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Volumn 1, Issue 5, 2002, Pages 351-371

Letrozole: An updated review of its use in postmenopausal women with advanced breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLUTETHIMIDE; ANASTROZOLE; AROMATASE INHIBITOR; CORTICOSTEROID; ESTRADIOL; ESTROGEN; ESTRONE; ESTRONE SULFATE; EXEMESTANE; FADROZOLE; FORMESTANE; LETROZOLE; MEGESTROL; TAMOXIFEN;

EID: 0042378908     PISSN: 11756357     EISSN: None     Source Type: Journal    
DOI: 10.2165/00024669-200201050-00007     Document Type: Review
Times cited : (8)

References (85)
  • 1
    • 0032790550 scopus 로고    scopus 로고
    • Comprehensive pharmacology and clinical efficacy of aromatase inhibitors
    • Njar VCO, Brodie AMH. Comprehensive pharmacology and clinical efficacy of aromatase inhibitors. Drugs 1999; 58: 233-55
    • (1999) Drugs , vol.58 , pp. 233-255
    • Njar, V.C.O.1    Brodie, A.M.H.2
  • 2
    • 0035945656 scopus 로고    scopus 로고
    • Estrogens and the risk of breast cancer
    • Jan 25
    • Clemons M, Goss P. Estrogens and the risk of breast cancer, N Engl J Med 2001 Jan 25; 344 (4): 276-85
    • (2001) N Engl J Med , vol.344 , Issue.4 , pp. 276-285
    • Clemons, M.1    Goss, P.2
  • 3
    • 0034016627 scopus 로고    scopus 로고
    • New generation aromatase inhibitors in breast cancer
    • Feb
    • Higa GM. New generation aromatase inhibitors in breast cancer. Pharmacoeconomics 2000 Feb; 17 (2): 121-32
    • (2000) Pharmacoeconomics , vol.17 , Issue.2 , pp. 121-132
    • Higa, G.M.1
  • 4
    • 0034984594 scopus 로고    scopus 로고
    • Endocrine therapy in the treatment of metastatic breast cancer
    • Jun
    • Buzdar AU. Endocrine therapy in the treatment of metastatic breast cancer. Semin Oncol 2001 Jun; 28 (3): 291-304
    • (2001) Semin Oncol , vol.28 , Issue.3 , pp. 291-304
    • Buzdar, A.U.1
  • 5
    • 0032420836 scopus 로고    scopus 로고
    • Letrozole: A review of its use in postmenopausal women with advanced breast cancer
    • Lamb HM, Adkins JC. Letrozole: a review of its use in postmenopausal women with advanced breast cancer, Drugs 1998; 56: 1125-40
    • (1998) Drugs , vol.56 , pp. 1125-1140
    • Lamb, H.M.1    Adkins, J.C.2
  • 6
    • 0036304429 scopus 로고    scopus 로고
    • Approval summary: Letrozole in the treatment of posrmenopausal women with advanced breast cancer
    • Mar
    • Cohen MH, Johnson JR, Li N, et al. Approval summary: letrozole in the treatment of posrmenopausal women with advanced breast cancer. Clin Cancer Res 2002 Mar; 8 (3): 665-9
    • (2002) Clin Cancer Res , vol.8 , Issue.3 , pp. 665-669
    • Cohen, M.H.1    Johnson, J.R.2    Li, N.3
  • 7
    • 0035692576 scopus 로고    scopus 로고
    • Preoperative treatment of postmenopausal breast cancer patients with letrozole: A randomized double-blind multicenter study
    • Nov
    • Eiermann W, Paepke S, Appfelstaedt J, et al. Preoperative treatment of postmenopausal breast cancer patients with letrozole: a randomized double-blind multicenter study. Ann Oncol 2001 Nov; 12 (11): 1527-32
    • (2001) Ann Oncol , vol.12 , Issue.11 , pp. 1527-1532
    • Eiermann, W.1    Paepke, S.2    Appfelstaedt, J.3
  • 8
    • 0035884620 scopus 로고    scopus 로고
    • Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: Evidence from a phase III randomized trial
    • Sep
    • Ellis MJ, Coop A, Singh B, et al. Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial. J Clin Oncol 2001 Sep; 19 (18): 3808-16
    • (2001) J Clin Oncol , vol.19 , Issue.18 , pp. 3808-3816
    • Ellis, M.J.1    Coop, A.2    Singh, B.3
  • 9
    • 0034913582 scopus 로고    scopus 로고
    • Letrozole as primary medical therapy for locally advanced and large operable breast cancer
    • Apr
    • Dixon JM, Love CDB, Bellamy COC, et al. Letrozole as primary medical therapy for locally advanced and large operable breast cancer. Breast Cancer Res Treat 2001 Apr; 66: 191-9
    • (2001) Breast Cancer Res Treat , vol.66 , pp. 191-199
    • Dixon, J.M.1    Love, C.D.B.2    Bellamy, C.O.C.3
  • 10
    • 0036098473 scopus 로고    scopus 로고
    • Letrozole in the treatment of breast cancer
    • May
    • Shaw HS, Ellis MJ. Letrozole in the treatment of breast cancer. Expert Opin Pharmacother 2002 May; 3 (5): 607-17
    • (2002) Expert Opin Pharmacother , vol.3 , Issue.5 , pp. 607-617
    • Shaw, H.S.1    Ellis, M.J.2
  • 11
    • 0032854914 scopus 로고    scopus 로고
    • Risks and benefits of aromatase inhibitors in postmenopausal breast cancer
    • Michaud LB, Buzdar AU. Risks and benefits of aromatase inhibitors in postmenopausal breast cancer. Drug Saf 1999; 21: 297-309
    • (1999) Drug Saf , vol.21 , pp. 297-309
    • Michaud, L.B.1    Buzdar, A.U.2
  • 12
    • 0032974458 scopus 로고    scopus 로고
    • Biology of aromatase inhibitors: Pharmacology/endocrinology within the breast
    • Miller WR. Biology of aromatase inhibitors: pharmacology/endocrinology within the breast. Endocr. Relat. Cancer. 1999; 6: 187-95
    • (1999) Endocr. Relat. Cancer , vol.6 , pp. 187-195
    • Miller, W.R.1
  • 13
    • 0035716365 scopus 로고    scopus 로고
    • Local endocrine effects of aromatase inhibitors within the breast
    • Dec
    • Miller WR, Dixon JM. Local endocrine effects of aromatase inhibitors within the breast. J Steroid Biochem Mol Biol 2001 Dec; 79 (1-5): 93-102
    • (2001) J Steroid Biochem Mol Biol , vol.79 , Issue.1-5 , pp. 93-102
    • Miller, W.R.1    Dixon, J.M.2
  • 14
    • 0000138390 scopus 로고    scopus 로고
    • Pharmacology of nonsteroidal aromatase inhibitors
    • Pasqualini JR, Katzenellenbogen BS. editors. New York: Marcel Dekker. Inc.
