-
1
-
-
41649112610
-
Bevacizumab for recurrent malignant gliomas: Efficacy, toxicity, and patterns of recurrence
-
Norden AD, Young GS, Setayesh K, Muzikansky A, Klufas R, Ross GL, et al. Bevacizumab for recurrent malignant gliomas: Efficacy, toxicity, and patterns of recurrence. Neurology 2008; 70: 779-87.
-
(2008)
Neurology
, vol.70
, pp. 779-787
-
-
Norden, A.D.1
Young, G.S.2
Setayesh, K.3
Muzikansky, A.4
Klufas, R.5
Ross, G.L.6
-
2
-
-
0026481269
-
Immunolocalization of basic fibroblast growth factor to the microvasculature of human brain tumors
-
Brem S, Tsanaclis AM, Gately S, Gross JL, Herblin WF. Immunolocalization of basic fibroblast growth factor to the microvasculature of human brain tumors. Cancer 1992; 70: 2673-80.
-
(1992)
Cancer
, vol.70
, pp. 2673-2680
-
-
Brem, S.1
Tsanaclis, A.M.2
Gately, S.3
Gross, J.L.4
Herblin, W.F.5
-
3
-
-
0029397222
-
Angiogenesis in malignant gliomas
-
Plate KH, Risau W. Angiogenesis in malignant gliomas. Glia 1995; 15: 339-47.
-
(1995)
Glia
, vol.15
, pp. 339-347
-
-
Plate, K.H.1
Risau, W.2
-
4
-
-
0030059969
-
Microvessel density is a prognostic indicator for patients with astroglial brain tumors
-
Leon SP, Folkerth RD, Black PM. Microvessel density is a prognostic indicator for patients with astroglial brain tumors. Cancer 1996; 77: 362-72.
-
(1996)
Cancer
, vol.77
, pp. 362-372
-
-
Leon, S.P.1
Folkerth, R.D.2
Black, P.M.3
-
5
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86: 353-64.
-
(1996)
Cell
, vol.86
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
6
-
-
0036780251
-
Clinical translation of angiogenesis inhibitors
-
Kerbel R, Folkman J. Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2002; 2: 727-39.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 727-739
-
-
Kerbel, R.1
Folkman, J.2
-
7
-
-
0021978223
-
Tumor angiogenesis
-
Folkman J. Tumor angiogenesis. Adv Cancer Res 1985; 43: 175-203.
-
(1985)
Adv Cancer Res
, vol.43
, pp. 175-203
-
-
Folkman, J.1
-
8
-
-
0032952010
-
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
-
Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 1999; 103: 159-65.
-
(1999)
J Clin Invest
, vol.103
, pp. 159-165
-
-
Benjamin, L.E.1
Golijanin, D.2
Itin, A.3
Pode, D.4
Keshet, E.5
-
9
-
-
0036124520
-
Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
-
Morikawa S, Baluk P, Kaidoh T, Haskell A, Jain RK, McDonald DM. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol 2002; 160: 985-1000.
-
(2002)
Am J Pathol
, vol.160
, pp. 985-1000
-
-
Morikawa, S.1
Baluk, P.2
Kaidoh, T.3
Haskell, A.4
Jain, R.K.5
McDonald, D.M.6
-
10
-
-
0033873782
-
Vasculogenic mimicry: How convincing, how novel, and how significant?
-
McDonald DM, Munn L, Jain RK. Vasculogenic mimicry: How convincing, how novel, and how significant? Am J Pathol 2000; 156: 383-8.
-
(2000)
Am J Pathol
, vol.156
, pp. 383-388
-
-
McDonald, D.M.1
Munn, L.2
Jain, R.K.3
-
11
-
-
0033580889
-
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
-
Holash J, Maisonpierre PC, Compton D, Boland P, Alexander CR, Zagzag D, et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 1999; 284: 1994-8.
-
(1999)
Science
, vol.284
, pp. 1994-1998
-
-
Holash, J.1
Maisonpierre, P.C.2
Compton, D.3
Boland, P.4
Alexander, C.R.5
Zagzag, D.6
-
12
-
-
0033588842
-
New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
-
Holash J, Wiegand SJ, Yancopoulos GD. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 1999; 18: 5356-62.
-
(1999)
Oncogene
, vol.18
, pp. 5356-5362
-
-
Holash, J.1
Wiegand, S.J.2
Yancopoulos, G.D.3
-
13
-
-
0026485002
-
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
-
Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359: 843-5.
-
(1992)
Nature
, vol.359
, pp. 843-845
-
-
Shweiki, D.1
Itin, A.2
Soffer, D.3
Keshet, E.4
-
14
-
-
2342436921
-
Anti-angiogenic chemotherapy in central nervous system tumors
-
Kieran MW. Anti-angiogenic chemotherapy in central nervous system tumors. Cancer Treat Res 2004; 117: 337-49.
-
(2004)
Cancer Treat Res
, vol.117
, pp. 337-349
-
-
Kieran, M.W.1
-
16
-
-
0029166443
-
Regulation of the expression of the VEGF/VPS and its receptors: Role in tumor angiogenesis
-
Kolch W, Martiny-Baron G, Kieser A, Marme D. Regulation of the expression of the VEGF/VPS and its receptors: Role in tumor angiogenesis. Breast Cancer Res Treat 1995; 36: 139-55.
-
(1995)
Breast Cancer Res Treat
, vol.36
, pp. 139-155
-
-
Kolch, W.1
Martiny-Baron, G.2
Kieser, A.3
Marme, D.4
-
17
-
-
0027980740
-
Detection and quantification of vascular endothelial growth factor/vascular permeability factor in brain tumor tissue and cyst fluid: The key to angiogenesis?
-
discussion 48-9
-
Weindel K, Moringlane JR, Marme D, Weich HA. Detection and quantification of vascular endothelial growth factor/vascular permeability factor in brain tumor tissue and cyst fluid: The key to angiogenesis? Neurosurgery 1994; 35: 439-48; discussion 48-9.
-
(1994)
Neurosurgery
, vol.35
, pp. 439-448
-
-
Weindel, K.1
Moringlane, J.R.2
Marme, D.3
Weich, H.A.4
-
18
-
-
0028090642
-
Vascular endothelial growth factor and glioma angiogenesis: Coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms
-
Plate KH, Breier G, Weich HA, Mennel HD, Risau W. Vascular endothelial growth factor and glioma angiogenesis: Coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int J Cancer 1994; 59: 520-9.
-
(1994)
Int J Cancer
, vol.59
, pp. 520-529
-
-
Plate, K.H.1
Breier, G.2
Weich, H.A.3
Mennel, H.D.4
Risau, W.5
-
19
-
-
0031035753
-
Expression and distribution of vascular endothelial growth factor protein in human brain tumors
-
Pietsch T, Valter MM, Wolf HK, von Deimling A, Huang HJ, Cavenee WK, et al. Expression and distribution of vascular endothelial growth factor protein in human brain tumors. Acta Neuropathol 1997; 93: 109-17.
-
(1997)
Acta Neuropathol
, vol.93
, pp. 109-117
-
-
Pietsch, T.1
Valter, M.M.2
Wolf, H.K.3
von Deimling, A.4
Huang, H.J.5
Cavenee, W.K.6
-
20
-
-
0023680176
-
Further characterization of malignant glioma-derived vascular permeability factor
-
Criscuolo GR, Merrill MJ, Oldfield EH. Further characterization of malignant glioma-derived vascular permeability factor. J Neurosurg 1988; 69: 254-62.
