Primaquine dipeptide derivatives bearing an imidazolidin-4-one moiety at the N-terminus as potential antimalarial prodrugs

European Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2009, Pages 2506-2516

  Vale, Nuno ^a   Nogueira, Fátima ^b   do Rosário, Virgílio E ^b   Gomes, Paula ^a   Moreira, Rui ^c  

^a UNIVERSITY OF PORTO   (Portugal)

^b INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^c RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

Gametocytocidal activity; Imidazolidin 4 ones; Malaria; Primaquine; Prodrugs

Indexed keywords

3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 1 BENZYL 2 OXOOCTYL] 1,4 DIAZASPIRO[4.5]DECAN 2 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 1 ISOBUTYL 2 OXOOCTYL] 1,4 DIAZASPIRO[4.5]DECAN 2 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 1 ISOBUTYL 2 OXOOCTYL] 2,2 DIMETHYLIMIDAZOLIDIN 4 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 1 METHYL 2 OXOOCTYL] 1,4 DIAZASPIRO[4.5]DECAN 2 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 1 METHYL 2 OXOOCTYL] 2,2,5 TRIMETHYLIMIDAZOLIDIN 4 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 1 METHYL 2 OXOOCTYL] 3 [(2 METHYLTHIO)ETHYL] 1,4 DIAZASPIRO[4.5]DECAN 2 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 1 METHYL 2 OXOOCTYL] 3 METHYL 1,4 DIAZASPIRO[4.5]DECAN 2 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 1 METHYL 2 OXOOCTYL] 5 [(2 METHYLTHIO)ETHYL]2,2 DIMETHYLIMIDAZOLIDIN 4 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 2 OXOOCTYL] 2,2 DIMETHYLIMIDAZOLIDIN 4 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 2 OXOOCTYL] 2,2,5 TRIMETHYLIMIDAZOLIDIN 4 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 2 OXOOCTYL] 3 BENZYL 1,4 DIAZASPIRO 8 METHYL[4.5]DECAN 2 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 2 OXOOCTYL] 3 BENZYL 1,4 DIAZASPIRO[4.4]NONAN 2 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 2 OXOOCTYL] 3 BENZYL 1,4 DIAZASPIRO[4.5]DECAN 2 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 2 OXOOCTYL] 3 BENZYL 1,4 DIAZASPIRO[4.6]UNDECAN 2 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 2 OXOOCTYL] 3 METHYL 1,4 DIAZASPIRO[4.5]DECAN 2 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 2 OXOOCTYL] 5 BENZYL 2,2 DIMETHYLIMIDAZOLIDIN 4 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 2 OXOOCTYL] 5 ISOBUTYL 2,2 DIMETHYLIMIDAZOLIDIN 4 ONE; 3 [7[(6 METHOXYQUINOLIN 8 YL)AMINO] 3 AZA 2 OXOOCTYL] 5 ISOPROPYL 2,2 DIMETHYLIMIDAZOLIDIN 4 ONE; ANTIMALARIAL AGENT; IMIDAZOLIDINE DERIVATIVE; PRIMAQUINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOPHELES STEPHENSI; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG HYDROLYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALARIA; MOUSE; NONHUMAN; PLASMODIUM BERGHEI;

ANIMALS; ANOPHELES; ANTIMALARIALS; DIPEPTIDES; DRUG DESIGN; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; IMIDAZOLIDINES; KINETICS; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM BERGHEI; PRIMAQUINE; PRODRUGS; STEREOISOMERISM;

EID: 64249118390     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.01.018     Document Type: Article

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