메뉴 건너뛰기




Volumn 1, Issue 2, 2009, Pages 145-152

Anti-inflammatory effect of Momordica grosvenori Swingle extract through suppressed LPS-induced upregulation of iNOS and COX-2 in murine macrophages

Author keywords

Cyclooxygenase 2 (COX 2); Inducible NO synthesis (iNOS); Lipopolysaccharide (LPS); Mitogen activated protein (MAPK); Momordica grosvenori Swingle; NF B; Phosphatidylinositol 3 kinase (PI3K); RAW 264.7 monocyte macrophages

Indexed keywords

MOMORDICA; MURINAE;

EID: 64349124504     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2009.01.003     Document Type: Article
Times cited : (47)

References (44)
  • 1
    • 13944269898 scopus 로고    scopus 로고
    • The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin
    • Agarwal A., Das K., Lerner N., Sathe S., Cicek M., Casey G., and Sizemore N. The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. Oncogene 24 (2005) 1021-1031
    • (2005) Oncogene , vol.24 , pp. 1021-1031
    • Agarwal, A.1    Das, K.2    Lerner, N.3    Sathe, S.4    Cicek, M.5    Casey, G.6    Sizemore, N.7
  • 2
    • 0028174061 scopus 로고
    • Function and activation of NF-kappa B in the immune system
    • Baeuerle P.A., and Henkel T. Function and activation of NF-kappa B in the immune system. Annual Review of Immunology 12 (1994) 141-179
    • (1994) Annual Review of Immunology , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 3
    • 0037044792 scopus 로고    scopus 로고
    • Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo
    • Bozinovski S., Jones J.E., Vlahos R., Hamilton J.A., and Anderson G.P. Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo. Journal of Biological Chemistry 277 (2002) 42808-42814
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 42808-42814
    • Bozinovski, S.1    Jones, J.E.2    Vlahos, R.3    Hamilton, J.A.4    Anderson, G.P.5
  • 6
    • 0033020781 scopus 로고    scopus 로고
    • p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages
    • Chen C.C., and Wang J.K. p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages. Molecular Pharmacology 55 (1999) 481-488
    • (1999) Molecular Pharmacology , vol.55 , pp. 481-488
    • Chen, C.C.1    Wang, J.K.2
  • 7
    • 1642270608 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras
    • Chen Y., Vallee S., Wu J., Vu D., Sondek J., and Ghosh G. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. Molecular Cell Biology 24 (2004) 3048-3056
    • (2004) Molecular Cell Biology , vol.24 , pp. 3048-3056
    • Chen, Y.1    Vallee, S.2    Wu, J.3    Vu, D.4    Sondek, J.5    Ghosh, G.6
  • 8
    • 1642534456 scopus 로고    scopus 로고
    • PKA-dependent activation of PKC, p38 MAPK and IKK in macrophage: Implication in the induction of inducible nitric oxide synthase and interleukin-6 by dibutyryl cAMP
    • Chio C.C., Chang Y.H., Hsu Y.W., Chi K.H., and Lin W.W. PKA-dependent activation of PKC, p38 MAPK and IKK in macrophage: Implication in the induction of inducible nitric oxide synthase and interleukin-6 by dibutyryl cAMP. Cell Signal 16 (2004) 565-575
    • (2004) Cell Signal , vol.16 , pp. 565-575
    • Chio, C.C.1    Chang, Y.H.2    Hsu, Y.W.3    Chi, K.H.4    Lin, W.W.5
  • 9
    • 1542399059 scopus 로고    scopus 로고
    • Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kappaB
    • Chun K.S., Cha H.H., Shin J.W., Na H.K., Park K.K., Chung W.Y., and Surh Y.J. Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kappaB. Carcinogenesis 25 (2004) 445-454
