Metabolism of primaquine by liver homogenate fractions. Evidence for monoamine oxidase and cytochrome P450 involvement in the oxidative deamination of primaquine to carboxyprimaquine

Experimental and Toxicologic Pathology

Volumn 51, Issue 4-5, 1999, Pages 299-303

  Constantino, L ^a   Paixao P ^a   Moreira, R ^a   Portela, M J ^a   Do Rosario, V E ^b   Iley, J ^c  

^a UNIVERSITY OF LISBON   (Portugal)

^b INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^c OPEN UNIVERSITY   (United Kingdom)

Author keywords

Carboxyprimaquine; Cytochrome P450; Liver metabolism; Monoamine oxidase; Primaquine

Indexed keywords

ALDEHYDE; AMINE OXIDASE (FLAVIN CONTAINING); BENZYLAMINE; CYTOCHROME P450; PRIMAQUINE;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; DEAMINATION; DRUG LIVER LEVEL; DRUG METABOLISM; DRUG TRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER HOMOGENATE; LIVER METABOLISM; MALARIA; NONHUMAN; OXIDATION; PLASMODIUM OVALE; PLASMODIUM VIVAX; RAT;

ANIMALIA; GYMNOMYZA SAMOENSIS; PLASMODIUM OVALE; PLASMODIUM VIVAX;

EID: 0032781772     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(99)80010-4     Document Type: Conference Paper

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