Peroxisome Proliferator-Activated Receptor α Controls Hepatic Heme Biosynthesis Through ALAS1

Journal of Molecular Biology

Volumn 388, Issue 2, 2009, Pages 225-238

  Degenhardt, Tatjana ^a   Väisänen, Sami ^a   Rakhshandehroo, Maryam ^b,c   Kersten, Sander ^b,c   Carlberg, Carsten ^a,d  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^c WAGENINGEN UNIVERSITY   (Netherlands)

^d UNIVERSITY OF LUXEMBOURG   (Luxembourg)

Author keywords

chromatin; metabolism; nuclear receptor; PPAR ; transcriptional regulation

Indexed keywords

2 [4 [2 [3 CYCLOHEXYL 1 (4 CYCLOHEXYLBUTYL)UREIDO]ETHYL]PHENYLTHIO] 2 METHYLPROPIONIC ACID; 5 AMINOLEVULINATE SYNTHASE; COPROPORPHYRINOGEN OXIDASE; HEME; MESSENGER RNA; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PORPHOBILINOGEN SYNTHASE; PROTOPORPHYRINOGEN OXIDASE; RETINOID X RECEPTOR; RNA POLYMERASE II; UROPORPHYRINOGEN DECARBOXYLASE; UROPORPHYRINOGEN III SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL STRAIN HEPG2; ENERGY METABOLISM; ENZYME REGULATION; GENE SILENCING; HEME SYNTHESIS; HUMAN; HUMAN CELL; LIVER CELL; MOUSE; NONHUMAN; OXYGEN TRANSPORT; PRIORITY JOURNAL; REGULATORY MECHANISM; TRANSCRIPTION INITIATION SITE;

EID: 64049107669     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.03.024     Document Type: Article

References (39)