-
(1988)
J Neurosurg
, vol.69
, pp. 254-262
-
-
Criscuolo, G.R.1
Merrill, M.J.2
Oldfield, E.H.3
-
21
-
-
0037234235
-
Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis
-
Gomez-Manzano C, Fueyo J, Jiang H, Glass TL, Lee HY, Hu M, et al. Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis. Ann Neurol 2003; 53: 109-17.
-
Ann Neurol 2003; 53: 109-17
-
-
Gomez-Manzano, C.1
Fueyo, J.2
Jiang, H.3
Glass, T.L.4
Lee, H.Y.5
Hu, M.6
-
22
-
-
34547673869
-
Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells
-
Yoshino Y, Aoyagi M, Tamaki M, Duan L, Morimoto T, Ohno K. Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells. Int J Oncol 2006; 29: 981-7.
-
(2006)
Int J Oncol
, vol.29
, pp. 981-987
-
-
Yoshino, Y.1
Aoyagi, M.2
Tamaki, M.3
Duan, L.4
Morimoto, T.5
Ohno, K.6
-
23
-
-
21644482527
-
Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3
-
Saino M, Maruyama T, Sekiya T, Kayama T, Murakami Y. Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3. Oncol Rep 2004; 12: 47-52.
-
(2004)
Oncol Rep
, vol.12
, pp. 47-52
-
-
Saino, M.1
Maruyama, T.2
Sekiya, T.3
Kayama, T.4
Murakami, Y.5
-
24
-
-
0029914374
-
Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients
-
Takano S, Yoshii Y, Kondo S, Suzuki H, Maruno T, Shirai S, et al. Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients. Cancer Res 1996; 56: 2185-90.
-
(1996)
Cancer Res
, vol.56
, pp. 2185-2190
-
-
Takano, S.1
Yoshii, Y.2
Kondo, S.3
Suzuki, H.4
Maruno, T.5
Shirai, S.6
-
25
-
-
0028868619
-
Coordinate expression of vascular endothelial growth factor receptor-1 (flt-1) and its ligand suggests a paracrine regulation of murine vascular development
-
Breier G, Clauss M, Risau W. Coordinate expression of vascular endothelial growth factor receptor-1 (flt-1) and its ligand suggests a paracrine regulation of murine vascular development. Dev Dyn 1995; 204: 228-39.
-
(1995)
Dev Dyn
, vol.204
, pp. 228-239
-
-
Breier, G.1
Clauss, M.2
Risau, W.3
-
26
-
-
0032941495
-
Levels of vascular endothelial growth factor, hepatocyte growth factor/scatter factor and basic fibroblast growth factor in human gliomas and their relation to angiogenesis
-
Schmidt NO, Westphal M, Hagel C, Ergun S, Stavrou D, Rosen EM, et al. Levels of vascular endothelial growth factor, hepatocyte growth factor/scatter factor and basic fibroblast growth factor in human gliomas and their relation to angiogenesis. Int J Cancer 1999; 84: 10-8.
-
(1999)
Int J Cancer
, vol.84
, pp. 10-18
-
-
Schmidt, N.O.1
Westphal, M.2
Hagel, C.3
Ergun, S.4
Stavrou, D.5
Rosen, E.M.6
-
27
-
-
0033025662
-
Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells
-
Bouloumie A, Schini-Kerth VB, Busse R. Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells. Cardiovasc Res 1999; 41: 773-80.
-
(1999)
Cardiovasc Res
, vol.41
, pp. 773-780
-
-
Bouloumie, A.1
Schini-Kerth, V.B.2
Busse, R.3
-
28
-
-
2642597076
-
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells
-
Papapetropoulos A, Garcia-Cardena G, Madri JA, Sessa WC. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest 1997; 100: 3131-9.
-
(1997)
J Clin Invest
, vol.100
, pp. 3131-3139
-
-
Papapetropoulos, A.1
Garcia-Cardena, G.2
Madri, J.A.3
Sessa, W.C.4
-
29
-
-
0028803509
-
Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
-
Alon T, Hemo I, Itin A, Pe'er J, Stone J, Keshet E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1995; 1: 1024-8.
-
(1995)
Nat Med
, vol.1
, pp. 1024-1028
-
-
Alon, T.1
Hemo, I.2
Itin, A.3
Pe'er, J.4
Stone, J.5
Keshet, E.6
-
30
-
-
0030446969
-
-
Wang W, Merrill MJ, Borchardt RT. Vascular endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro. Am J Physiol 1996; 271: C1973-80.
-
Wang W, Merrill MJ, Borchardt RT. Vascular endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro. Am J Physiol 1996; 271: C1973-80.
-
-
-
-
31
-
-
0041353794
-
Angiogenic factors in the central nervous system
-
discussion 60-1
-
Harrigan MR. Angiogenic factors in the central nervous system. Neurosurgery 2003; 53: 639-60; discussion 60-1.
-
(2003)
Neurosurgery
, vol.53
, pp. 639-660
-
-
Harrigan, M.R.1
-
32
-
-
0034470379
-
Vascular microenvironment in gliomas
-
Vajkoczy P, Menger MD. Vascular microenvironment in gliomas. J Neurooncol 2000; 50: 99-108.
-
(2000)
J Neurooncol
, vol.50
, pp. 99-108
-
-
Vajkoczy, P.1
Menger, M.D.2
-
33
-
-
0343920277
-
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
-
Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996; 380: 435-9.
-
(1996)
Nature
, vol.380
, pp. 435-439
-
-
Carmeliet, P.1
Ferreira, V.2
Breier, G.3
Pollefeyt, S.4
Kieckens, L.5
Gertsenstein, M.6
-
34
-
-
0030004485
-
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
-
Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O'Shea KS, et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996; 380: 439-42.
-
(1996)
Nature
, vol.380
, pp. 439-442
-
-
Ferrara, N.1
Carver-Moore, K.2
Chen, H.3
Dowd, M.4
Lu, L.5
O'Shea, K.S.6
-
35
-
-
0027942607
-
Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
-
Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994; 331: 1480-7.
-
(1994)
N Engl J Med
, vol.331
, pp. 1480-1487
-
-
Aiello, L.P.1
Avery, R.L.2
Arrigg, P.G.3
Keyt, B.A.4
Jampel, H.D.5
Shah, S.T.6
-
36
-
-
0028123090
-
Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy
-
Adamis AP, Miller JW, Bernal MT, D'Amico DJ, Folkman J, Yeo TK, et al. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol 1994; 118: 445-50.
-
(1994)
Am J Ophthalmol
, vol.118
, pp. 445-450
-
-
Adamis, A.P.1
Miller, J.W.2
Bernal, M.T.3
D'Amico, D.J.4
Folkman, J.5
Yeo, T.K.6
-
37
-
-
33745767945
-
Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas
-
Jensen RL, Ragel BT, Whang K, Gillespie D. Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas. J Neurooncol 2006; 78: 233-47.
-
(2006)
J Neurooncol
, vol.78
, pp. 233-247
-
-
Jensen, R.L.1
Ragel, B.T.2
Whang, K.3
Gillespie, D.4
-
38
-
-
17744386137
-
Cyclooxygenase-2 increases hypoxia-inducible factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinoma
-
Huang SP, Wu MS, Shun CT, Wang HP, Hsieh CY, Kuo ML, et al. Cyclooxygenase-2 increases hypoxia-inducible factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinoma. J Biomed Sci 2005; 12: 229-41.