    • Bhatnagar AS, Batzl C, Häusler A, et al. Pharmacology of nonsteroidal aromatase inhibitors. In: Pasqualini JR, Katzenellenbogen BS. editors. Hormone-dependent cancer. New York: Marcel Dekker. Inc., 1996: 155-68
    • (1996) Hormone-Dependent Cancer , pp. 155-168
    • Bhatnagar, A.S.1    Batzl, C.2    Häusler, A.3
  • 15
    • 0030013560 scopus 로고    scopus 로고
    • Binding characteristics of seven inhibitors of human aromatase: A site-directed mutagenesis study
    • Kao Y-C, Cam LL, Laughton CA, et al. Binding characteristics of seven inhibitors of human aromatase: a site-directed mutagenesis study. Cancer Res 1996; 56: 3451-60
    • (1996) Cancer Res , vol.56 , pp. 3451-3460
    • Kao, Y.-C.1    Cam, L.L.2    Laughton, C.A.3
  • 16
    • 0028838392 scopus 로고
    • The potent and selective inhibition of estrogen production by non-steroidal aromatase inhibitor, YM511
    • Kudoh M, Susaki Y, Ideyama Y, et al. The potent and selective inhibition of estrogen production by non-steroidal aromatase inhibitor, YM511. J Steroid Biochem Mol Biol 1995; 54: 265-71
    • (1995) J Steroid Biochem Mol Biol , vol.54 , pp. 265-271
    • Kudoh, M.1    Susaki, Y.2    Ideyama, Y.3
  • 17
    • 0029560237 scopus 로고
    • In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in postmenopausal patients with breast cancer
    • Dowsett M, Jones A, Johnston SRD, et al. In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in postmenopausal patients with breast cancer. Clin Cancer Res 1995; 1: 1511-5
    • (1995) Clin Cancer Res , vol.1 , pp. 1511-1515
    • Dowsett, M.1    Jones, A.2    Johnston, S.R.D.3
  • 18
    • 0030057071 scopus 로고    scopus 로고
    • Pharmacology of new aromatase inhibitors
    • Lønning PE. Pharmacology of new aromatase inhibitors. Breast 1996; 5 (3): 202-8
    • (1996) Breast , vol.5 , Issue.3 , pp. 202-208
    • Lønning, P.E.1
  • 19
    • 0036467847 scopus 로고    scopus 로고
    • Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study
    • Feb 1
    • Geisler J, Haynes B, Anker G, et al. Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study. J Clin Oncol 2002 Feb 1; 20 (3): 751-7
    • (2002) J Clin Oncol , vol.20 , Issue.3 , pp. 751-757
    • Geisler, J.1    Haynes, B.2    Anker, G.3
  • 20
    • 0027228206 scopus 로고
    • Phase I study of the oral nonsteroidal aromatase inhibitor CGS 20267 in healthy postmenopausal women
    • Iveson TJ, Smith IE, Ahern J, et al. Phase I study of the oral nonsteroidal aromatase inhibitor CGS 20267 in healthy postmenopausal women. J Clin Endocrinol Metab 1993; 77: 324-31
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 324-331
    • Iveson, T.J.1    Smith, I.E.2    Ahern, J.3
  • 21
    • 0027535830 scopus 로고
    • Phase I study of the oral nonsteroidal aromatase inhibitor CGS 20267 in postmenopausal patients with advanced breast cancer
    • Iveson TJ, Smith IE, Ahern J, et al. Phase I study of the oral nonsteroidal aromatase inhibitor CGS 20267 in postmenopausal patients with advanced breast cancer. Cancer Res 1993; 53: 266-70
    • (1993) Cancer Res , vol.53 , pp. 266-270
    • Iveson, T.J.1    Smith, I.E.2    Ahern, J.3
  • 22
    • 0028943384 scopus 로고
    • Letrozole (CGS 20267): A phase I study of a new potent oral aromatase inhibitor of breast cancer
    • Lipton A, Demers LM, Harvey HA, et al. Letrozole (CGS 20267): a phase I study of a new potent oral aromatase inhibitor of breast cancer. Cancer 1995; 75: 2132-8
    • (1995) Cancer , vol.75 , pp. 2132-2138
    • Lipton, A.1    Demers, L.M.2    Harvey, H.A.3
  • 23
    • 0027992634 scopus 로고
    • Effects of fadrozole (CGS 16949A) and letrozole (CGS 20267) on the inhibition of aromatase activity in breast cancer patients
    • Demers LM. Effects of fadrozole (CGS 16949A) and letrozole (CGS 20267) on the inhibition of aromatase activity in breast cancer patients. Breast Cancer Res Treat 1994; 30 (1): 95-102
    • (1994) Breast Cancer Res Treat , vol.30 , Issue.1 , pp. 95-102
    • Demers, L.M.1
  • 24
    • 0029114143 scopus 로고
    • Use of ultrasensitive recombinant cell bioassay to measure estrogen levels in women with breast cancer receiving the aromatase inhibitor, letrozole
    • Klein KO, Demers LM, Santner SJ, et al. Use of ultrasensitive recombinant cell bioassay to measure estrogen levels in women with breast cancer receiving the aromatase inhibitor, letrozole. J Clin Endocrinol Metab 1995; 80: 2658-60
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 2658-2660
    • Klein, K.O.1    Demers, L.M.2    Santner, S.J.3
  • 25
    • 0032711815 scopus 로고    scopus 로고
    • The effect of combining aromatase inhibitors with antiestrogens on tumor growth in a nude mouse model for breast cancer
