Adrenocorticotropic hormone regulates the activities of the orphan nuclear receptor Nur77 through modulation of phosphorylation

Endocrinology

Volumn 138, Issue 10, 1997, Pages 4138-4146

  Li, Yanzhuang ^a   Lau, Lester F ^a,b  

^a UNIVERSITY OF ILLINOIS   (United States)

^b AMERICAN HEART ASSOCIATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CORTICOTROPIN; TRANSCRIPTION FACTOR;

ADRENAL CORTEX CELL; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION REGULATION; HORMONE ACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS;

EID: 0030930438     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.10.5464     Document Type: Article

References (52)

1. Simpson ER, Waterman MR 1988 Regulation of the synthesis of steroidogenic enzymes in adrenal cortical cells by ACTH. Annu Rev Physiol 50:427-440
2. Wilson TE, Mouw AR, Weaver CA, Milbrandt J, Parker KL 1993 The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase. Mol Cell Biol 13:861-868
3. Paker KL, Schimmer BP 1993 Transcriptional regulation of the adrenal steroidogenic enzymes. Trends Endocrinol Metab 4:46-50
4. Ikeda Y, Lala DS, Luo X, Kim E, Moisan M-P, Parker KL 1993 Characterization of the mouse FTZ-1 gene, which encodes a key regulator of steroid hydroxylase gene expression. Mol Endocrinol 7:852-860
5. Morohashi K-I, Honda S-I, Inomata Y, Handa H, Omura T 1992 A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s. J Biol Chem 267:17913-17919
6. Rice DA, Mouw AR, Bogerd AM, Parker KL 1991 A shared promoter element regulates the expression of three steroidogenic enzymes. Mol Endocrinol 5:1552-1561
7. Davis IJ, Lau LF 1994 Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal gland. Mol Cell Biol 14:3469-3483
8. Crawford PA, Sadovsky Y, Woodson K, Lee SL, Milbrandt J 1995 Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice. Mol Cell Biol 15:4331-4336
9. Hazel TG, Nathans D, Lau LF 1988 A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proc Natl Acad Sci USA 85:8444-8448
10. Milbrandt J 1988 Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene. Neuron 1:183-188
11. Nakai A, Kartha S, Sakurai A, Toback FG, DeGroot LJ 1990 A human early response gene homologous to murine nur77 and rat NGFI-B and related to the nuclear receptor superfamily. Mol Endocrinol 4:1438-1443
12. Ryseck RP, MacDonald Bravo H, Mattei MG, Ruppert S, Bravo R 1989 Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor. EMBO J 8:3327-3335
13. Wilson TE, Fahrner TJ, Johnston M, Milbrandt J 1991 Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science 252:1296-1300
14. Wilson TE, Fahrner TJ, Milbrandt J 1993 The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction. Mol Cell Biol 13:5794-5804
15. Perlmann T, Jansson L 1995 A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev 9:769-782
16. Scearce LM, Laz TM, Hazel TG, Lau LF, Taub R 1993 RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver. J Biol Chem 268:8855-8861
17. Liu Z-G, Smith SW, McLaughlin KA, Schwartz LM, Osborne BA 1994 Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77. Nature 367:281-284
18. Woronicz JD, Calnan B, Ngo V, Winoto A 1994 Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas. Nature 367:277-281
19. Lee SL, Wesselschmidt RL, Linette GP, Kanagawa O, Russell JH, Milbrandt J 1995 Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77). Science 269:532-535
20. Hazel TG, Misra R, Davis IJ, Greenberg ME, Lau LF 1991 Nur77 is differentially modified in PC12 cells upon membrane depolarization and growth factor treatment. Mol Cell Biol 11:3239-3246
21. Davis IJ, Hazel TG, Chen R-H, Blenis J, Lau LF 1993 Functional domains and phosphorylation of the orphan receptor Nur77. Mol Endocrinol 7:953-964
22. Wilson TE, Paulsen RE, Padgett KA, Milbrandt J 1992 Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors. Science 256:107-110
23. Hirata Y, Kiuchi K, Chen H-C, Milbrandt J, Guroff G 1993 The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B. J Biol Chem 268:24808-24812
24. Adra CN, Boer PH, McBurney MW 1987 Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter. Gene 60:65-74