    • (2004) Carcinogenesis , vol.25 , pp. 445-454
    • Chun, K.S.1    Cha, H.H.2    Shin, J.W.3    Na, H.K.4    Park, K.K.5    Chung, W.Y.6    Surh, Y.J.7
  • 11
    • 0029954682 scopus 로고    scopus 로고
    • Heat shock protein 70 suppresses astroglial-inducible nitric-oxide synthase expression by decreasing NFkappaB activation
    • Feinstein D.L., Galea E., Aquino D.A., Li G.C., Xu H., and Reis D.J. Heat shock protein 70 suppresses astroglial-inducible nitric-oxide synthase expression by decreasing NFkappaB activation. Journal of Biological Chemistry 271 (1996) 17724-17732
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 17724-17732
    • Feinstein, D.L.1    Galea, E.2    Aquino, D.A.3    Li, G.C.4    Xu, H.5    Reis, D.J.6
  • 13
    • 0030843887 scopus 로고    scopus 로고
    • Functional coupling of endogenous serotonin (5-HT1B) and calcitonin (C1a) receptors in CHO cells to a cyclic AMP-responsive luciferase reporter gene
    • George S.E., Bungay P.J., and Naylor L.H. Functional coupling of endogenous serotonin (5-HT1B) and calcitonin (C1a) receptors in CHO cells to a cyclic AMP-responsive luciferase reporter gene. Journal of Neurochemistry 69 (1997) 1278-1285
    • (1997) Journal of Neurochemistry , vol.69 , pp. 1278-1285
    • George, S.E.1    Bungay, P.J.2    Naylor, L.H.3
  • 14
    • 0029912242 scopus 로고    scopus 로고
    • Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B
    • Griscavage J.M., Wilk S., and Ignarro L.J. Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B. Proceedings of the National Academy of Sciences USA 93 (1996) 3308-3312
    • (1996) Proceedings of the National Academy of Sciences USA , vol.93 , pp. 3308-3312
    • Griscavage, J.M.1    Wilk, S.2    Ignarro, L.J.3
  • 15
    • 0345690083 scopus 로고    scopus 로고
    • Lipopolysaccharide activates Akt in vascular smooth muscle cells resulting in induction of inducible nitric oxide synthase through nuclear factor-kappa B activation
    • Hattori Y., Hattori S., and Kasai K. Lipopolysaccharide activates Akt in vascular smooth muscle cells resulting in induction of inducible nitric oxide synthase through nuclear factor-kappa B activation. European Journal of Pharmacology 481 (2003) 153-158
    • (2003) European Journal of Pharmacology , vol.481 , pp. 153-158
    • Hattori, Y.1    Hattori, S.2    Kasai, K.3
  • 16
    • 1942472468 scopus 로고    scopus 로고
    • The anti-inflammatory carbazole, LCY-2-CHO, inhibits lipopolysaccharide-induced inflammatory mediator expression through inhibition of the p38 mitogen-activated protein kinase signaling pathway in macrophages
    • Ho F.M., Lai C.C., Huang L.J., Kuo T.C., Chao C.M., and Lin W.W. The anti-inflammatory carbazole, LCY-2-CHO, inhibits lipopolysaccharide-induced inflammatory mediator expression through inhibition of the p38 mitogen-activated protein kinase signaling pathway in macrophages. British Journal of Pharmacology 141 (2004) 1037-1047
    • (2004) British Journal of Pharmacology , vol.141 , pp. 1037-1047
    • Ho, F.M.1    Lai, C.C.2    Huang, L.J.3    Kuo, T.C.4    Chao, C.M.5    Lin, W.W.6
  • 17
    • 2442693082 scopus 로고    scopus 로고
    • NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway
    • Je J.H., Lee J.Y., Jung K.J., Sung B., Go E.K., Yu B.P., and Chung H.Y. NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway. FEBS Letters 566 (2004) 183-189