    • Lu Q, Liu Y, Long BJ, et al. The effect of combining aromatase inhibitors with antiestrogens on tumor growth in a nude mouse model for breast cancer. Breast Cancer Res Treat 1999; 57: 183-92
    • (1999) Breast Cancer Res Treat , vol.57 , pp. 183-192
    • Lu, Q.1    Liu, Y.2    Long, B.J.3
  • 26
    • 0031720769 scopus 로고    scopus 로고
    • Intratumoral aromatase model: The effects of letrozole (CGS 20267)
    • Brodie A, Lu Q, Yue W, et al. Intratumoral aromatase model: the effects of letrozole (CGS 20267). Breast Cancer Res Treat 1998; 49 (Suppl.): S23-6
    • (1998) Breast Cancer Res Treat , vol.49 , Issue.SUPPL.
    • Brodie, A.1    Lu, Q.2    Yue, W.3
  • 27
    • 0029032231 scopus 로고
    • Effect of aromatase inhibitors on growth of mammary tumors in a nude mouse model
    • Yue W, Wang J, Savinov A, et al. Effect of aromatase inhibitors on growth of mammary tumors in a nude mouse model. Cancer Res 1995; 55: 3073-7
    • (1995) Cancer Res , vol.55 , pp. 3073-3077
    • Yue, W.1    Wang, J.2    Savinov, A.3
  • 28
    • 0031726080 scopus 로고    scopus 로고
    • The effects of aromatase inhibitors and antiestrogens in the nude mouse model
    • Lu Q, Yue W, Wang J, et al. The effects of aromatase inhibitors and antiestrogens in the nude mouse model. Breast Cancer Res Treat 1998; 50: 63-71
    • (1998) Breast Cancer Res Treat , vol.50 , pp. 63-71
    • Lu, Q.1    Yue, W.2    Wang, J.3
  • 29
    • 0035992421 scopus 로고    scopus 로고
    • The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: Long-term studies using the intratumoral aromatase postmenopausal breast cancer model
    • Jul
    • Long BJ, Jelovac D, Thiantanawat A, et al. The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: long-term studies using the intratumoral aromatase postmenopausal breast cancer model. Clin Cancer Res 2002 Jul; 8 (7): 2378-88
    • (2002) Clin Cancer Res , vol.8 , Issue.7 , pp. 2378-2388
    • Long, B.J.1    Jelovac, D.2    Thiantanawat, A.3
  • 30
    • 0001698675 scopus 로고    scopus 로고
    • The effect of alternating letrozole and tamoxifen in comparison to sequential treatment with each drug alone or in combination
    • Oct
    • Long BJ, Jelovac D, Thiantanawat A, et al. The effect of alternating letrozole and tamoxifen in comparison to sequential treatment with each drug alone or in combination [abstract no. 444 and poster]. Breast Cancer Res Treat 2001 Oct; 69 (3): 287
    • (2001) Breast Cancer Res Treat , vol.69 , Issue.3 , pp. 287
    • Long, B.J.1    Jelovac, D.2    Thiantanawat, A.3
  • 31
    • 0027230575 scopus 로고
    • Anti-tumor and endocrine effects of non-steroidal aromatase inhibitors on estrogen-dependent rat mamniary tomors
    • Schieweck K, Bhatnagar AS, Batzl C, et al. Anti-tumor and endocrine effects of non-steroidal aromatase inhibitors on estrogen-dependent rat mamniary tomors. J Steroid Biochem Mol Biol 1993; 44: 633-6
    • (1993) J Steroid Biochem Mol Biol , vol.44 , pp. 633-636
    • Schieweck, K.1    Bhatnagar, A.S.2    Batzl, C.3
  • 32
    • 0033082373 scopus 로고    scopus 로고
    • Double-blind, randomised, multicentre endocrine trial comparing two letrozole doses, in postmenopausal breast cancer patients
    • Bajetta E, Zilembo N, Dowsett M, et al. Double-blind, randomised, multicentre endocrine trial comparing two letrozole doses, in postmenopausal breast cancer patients. Eur J Cancer 1999; 35: 208-13
    • (1999) Eur J Cancer , vol.35 , pp. 208-213
    • Bajetta, E.1    Zilembo, N.2    Dowsett, M.3
  • 33
    • 0036133521 scopus 로고    scopus 로고
    • Role of low levels of endogenous estrogen in regulation of bone resorption in late postmenopausal women
    • Jan
    • Heshmati HM, Khosla S, Robins SP, et al. Role of low levels of endogenous estrogen in regulation of bone resorption in late postmenopausal women. J Bone Miner Res 2002 Jan; 17 (1): 172-8
    • (2002) J Bone Miner Res , vol.17 , Issue.1 , pp. 172-178
    • Heshmati, H.M.1    Khosla, S.2    Robins, S.P.3
  • 34
    • 0036317949 scopus 로고    scopus 로고
    • Effects of the aromatase inhibitor letrozole on normal breast epithelial cell proliferation and metabolic indices in postmenopausal women: A pilot study for breast cancer prevention
    • Jul
    • Harper-Wynne C, Ross G, Sacks N, et al. Effects of the aromatase inhibitor letrozole on normal breast epithelial cell proliferation and metabolic indices in postmenopausal women: a pilot study for breast cancer prevention. Cancer Epidemiol Biomarkers Prev 2002 Jul; 11 (7): 614-21
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , Issue.7 , pp. 614-621
    • Harper-Wynne, C.1    Ross, G.2    Sacks, N.3
  • 35
    • 0034885923 scopus 로고    scopus 로고
    • Effect of letrozole on the lipid profile in postmenopausal women with breast cancer
