Gene, cell, and axon changes in the familial amyotrophic lateral sclerosis mouse sensorimotor cortex

Journal of Neuropathology and Experimental Neurology

Volumn 68, Issue 1, 2009, Pages 59-72

  Kassa, Roman M ^a,b   Mariotti, Raffaella ^a   Bonaconsa, Marta ^a   Bertini, Giuseppe ^a   Bentivoglio, Marina ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b Faculty of Medicine   (Italy)

Author keywords

amyloid precursor protein; Amyotrophic lateral sclerosis; Astrocytes; Corticospinal tract; Cytokines; Gene expression; Microglia

Indexed keywords

AMYLOID PRECURSOR PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; 2 HYDROXY 4,4' DIAMIDINOSTILBENE, METHANESULFONATE SALT; 2-HYDROXY-4,4'-DIAMIDINOSTILBENE, METHANESULFONATE SALT; CD11B ANTIGEN; CYTOKINE; GLIAL FIBRILLARY ACIDIC PROTEIN; STILBAMIDINE; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AXONAL INJURY; BIOACCUMULATION; CAPSULA INTERNA; CELL ACTIVATION; CELL LABELING; CELL SIZE; CONTROLLED STUDY; DISEASE MODEL; DISEASE SEVERITY; FAMILIAL DISEASE; GENE EXPRESSION REGULATION; GENE INDUCTION; GLIA CELL; IMMUNOHISTOCHEMISTRY; MICROGLIA; MOTOR CORTEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; PYRAMIDAL TRACT; SENSORIMOTOR CORTEX; SIGNAL TRANSDUCTION; TISSUE LEVEL; ANIMAL; GENE EXPRESSION; GENETICS; GLIA; HUMAN; METABOLISM; NERVE CELL; NERVE FIBER; PATHOLOGY; PATHOPHYSIOLOGY; SOMATOSENSORY CORTEX; TRANSGENIC MOUSE;

AMYLOID BETA-PROTEIN PRECURSOR; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANTIGENS, CD11B; AXONS; CYTOKINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MICE; MICE, TRANSGENIC; NEUROGLIA; NEURONS; PYRAMIDAL TRACTS; SOMATOSENSORY CORTEX; STILBAMIDINES; SUPEROXIDE DISMUTASE;

EID: 64049091552     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181922572     Document Type: Article

References (54)