25. Davis IJ, Hazel TG, Lau LF 1991 Transcriptional activation by Nur77, a growth factor-inducible member of the steroid hormone receptor superfamily. Mol Endocrinol 5:854-859
26. Webster N, Jin JR, Green S, Hollis M, Chambon P 1988 The yeast UASg is a transcriptional enhancer in human HeLa cells in the presence of the GAL4 transactivator. Cell 52:169-178
27. Sun H, Charles CH, Lau LF, Tonks NK 1993 MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 75:467-493
28. Konig H, Ponta H, Rahmsdorf U, Buscher M, Schonthal A, Rahmsdorf HJ, Herrlich P 1989 Autoregulation of fos: the dyad symmetry element as the major target of repression. EMBO J 8:2559-2566
29. Bialojan C, Takai A 1988 Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Biochem J 256:283-290
30. Haystead TAJ, Sim ATR, Carling D, Honnor RC, Tsukitani Y, Cohen P, Hardie DG 1989 Effects of the tumor promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature 337:78-81
31. Arnold SF, Vorojeikina DP, Notides AC 1995 Phosphorylation of tyrosine 537 on the human estrogen receptor is required for binding to an estrogen response element. J Biol Chem 270:30205-30212
32. Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME 1993 A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. Mol Cell Biol 13:6260-6273
33. Marais RM, Hsuan JJ, McGuigan C, Wynne J, Treisman R 1992 Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange. EMBO J 11:97-105
34. Raychaudhuri P, Bagchi S, Nevins JR 1989 DNA-binding activity of the adenovirus-induced E4F transcripton factor is regulated by phosphorylation. Genes Dev 3:620-627
35. Huang W, Erikson RL 1994 Constitutive activation of Mek by mutation of serine phosphorylation sites. Proc Natl Acad Sci USA 91:8960-8963
36. Mansour SJ, Matten WT, Hermann AS, Candia JM, Rong S, Fukasawa K, Vande Woude GF, Ahn NG 1994 Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265:966-970
37. Crews CM, Alessandrini A, Erikson RL 1992 Erks: their fifteen minutes has arrived. Cell Growth Differ 3:135-142
38. Blenis J 1993 Signal transduction via the MAP kinases: proceed at your own RSK. Proc Natl Acad Sci USA 90:5889-5892
39. Vaillancourt RR, Gardner AM, Johnson GL 1994 B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP. Mol Cell Biol 14:6522-6530
40. Cook SJ, McCormick F 1993 Inhibition by cAMP of Ras-dependent activation of Raf. Science 262:1069-1072
41. Wu J, Dent P, Jelinek T, Wolfman A, Weber MJ, Sturgill TW 1993 Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′,5′-monophosphate. Science 262:1065-1069
42. Graves LM, Bornfeldt KE, Raines EW, Potts BC, MacDonald SG, Ross R, Krebs EG 1993 Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. Proc Natl Acad Sci USA 90:10300-10304
43. Sevetson BR, Kong X, Lawrence JC 1993 Increasing cAMP attenuates activation of mitogen-activated protein kinase. Proc Natl Acad Sci USA 90:10305-10309
44. ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J 12:4211-4220
45. Charles CH, Sun H, Lau LF, Tonks NK 1993 The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase. Proc Natl Acad Sci USA 90:5292-5296
46. Treisman R 1994 Ternary complex factors: growth factor regulated transcriptional activators. Curr Opin Genet Dev 4:96-101
47. Yamamoto KK, Gonzalez GA, Biggs III WH, Montminy MR 1988 Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. Nature 334:494-498
48. Hunter T, Karin M 1992 The regulation of transcription by phosphorylation. Cell 70:375-387
49. Zhang P, Mellon SH 1996 The orphan nuclear receptor steroidogenic factor-1 regulates the cyclic adenosine 3′,5′-monophosphate-mediated transcriptional activation of rat cytochrome P450c17 (17α-hydroxylase/c17-20 lyase). Mol Endocrinol 10:147-158
50. Rastinejad F, Perlmann T, Evans RM, Sigler PB 1995 Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature 375:203-211
51. Simpson ER, Waterman MR 1989 Steroid hormone biosynthesis in the adrenal cortex and its regulation by adrenocorticotropin. In: DeGroot LJ (ed) Endocrinology. Saunders, Philadelphia, pp 1543-1556
52. Hirata Y, Whalin M, Ginty DD, Xing J, Greenberg ME, Milbrandt J, Guroff G 1995 Induction of a nerve growth factor-sensitive kinase that phosphorylates the DNA-binding domain of the orphan nuclear receptor NGFI-B. J Neurochem 65:1780-1788