    • Elisal MS, Bairaktari ET, Nicolaides C, et al. Effect of letrozole on the lipid profile in postmenopausal women with breast cancer. Eur J Cancer 2001; 37: 1510-3
    • (2001) Eur J Cancer , vol.37 , pp. 1510-1513
    • Elisal, M.S.1    Bairaktari, E.T.2    Nicolaides, C.3
  • 37
    • 0035207127 scopus 로고    scopus 로고
    • Effect of age and single versus multiple dose pharmacokinetics of letrozole (Femara) in breast cancer patients
    • Jul
    • Pfister CU, Martoni A, Zamagni C, et al. Effect of age and single versus multiple dose pharmacokinetics of letrozole (Femara) in breast cancer patients. Biopharm Drug Dispos 2001 Jul; 22 (5): 191-7
    • (2001) Biopharm Drug Dispos , vol.22 , Issue.5 , pp. 191-197
    • Pfister, C.U.1    Martoni, A.2    Zamagni, C.3
  • 38
    • 0030662215 scopus 로고    scopus 로고
    • Absolute bioavailability of letrozole in healthy postmenopausal women
    • Sioufi A, Gauducheau N, Pineau V, et al. Absolute bioavailability of letrozole in healthy postmenopausal women, Biopharm Drug Dispos 1997; 18: 779-89
    • (1997) Biopharm Drug Dispos , vol.18 , pp. 779-789
    • Sioufi, A.1    Gauducheau, N.2    Pineau, V.3
  • 39
    • 0031840443 scopus 로고    scopus 로고
    • Plasma protein binding of letrozole, a new nonsteroidal aromatase enzyme inhibitor
    • Colussi DM, Parisot CY, Lefevre GY. Plasma protein binding of letrozole, a new nonsteroidal aromatase enzyme inhibitor. J Clin Pharmacol 1998; 38: 727-35
    • (1998) J Clin Pharmacol , vol.38 , pp. 727-735
    • Colussi, D.M.1    Parisot, C.Y.2    Lefevre, G.Y.3
  • 40
    • 0030758005 scopus 로고    scopus 로고
    • Comparative bioavailability of letrozole under fed and fasting conditions in 12 healthy subjects after a 2.5 mg single oral administration
    • Sioufi A, Sandrenan N, Godbillon J, et al. Comparative bioavailability of letrozole under fed and fasting conditions in 12 healthy subjects after a 2. 5 mg single oral administration. Biopharm Drug Dispos 1997; 18: 489-97
    • (1997) Biopharm Drug Dispos , vol.18 , pp. 489-497
    • Sioufi, A.1    Sandrenan, N.2    Godbillon, J.3
  • 44
    • 0032836573 scopus 로고    scopus 로고
    • Impact of tamoxifen on the pharmacokinetics and endocrine effects of the aromatase inhibitor letrozole in postmenopausal women with breast cancer
    • Dowsett M, Pfister C, Johnston SR, et al. Impact of tamoxifen on the pharmacokinetics and endocrine effects of the aromatase inhibitor letrozole in postmenopausal women with breast cancer. Clin Cancer Res 1999; 5: 2338-43
    • (1999) Clin Cancer Res , vol.5 , pp. 2338-2343
    • Dowsett, M.1    Pfister, C.2    Johnston, S.R.3
  • 45
    • 0032765869 scopus 로고    scopus 로고
    • Evaluation of tamoxifen plus letrozole with assessment of pharmacokinetic interaction in postmenopausal women with metastatic breast cancer
    • Ingle JN, Suman VJ, Johnson PA, et al. Evaluation of tamoxifen plus letrozole with assessment of pharmacokinetic interaction in postmenopausal women with metastatic breast cancer. Clin Cancer Res 1999; 5: 1642-9
    • (1999) Clin Cancer Res , vol.5 , pp. 1642-1649
    • Ingle, J.N.1    Suman, V.J.2    Johnson, P.A.3
  • 46
    • 0041812038 scopus 로고    scopus 로고
    • Pharmacokinetic effect of cimetidine on a single 2.5 mg dose of letrozole in healthy subjects
    • Morgan JM, Palmisano M, Spencer S, et al. Pharmacokinetic effect of cimetidine on a single 2.5 mg dose of letrozole in healthy subjects [abstract no. 26]. J Clin Pharmacol 1996; 36: 852
    • (1996) J Clin Pharmacol , vol.36 , pp. 852
    • Morgan, J.M.1    Palmisano, M.2    Spencer, S.3
  • 47
    • 0343584508 scopus 로고    scopus 로고
    • Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: Results of a phase III study of the International Letrozole Breast Cancer Group
    • Mouridsen H, Gershanovich M, Sun Y, et al. Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group. J Clin Oncol 2001; 19: 2596-606
    • (2001) J Clin Oncol , vol.19 , pp. 2596-2606
    • Mouridsen, H.1    Gershanovich, M.2    Sun, Y.3
  • 48
    • 0005994975 scopus 로고    scopus 로고
    • First-line therapy with letrozole (Femara®) for advanced breast cancer prolongs time to worsening of Karnofsky Performance Status (KPS) compared with tamoxifen
    • Oct
    • Mouridsen H, Sun Y, Gershanovich M, et al. First-line therapy with letrozole (Femara®) for advanced breast cancer prolongs time to worsening of Karnofsky Performance Status (KPS) compared with tamoxifen [abstract no. 458 and poster]. Breast Cancer Res Treat 2001 Oct; 69 (3): 291
    • (2001) Breast Cancer Res Treat , vol.69 , Issue.3 , pp. 291
    • Mouridsen, H.1    Sun, Y.2    Gershanovich, M.3
  • 49
    • 0042312782 scopus 로고    scopus 로고
