Reactivity of imidazolidin-4-one derivatives of primaquine: implications for prodrug design

Tetrahedron

Volumn 62, Issue 42, 2006, Pages 9883-9891

  Chambel, Paula ^a   Capela, Rita ^a   Lopes, Francisca ^a   Iley, Jim ^b   Morais, José ^a   Gouveia, Luís ^a   Gomes, José R B ^c   Gomes, Paula ^c   Moreira, Rui ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b OPEN UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

Imidazolidin 4 ones; Kinetics; Mechanism of hydrolysis; Primaquine; Prodrugs; Substituent effects

Indexed keywords

IMIDAZOLINE DERIVATIVE; PRIMAQUINE DERIVATIVE; PRODRUG;

ARTICLE; CHEMICAL BOND; DRUG DECOMPOSITION; DRUG DESIGN; DRUG HYDROLYSIS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; PH MEASUREMENT; PKA; PRIORITY JOURNAL; PROTON TRANSPORT; STEREOSPECIFICITY;

EID: 33748140661     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2006.08.026     Document Type: Article

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