-
(2005)
J Biomed Sci
, vol.12
, pp. 229-241
-
-
Huang, S.P.1
Wu, M.S.2
Shun, C.T.3
Wang, H.P.4
Hsieh, C.Y.5
Kuo, M.L.6
-
39
-
-
23044452436
-
Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins
-
Abdelrahim M, Safe S. Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins. Mol Pharmacol 2005; 68: 317-29
-
(2005)
Mol Pharmacol
, vol.68
, pp. 317-329
-
-
Abdelrahim, M.1
Safe, S.2
-
40
-
-
0030480322
-
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
-
Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 1996; 87: 1171-80.
-
(1996)
Cell
, vol.87
, pp. 1171-1180
-
-
Suri, C.1
Jones, P.F.2
Patan, S.3
Bartunkova, S.4
Maisonpierre, P.C.5
Davis, S.6
-
41
-
-
15144358851
-
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
-
Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997; 277: 55-60.
-
(1997)
Science
, vol.277
, pp. 55-60
-
-
Maisonpierre, P.C.1
Suri, C.2
Jones, P.F.3
Bartunkova, S.4
Wiegand, S.J.5
Radziejewski, C.6
-
42
-
-
1442290142
-
Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
-
Erber R, Thurnher A, Katsen AD, Groth G, Kerger H, Hammes HP, et al. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J 2004; 18: 338-40.
-
(2004)
FASEB J
, vol.18
, pp. 338-340
-
-
Erber, R.1
Thurnher, A.2
Katsen, A.D.3
Groth, G.4
Kerger, H.5
Hammes, H.P.6
-
43
-
-
0031737425
-
Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis
-
Stratmann A, Risau W, Plate KH. Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis. Am J Pathol 1998; 153: 1459-66.
-
(1998)
Am J Pathol
, vol.153
, pp. 1459-1466
-
-
Stratmann, A.1
Risau, W.2
Plate, K.H.3
-
44
-
-
2542453735
-
The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies
-
Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt JM, et al. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 2004; 103: 4150-6.
-
(2004)
Blood
, vol.103
, pp. 4150-4156
-
-
Fiedler, U.1
Scharpfenecker, M.2
Koidl, S.3
Hegen, A.4
Grunow, V.5
Schmidt, J.M.6
-
45
-
-
0032843659
-
In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis
-
Zagzag D, Hooper A, Friedlander DR, Chan W, Holash J, Wiegand SJ, et al. In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis. Exp Neurol 1999; 159: 391-400.
-
(1999)
Exp Neurol
, vol.159
, pp. 391-400
-
-
Zagzag, D.1
Hooper, A.2
Friedlander, D.R.3
Chan, W.4
Holash, J.5
Wiegand, S.J.6
-
46
-
-
39749174416
-
Angiopoietin-2 decreases vascular endothelial growth factor expression by modulating HIF-1 alpha levels in gliomas
-
Lee OH, Xu J, Fueyo J, Alonso MM, Liu D, Martin V, et al. Angiopoietin-2 decreases vascular endothelial growth factor expression by modulating HIF-1 alpha levels in gliomas. Oncogene 2008; 27: 1310-4.
-
(2008)
Oncogene
, vol.27
, pp. 1310-1314
-
-
Lee, O.H.1
Xu, J.2
Fueyo, J.3
Alonso, M.M.4
Liu, D.5
Martin, V.6
-
47
-
-
0025214980
-
Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line
-
Morrison RS, Gross JL, Herblin WF, Reilly TM, LaSala PA, Alterman RL, et al. Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line. Cancer Res 1990; 50: 2524-9.
-
(1990)
Cancer Res
, vol.50
, pp. 2524-2529
-
-
Morrison, R.S.1
Gross, J.L.2
Herblin, W.F.3
Reilly, T.M.4
LaSala, P.A.5
Alterman, R.L.6
-
48
-
-
0028941001
-
Vascular endothelial growth factor in human glioma cell lines: Induced secretion by EGF, PDGF-BB, and bFGF
-
Tsai JC, Goldman CK, Gillespie GY. Vascular endothelial growth factor in human glioma cell lines: Induced secretion by EGF, PDGF-BB, and bFGF. J Neurosurg 1995; 82: 864-73.
-
(1995)
J Neurosurg
, vol.82
, pp. 864-873
-
-
Tsai, J.C.1
Goldman, C.K.2
Gillespie, G.Y.3
-
49
-
-
0026439870
-
Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas
-
Plate KH, Breier G, Farrell CL, Risau W. Platelet-derived growth factor receptor-beta is induced during tumor development and upregulated during tumor progression in endothelial cells in human gliomas. Lab Invest 1992; 67: 529-34.
-
(1992)
Lab Invest
, vol.67
, pp. 529-534
-
-
Plate, K.H.1
Breier, G.2
Farrell, C.L.3
Risau, W.4
-
50
-
-
0031834239
-
A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
-
Benjamin LE, Hemo I, Keshet E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 1998; 125: 1591-8.
-
(1998)
Development
, vol.125
, pp. 1591-1598
-
-
Benjamin, L.E.1
Hemo, I.2
Keshet, E.3
-
51
-
-
0030756325
-
Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
-
Lindahl P, Johansson BR, Leveen P, Betsholtz C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 1997; 277: 242-5.
-
(1997)
Science
, vol.277
, pp. 242-245
-
-
Lindahl, P.1
Johansson, B.R.2
Leveen, P.3
Betsholtz, C.4
-
52
-
-
0027097806
-
Interleukin-8 as a macrophage-derived mediator of angiogenesis
-
Koch AE, Polverini PJ, Kunkel SL, Harlow LA, DiPietro LA, Elner VM, et al. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 1992; 258: 1798-801.
-
(1992)
Science
, vol.258
, pp. 1798-1801
-
-
Koch, A.E.1
Polverini, P.J.2
Kunkel, S.L.3
Harlow, L.A.4
DiPietro, L.A.5
Elner, V.M.6
-
53
-
-
0027934320
-
Interleukin-8 and tumor necrosis factor-alpha are involved in human aortic endothelial cell migration. The possible role of these cytokines in human aortic aneurysmal blood vessel growth
-
Szekanecz Z, Shah MR, Harlow LA, Pearce WH, Koch AE. Interleukin-8 and tumor necrosis factor-alpha are involved in human aortic endothelial cell migration. The possible role of these cytokines in human aortic aneurysmal blood vessel growth. Pathobiology 1994; 62: 134-9.
-
(1994)
Pathobiology
, vol.62
, pp. 134-139
-
-
Szekanecz, Z.1
Shah, M.R.2
Harlow, L.A.3
Pearce, W.H.4
Koch, A.E.5
-
54
-
-
0037443760
-
IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis
-
Li A, Dubey S, Varney ML, Dave BJ, Singh RK. IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol 2003; 170: 3369-76
-
(2003)
J Immunol
, vol.170
, pp. 3369-3376
-
-
Li, A.1
Dubey, S.2
Varney, M.L.3
Dave, B.J.4
Singh, R.K.5
-
55
-
-
0033194582
-
Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivo
-
Deininger MH, Weller M, Streffer J, Mittelbronn M, Meyermann R. Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivo. Acta Neuropathol 1999; 98: 240-4.
-
(1999)
Acta Neuropathol
, vol.98
, pp. 240-244
-
-
Deininger, M.H.1
Weller, M.2
Streffer, J.3
Mittelbronn, M.4
Meyermann, R.5
-
56
-
-
0035809312
-
Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: Roles of the nuclear factor of activated T cells and cyclooxygenase 2
-
Hernandez GL, Volpert OV, Iniguez MA, Lorenzo E, Martinez-Martinez S, Grau R, et al. Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: Roles of the nuclear factor of activated T cells and cyclooxygenase 2. J Exp Med 2001; 193: 607-20.