1. Atamna H. Heme, iron, and the mitochondrial decay of ageing. Ageing Res. Rev. 3 (2004) 303-318
2. Ponka P. Cell biology of heme. Am. J. Med. Sci. 318 (1999) 241-256
3. Tsiftsoglou A.S., Tsamadou A.I., and Papadopoulou L.C. Heme as key regulator of major mammalian cellular functions: molecular, cellular, and pharmacological aspects. Pharmacol. Ther. 111 (2006) 327-345
4. Li B., Holloszy J.O., and Semenkovich C.F. Respiratory uncoupling induces delta-aminolevulinate synthase expression through a nuclear respiratory factor-1-dependent mechanism in HeLa cells. J. Biol. Chem. 274 (1999) 17534-17540
5. Anderson K.E., Bloomer J.R., Bonkovsky H.L., Kushner J.P., Pierach C.A., Pimstone N.R., and Desnick R.J. Recommendations for the diagnosis and treatment of the acute porphyrias. Ann. Intern. Med. 142 (2005) 439-450
6. Kauppinen R. Porphyrias. Lancet 365 (2005) 241-252
7. Kolluri S., Sadlon T.J., May B.K., and Bonkovsky H.L. Haem repression of the housekeeping 5-aminolaevulinic acid synthase gene in the hepatoma cell line LMH. Biochem. J. 392 (2005) 173-180
8. May B.K., Dogra S.C., Sadlon T.J., Bhasker C.R., Cox T.C., and Bottomley S.S. Molecular regulation of heme biosynthesis in higher vertebrates. Prog. Nucleic Acid Res. Mol. Biol. 51 (1995) 1-51
9. Thunell S., Harper P., and Brun A. Porphyrins, porphyrin metabolism and porphyrias: IV. Pathophysiology of erythyropoietic protoporphyria-diagnosis, care and monitoring of the patient. Scand. J. Clin. Lab. Invest. 60 (2000) 581-604
10. Fraser D.J., Podvinec M., Kaufmann M.R., and Meyer U.A. Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR). J. Biol. Chem. 277 (2002) 34717-34726
11. Fraser D.J., Zumsteg A., and Meyer U.A. Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene. J. Biol. Chem. 278 (2003) 39392-39401
12. Podvinec M., Handschin C., Looser R., and Meyer U.A. Identification of the xenosensors regulating human 5-aminolevulinate synthase. Proc. Natl. Acad. Sci. USA 101 (2004) 9127-9132
13. Peyer A.K., Jung D., Beer M., Gnerre C., Keogh A., Stroka D., et al. Regulation of human liver delta-aminolevulinic acid synthase by bile acids. Hepatology 46 (2007) 1960-1970
14. Handschin C., Lin J., Rhee J., Peyer A.K., Chin S., Wu P.H., et al. Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell 122 (2005) 505-515
15. Chawla A., Repa J.J., Evans R.M., and Mangelsdorf D.J. Nuclear receptors and lipid physiology: opening the X-files. Science 294 (2001) 1866-1870
16. Willson T.M., Brown P.J., Sternbach D.D., and Henke B.R. The PPARs: from orphan receptors to drug discovery. J. Med. Chem. 43 (2000) 527-550
17. Mandard S., Müller M., and Kersten S. Peroxisome proliferator-activated receptor alpha target genes. Cell. Mol. Life Sci. 61 (2004) 393-416
18. Akiyama T.E., Lambert G., Nicol C.J., Matsusue K., Peters J.M., Brewer Jr. H.B., and Gonzalez F.J. Peroxisome proliferator-activated receptor beta/delta regulates very low density lipoprotein production and catabolism in mice on a Western diet. J. Biol. Chem. 279 (2004) 20874-20881
19. Di-Poi N., Tan N.S., Michalik L., Wahli W., and Desvergne B. Antiapoptotic role of PPARβ in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol. Cell 10 (2002) 721-733
20. Yamazaki K., Kuromitsu J., and Tanaka I. Microarray analysis of gene expression changes in mouse liver induced by peroxisome proliferator-activated receptor α agonists. Biochem. Biophys. Res. Commun. 290 (2002) 1114-1122
21. Frederiksen K.S., Wulff E.M., Sauerberg P., Mogensen J.P., Jeppesen L., and Fleckner J. Prediction of PPARα ligand-mediated physiological changes using gene expression profiles. J. Lipid Res. 45 (2004) 592-601
22. Vanden Heuvel J.P., Kreder D., Belda B., Hannon D.B., Nugent C.A., Burns K.A., and Taylor M.J. Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643. Toxicol. Appl. Pharmacol. 188 (2003) 185-198
23. Kersten S., Desvergne B., and Wahli W. Roles of PPARs in health and disease. Nature 405 (2000) 421-424
24. Kliewer S.A., Umesono K., Noonan D.J., Heyman R.A., and Evans R.M. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 358 (1992) 771-774
25. Jpenberg A., Jeannin E., Wahli W., and Desvergne B. Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element. J. Biol. Chem. 272 (1997) 20108-20117
26. Vega R.B., Huss J.M., and Kelly D.P. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell. Biol. 20 (2000) 1868-1876
27. Tudor C., Feige J.N., Pingali H., Lohray V.B., Wahli W., Desvergne B., et al. Association with coregulators is the major determinant governing peroxisome proliferator-activated receptor mobility in living cells. J. Biol. Chem. 282 (2007) 4417-4426
28. Yuan C.-X., Ito M., Fondell J.D., Fu Z.-Y., and Roeder R.G. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc. Natl. Acad. Sci. USA 95 (1998) 7939-7944
29. Degenhardt T., Matilainen M., Herzig K.H., Dunlop T.W., and Carlberg C. The insulin-like growth factor-binding protein 1 gene is a primary target of peroxisome proliferator-activated receptors. J. Biol. Chem. 281 (2006) 39607-39619
30. Heinäniemi M., Uski J.O., Degenhardt T., and Carlberg C. Meta-analysis of primary target genes of peroxisome proliferator-activated receptors. Genome Biol. 8 (2007) R147
31. Mascaro C., Acosta E., Ortiz J.A., Marrero P.F., Hegardt F.G., and Haro D. Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor. J. Biol. Chem. 273 (1998) 8560-8563
32. Rakhshandehroo M., Sanderson L.M., Matilainen M., Stienstra R., Carlberg C., de Groot P.J., et al. Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling. PPAR Res. 2007 (2007) 26839
33. Granick S., Sinclair P., Sassa S., and Grieninger G. Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition. J. Biol. Chem. 250 (1975) 9215-9225
34. Lindberg R.L., Porcher C., Grandchamp B., Ledermann B., Burki K., Brandner S., et al. Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria. Nat. Genet. 12 (1996) 195-199
35. Sassa S. The porphyrias. Photodermatol. Photoimmunol. Photomed. 18 (2002) 56-67
36. Wang X., and Seed B. A PCR primer bank for quantitative gene expression analysis. Nucleic Acids Res. 31 (2003) e154
37. Kohany O., Gentles A.J., Hankus L., and Jurka J. Annotation, submission and screening of repetitive elements in Repbase: RepbaseSubmitter and Censor. BMC Bioinformatics 7 (2006) 474
38. Sher T., Yi H.-F., McBride O.W., and Gonzalez F.J. cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 32 (1993) 5598-5604
39. Mangelsdorf D.J., Ong E.S., Dyck J.A., and Evans R.M. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 345 (1990) 224-229