    • Cost utility of first line hormonal therapy in advanced breast cancer: A comparison of two aromatase inhibitors to tamoxifen
    • Dec 10-13; San Antonio (TX)
    • Dranitsaris G, Verma S, Trudeau M. Cost utility of first line hormonal therapy in advanced breast cancer: a comparison of two aromatase inhibitors to tamoxifen [poster]. 24th Annual San Antonio Breast Cancer Symposium; 2001 Dec 10-13; San Antonio (TX)
    • (2001) 24th Annual San Antonio Breast Cancer Symposium
    • Dranitsaris, G.1    Verma, S.2    Trudeau, M.3
  • 50
    • 25744440306 scopus 로고    scopus 로고
    • A stochastic economic evaluation of letrozole versus tamoxifen as a first-line therapy for postmenopausal women with advanced breast cancer
    • Oct
    • Karnon JD, Jones TED. A stochastic economic evaluation of letrozole versus tamoxifen as a first-line therapy for postmenopausal women with advanced breast cancer [abstract no. 853]. Eur J Cancer 2001 Oct; 37 (Suppl. 6): S232
    • (2001) Eur J Cancer , vol.37 , Issue.SUPPL. 6
    • Karnon, J.D.1    Jones, T.E.D.2
  • 51
    • 7344242595 scopus 로고    scopus 로고
    • Letrozole, a new oral aromatase inhibitor: Randomised trial comparing 2. 5 mg daily, 0.5 mg daily and aminoglutethimide in postmenopausal women with advanced breast cancer
    • Gersharovich M, Chaudri HA, Campos D, et al. Letrozole, a new oral aromatase inhibitor: randomised trial comparing 2.5 mg daily, 0.5 mg daily and aminoglutethimide in postmenopausal women with advanced breast cancer, Ann Oncol 1998; (9): 639-45
    • (1998) Ann Oncol , Issue.9 , pp. 639-645
    • Gersharovich, M.1    Chaudri, H.A.2    Campos, D.3
  • 52
    • 0031943424 scopus 로고    scopus 로고
    • Letrozole, a new oral aromatase inhibitor for advanced breast cancer: Double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate
    • Dombernowsky P, Smith I, Falkson G, et al. Letrozole, a new oral aromatase inhibitor for advanced breast cancer: double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate. J Clin Oncol 1998; 16: 453-61
    • (1998) J Clin Oncol , vol.16 , pp. 453-461
    • Dombernowsky, P.1    Smith, I.2    Falkson, G.3
  • 53
    • 0035879215 scopus 로고    scopus 로고
    • Phase III, multicenter, double-blind, randomized study of letrozole, an aromatase inhibitor, for advanced breast cancer versus megestrol acetate
    • Jul 15
    • Buzdar A, Douma J, Davidson N, et al. Phase III, multicenter, double-blind, randomized study of letrozole, an aromatase inhibitor, for advanced breast cancer versus megestrol acetate. J Clin Oncol 2001 Jul 15; 19 (14): 3357-66
    • (2001) J Clin Oncol , vol.19 , Issue.14 , pp. 3357-3366
    • Buzdar, A.1    Douma, J.2    Davidson, N.3
  • 54
    • 0000990648 scopus 로고    scopus 로고
    • Letrozole (Femara) vs. anastrozole (Arimidex): Second-line treatment in postmenopausal women with advanced breast cancer
    • Rose C, Vtoraya O, Pluzanska A, et al. Letrozole (Femara) vs. anastrozole (Arimidex): second-line treatment in postmenopausal women with advanced breast cancer [abstract no. 131]. Proceedings of the American Society of Clinical Oncology 2002; 21 (Pt 1): 34a
    • (2002) Proceedings of the American Society of Clinical Oncology , vol.21 , Issue.PART 1
    • Rose, C.1    Vtoraya, O.2    Pluzanska, A.3
  • 55
    • 0010406908 scopus 로고    scopus 로고
    • A pivotal double-blind trial in Japan of an aromatase inhibitor letrozole (third generation) vs. its predecessor fadrozole hydrochloride (second generation): Japan Letrozole Study Group
    • Tominaga T, Morimoto T, Ohashi J, et al. A pivotal double-blind trial in Japan of an aromatase inhibitor letrozole (third generation) vs. its predecessor fadrozole hydrochloride (second generation): Japan Letrozole Study Group [abstract no. 100]. Ann Oncol 2000; 11 (Suppl. 4): 25
    • (2000) Ann Oncol , vol.11 , Issue.SUPPL. 4 , pp. 25
    • Tominaga, T.1    Morimoto, T.2    Ohashi, J.3
  • 56
    • 0030927955 scopus 로고    scopus 로고
    • A randomized phase II trial of two dosage levels of letrozole as third-line hormonal therapy for women with metastatic breast carcinoma
    • Ingle JN, Johnson PA, Suman VJ, et al. A randomized phase II trial of two dosage levels of letrozole as third-line hormonal therapy for women with metastatic breast carcinoma. Cancer 1997; 80: 218-24
    • (1997) Cancer , vol.80 , pp. 218-224
    • Ingle, J.N.1    Johnson, P.A.2    Suman, V.J.3
  • 57
    • 0000499356 scopus 로고    scopus 로고
    • Phase II trial of letrozole (a novel oral nonsteroidal aromatase inhibitor) in postmenopausal patients with advanced or recurrent breast cancer
    • Tominaga T, Ohashi Y, Abe R, et al. Phase II trial of letrozole (a novel oral nonsteroidal aromatase inhibitor) in postmenopausal patients with advanced or recurrent breast cancer [abstract no. 490]. Eur J Cancer 1998; (31A): S81
