Identification and characterization of small-molecule inhibitors of Tie2 kinase

FEBS Letters

Volumn 582, Issue 5, 2008, Pages 785-791

  Liu, Jinqi ^a   Lin, Tsung H ^a   Cole, Andrew G ^a   Wen, Rong ^b   Zhao, Lian ^b   Brescia, Marc Raleigh ^a   Jacob, Biji ^a   Hussain, Zahid ^a   Appell, Kenneth C ^a   Henderson, Ian ^a   Webb, Maria L ^a  

^a PHARMACOPEIA INC   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Angiogenesis; Choroidal neovascularization; CYP450, selectivity; Small molecule inhibitor; Solubility; Stability; Tie2

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN RECEPTOR; CYTOCHROME P450;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME STRUCTURE; FEMALE; HUMAN; HUMAN CELL; IC 50; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RAT;

ANGIOPOIETIN-1; ANIMALS; CELLS, CULTURED; CHOROID; CHOROIDAL NEOVASCULARIZATION; COLLAGEN; CYTOCHROME P-450 ENZYME SYSTEM; DRUG COMBINATIONS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HUMANS; LAMININ; MICROSOMES, LIVER; PHOSPHORYLATION; PROTEOGLYCANS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TIE-2; SIGNAL TRANSDUCTION; SOLUBILITY;

RATTUS;

EID: 39649107340     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.02.003     Document Type: Article

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