-
(2001)
J Exp Med
, vol.193
, pp. 607-620
-
-
Hernandez, G.L.1
Volpert, O.V.2
Iniguez, M.A.3
Lorenzo, E.4
Martinez-Martinez, S.5
Grau, R.6
-
57
-
-
0033567459
-
Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis
-
Daniel TO, Liu H, Morrow JD, Crews BC, Marnett LJ. Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis. Cancer Res 1999; 59: 4574-7.
-
(1999)
Cancer Res
, vol.59
, pp. 4574-4577
-
-
Daniel, T.O.1
Liu, H.2
Morrow, J.D.3
Crews, B.C.4
Marnett, L.J.5
-
59
-
-
0035911953
-
Angiomotin: An angiostatin binding protein that regulates endothelial cell migration and tube formation
-
Troyanovsky B, Levchenko T, Mansson G, Matvijenko O, Holmgren L. Angiomotin: An angiostatin binding protein that regulates endothelial cell migration and tube formation. J Cell Biol 2001; 152: 1247-54.
-
(2001)
J Cell Biol
, vol.152
, pp. 1247-1254
-
-
Troyanovsky, B.1
Levchenko, T.2
Mansson, G.3
Matvijenko, O.4
Holmgren, L.5
-
60
-
-
0031454617
-
Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
-
O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, et al. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth. Cell 1997; 88: 277-85.
-
(1997)
Cell
, vol.88
, pp. 277-285
-
-
O'Reilly, M.S.1
Boehm, T.2
Shing, Y.3
Fukai, N.4
Vasios, G.5
Lane, W.S.6
-
61
-
-
0010712792
-
Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity
-
Brooks PC, Silletti S, von Schalscha TL, Friedlander M, Cheresh DA. Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. Cell 1998; 92: 391-400.
-
Cell 1998; 92: 391-400
-
-
Brooks, P.C.1
Silletti, S.2
von Schalscha, T.L.3
Friedlander, M.4
Cheresh, D.A.5
-
62
-
-
0035893737
-
Simultaneous inhibition of glioma angiogenesis, cell proliferation, and invasion by a naturally occurring fragment of human metalloproteinase-2
-
Bello L, Lucini V, Carrabba G, Giussani C, Machluf M, Pluderi M, et al. Simultaneous inhibition of glioma angiogenesis, cell proliferation, and invasion by a naturally occurring fragment of human metalloproteinase-2. Cancer Res 2001; 61: 8730-6.
-
(2001)
Cancer Res
, vol.61
, pp. 8730-8736
-
-
Bello, L.1
Lucini, V.2
Carrabba, G.3
Giussani, C.4
Machluf, M.5
Pluderi, M.6
-
63
-
-
0036847733
-
Suppression of malignant glioma recurrence in a newly developed animal model by endogenous inhibitors
-
Bello L, Giussani C, Carrabba G, Pluderi M, Lucini V, Pannacci M, et al. Suppression of malignant glioma recurrence in a newly developed animal model by endogenous inhibitors. Clin Cancer Res 2002; 8: 3539-48.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3539-3548
-
-
Bello, L.1
Giussani, C.2
Carrabba, G.3
Pluderi, M.4
Lucini, V.5
Pannacci, M.6
-
64
-
-
12944331952
-
Combined effects of radiotherapy and angiostatin gene therapy in glioma tumor model
-
Griscelli F, Li H, Cheong C, Opolon P, Bennaceur-Griscelli A, Vassal G, et al. Combined effects of radiotherapy and angiostatin gene therapy in glioma tumor model. Proc Natl Acad Sci USA 2000; 97: 6698-703.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 6698-6703
-
-
Griscelli, F.1
Li, H.2
Cheong, C.3
Opolon, P.4
Bennaceur-Griscelli, A.5
Vassal, G.6
-
65
-
-
0038577557
-
Models for neurooncological preclinical studies: Solid orthotopic and heterotopic grafts of human gliomas into nude mice
-
Taillandier L, Antunes L, Angioi-Duprez KS. Models for neurooncological preclinical studies: Solid orthotopic and heterotopic grafts of human gliomas into nude mice. J Neurosci Methods 2003; 125: 147-57.
-
(2003)
J Neurosci Methods
, vol.125
, pp. 147-157
-
-
Taillandier, L.1
Antunes, L.2
Angioi-Duprez, K.S.3
-
66
-
-
0029782859
-
Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor
-
Cheng SY, Huang HJ, Nagane M, Ji XD, Wang D, Shih CC, et al. Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor. Proc Natl Acad Sci USA 1996; 93: 8502-7.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 8502-8507
-
-
Cheng, S.Y.1
Huang, H.J.2
Nagane, M.3
Ji, X.D.4
Wang, D.5
Shih, C.C.6
-
67
-
-
0033557535
-
Antiangiogenesis treatment for gliomas: Transfer of antisensevascular endothelial growth factor inhibits tumor growth in vivo
-
Im SA, Gomez-Manzano C, Fueyo J, Liu TJ, Ke LD, Kim JS, et al. Antiangiogenesis treatment for gliomas: Transfer of antisensevascular endothelial growth factor inhibits tumor growth in vivo. Cancer Res 1999; 59: 895-900.
-
(1999)
Cancer Res
, vol.59
, pp. 895-900
-
-
Im, S.A.1
Gomez-Manzano, C.2
Fueyo, J.3
Liu, T.J.4
Ke, L.D.5
Kim, J.S.6
-
68
-
-
0033822622
-
Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption
-
Rubenstein JL, Kim J, Ozawa T, Zhang M, Westphal M, Deen DF, et al. Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia 2000; 2: 306-14
-
(2000)
Neoplasia
, vol.2
, pp. 306-314
-
-
Rubenstein, J.L.1
Kim, J.2
Ozawa, T.3
Zhang, M.4
Westphal, M.5
Deen, D.F.6
-
69
-
-
0035884609
-
Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2
-
Kunkel P, Ulbricht U, Bohlen P, Brockmann MA, Fillbrandt R, Stavrou D, et al. Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2. Cancer Res 2001; 61: 6624-8.
-
(2001)
Cancer Res
, vol.61
, pp. 6624-6628
-
-
Kunkel, P.1
Ulbricht, U.2
Bohlen, P.3
Brockmann, M.A.4
Fillbrandt, R.5
Stavrou, D.6
-
70
-
-
0034306974
-
Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions
-
Lee CG, Heijn M, di Tomaso E, Griffon-Etienne G, Ancukiewicz M, Koike C, et al. Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res 2000; 60: 5565-70.
-
(2000)
Cancer Res
, vol.60
, pp. 5565-5570
-
-
Lee, C.G.1
Heijn, M.2
di Tomaso, E.3
Griffon-Etienne, G.4
Ancukiewicz, M.5
Koike, C.6
-
71
-
-
13444278498
-
Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies
-
Gerber HP, Ferrara N. Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. Cancer Res 2005; 65: 671-80.
-
(2005)
Cancer Res
, vol.65
, pp. 671-680
-
-
Gerber, H.P.1
Ferrara, N.2
-
72
-
-
0035132923
-
Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts
-
Kozin SV, Boucher Y, Hicklin DJ, Bohlen P, Jain RK, Suit HD. Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. Cancer Res 2001; 61: 39-44.