    • (1998) Eur J Cancer , Issue.31 A
    • Tominaga, T.1    Ohashi, Y.2    Abe, R.3
  • 58
    • 0032776699 scopus 로고    scopus 로고
    • Letrozole: Updated duration of response
    • Chaudri HA, Trunet PF. Letrozole: updated duration of response [letter]. J Clin Oncol 1999; 17: 3856-60
    • (1999) J Clin Oncol , vol.17 , pp. 3856-3860
    • Chaudri, H.A.1    Trunet, P.F.2
  • 59
    • 0009673266 scopus 로고    scopus 로고
    • Comparison of letrozole 2.5 mg (Femara®) with megestrol acetate (MA) and with aminoglutethimide (AG) in patients with visceral disease
    • Gershanovich M, Chaudri HA, Hornberger U, et al. Comparison of letrozole 2.5 mg (Femara®) with megestrol acetate (MA) and with aminoglutethimide (AG) in patients with visceral disease [abstract no. 212]. Breast Cancer Res Treat 1998; 46: 53
    • (1998) Breast Cancer Res Treat , vol.46 , pp. 53
    • Gershanovich, M.1    Chaudri, H.A.2    Hornberger, U.3
  • 60
    • 25744480553 scopus 로고    scopus 로고
    • Long duration of response with letrozole 2.5 mg (Femara®) in two trials in postmenopausal women with advanced breast cancer after anti-estrogen therapy
    • Sep
    • Gardin G, Fornasiero A, Romieu G, et al. Long duration of response with letrozole 2.5 mg (Femara®) in two trials in postmenopausal women with advanced breast cancer after anti-estrogen therapy [abstract no. 461. Eur J Cancer 1998 Sep; 34 (Suppl. 5): S13-4
    • (1998) Eur J Cancer , vol.34 , Issue.SUPPL. 5
    • Gardin, G.1    Fornasiero, A.2    Romieu, G.3
  • 61
    • 0012870086 scopus 로고    scopus 로고
    • Letrozole is highly effective in patients with soft tissue metastases
    • Possinger K, Schmid P, Wischnewsky MB. Letrozole is highly effective in patients with soft tissue metastases [abstract no. 171]. Breast Cancer Res Treat 2000; 64: 53
    • (2000) Breast Cancer Res Treat , vol.64 , pp. 53
    • Possinger, K.1    Schmid, P.2    Wischnewsky, M.B.3
  • 62
    • 0012869666 scopus 로고    scopus 로고
    • Letrozole and megestrol acetate in patients with advanced breast cancer resistant to tamoxifen
    • Wischnewsky MB, Schmid P, Boehm R, et al. Letrozole and megestrol acetate in patients with advanced breast cancer resistant to tamoxifen [abstract no. 174]. Breast Cancer Res Treat 2000; 64: 54
    • (2000) Breast Cancer Res Treat , vol.64 , pp. 54
    • Wischnewsky, M.B.1    Schmid, P.2    Boehm, R.3
  • 63
    • 0038586429 scopus 로고    scopus 로고
    • Empowering patients to make informed treatment decisions based on tolerability, quality of life patient preference: A comparison of letrozole and anastrozole in a multicentre, randomised, single-blind cross over study
    • Mar
    • Thomas R, Makris A, Bloomfield D, et al. Empowering patients to make informed treatment decisions based on tolerability, quality of life patient preference: a comparison of letrozole and anastrozole in a multicentre, randomised, single-blind cross over study [abstract no. 171 and poster]. Eur J Cancer 2002 Mar; 38 (Suppl. 3): S83
    • (2002) Eur J Cancer , vol.38 , Issue.SUPPL. 3
    • Thomas, R.1    Makris, A.2    Bloomfield, D.3
  • 64
    • 0032727949 scopus 로고    scopus 로고
    • Cost effectiveness of letrozole in the treatment of advanced breast cancer in postmenopausal women in the UK
    • Nuijten M, Meester L, Waibel F, et al. Cost effectiveness of letrozole in the treatment of advanced breast cancer in postmenopausal women in the UK. Pharmacoeconomics 1999; 16 (4): 379-91
    • (1999) Pharmacoeconomics , vol.16 , Issue.4 , pp. 379-391
    • Nuijten, M.1    Meester, L.2    Waibel, F.3
  • 65
    • 0034058430 scopus 로고    scopus 로고
    • Economic evaluation of letrozole in the treatment of advanced breast cancer in postmenopausal women in Canada
    • Nuijten M, McCormick J, Waibel F, et al. Economic evaluation of letrozole in the treatment of advanced breast cancer in postmenopausal women in Canada. Value Health 2000; 3 (1): 31-9
    • (2000) Value Health , vol.3 , Issue.1 , pp. 31-39
    • Nuijten, M.1    McCormick, J.2    Waibel, F.3
  • 66
    • 0033805663 scopus 로고    scopus 로고
    • Cost-utility analysis of second-line hormonal therapy in advanced breast cancer: A comparison of two aromatase inhibitors to megestrol acetate
    • Dranitsaris G, Leung P, Mather J, et al. Cost-utility analysis of second-line hormonal therapy in advanced breast cancer: a comparison of two aromatase inhibitors to megestrol acetate. Anticancer Drugs 2000; 11: 591-601
    • (2000) Anticancer Drugs , vol.11 , pp. 591-601
    • Dranitsaris, G.1    Leung, P.2    Mather, J.3
  • 68
    • 0033891737 scopus 로고    scopus 로고
    • Is there a growing role for endocrine therapy in the treatment of breast cancer?