1. Bendotti C, Carrý MT. Lessons from models of SOD-linked familial ALS. Trends Mol Med 2004;10:393-400
2. Kato S. Amyotrophic lateral sclerosis models and human neuropathology: Similarities and differences. Acta Neuropathol 2008;115: 97-114
3. Turner BJ, Talbot K. Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS. Progr Neurobiol 2008; 85:94-134
4. Lobsinger CS, Cleveland DW. Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease. Nat Neurosci 2007;10: 1355-60
5. Alexander GM, Deitch JS, Seeburger JL, et al. Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase. J Neurochem 2000;74: 1666-73
6. Browne SE, Yang L, DiMauro JP, et al. Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS. Neurobiol Dis 2006;22: 599-610
7. Liu D, Bao F, Wen J, et al. Mutation of superoxide dismutase elevates reactive species: Comparison of nitration and oxidation of proteins in different brain regions of transgenic mice with amyotrophic lateral sclerosis. Neuroscience 2007;146:255-64
8. Petrik MS, Wilson JMB, Grant SC, et al. Magnetic resonance microscopy and immunohistochemistry of the CNS of the mutant SOD murine model of ALS reveals widespread neuronal deficits. Neuromol Med 2007;9:216-29
9. Zang DW, Cheema SS. Degeneration of corticospinal and bulbospinal systems in the superoxide dismutase 1 (G93A G1H) transgenic mouse model of familial amyotrophic lateral sclerosis. Neurosci Lett 2002;332: 99-102
10. Kuypers HGJM. Anatomy of the descending pathways. In: Handbook of Physiology: The Nervous System II. Baltimore, MD: Lippincott Williams and Wilkins, 1981:596-666
11. Steward O, Zheng B, Ho C, et al. The dorsolateral corticospinal tract in mice: An alternative route for corticospinal input to caudal segments following dorsal column lesions. J Comp Neurol 2004;472:463-77
12. Leichsenring A, Linnartz B, Zhu XR, et al. Ascending neuropathology in the CNS of a mutant SOD1 mouse model of amyotrophic lateral sclerosis. Brain Res 2006;1096:180-95
13. Jaarsma D, Teuling E, Haasdijk ED, et al. Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice. J Neurosci 2008;28:2075-88
14. Wang L, Sharma K, Deng H-X, et al. Restricted expression of mutant SOD-1 in spinal motoneurons and interneurons induces neuron pathology. Neurobiol Dis 2008;29:400-8
15. Boillée S, Cleveland DW. Revisiting oxidative damage in ALS: Microglia, Nox, and mutant SOD1. J Clin Invest 2008;118:474-78
16. Stone JR, Singleton RH, Povlishock JT. Antibodies to the C-terminus of the A-amyloid precursor protein (APP): A site specific marker for the detection of traumatic axonal injury. Brain Res 2000;871:288-302
17. Gurney ME, Pu H, Chiu AY, et al. Motor neuron degeneration in mice expressing a human Cu, Zn superoxide dismutase mutation. Science 1994;264:1772-75 (Pubitemid 24227760)
18. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and 2j$$Ct. Methods 2001;25:402-8
19. Bentivoglio M, Kuypers HGJM, Catsman-Berrevoets CE, et al. Two new fluorescent retrograde neuronal tracers which are transported over long distances. Neurosci Lett 1980;18:25-30
20. Schmued LC, Fallon JH. Fluoro-Gold: A new fluorescent retrograde axonal tracer with numerous unique properties. Brain Res 1986;377: 147-54
21. Burry RW. Specificity controls for immunocytochemical methods. J Histochem Cytochem 2000;48:163-65
22. Lorincz A, Nusser Z. Specificity of immunoreactions: The importance of testing specificity in each method. J Neurosci 2008;10:9083-86
23. Stone JR, Walker SA, Povlishock JT. The visualization of a new class of traumatically injured axons through the use of a modified method of microwave antigen retrieval. Acta Neuropathol 1999;97: 335-45
24. Ladeby R, Wirenfeldt M, Garcia-Ovejero D, et al. Microglial cell population dynamics in the injured adult central nervous system. Brain Res Rev 2005;48:196-206
25. Franklin KBJ, Paxinos G. The mouse brain in stereotaxic coordinates. San Diego, CA: Academic Press, 1997
26. Fabene PF, Marzola P, Sbarbati A, et al. Magnetic resonance imaging of changes elicited by status epilepticus in the rat brain: Diffusionweighted and T2-weighted images, regional blood volume maps, and direct correlation with tissue and cell damage. Neuroimage 2003;18: 375-89
27. Kassa RM, Bentivoglio M, Mariotti R. Changes in the expression of P2X1 and P2X2 purinergic receptors in facial motoneurons after nerve lesions in rodents and correlation with motoneuron degeneration. Neurobiol Dis 2007;25:121-33
28. Hensley K, Floyd RA, Gordon B, et al. Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. J Neurochem 2002;82:365-74
29. Elliott JL. Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis. Brain Res Mol Brain Res 2001;95:172-78
30. Basu A, Krady JK, Levison SW. Interleukin-1: A master regulator of neuroinflammation. J Neurosci Res 2004;78:151-56
31. Allan SM, Tyrrell PJ, Rothwell NJ. Interleukin-1 and neuronal injury. Nat Rev Immunol 2005;5:629-40
32. Bartfai T, Sanchez-Alvarez M, Andell-Jonsson S, et al. Interleukin-1 system in CNS stress: Seizure, fever, and neurotrauma. Ann N Y Acad Sci 2007;1113:173-77
33. Almer G, Vukosavic S, Romero N, et al. Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem 1999;72:2415-25
34. Martin LJ, Liu Z, Chen K, et al. Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: Mechanisms of mitochondriopathy and cell death. J Comp Neurol 2007;500:20-46
35. Heneka MT, Feinstein DL. Expression and function of inducible nitric oxide synthase in neurons. J Neuroimmunol 2001;114:8-18
36. Sasaki S, Shibata N, Komori T, et al. iNOS and nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis. Neurosci Lett 2000
37. Mattson MP. NF-kappaB in the survival and plasticity of neurons. Neurochem Res 2005;30:883-93
38. Zang DW, Lopes EC, Cheema SS. Loss of synaptophysin-positive boutons on lumbar motor neurons innervating the medial gastrocnemius muscle of the SOD1G93A G1H transgenic mouse model of ALS. J Neurosci Res 2005;79:694-99
39. Schütz B. Imbalanced excitatory to inhibitory synaptic input precedes motor neuron degeneration in an animal model of amyotrophic lateral sclerosis. Neurobiol Dis 2005;20:131-40
40. Kiernan JA, Hudson AJ. Changes in sizes of cortical and lower motor neurons in amyotrophic lateral sclerosis. Brain 1991;114:843-53
41. Toft MH, Gredal O, Pakkenberg B. The size distribution of neurons in the motor cortex in amyotrophic lateral sclerosis. J Anat 2005;207: 399-407
42. Minciacchi D, Kassa RM, Del Tongo C, et al. Voronoi-based spatial analysis reveals selective interneuron changes in the cortex of FALS mice. Exp Neurol 2008; doi: 10.1016/j.expneurol.2008.09.005.
43. Fischer LR, Culver DG, Tennant P, et al. Amyotrophic lateral sclerosis is a distal axonopathy: Evidence in mice and man. Exp Neurol 2004;185: 232-40
44. Koo EH, Sisodia SS, Archer DR, et al. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci U S A 1990;87:1561-65
45. Ferguson B, Matyszak MK, Esiri MM, et al. Axonal damage in acute multiple sclerosis lesions. Brain 1997;120:393-99
46. Chevalier-Larsen E, Holzbaur ELF. Axonal transport and neurodegenerative disease. Biochim Biophys Acta 2006;1762:1094-108!
47. Sasaki S, Iwata M. Immunoreactivity of A-amyloid precursor protein in amyotrophic lateral sclerosis. Acta Neuropathol 1999;97:463-68
48. Singleton RH, Zhu J, Stone JR, et al. Traumatically induced axotomy adjacent to the soma does not result in acute neuronal death. J Neurosci 2002;22:791-802
49. Nagy D, Kato T, Kushner PD. Reactive astrocytes are widespread in the cortical gray matter of amyotrophic lateral sclerosis. J Neurosci Res 1994;38:336-47
50. Di Giorgio FP, Carasco MA, Siao MC, et al. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat Neurosci 2007;10:608-14
51. Julien JP. ALS: Astrocytes move in as deadly neighbors. Nat Neurosci 2007;10:535-37
52. Nagai M, Re DB, Nagata T, et al. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci 2007;10:615-22
53. Yamanaka K, Chun SJ, Boillée S, et al. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci 2008;11:251-53
54. Alexianu ME, Kozovska M, Appel SH. Immune reactivity in a mouse model of familial ALS correlates with disease progression. Neurology 2001;57:1282-89