NOD2 engagement induces proinflammatory cytokine production, but not apoptosis, in leukocytes isolated from patients with Crohn's disease

European Cytokine Network

Volumn 19, Issue 4, 2008, Pages 185-189

  Bodar, Evelien ^a   Netea, Mihai G ^a   De Jong, Dirk J ^a   Kullberg, Bart Jan ^a   Joosten, Leo A B ^a   Van Der Meer, Jos W M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apoptosis; Crohn's disease; Cytokines; NOD2

Indexed keywords

ANISOMYCIN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; MURAMYL DIPEPTIDE; CYTOKINE; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINE;

ALLELE; APOPTOSIS; ARTICLE; CELL ISOLATION; COMPARATIVE STUDY; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; GRANULOCYTE; HOMOZYGOSITY; HUMAN; HUMAN CELL; IMMUNOASSAY; INFLAMMATION; LEUKOCYTE; LYMPHOCYTE; MONONUCLEAR CELL; MUTATION; NEUTROPHIL; BIOSYNTHESIS; CELL CULTURE; CELL SEPARATION; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM;

BACTERIA (MICROORGANISMS);

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; APOPTOSIS; CELL SEPARATION; CELLS, CULTURED; CROHN DISEASE; CYTOKINES; HUMANS; LEUKOCYTES; MUTATION; NOD2 SIGNALING ADAPTOR PROTEIN;

EID: 64049111891     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: 10.1684/ecn.2008.0140     Document Type: Article

References (26)

1. Kufer TA, Fritz JH, Philpott DJ. NACHT-LRR proteins (NLRs) in bacterial infection and immunity. Trends Microbiol 2005; 13: 381-8.
2. Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, Thomas G, et al Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 2003; 278: 8869-72.
3. Hugot J-P, Chamaillard M, Zouali H, Lesage S, Cézard JP, Belaiche J, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001; 411: 599-603.
4. Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001; 411: 603-6.
5. Eckmann L, Karin M. NOD2 and Crohn's disease: loss or gain of function? Immunity 2005; 22: 661-7.
6. Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, et al. Host recognition of bacterial muramyl dipeptide mediated through Nod2. J Biol Chem 2003; 278: 5509-12.
7. Netea MG, Kullberg BJ, de Jong D, Franke B, Sprong T, Naber TH, et al. NOD2 mediates induction of the antiinflamma- tory signals induced by TLR2-ligands: implications for Crohn's disease. Eur JImmunol 2004; 34: 2052-9.
8. Netea MG, Ferwerda G, De Jong DJ, Jansen T, Jacobs L, Kramer M, et al. NOD2 modulates specific Toll-like receptor pathways for the induction of cytokine release. J Immunol 2005; 174: 6518-23.
9. van Heel DA, Ghosh S, Butler M, Hunt KA, Lundberg AM, Ahmad T, et al. Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease. Lancet 2005; 365: 1794-6.
10. Kullberg BJ, Ferwerda G, de Jong DJ, Drenth JP, Joosten LA, Van der Meer JW, et al Crohn's disease patients homozygous for the 3020insC NOD2 mutation have a defective NOD2/TLR4 cross-tolerance to intestinal stimuli. Immunology 2008; 123: 600-5.
11. Hedl M, Li J, Cho JH, Abraham C. Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc Natl Acad Sci USA 2007; 104: 19440-5.
12. Inohara N, Nunez G. NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol 2003; 3: 371-82.
13. Bertin J, Nir WJ, Fischer CM, Tayber OV, Errada PR, Grant JR, et al. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB. J Biol Chem 1999; 274: 12955-8.
14. Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, et al. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor- kappaB. J Biol Chem 1999; 274: 14560-7.
15. Beutler B. Autoimmunity and apoptosis: the Crohn's connection. Immunity 2001; 15: 5-14.
16. Zelinkova Z, van Beelen AJ, de Kort F, Moerland PD, Ver Loren van Themaat E, te Velde AA, et al. Muramyl dipeptide-induced differential gene expression in NOD2 mutant and wild-type Crohn's disease patient-derived dendritic cells. Inflamm Bowel Dis 2008; 14: 186-94.
17. Wehkamp J, Harder J, Weichenthal M, Schwab M, Schäffeler E, Schlee M, et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defesin expression. Gut 2004; 53: 1658-64.
18. Chen M, Wang YH, Wang Y, Huang L, Sandoval H, Liu YJ, et al. Dendritic cell apoptosis in the maintenance of immune tolerance. Science 2006; 311: 1160-4.
19. Mudter J, Neurath MF. Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications. Gut 2007; 56: 293-303.
20. Beutler B. Autoimmunity and apoptosis: the Crohn's connection. Immunity 2001; 15: 5-14.
21. Martinon F, Agostini L, Meylan E, Tschopp J. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol 2004; 14: 1929-34.
22. Faustin B, Lartigue L, Bruey JM, Luciano F, Sergienko E, Bailly- Maitre B, et al. Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Mol Cell 2007; 25: 713-24.
23. Ferwerda G, Girardin SE, Kullberg BJ, Le Bourhis L, de Jong DJ, Langenberg DM, et al. NOD2 and Toll-LIKE Receptors are two non-redundant recognition systems of Mycobacterium tuberculosis. PLoSPathogens 2005; 1: 279-85.
24. Opitz B, Puschel A, Schmeck B, Hocke AC, Rosseau S, Ham- merschmidt S, et al. Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. J Biol Chem 2004; 35: 36426-32.
25. Opitz B, Forster S, Hocke AC, Maass M, Schmeck B, Hippenstiel S, et al. Nod1-mediated endothelial cell activation by Chlamydo- phila pneumoniae. Circ Res 2005; 96: 319-26.
26. Bocchino M, Galati D, Sanduzzi A, Colizzi V, Brunetti E, Man- cino G. Role of mycobacteria-induced monocyte/macrophage apoptosis in the pathogenesis of human tuberculosis. Int J Tuberc Lung Dis 2005; 9: 375-83.