Antiangiogenic effect of deguelin on choroidal neovascularization

Journal of Pharmacology and Experimental Therapeutics

Volumn 324, Issue 2, 2008, Pages 643-647

  Jeong, Hun Kim ^a   Jin, Hyoung Kim ^a   Young, Suk Yu ^a   Kyu, Hyung Park ^b   Hye, Jin Kang ^c   Lee, Ho Young ^d   Kim, Kyu Won ^c  

^a Seoul National University Hospital   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

^c Seoul National University   (South Korea)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGUELIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL FUNCTION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFECT; DRUG SAFETY; FLUORESCENCE ANGIOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA DISEASE; SUBRETINAL NEOVASCULARIZATION; VASCULAR ENDOTHELIUM; VISUAL IMPAIRMENT; WESTERN BLOTTING;

ANIMALS; CELLS, CULTURED; CHOROID; CHOROIDAL NEOVASCULARIZATION; FEMALE; HUMANS; MICE; MICE, INBRED C57BL; ROTENONE;

EID: 38749143267     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.132720     Document Type: Article

References (20)

1. Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE, et al. (1994) Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331:1480-1487.
2. Anzenveno PB (1979) Rotenoid interconversion: synthesis of deguelin from rotenone. J Org Chem 44:2578-2580.
3. Chun KH, Kosmeder JW 2nd, Sun S, Pezzuto JM, Lotan R, Hong WK, and Lee HY (2003) Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J Natl Cancer Inst 95:291-302.
4. Edelman JL and Castro MR (2000) Quantitative image analysis of laser-induced choroidal neovascularization in rat. Exp Eye Res 71:523-533.
5. Fang N and Casida JE (1998) Anticancer action of cubé insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities. Proc Natl Acad Sci U S A 95:3380-3384.
6. Folkman J (2006) Angiogenesis. Annu Rev Med 57:1-18.
7. Gehrs KM, Anderson DH, Johnson LV, and Hageman GS (2006) Age-related macular degeneration: emerging pathogenetic and therapeutic concepts. Ann Med 38:450-471.
8. Gerhäuser C, Lee SK, Kosmeder JW, Moriarty RM, Hamel E, Mehta RG, Moon RC, and Pezzuto JM (1997) Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent. Cancer Res 57:3429-3435.
9. Gerhäuser C, Mar W, Lee SK, Suh N, Luo Y, Kosmeder J, Luyengi L, Fong HH, Kinghorn AD, Moriarty RM, et al. (1995) Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase. Nat Med 1:260-266.
10. Klein R, Wang Q, Klein BE, Moss SE, and Meuer SM (1995) The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity. Invest Ophthalmol Vis Sci 36:182-191.
11. Lee HY (2004) Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells. Biochem Pharmacol 68:1119-1124.
12. Lee HY, Suh YA, Kosmeder JW, Pezzuto JM, Hong WK, and Kurie JM (2004) Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells. Clin Cancer Res 10:1074-1079.
13. Lee HY, Oh SH, Woo JK, Kim WY, Van Pelt CS, Price RE, Cody D, Tran H, Pezzuto JM, Moriarty RM, et al. (2005) Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis. J Natl Cancer Inst 97:1695-1699.
14. Macular Photocoagulation Group (1991) Argon laser photocoagulation for neovascular maculopathy: five-year results from randomized clinical trials. Arch Ophthalmol 109:1109-1114.
15. Marshall LE and Himes RH (1978) Rotenone inhibition of tubulin self-assembly. Biochim Biophys Acta 543:590-594.
16. Miller H, Miller B, and Ryan SJ (1986) The role of retinal pigment epithelium in the involution of subretinal neovascularization. Invest Ophthalmol Vis Sci 27:1644-1652.
17. Min JK, Cho YL, Choi JH, Kim Y, Kim JH, Yu YS, Rho J, Mochizuki N, Kim YM, Oh GT, et al. (2007) Receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) increases vascular permeability: impaired permeability and angiogenesis in eNOS-deficient mice. Blood 109:1495-1502.
18. Oh SH, Woo JK, Yazici YD, Myers JN, Kim WY, Jin Q, Hong SS, Park HJ, Suh YG, Kim KW, et al. (2007) Structural basis for depletion of heat shock protein 90 client proteins by deguelin. J Natl Cancer Inst 99:949-961.
19. Risau W (2003) Mechanism of angiogenesis. Nature 386:671-674.
20. Srivastava P and Panda D (2007) Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding. FEBS J 274:4788-4801.