    • Lønning PE. Is there a growing role for endocrine therapy in the treatment of breast cancer? Drugs 2000; 60: 11-21
    • (2000) Drugs , vol.60 , pp. 11-21
    • Lønning, P.E.1
  • 69
    • 0034326445 scopus 로고    scopus 로고
    • NCCN practice guidelines for breast cancer
    • Nov
    • National Comprehensive Cancer Network. NCCN Practice Guidelines for Breast Cancer. Oncology 2000 Nov; 14 (11 A): 33-49
    • (2000) Oncology , vol.14 , Issue.11 A , pp. 33-49
  • 71
    • 0034669435 scopus 로고    scopus 로고
    • Anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in 668 postmenopausal women: Results of the Tamoxifen or Arimidex Randomized Group Efficacy and Tolerability study
    • Nov 15
    • Bonneterre J, Thürlimann B, Robertson JFR, et al. Anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in 668 postmenopausal women: results of the Tamoxifen or Arimidex Randomized Group Efficacy and Tolerability study. J Clin Oncol 2000 Nov 15; 18: 3748-57
    • (2000) J Clin Oncol , vol.18 , pp. 3748-3757
    • Bonneterre, J.1    Thürlimann, B.2    Robertson, J.F.R.3
  • 72
    • 0034669484 scopus 로고    scopus 로고
    • Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: Results of a North American multicenter randomized trial
    • Nov 15
    • Nabholtz JM, Buzdar A, Pollak M, et al. Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial. J Clin Oncol 2000 Nov 15; 18: 3758-67
    • (2000) J Clin Oncol , vol.18 , pp. 3758-3767
    • Nabholtz, J.M.1    Buzdar, A.2    Pollak, M.3
  • 73
    • 0003274281 scopus 로고    scopus 로고
    • Anastrozole (Arimidex) versus tamoxifen as first-line therapy for advanced breast cancer (Abc) in postmenopausal (Pro) women - Combined analysis from two identically designed multicenter trials
    • Buzdar A, Nabholtz JM, Robertson JF, et al. Anastrozole (Arimidex) versus tamoxifen as first-line therapy for advanced breast cancer (Abc) in postmenopausal (Pro) women - combined analysis from two identically designed multicenter trials [abstract no. 609D]. Proceedings of the American Society of Clinical Oncology 2000; 19: 154
    • (2000) Proceedings of the American Society of Clinical Oncology , vol.19 , pp. 154
    • Buzdar, A.1    Nabholtz, J.M.2    Robertson, J.F.3
  • 74
    • 0038478620 scopus 로고    scopus 로고
    • First-line fadrozole HCI (CGS 16949A) versus tamoxifen in postmenopausal women with advanced breast cancer: Prospective randomised trial of the Swiss Group for Clinical Cancer Research SAKK 20/88
    • Thürlimann B, Beretta K, Bacchi M, et al. First-line fadrozole HCI (CGS 16949A) versus tamoxifen in postmenopausal women with advanced breast cancer: prospective randomised trial of the Swiss Group for Clinical Cancer Research SAKK 20/88. Ann Oncol 1996; 7: 471-9
    • (1996) Ann Oncol , vol.7 , pp. 471-479
    • Thürlimann, B.1    Beretta, K.2    Bacchi, M.3
  • 75
    • 0030035607 scopus 로고    scopus 로고
    • A ramdomised study of CGS-16949A (fadrozole) versus tamoxifen in previously untreated postmenopausal patients with metastatic breast cancer
    • Falkson CI, Falkson HC. A ramdomised study of CGS-16949A (fadrozole) versus tamoxifen in previously untreated postmenopausal patients with metastatic breast cancer, Ann Oncol 1996; 7: 465-9
    • (1996) Ann Oncol , vol.7 , pp. 465-469
    • Falkson, C.I.1    Falkson, H.C.2
  • 76
    • 0001946288 scopus 로고    scopus 로고
    • Exemestane (Aromasin) is active and well tolerated as first-line hormonal therapy (HT) of metastatic breast cancer (MBC) patients (Pts): Results of a randomized phase II trial
    • Paridaens R, Dirix LY, Beex L, et al. Exemestane (Aromasin) is active and well tolerated as first-line hormonal therapy (HT) of metastatic breast cancer (MBC) patients (Pts): results of a randomized phase II trial [abstract no. 316], Proceedings of the American Society of Clinical Oncology 2000; 19: 83
    • (2000) Proceedings of the American Society of Clinical Oncology , vol.19 , pp. 83
    • Paridaens, R.1    Dirix, L.Y.2    Beex, L.3
  • 77
    • 9244245282 scopus 로고    scopus 로고
    • A randomised trial comparing two doses of the new selective aromatase inhibitor anastrozole (Arimidex) with megestrol acetate in postmenopausal patients with advanced breast cancer
    • Jonat W, Howell A, Blomqvist C, et al. A randomised trial comparing two doses of the new selective aromatase inhibitor anastrozole (Arimidex) with megestrol acetate in postmenopausal patients with advanced breast cancer. Eur J Cancer 1996; 32A: 404-12