-
(2001)
Cancer Res
, vol.61
, pp. 39-44
-
-
Kozin, S.V.1
Boucher, Y.2
Hicklin, D.J.3
Bohlen, P.4
Jain, R.K.5
Suit, H.D.6
-
73
-
-
0037143764
-
VEGF-Trap: A VEGF blocker with potent antitumor effects
-
Holash J, Davis S, Papadopoulos N, Croll SD, Ho L, Russell M, et al. VEGF-Trap: A VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 2002; 99: 11393-8.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11393-11398
-
-
Holash, J.1
Davis, S.2
Papadopoulos, N.3
Croll, S.D.4
Ho, L.5
Russell, M.6
-
74
-
-
33947531672
-
VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma
-
Wachsberger PR, Burd R, Cardi C, Thakur M, Daskalakis C, Holash J, et al. VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma. Int J Radiat Oncol Biol Phys 2007; 67: 1526-37
-
(2007)
Int J Radiat Oncol Biol Phys
, vol.67
, pp. 1526-1537
-
-
Wachsberger, P.R.1
Burd, R.2
Cardi, C.3
Thakur, M.4
Daskalakis, C.5
Holash, J.6
-
75
-
-
3543028023
-
PTK787/ZK222584, an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, decreases glioma growth and vascularization
-
discussion 32
-
Goldbrunner RH, Bendszus M, Wood J, Kiderlen M, Sasaki M, Tonn JC. PTK787/ZK222584, an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, decreases glioma growth and vascularization. Neurosurgery 2004; 55: 426-32; discussion 32.
-
(2004)
Neurosurgery
, vol.55
, pp. 426-432
-
-
Goldbrunner, R.H.1
Bendszus, M.2
Wood, J.3
Kiderlen, M.4
Sasaki, M.5
Tonn, J.C.6
-
76
-
-
3142774878
-
AEE788: A dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity
-
Traxler P, Allegrini PR, Brandt R, Brueggen J, Cozens R, Fabbro D, et al. AEE788: A dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res 2004; 64: 4931-41.
-
(2004)
Cancer Res
, vol.64
, pp. 4931-4941
-
-
Traxler, P.1
Allegrini, P.R.2
Brandt, R.3
Brueggen, J.4
Cozens, R.5
Fabbro, D.6
-
77
-
-
13944269599
-
Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition
-
Goudar RK, Shi Q, Hjelmeland MD, Keir ST, McLendon RE, Wikstrand CJ, et al. Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Mol Cancer Ther 2005; 4: 101-12
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 101-112
-
-
Goudar, R.K.1
Shi, Q.2
Hjelmeland, M.D.3
Keir, S.T.4
McLendon, R.E.5
Wikstrand, C.J.6
-
78
-
-
5044240201
-
The tyrosine kinase inhibitor ZD6474 inhibits tumour growth in an intracerebral rat glioma model
-
Sandstrom M, Johansson M, Andersson U, Bergh A, Bergenheim AT, Henriksson R. The tyrosine kinase inhibitor ZD6474 inhibits tumour growth in an intracerebral rat glioma model. Br J Cancer 2004; 91: 1174-80.
-
(2004)
Br J Cancer
, vol.91
, pp. 1174-1180
-
-
Sandstrom, M.1
Johansson, M.2
Andersson, U.3
Bergh, A.4
Bergenheim, A.T.5
Henriksson, R.6
-
79
-
-
28144450936
-
ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors
-
Rich JN, Sathornsumetee S, Keir ST, Kieran MW, Laforme A, Kaipainen A, et al. ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors. Clin Cancer Res 2005; 11: 8145-57.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 8145-8157
-
-
Rich, J.N.1
Sathornsumetee, S.2
Keir, S.T.3
Kieran, M.W.4
Laforme, A.5
Kaipainen, A.6
-
80
-
-
23044500424
-
Cooperative antitumor effect of multitargeted kinase inhibitor ZD6474 and ionizing radiation in glioblastoma
-
Damiano V, Melisi D, Bianco C, Raben D, Caputo R, Fontanini G, et al. Cooperative antitumor effect of multitargeted kinase inhibitor ZD6474 and ionizing radiation in glioblastoma. Clin Cancer Res 2005; 11: 5639-44.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 5639-5644
-
-
Damiano, V.1
Melisi, D.2
Bianco, C.3
Raben, D.4
Caputo, R.5
Fontanini, G.6
-
81
-
-
0041672482
-
SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models
-
Schueneman AJ, Himmelfarb E, Geng L, Tan J, Donnelly E, Mendel D, et al. SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res 2003; 63: 4009-16.
-
(2003)
Cancer Res
, vol.63
, pp. 4009-4016
-
-
Schueneman, A.J.1
Himmelfarb, E.2
Geng, L.3
Tan, J.4
Donnelly, E.5
Mendel, D.6
-
82
-
-
33749016521
-
AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant glioma
-
Sathornsumetee S, Hjelmeland AB, Keir ST, McLendon RE, Batt D, Ramsey T, et al. AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant glioma. Cancer Res 2006; 66: 8722-30.
-
(2006)
Cancer Res
, vol.66
, pp. 8722-8730
-
-
Sathornsumetee, S.1
Hjelmeland, A.B.2
Keir, S.T.3
McLendon, R.E.4
Batt, D.5
Ramsey, T.6
-
83
-
-
33646586669
-
Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor
-
Albert DH, Tapang P, Magoc TJ, Pease LJ, Reuter DR, Wei RQ, et al. Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol Cancer Ther 2006; 5: 995-1006.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 995-1006
-
-
Albert, D.H.1
Tapang, P.2
Magoc, T.J.3
Pease, L.J.4
Reuter, D.R.5
Wei, R.Q.6
-
84
-
-
17844371306
-
Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis
-
Kaur B, Khwaja FW, Severson EA, Matheny SL, Brat DJ, Van Meir EG. Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis. Neuro Oncol 2005; 7: 134-53.
-
(2005)
Neuro Oncol
, vol.7
, pp. 134-153
-
-
Kaur, B.1
Khwaja, F.W.2
Severson, E.A.3
Matheny, S.L.4
Brat, D.J.5
Van Meir, E.G.6
-
85
-
-
33748050780
-
Hypoxia-inducible factor-1 inhibition in combination with temozolomide treatment exhibits robust antitumor efficacy in vivo
-
Li L, Lin X, Shoemaker AR, Albert DH, Fesik SW, Shen Y. Hypoxia-inducible factor-1 inhibition in combination with temozolomide treatment exhibits robust antitumor efficacy in vivo. Clin Cancer Res 2006; 12: 4747-54.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4747-4754
-
-
Li, L.1
Lin, X.2
Shoemaker, A.R.3
Albert, D.H.4
Fesik, S.W.5
Shen, Y.6
-
86
-
-
33846240027
-
Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model
-
Kang SH, Cho HT, Devi S, Zhang Z, Escuin D, Liang Z, et al. Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model. Cancer Res 2006; 66: 11991-7.
-
(2006)
Cancer Res
, vol.66
, pp. 11991-11997
-
-
Kang, S.H.1
Cho, H.T.2
Devi, S.3
Zhang, Z.4
Escuin, D.5
Liang, Z.6
-
87
-
-
33744829739
-
Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth
-
Lee OH, Fueyo J, Xu J, Yung WK, Lemoine MG, Lang FF, et al. Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth. Neoplasia 2006; 8: 419-28.
-
(2006)
Neoplasia
, vol.8
, pp. 419-428
-
-
Lee, O.H.1
Fueyo, J.2
Xu, J.3
Yung, W.K.4
Lemoine, M.G.5
Lang, F.F.6
-
88
-
-
7244229595
-
Angiopoietin-1 promotes tumor angiogenesis in a rat glioma model
-
Machein MR, Knedla A, Knoth R, Wagner S, Neuschl E, Plate KH. Angiopoietin-1 promotes tumor angiogenesis in a rat glioma model. Am J Pathol 2004; 165: 1557-70.
