Evidence for highly cooperative binding between molecular umbrella-spermine conjugates and DNA

Bioconjugate Chemistry

Volumn 8, Issue 6, 1997, Pages 891-895

  Janout, Vaclav ^a   Lanier, Marion ^a   Deng, Gang ^a   Regen, Steven L ^a  

^a LEHIGH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM CHLORIDE;

CALF THYMUS; COOPERATIVE BINDING; COOPERATIVE INTERACTIONS; HIGH SALT CONCENTRATION; HIGHLY COOPERATIVES; MELTING BEHAVIOR; SALT CONCENTRATION; SINGLE-WALLED; STRONG BINDING; SYNTHESISED;

DNA;

EID: 0031281777     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc970142r     Document Type: Article

References (10)

1. Janout, V., Lanier, M., and Regen, S. L. (1996) Molecular Umbrellas. J. Am. Chem. Soc. 118, 1573-1574.
2. Janout, V., Lanier, M., and Regen, S. L. (1997) Design and Synthesis of Molecular Umbrellas. J. Am. Chem. Soc. 119, 640-647.
3. Schmid, N., and Behr, J-P. (1991) Location of Spermine and Other Polyamines on DNA As Revealed By Photoaffinity Cleavage With Polyaminobenzenediazonium Salts. Biochemistry 30, 4357-4361.
4. Hsieh, H. P., Muller, J. G., and Burrows, C. J. (1994) Structural Effects In Novel Steroidal Polyamine-DNA Binding. J. Am. Chem. Soc. 116, 12077-12078.
5. Cain, B. F., Baguley, B. C., and Denny, W. A. (1978) Potential Antitumor Agents. 28. Deoxyribonucleic Acid Poly-intercalating Agents. J. Med. Chem. 21, 658-668.
6. Stewart, K. D. (1988) The Effect Of Structural Changes In A Polyamine Backbone On Its DNA-Binding Properties. Biochem. Biophys. Res. Commun. 152, 1441-1446.
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8. Braunlin, W. H., Strick, T. J., and Record, Jr., M. T. (1982) Equilibrium Dialysis Studies Of Polyamine Binding To DNA. Biopolymers 21, 1301-1314.
9. Mel'nikov, S. M., Sergeyev, V. G., and Yoshikawa, K. (1995) Transition Of Double-Stranded DNA Chains Between Random Coil And Globule States Induced By Cooperative Binding Of Cationic Surfactant. J. Am. Chem. Soc. 117, 9951-9956.
10. Walker, S., Sofia, M. J., Kakarla, R., Kogan, N. A., Wierichs, L., Longley, C. B., Bruker, K., Axelrod, H. R., Midha, S., Babu, S., and Kahne, D. (1996) Cationic Facial Amphiphiles: A Promising Class Of Transfection Agents. Proc. Natl. Acad. Sci. U.S.A. 93, 1585-1590.