    • (1996) Eur J Cancer , vol.32 A , pp. 404-412
    • Jonat, W.1    Howell, A.2    Blomqvist, C.3
  • 78
    • 0031054095 scopus 로고    scopus 로고
    • A phase III trial comparing anastrozole (1 and 10 milligrams), a potent and selective aromatase inhibitor, with megestrol acetate in postmenopausal women with advanced breast carcinoma
    • Feb 15
    • Buzdar AU, Jones SE, Vogel CL, et al. A phase III trial comparing anastrozole (1 and 10 milligrams), a potent and selective aromatase inhibitor, with megestrol acetate in postmenopausal women with advanced breast carcinoma. Cancer 1997 Feb 15; 79: 730-9
    • (1997) Cancer , vol.79 , pp. 730-739
    • Buzdar, A.U.1    Jones, S.E.2    Vogel, C.L.3
  • 79
    • 0032530988 scopus 로고    scopus 로고
    • Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma: Results of a survival update based on a combined analysis of data from two mature phase III trials
    • Sep 15
    • Buzdar AU, Jonat W, Howell A, et al. Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma: results of a survival update based on a combined analysis of data from two mature phase III trials. Cancer 1998 Sep 15; 83: 1142-52
    • (1998) Cancer , vol.83 , pp. 1142-1152
    • Buzdar, A.U.1    Jonat, W.2    Howell, A.3
  • 80
    • 0029940269 scopus 로고    scopus 로고
    • Fadrozole HC1 (CGS-16949A) versus megestrol acetate treatment of postmenopausal patients with metastatic breast carcinoma: Results of two randomized double-blind controlled multiinstitutional trials
    • Jun 15
    • Buzdar AU, Smith R, Vogel C, et al. Fadrozole HC1 (CGS-16949A) versus megestrol acetate treatment of postmenopausal patients with metastatic breast carcinoma: results of two randomized double-blind controlled multiinstitutional trials. Cancer 1996 Jun 15; 77: 2503-13
    • (1996) Cancer , vol.77 , pp. 2503-2513
    • Buzdar, A.U.1    Smith, R.2    Vogel, C.3
  • 81
    • 17144434022 scopus 로고    scopus 로고
    • High activity and tolerability demonstrated for exemestane in postmenopausal women with metastatic breast cancer who had previously failed on tamoxifen treatment
    • Kvinnsland S, Anker G, Dirix L-Y, et al. High activity and tolerability demonstrated for exemestane in postmenopausal women with metastatic breast cancer who had previously failed on tamoxifen treatment. Eur J Cancer 2000; 36: 976-82
    • (2000) Eur J Cancer , vol.36 , pp. 976-982
    • Kvinnsland, S.1    Anker, G.2    Dirix, L.-Y.3
  • 82
    • 0034128928 scopus 로고    scopus 로고
    • Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: Results of a phase III randomized double-blind trial
    • Apr
    • Kaufmann M, Bajetta E, Dirix LY, et al. Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: results of a phase III randomized double-blind trial. J Clin Oncol 2000 Apr; 18: 1399-411
    • (2000) J Clin Oncol , vol.18 , pp. 1399-1411
    • Kaufmann, M.1    Bajetta, E.2    Dirix, L.Y.3
  • 83
    • 0343924363 scopus 로고    scopus 로고
    • Formestane versus megestrol acetate in postmenopausal breast cancer patients after failure of tamoxifen: A phase III prospective randomised cross over trial of second-line hormonal treatment (SAKK 20/90)
    • Thürlimann B, Castiglione M, Hsu-Schmitz SF, et al. Formestane versus megestrol acetate in postmenopausal breast cancer patients after failure of tamoxifen: a phase III prospective randomised cross over trial of second-line hormonal treatment (SAKK 20/90). Eur J Cancer 1997; 33: 1017-24
    • (1997) Eur J Cancer , vol.33 , pp. 1017-1024
    • Thürlimann, B.1    Castiglione, M.2    Hsu-Schmitz, S.F.3
  • 84
    • 0037087535 scopus 로고    scopus 로고
    • Elevated serum HER-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer
    • Mar 15
    • Lipton A, Ali SM, Leitzel K, et al. Elevated serum HER-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer. J Clin Oncol 2002 Mar 15; 20 (6): 1467-72
    • (2002) J Clin Oncol , vol.20 , Issue.6 , pp. 1467-1472
    • Lipton, A.1    Ali, S.M.2    Leitzel, K.3
  • 85
    • 0035253379 scopus 로고    scopus 로고
    • Aromatase inhibitors in the treatment and prevention of breast cancer
    • Feb 1
    • Goss PE, Strasser K. Aromatase inhibitors in the treatment and prevention of breast cancer. J Clin Oncol 2001 Feb 1; 19 (3): 881-94
    • (2001) J Clin Oncol , vol.19 , Issue.3 , pp. 881-894
    • Goss, P.E.1    Strasser, K.2


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