-
(2004)
Am J Pathol
, vol.165
, pp. 1557-1570
-
-
Machein, M.R.1
Knedla, A.2
Knoth, R.3
Wagner, S.4
Neuschl, E.5
Plate, K.H.6
-
89
-
-
7944220649
-
Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2
-
Oliner J, Min H, Leal J, Yu D, Rao S, You E, et al. Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell 2004; 6: 507-16.
-
(2004)
Cancer Cell
, vol.6
, pp. 507-516
-
-
Oliner, J.1
Min, H.2
Leal, J.3
Yu, D.4
Rao, S.5
You, E.6
-
90
-
-
33644875655
-
Regulation of the pathological vasculature of malignant astrocytomas by angiopoietin-1
-
Zadeh G, Reti R, Koushan K, Baoping Q, Shannon P, Guha A. Regulation of the pathological vasculature of malignant astrocytomas by angiopoietin-1. Neoplasia 2005; 7: 1081-90.
-
(2005)
Neoplasia
, vol.7
, pp. 1081-1090
-
-
Zadeh, G.1
Reti, R.2
Koushan, K.3
Baoping, Q.4
Shannon, P.5
Guha, A.6
-
91
-
-
33846303242
-
Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta1-dependent adhesion to the extracellular matrix
-
Lee OH, Xu J, Fueyo J, Fuller GN, Aldape KD, Alonso MM, et al. Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta1-dependent adhesion to the extracellular matrix. Mol Cancer Res 2006; 4: 915-26.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 915-926
-
-
Lee, O.H.1
Xu, J.2
Fueyo, J.3
Fuller, G.N.4
Aldape, K.D.5
Alonso, M.M.6
-
92
-
-
24944587964
-
Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
-
De Palma M, Venneri MA, Galli R, Sergi Sergi L, Politi LS, Sampaolesi M, et al. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 2005; 8: 211-26.
-
(2005)
Cancer Cell
, vol.8
, pp. 211-226
-
-
De Palma, M.1
Venneri, M.A.2
Galli, R.3
Sergi Sergi, L.4
Politi, L.S.5
Sampaolesi, M.6
-
93
-
-
0028341678
-
Basic fibroblast growth factor and fibroblast growth factor receptor I are implicated in the growth of human astrocytomas
-
Morrison RS, Yamaguchi F, Saya H, Bruner JM, Yahanda AM, Donehower LA, et al. Basic fibroblast growth factor and fibroblast growth factor receptor I are implicated in the growth of human astrocytomas. J Neurooncol 1994; 18: 207-16.
-
(1994)
J Neurooncol
, vol.18
, pp. 207-216
-
-
Morrison, R.S.1
Yamaguchi, F.2
Saya, H.3
Bruner, J.M.4
Yahanda, A.M.5
Donehower, L.A.6
-
94
-
-
20844441262
-
Inhibition of FGF receptor activity in glioma implanted into the mouse brain using the tetracyclin-regulated expression system
-
Miraux S, Lemiere S, Pineau R, Pluderi M, Canioni P, Franconi JM, et al. Inhibition of FGF receptor activity in glioma implanted into the mouse brain using the tetracyclin-regulated expression system. Angiogenesis 2004; 7: 105-13.
-
(2004)
Angiogenesis
, vol.7
, pp. 105-113
-
-
Miraux, S.1
Lemiere, S.2
Pineau, R.3
Pluderi, M.4
Canioni, P.5
Franconi, J.M.6
-
95
-
-
0028110421
-
Suramin inhibits glioma cell proliferation in vitro and in the brain
-
Takano S, Gately S, Engelhard H, Tsanaclis AM, Brem S. Suramin inhibits glioma cell proliferation in vitro and in the brain. J Neurooncol 1994; 21: 189-201.
-
(1994)
J Neurooncol
, vol.21
, pp. 189-201
-
-
Takano, S.1
Gately, S.2
Engelhard, H.3
Tsanaclis, A.M.4
Brem, S.5
-
96
-
-
0034665138
-
Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class
-
Kilic T, Alberta JA, Zdunek PR, Acar M, Iannarelli P, O'Reilly T, et al. Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class. Cancer Res 2000; 60: 5143-50.
-
(2000)
Cancer Res
, vol.60
, pp. 5143-5150
-
-
Kilic, T.1
Alberta, J.A.2
Zdunek, P.R.3
Acar, M.4
Iannarelli, P.5
O'Reilly, T.6
-
97
-
-
29244438974
-
STI571 (Gleevec) improves tumor growth delay and survival in irradiated mouse models of glioblastoma
-
Geng L, Shinohara ET, Kim D, Tan J, Osusky K, Shyr Y, et al. STI571 (Gleevec) improves tumor growth delay and survival in irradiated mouse models of glioblastoma. Int J Radiat Oncol Biol Phys 2006; 64: 263-71.
-
(2006)
Int J Radiat Oncol Biol Phys
, vol.64
, pp. 263-271
-
-
Geng, L.1
Shinohara, E.T.2
Kim, D.3
Tan, J.4
Osusky, K.5
Shyr, Y.6
-
98
-
-
3242748417
-
Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib
-
Nam DH, Park K, Park C, Im YH, Kim MH, Lee S, et al. Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib. Oncol Rep 2004; 11: 263-8.
-
(2004)
Oncol Rep
, vol.11
, pp. 263-268
-
-
Nam, D.H.1
Park, K.2
Park, C.3
Im, Y.H.4
Kim, M.H.5
Lee, S.6
-
99
-
-
33846805646
-
Enhancement of glioblastoma radioresponse by a selective COX-2 inhibitor celecoxib: Inhibition of tumor angiogenesis with extensive tumor necrosis
-
Kang KB, Wang TT, Woon CT, Cheah ES, Moore XL, Zhu C, et al. Enhancement of glioblastoma radioresponse by a selective COX-2 inhibitor celecoxib: Inhibition of tumor angiogenesis with extensive tumor necrosis. Int J Radiat Oncol Biol Phys 2007; 67: 888-96.
-
(2007)
Int J Radiat Oncol Biol Phys
, vol.67
, pp. 888-896
-
-
Kang, K.B.1
Wang, T.T.2
Woon, C.T.3
Cheah, E.S.4
Moore, X.L.5
Zhu, C.6
-
100
-
-
17844397949
-
The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis
-
Brat DJ, Bellail AC, Van Meir EG. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol 2005; 7: 122-33.
-
(2005)
Neuro Oncol
, vol.7
, pp. 122-133
-
-
Brat, D.J.1
Bellail, A.C.2
Van Meir, E.G.3
-
101
-
-
0344823964
-
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
-
Rubin JB, Kung AL, Klein RS, Chan JA, Sun Y, Schmidt K, et al. A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci USA 2003; 100: 13513-8.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 13513-13518
-
-
Rubin, J.B.1
Kung, A.L.2
Klein, R.S.3
Chan, J.A.4
Sun, Y.5
Schmidt, K.6
-
102
-
-
34447632643
-
Angiogenesis in brain tumours
-
Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT. Angiogenesis in brain tumours. Nat Rev Neurosci 2007; 8: 610-22.
-
(2007)
Nat Rev Neurosci
, vol.8
, pp. 610-622
-
-
Jain, R.K.1
di Tomaso, E.2
Duda, D.G.3
Loeffler, J.S.4
Sorensen, A.G.5
Batchelor, T.T.6
-
104
-
-
36948998969
-
Antiangiogenic therapy in malignant glioma: Promise and challenge
-
Sathornsumetee S, Rich JN. Antiangiogenic therapy in malignant glioma: promise and challenge. Curr Pharm Des 2007; 13: 3545-58.
