Dipeptide derivatives of primaquine as transmission-blocking antimalarials: Effect of aliphatic side-chain acylation on the gametocytocidal activity and on the formation of carboxyprimaquine in rat liver homogenates

Pharmaceutical Research

Volumn 16, Issue 6, 1999, Pages 949-955

  Portela, Maria João ^a   Moreira, Rui ^a   Valente, Emília ^a   Constantino, Luis ^a   Iley, Jim ^b   Pinto, João ^c   Rosa, Ricardo ^c   Cravo, Pedro ^c   Do Rosario, Virgílio E ^c  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b OPEN UNIVERSITY   (United Kingdom)

^c INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

Author keywords

Gametocytocidal activity; Liver homogenates; Peptide derivatives; Primaquine

Indexed keywords

4 (6 METHOXY 8 QUINOLYLAMINO)VALERIC ACID; ANTIMALARIAL AGENT; DRUG METABOLITE; MEFLOQUINE; PRIMAQUINE DERIVATIVE; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOPHELES STEPHENSI; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG RESISTANCE; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER HOMOGENATE; LIVER METABOLISM; MALARIA; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PRIORITY JOURNAL; RAT;

ACYLATION; ANIMALS; ANTIMALARIALS; DIPEPTIDES; LIVER; MICE; MICE, INBRED BALB C; PLASMODIUM BERGHEI; PRIMAQUINE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033020951     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018922425551     Document Type: Article

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