N-terminal 4-imidazolidinone prodrugs of Leu-enkephalin: Synthesis, chemical and enzymatic stability studies

European Journal of Pharmaceutical Sciences

Volumn 7, Issue 4, 1999, Pages 317-323

  Bak, Annette ^a   Fich, Mette ^a   Larsen, Bjarne D ^b   Frokjaer, Sven ^a   Friis, Gitte J ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Aminopeptidase N; Angiotensin converting enzyme; Enkephalin, leucine; Plasma, human; Prodrugs; Stability

Indexed keywords

BUFFER; DIPEPTIDYL CARBOXYPEPTIDASE; IMIDAZOLIDINE DERIVATIVE; LEUCINE ENKEPHALIN DERIVATIVE; MICROSOMAL AMINOPEPTIDASE; PRODRUG;

ARTICLE; BLOOD BRAIN BARRIER; DRUG STABILITY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; PRIORITY JOURNAL;

ANTIGENS, CD13; BLOOD-BRAIN BARRIER; BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENKEPHALIN, LEUCINE; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; IMIDAZOLES; PEPTIDYL-DIPEPTIDASE A; PRODRUGS; SOLUTIONS;

EID: 0033054737     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(98)00044-X     Document Type: Article

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