-
(2007)
Curr Pharm Des
, vol.13
, pp. 3545-3558
-
-
Sathornsumetee, S.1
Rich, J.N.2
-
105
-
-
42149192674
-
Glioblastoma multiforme: An emerging paradigm of anti-VEGF therapy
-
Reardon DA, Wen PY, Desjardins A, Batchelor TT, Vredenburgh JJ. Glioblastoma multiforme: An emerging paradigm of anti-VEGF therapy. Expert Opin Biol Ther 2008; 8: 541-53.
-
(2008)
Expert Opin Biol Ther
, vol.8
, pp. 541-553
-
-
Reardon, D.A.1
Wen, P.Y.2
Desjardins, A.3
Batchelor, T.T.4
Vredenburgh, J.J.5
-
106
-
-
20144370978
-
AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
-
Wedge SR, Kendrew J, Hennequin LF, Valentine PJ, Barry ST, Brave SR, et al. AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 2005; 65: 4389-400.
-
(2005)
Cancer Res
, vol.65
, pp. 4389-4400
-
-
Wedge, S.R.1
Kendrew, J.2
Hennequin, L.F.3
Valentine, P.J.4
Barry, S.T.5
Brave, S.R.6
-
107
-
-
33846149645
-
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
-
Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007; 11: 83-95.
-
(2007)
Cancer Cell
, vol.11
, pp. 83-95
-
-
Batchelor, T.T.1
Sorensen, A.G.2
di Tomaso, E.3
Zhang, W.T.4
Duda, D.G.5
Cohen, K.S.6
-
108
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain RK. Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 2005; 307: 58-62.
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
109
-
-
2442621619
-
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
-
Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004; 3: 391-400.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 391-400
-
-
Ferrara, N.1
Hillan, K.J.2
Gerber, H.P.3
Novotny, W.4
-
110
-
-
33745738260
-
Vascular endothelial growth factor (VEGF) as a target of bevacizumab in cancer: From the biology to the clinic
-
Ranieri G, Patruno R, Ruggieri E, Montemurro S, Valerio P, Ribatti D. Vascular endothelial growth factor (VEGF) as a target of bevacizumab in cancer: From the biology to the clinic. Curr Med Chem 2006; 13: 1845-57.
-
(2006)
Curr Med Chem
, vol.13
, pp. 1845-1857
-
-
Ranieri, G.1
Patruno, R.2
Ruggieri, E.3
Montemurro, S.4
Valerio, P.5
Ribatti, D.6
-
111
-
-
33947191055
-
Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
-
Vredenburgh JJ, Desjardins A, Herndon JE, 2nd, Dowell JM, Reardon DA, Quinn JA, et al. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res 2007; 13: 1253-9.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1253-1259
-
-
Vredenburgh, J.J.1
Desjardins, A.2
Herndon 2nd, J.E.3
Dowell, J.M.4
Reardon, D.A.5
Quinn, J.A.6
-
112
-
-
36049037819
-
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
-
Vredenburgh JJ, Desjardins A, Herndon JE, 2nd, Marcello J, Reardon DA, Quinn JA, et al. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol 2007; 25: 4722-9.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4722-4729
-
-
Vredenburgh, J.J.1
Desjardins, A.2
Herndon 2nd, J.E.3
Marcello, J.4
Reardon, D.A.5
Quinn, J.A.6
-
113
-
-
38349155463
-
Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan
-
Sathornsumetee S, Cao Y, Marcello JE, Herndon JE, 2nd, McLendon RE, Desjardins A, et al. Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J Clin Oncol 2008; 26: 271-8.
-
(2008)
J Clin Oncol
, vol.26
, pp. 271-278
-
-
Sathornsumetee, S.1
Cao, Y.2
Marcello, J.E.3
Herndon 2nd, J.E.4
McLendon, R.E.5
Desjardins, A.6
-
114
-
-
0345060442
-
Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model
-
Byrne AT, Ross L, Holash J, Nakanishi M, Hu L, Hofmann JI, et al. Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin Cancer Res 2003; 9: 5721-8.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5721-5728
-
-
Byrne, A.T.1
Ross, L.2
Holash, J.3
Nakanishi, M.4
Hu, L.5
Hofmann, J.I.6
-
115
-
-
0037143739
-
Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma
-
Kim ES, Serur A, Huang J, Manley CA, McCrudden KW, Frischer JS, et al. Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Proc Natl Acad Sci USA 2002; 99: 11399-404.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11399-11404
-
-
Kim, E.S.1
Serur, A.2
Huang, J.3
Manley, C.A.4
McCrudden, K.W.5
Frischer, J.S.6
-
116
-
-
34547657584
-
Vascular endothelial growth factor trap in non small cell lung cancer
-
Riely GJ, Miller VA. Vascular endothelial growth factor trap in non small cell lung cancer. Clin Cancer Res 2007; 13: S4623-7.
-
(2007)
Clin Cancer Res
, vol.13
-
-
Riely, G.J.1
Miller, V.A.2
-
117
-
-
34547093162
-
Vascular endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic murine renal cell cancer model
-
Verheul HM, Hammers H, van Erp K, Wei Y, Sanni T, Salumbides B, et al. Vascular endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic murine renal cell cancer model. Clin Cancer Res 2007; 13: 4201-8.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4201-4208
-
-
Verheul, H.M.1
Hammers, H.2
van Erp, K.3
Wei, Y.4
Sanni, T.5
Salumbides, B.6
-
118
-
-
39649107340
-
Identification and characterization of small-molecule inhibitors of Tie2 kinase
-
Liu J, Lin TH, Cole AG, Wen R, Zhao L, Brescia MR, et al. Identification and characterization of small-molecule inhibitors of Tie2 kinase. FEBS Lett 2008; 582: 785-91.
-
(2008)
FEBS Lett
, vol.582
, pp. 785-791
-
-
Liu, J.1
Lin, T.H.2
Cole, A.G.3
Wen, R.4
Zhao, L.5
Brescia, M.R.6
-
119
-
-
34547543902
-
Pyridinylimidazole inhibitors of Tie2 kinase
-
Semones M, Feng Y, Johnson N, Adams JL, Winkler J, Hansbury M. Pyridinylimidazole inhibitors of Tie2 kinase. Bioorg Med Chem Lett 2007; 17: 4756-60.
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 4756-4760
-
-
Semones, M.1
Feng, Y.2
Johnson, N.3
Adams, J.L.4
Winkler, J.5
Hansbury, M.6
-
120
-
-
4944250781
-
Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
-
Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, De Vitis S, et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004; 64: 7011-21.
-
(2004)
Cancer Res
, vol.64
, pp. 7011-7021
-
-
Galli, R.1
Binda, E.2
Orfanelli, U.3
Cipelletti, B.4
Gritti, A.5
De Vitis, S.6
-
122
-
-
9244241576
-
Identification of human brain tumour initiating cells
-
Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, et al. Identification of human brain tumour initiating cells. Nature 2004; 432: 396-401.
-
(2004)
Nature
, vol.432
, pp. 396-401
-
-
Singh, S.K.1
Hawkins, C.2
Clarke, I.D.3
Squire, J.A.4
Bayani, J.5
Hide, T.6
-
123
-
-
33845317573
-
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
-
Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006; 444: 756-60.
-
(2006)
Nature
, vol.444
, pp. 756-760
-
-
Bao, S.1
Wu, Q.2
McLendon, R.E.3
Hao, Y.4
Shi, Q.5
Hjelmeland, A.B.6
-
124
-
-
33748051406
-
Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
-
Bao S, Wu Q, Sathornsumetee S, Hao Y, Li Z, Hjelmeland AB, et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res 2006; 66: 7843-8.