    • (2004) FEBS Letters , vol.566 , pp. 183-189
    • Je, J.H.1    Lee, J.Y.2    Jung, K.J.3    Sung, B.4    Go, E.K.5    Yu, B.P.6    Chung, H.Y.7
  • 18
    • 0029071790 scopus 로고
    • Chloromethyl ketones block induction of nitric oxide synthase in murine macrophages by preventing activation of nuclear factor-kappa B
    • Kim H., Lee H.S., Chang K.T., Ko T.H., Baek K.J., and Kwon N.S. Chloromethyl ketones block induction of nitric oxide synthase in murine macrophages by preventing activation of nuclear factor-kappa B. Journal of Immunology 154 (1995) 4741-4748
    • (1995) Journal of Immunology , vol.154 , pp. 4741-4748
    • Kim, H.1    Lee, H.S.2    Chang, K.T.3    Ko, T.H.4    Baek, K.J.5    Kwon, N.S.6
  • 19
    • 20444462829 scopus 로고    scopus 로고
    • Induction of proinflammatory mediators requires activation of the TRAF, NIK, IKK and NF-kappaB signal transduction pathway in astrocytes infected with Escherichia coli
    • Kim J.M., Oh Y.K., Lee J.H., Im D.Y., Kim Y.J., Youn J., Lee C.H., Son H., Lee Y.S., Park J.Y., and Choi I.H. Induction of proinflammatory mediators requires activation of the TRAF, NIK, IKK and NF-kappaB signal transduction pathway in astrocytes infected with Escherichia coli. Clinical and Experimental Immunology 140 (2005) 450-460
    • (2005) Clinical and Experimental Immunology , vol.140 , pp. 450-460
    • Kim, J.M.1    Oh, Y.K.2    Lee, J.H.3    Im, D.Y.4    Kim, Y.J.5    Youn, J.6    Lee, C.H.7    Son, H.8    Lee, Y.S.9    Park, J.Y.10    Choi, I.H.11
  • 21
    • 0030894288 scopus 로고    scopus 로고
    • Prostaglandin H synthases, nonsteroidal anti-inflammatory drugs, and colon cancer
    • Levy G.N. Prostaglandin H synthases, nonsteroidal anti-inflammatory drugs, and colon cancer. FASEB Journal 11 (1997) 234-247
    • (1997) FASEB Journal , vol.11 , pp. 234-247
    • Levy, G.N.1
  • 22
    • 0006812769 scopus 로고
    • Potential genotoxicity of chronically elevated nitric oxide: A review
    • Liu R.H., and Hotchkiss J.H. Potential genotoxicity of chronically elevated nitric oxide: A review. Mutation Research 339 (1995) 73-89
    • (1995) Mutation Research , vol.339 , pp. 73-89
    • Liu, R.H.1    Hotchkiss, J.H.2
  • 24
    • 0025883342 scopus 로고
    • Nitric oxide: Physiology, pathophysiology, and pharmacology
    • Moncada S., Palmer R.M., and Higgs E.A. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacological Reviews 43 (1991) 109-142
    • (1991) Pharmacological Reviews , vol.43 , pp. 109-142
    • Moncada, S.1    Palmer, R.M.2    Higgs, E.A.3
  • 25
    • 0028092958 scopus 로고
    • Nitric oxide synthases: Roles, tolls, and controls
    • Nathan C., and Xie Q.W. Nitric oxide synthases: Roles, tolls, and controls. Cell 78 (1994) 915-918
    • (1994) Cell , vol.78 , pp. 915-918
    • Nathan, C.1    Xie, Q.W.2
  • 26
    • 38449107785 scopus 로고    scopus 로고
    • Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation
    • Nicholas C., Batra S., Vargo M.A., Voss O.H., Gavrilin M.A., Wewers M.D., Guttridge D.C., Grotewold E., and Doseff A.I. Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation. Journal of Immunology 179 (2007) 7121-7127
    • (2007) Journal of Immunology , vol.179 , pp. 7121-7127
    • Nicholas, C.1    Batra, S.2    Vargo, M.A.3    Voss, O.H.4    Gavrilin, M.A.5    Wewers, M.D.6    Guttridge, D.C.7    Grotewold, E.8    Doseff, A.I.9
  • 28
