Angiopoietin-2 decreases vascular endothelial growth factor expression by modulating HIF-1α levels in gliomas

Oncogene

Volumn 27, Issue 9, 2008, Pages 1310-1314

  Lee, O H ^a   Xu, J ^a   Fueyo, J ^a   Alonso, M M ^a   Liu, D ^a   Martin, V ^a   Jiang, H ^a   Piao, Y ^a   Liu, T J ^a   Gomez Manzano, C ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Angiopoietin 2; Gliomas; HIF 1 ; Tie2; VEGF

Indexed keywords

ANGIOPOIETIN 2; ANGIOPOIETIN RECEPTOR; MESSENGER RNA; SMALL INTERFERING RNA; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; ASTROCYTE; DNA BINDING; GENE SILENCING; GLIOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANGIOPOIETIN-2; CELL LINE, TUMOR; DNA, NEOPLASM; GLIOMA; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIGANDS; PROTEIN BINDING; RECEPTOR, TIE-2; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 39749174416     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210731     Document Type: Article

References (18)

1. Beck H, Acker T, Wiessner C, Allegrini PR, Plate KH. (2000). Expression of angiopoietin-1, angiopoietin-2, and tie receptors after middle cerebral artery occlusion in the rat. Am J Pathol 157: 1473-1483.
2. Cascone I, Napione L, Maniero F, Serini G, Bussolino F. (2005). Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1. J Cell Biol 170: 993-1004.
3. Ferrara N, Alitalo K. (1999). Clinical applications of angiogenic growth factors and their inhibitors. Nat Med 5: 1359-1364.
4. Goede V, Schmidt T, Kimmina S, Kozian D, Augustin HG. (1998). Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis. Lab Invest 78: 1385-1394.
5. Gomez-Manzano C, Fueyo J, Jiang H, Glass TL, Lee HY, Hu M et al. (2003). Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis. Ann Neurol 53: 109-117.
6. Holash J, Maisonpierre PC, Compton D, Boland P, Alexander CR, Zagzag D et al. (1999). Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 284: 1994-1998.
7. 1 integrin and focal adhesion kinase signaling pathway. Cancer Res 66: 775-783.
8. Kukk E, Wartiovaara U, Gunji Y, Kaukonen J, Buhring HJ, Rappold I et al. (1997). Analysis of Tie receptor tyrosine kinase in haemopoietic progenitor and leukaemia cells. Br J Haematol 98: 195-203.
9. Lee OH, Fueyo J, Xu J, Yung WK, Lemoine MG, Lang FF et al. (2006a). Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth. Neoplasia 8: 419-428.
10. Lee OH, Xu J, Fueyo J, Fuller GN, Aldape KD, Alonso MM et al. (2006b). Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta1-dependent adhesion to the extracellular matrix. Mol Cancer Res 4: 915-926.
11. Livak KJ, Schmittgen TD. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25: 402-408.
12. Loureiro RM, D'Amore PA. (2005). Transcriptional regulation of vascular endothelial growth factor in cancer. Cytokine Growth Factor Rev 16: 77-89.
13. Machein MR, Knedla A, Knoth R, Wagner S, Neuschl E, Plate KH. (2004). Angiopoietin-1 promotes tumor angiogenesis in a rat glioma model. Am J Pathol 165: 1557-1570.
14. Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C et al. (1997). Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277: 55-60.
15. Shirakawa K, Shibuya M, Heike Y, Takashima S, Watanabe I, Konishi F et al. (2002). Tumor-infiltrating endothelial cells and endothelial precursor cells in inflammatory breast cancer. Int J Cancer 99: 344-351.
16. Suri C, McClain J, Thurston G, McDonald DM, Zhou H, Oldmixon EH et al. (1998). Increased vascularization in mice overexpressing angiopoietin-1. Science 282: 468-471.
17. Wang J, Wu K, Zhang D, Tang H, Xie H, Hong L et al. (2005). Expressions and clinical significances of angiopoietin-1, -2 and Tie2 in human gastric cancer. Biochem Biophys Res Commun 337: 386-393.
18. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. (2000). Vascular-specific growth factors and blood vessel formation. Nature 407: 242-248.