-
(2006)
Cancer Res
, vol.66
, pp. 7843-7848
-
-
Bao, S.1
Wu, Q.2
Sathornsumetee, S.3
Hao, Y.4
Li, Z.5
Hjelmeland, A.B.6
-
125
-
-
33846029123
-
A perivascular niche for brain tumor stem cells. Cancer
-
Calabrese C, Poppleton H, Kocak M, Hogg TL, Fuller C, Hamner B, et al. A perivascular niche for brain tumor stem cells. Cancer Cell 2007; 11: 69-82.
-
(2007)
Cell
, vol.11
, pp. 69-82
-
-
Calabrese, C.1
Poppleton, H.2
Kocak, M.3
Hogg, T.L.4
Fuller, C.5
Hamner, B.6
-
126
-
-
34648821254
-
Making a tumour's bed: Glioblastoma stem cells and the vascular niche
-
Gilbertson RJ, Rich JN. Making a tumour's bed: Glioblastoma stem cells and the vascular niche. Nat Rev Cancer 2007; 7: 733-6.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 733-736
-
-
Gilbertson, R.J.1
Rich, J.N.2
-
127
-
-
36048955738
-
Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorofluorothymidine positron emission tomography: A pilot study
-
Chen W, Delaloye S, Silverman DH, Geist C, Czernin J, Sayre J, et al. Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorofluorothymidine positron emission tomography: A pilot study. J Clin Oncol 2007; 25: 4714-21.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4714-4721
-
-
Chen, W.1
Delaloye, S.2
Silverman, D.H.3
Geist, C.4
Czernin, J.5
Sayre, J.6
-
128
-
-
27644450912
-
Inhibition of glioblastoma angiogenesis and invasion by combined treatments directed against vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and vascular endothelial-cadherin
-
Lamszus K, Brockmann MA, Eckerich C, Bohlen P, May C, Mangold U, et al. Inhibition of glioblastoma angiogenesis and invasion by combined treatments directed against vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and vascular endothelial-cadherin. Clin Cancer Res 2005; 11: 4934-40.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4934-4940
-
-
Lamszus, K.1
Brockmann, M.A.2
Eckerich, C.3
Bohlen, P.4
May, C.5
Mangold, U.6
-
129
-
-
0041382820
-
The hypoxic response of tumors is dependent on their microenvironment
-
Blouw B, Song H, Tihan T, Bosze J, Ferrara N, Gerber HP, et al. The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 2003; 4: 133-46.
-
(2003)
Cancer Cell
, vol.4
, pp. 133-146
-
-
Blouw, B.1
Song, H.2
Tihan, T.3
Bosze, J.4
Ferrara, N.5
Gerber, H.P.6
-
130
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005; 8: 299-309.
-
(2005)
Cancer Cell
, vol.8
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
131
-
-
19944422751
-
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases
-
Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 2004; 6: 553-63.
-
(2004)
Cancer Cell
, vol.6
, pp. 553-563
-
-
Winkler, F.1
Kozin, S.V.2
Tong, R.T.3
Chae, S.S.4
Booth, M.F.5
Garkavtsev, I.6
-
132
-
-
40749125285
-
Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation
-
Kadenhe-Chiweshe A, Papa J, McCrudden KW, Frischer J, Bae JO, Huang J, et al. Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation. Mol Cancer Res 2008; 6: 1-9.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 1-9
-
-
Kadenhe-Chiweshe, A.1
Papa, J.2
McCrudden, K.W.3
Frischer, J.4
Bae, J.O.5
Huang, J.6
-
133
-
-
33845877157
-
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
-
Noguera-Troise I, Daly C, Papadopoulos NJ, Coetzee S, Boland P, Gale NW, et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 2006; 444: 1032-7.
-
(2006)
Nature
, vol.444
, pp. 1032-1037
-
-
Noguera-Troise, I.1
Daly, C.2
Papadopoulos, N.J.3
Coetzee, S.4
Boland, P.5
Gale, N.W.6
-
134
-
-
38849202330
-
Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting
-
Pietras K, Pahler J, Bergers G, Hanahan D. Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med 2008; 5: E19.
-
(2008)
PLoS Med
, vol.5
-
-
Pietras, K.1
Pahler, J.2
Bergers, G.3
Hanahan, D.4
-
135
-
-
33644833910
-
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
-
Motzer RJ, Michaelson MD, Redman BG, Hudes GR, Wilding G, Figlin RA, et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2006; 24: 16-24.
-
(2006)
J Clin Oncol
, vol.24
, pp. 16-24
-
-
Motzer, R.J.1
Michaelson, M.D.2
Redman, B.G.3
Hudes, G.R.4
Wilding, G.5
Figlin, R.A.6
-
136
-
-
34347235531
-
Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors
-
Rosen LS, Kurzrock R, Mulay M, Van Vugt A, Purdom M, Ng C, et al. Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors. J Clin Oncol 2007; 25: 2369-76.
-
(2007)
J Clin Oncol
, vol.25
, pp. 2369-2376
-
-
Rosen, L.S.1
Kurzrock, R.2
Mulay, M.3
Van Vugt, A.4
Purdom, M.5
Ng, C.6
-
137
-
-
30944452436
-
Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase I trial in rectal cancer patients
-
Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, et al. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase I trial in rectal cancer patients. J Clin Oncol 2005; 23: 8136-9.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8136-8139
-
-
Willett, C.G.1
Boucher, Y.2
Duda, D.G.3
di Tomaso, E.4
Munn, L.L.5
Tong, R.T.6
-
138
-
-
35548982639
-
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
-
Fischer C, Jonckx B, Mazzone M, Zacchigna S, Loges S, Pattarini L, et al. Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell 2007; 131: 463-75.
-
(2007)
Cell
, vol.131
, pp. 463-475
-
-
Fischer, C.1
Jonckx, B.2
Mazzone, M.3
Zacchigna, S.4
Loges, S.5
Pattarini, L.6
-
139
-
-
33947732977
-
Angiogenesis: An organizing principle for drug discovery?
-
Folkman J. Angiogenesis: An organizing principle for drug discovery? Nat Rev Drug Discov 2007; 6: 273-86.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 273-286
-
-
Folkman, J.1
-
140
-
-
43449103949
-
Characterization of compound 584, an Abl kinase inhibitor with lasting effects
-
Puttini M, Redaelli S, Moretti L, Brussolo S, Gunby RH, Mologni L, et al. Characterization of compound 584, an Abl kinase inhibitor with lasting effects. Haematologica 2008; 93(5): 653-61.
-
(2008)
Haematologica
, vol.93
, Issue.5
, pp. 653-661
-
-
Puttini, M.1
Redaelli, S.2
Moretti, L.3
Brussolo, S.4
Gunby, R.H.5
Mologni, L.6
-
141
-
-
39749164113
-
Cell death: Tipping the balance of autoimmunity and tissue repair
-
Rovere-Querini P, Brunelli S, Clementi E, Manfredi AA. Cell death: tipping the balance of autoimmunity and tissue repair. Curr Pharm Des 2008; 14(3): 269-77.
-
(2008)
Curr Pharm Des
, vol.14
, Issue.3
, pp. 269-277
-
-
Rovere-Querini, P.1
Brunelli, S.2
Clementi, E.3
Manfredi, A.A.4
-
142
-
-
42049118552
-
Models for the study of angiogenesis
-
Shiba Y, Takahashi M, Ikeda U. Models for the study of angiogenesis. Curr Pharm Des 2008; 14(4): 371-7.
-
(2008)
Curr Pharm Des
, vol.14
, Issue.4
, pp. 371-377
-
-
Shiba, Y.1
Takahashi, M.2
Ikeda, U.3
|