    • 19844380348 scopus 로고    scopus 로고
    • Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis
    • Nosho K., Yoshida M., Yamamoto H., Taniguchi H., Adachi Y., Mikami M., Hinoda Y., and Imai K. Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. Carcinogenesis 26 (2005) 892-899
    • (2005) Carcinogenesis , vol.26 , pp. 892-899
    • Nosho, K.1    Yoshida, M.2    Yamamoto, H.3    Taniguchi, H.4    Adachi, Y.5    Mikami, M.6    Hinoda, Y.7    Imai, K.8
  • 29
    • 33750023475 scopus 로고    scopus 로고
    • Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice
    • Pan M.H., Lai C.S., Wang Y.J., and Ho C.T. Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. Biochemical Pharmacology 72 (2006) 1293-1303
    • (2006) Biochemical Pharmacology , vol.72 , pp. 1293-1303
    • Pan, M.H.1    Lai, C.S.2    Wang, Y.J.3    Ho, C.T.4
  • 30
    • 0033976073 scopus 로고    scopus 로고
    • Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages
    • Pan M.H., Lin-Shiau S.Y., Ho C.T., Lin J.H., and Lin J.K. Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages. Biochemical Pharmacology 59 (2000) 357-367
    • (2000) Biochemical Pharmacology , vol.59 , pp. 357-367
    • Pan, M.H.1    Lin-Shiau, S.Y.2    Ho, C.T.3    Lin, J.H.4    Lin, J.K.5
  • 31
    • 0028935270 scopus 로고
    • Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    • Raingeaud J., Gupta S., Rogers J.S., Dickens M., Han J., Ulevitch R.J., and Davis R.J. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. Journal of Biological Chemistry 270 (1995) 7420-7426
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 7420-7426
    • Raingeaud, J.1    Gupta, S.2    Rogers, J.S.3    Dickens, M.4    Han, J.5    Ulevitch, R.J.6    Davis, R.J.7
  • 32
    • 0031961752 scopus 로고    scopus 로고
    • Stimulation of inducible nitric oxide synthase in rat liver by hyaluronan fragments
    • Rockey D.C., Chung J.J., McKee C.M., and Noble P.W. Stimulation of inducible nitric oxide synthase in rat liver by hyaluronan fragments. Hepatology 27 (1998) 86-92
    • (1998) Hepatology , vol.27 , pp. 86-92
    • Rockey, D.C.1    Chung, J.J.2    McKee, C.M.3    Noble, P.W.4
  • 33
    • 19344363575 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-kinase in response to inflammation and nitric oxide leads to the up-regulation of cyclooxygenase-2 expression and subsequent cell proliferation in mesangial cells
    • Sheu M.L., Chao K.F., Sung Y.J., Lin W.W., Lin-Shiau S.Y., and Liu S.H. Activation of phosphoinositide 3-kinase in response to inflammation and nitric oxide leads to the up-regulation of cyclooxygenase-2 expression and subsequent cell proliferation in mesangial cells. Cell Signal 17 (2005) 975-984
    • (2005) Cell Signal , vol.17 , pp. 975-984
    • Sheu, M.L.1    Chao, K.F.2    Sung, Y.J.3    Lin, W.W.4    Lin-Shiau, S.Y.5    Liu, S.H.6
  • 34
    • 11844281509 scopus 로고    scopus 로고
    • Siraitic acid F, a new nor-cucurbitacin with novel skeleton, from the roots of Siraitia grosvenorii
    • Si J.Y., Chen D.H., and Tu G.Z. Siraitic acid F, a new nor-cucurbitacin with novel skeleton, from the roots of Siraitia grosvenorii. Journal of Asian Natural Products Research 7 (2005) 37-41
    • (2005) Journal of Asian Natural Products Research , vol.7 , pp. 37-41
    • Si, J.Y.1    Chen, D.H.2    Tu, G.Z.3
  • 35
    • 0033038491 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit
    • Sizemore N., Leung S., and Stark G.R. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Molecular and Cellular Biology 19 (1999) 4798-4805
    • (1999) Molecular and Cellular Biology , vol.19 , pp. 4798-4805
    • Sizemore, N.1    Leung, S.2    Stark, G.R.3
  • 36
    • 33746021379 scopus 로고    scopus 로고
    • A natural sweetener, Momordica grosvenori, attenuates the imbalance of cellular immune functions in alloxan-induced diabetic mice
    • Song F., Chen W., Jia W., Yao P., Nussler A.K., Sun X., and Liu L. A natural sweetener, Momordica grosvenori, attenuates the imbalance of cellular immune functions in alloxan-induced diabetic mice. Phytotherapy Research 20 (2006) 552-560
    • (2006) Phytotherapy Research , vol.20 , pp. 552-560
    • Song, F.1    Chen, W.2    Jia, W.3    Yao, P.4    Nussler, A.K.5    Sun, X.6    Liu, L.7
  • 37
    • 33847091174 scopus 로고    scopus 로고
    • Effect of Momordica grosvenori on oxidative stress pathways in renal mitochondria of normal and alloxan-induced diabetic mice. Involvement of heme oxygenase-1
    • Song F., Qi X., Chen W., Jia W., Yao P., Nussler A.K., Sun X., and Liu L. Effect of Momordica grosvenori on oxidative stress pathways in renal mitochondria of normal and alloxan-induced diabetic mice. Involvement of heme oxygenase-1. European Journal of Nutrition 46 (2007) 61-69
    • (2007) European Journal of Nutrition , vol.46 , pp. 61-69
    • Song, F.1    Qi, X.2    Chen, W.3    Jia, W.4    Yao, P.5    Nussler, A.K.6    Sun, X.7    Liu, L.8
  • 39
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh Y.J. Cancer chemoprevention with dietary phytochemicals. Nature Reviews Cancer 3 (2003) 768-780
    • (2003) Nature Reviews Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 41
    • 0037032289 scopus 로고    scopus 로고
    • Inhibitory effects of cucurbitane glycosides and other triterpenoids from the fruit of Momordica grosvenori on epstein-barr virus early antigen induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate
    • Ukiya M., Akihisa T., Tokuda H., Toriumi M., Mukainaka T., Banno N., Kimura Y., Hasegawa J., and Nishino H. Inhibitory effects of cucurbitane glycosides and other triterpenoids from the fruit of Momordica grosvenori on epstein-barr virus early antigen induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Journal of Agricultural and Food Chemistry 50 (2002) 6710-6715
    • (2002) Journal of Agricultural and Food Chemistry , vol.50 , pp. 6710-6715
    • Ukiya, M.1    Akihisa, T.2    Tokuda, H.3    Toriumi, M.4    Mukainaka, T.5    Banno, N.6    Kimura, Y.7    Hasegawa, J.8    Nishino, H.9
  • 42
    • 0027939931 scopus 로고
    • Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase
    • Xie Q.W., Kashiwabara Y., and Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. Journal of Biological Chemistry 269 (1994) 4705-4708
    • (1994) Journal of Biological Chemistry , vol.269 , pp. 4705-4708
    • Xie, Q.W.1    Kashiwabara, Y.2    Nathan, C.3
  • 43
    • 0037851769 scopus 로고    scopus 로고
    • IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide
    • Yang F., Tang E., Guan K., and Wang C.Y. IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. Journal of Immunology 170 (2003) 5630-5635
    • (2003) Journal of Immunology , vol.170 , pp. 5630-5635
    • Yang, F.1    Tang, E.2    Guan, K.3    Wang, C.Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.