiological hypoxia' is the stimulus for normal retinal vasculogenesis. Invest Ophthalmol Vis Sci. 1995 36 : 1201 14.
22. Smith LE, Shen W, Perruzzi C, Soker S, Kinose F, Xu X, Robinson G, Driver S, Bischoff J, Zhang B, Schaeffer JM, Senger DR. Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor. Nat Med. 1999 5 : 1390 5.