Revisiting oxidative damage in ALS: Microglia, Nox, and mutant SOD1

Journal of Clinical Investigation

Volumn 118, Issue 2, 2008, Pages 474-478

  Boillée, Séverine ^a   Cleveland, Don W ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOCYNIN; COPPER ZINC SUPEROXIDE DISMUTASE; PROTEIN INHIBITOR; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2;

AMYOTROPHIC LATERAL SCLEROSIS; CELL ACTIVATION; DISEASE COURSE; ENZYME BINDING; GENE MUTATION; INFLAMMATION; MICROGLIA; NERVE CELL LESION; NONHUMAN; NOTE; OXIDATIVE STRESS; PATHOGENESIS; PHOSPHORYLATION; PRIORITY JOURNAL; SUPEROXIDE DISMUTASE 1 GENE;

ACETOPHENONES; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ENZYME INHIBITORS; HUMANS; MICE; MICROGLIA; MOTOR NEURONS; NADPH OXIDASE; OXIDATIVE STRESS; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 38849143389     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI34613     Document Type: Note

References (23)

1. Crow, J.P., Calingasan, N.Y., Chen, J., Hill, J.L., and Beal, M.F. 2005. Manganese porphyrin given at symptom onset markedly extends survival of ALS mice. Ann. Neurol. 58:258-265.
2. Boillee, S., Vande Velde, C., and Cleveland, D.W. 2006. ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron. 52:39-59.
3. Clement, A.M., et al. 2003. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science. 302:113-117.
4. Rothstein, J.D., Jin, L., Dykes-Hoberg, M., and Kuncl, R.W. 1993. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc. Natl. Acad. Sci. U. S. A. 90:6591-6595.
5. Di Giorgio, F.P., Carrasco, M.A., Siao, M.C., Maniatis, T., and Eggan, K. 2007. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat. Neurosci. 10:608-614.
6. Nagai, M., et al. 2007. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat. Neurosci. 10:615-622.
7. Van Damme, P., et al. 2007. Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity. Proc. Natl. Acad. Sci. U. S. A. 104:14825-14830.
8. Kriz, J., Nguyen, M.D., and Julien, J.P. 2002. Mino-cycline slows disease progression in a mouse model of amyotrophic lateral sclerosis. Neurobiol. Dis. 10:268-278.
9. Van Den Bosch, L., Tilkin, P., Lemmens, G., and Robberecht, W. 2002. Minocycline delays disease onset and mortality in a transgenic model of ALS. Neuroreport. 13:1067-1070.
10. Nguyen, M.D., D'Aigle, T., Gowing, G., Julien, J.P., and Rivest, S. 2004. Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. J. Neurosci. 24:1340-1349.
11. Boillee, S., et al. 2006. Onset and progression in inherited ALS determined by motor neurons and microglia. Science. 312:1389-1392.
12. Beers, D.R., et al. 2006. Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U. S. A. 103:16021-16026.
13. Wu, D.C., Re, D.B., Nagai, M., Ischiropoulos, H., and Przedborski, S. 2006. The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice. Proc. Natl. Acad. Sci. U. S. A. 103:12132-12137.
14. Marden, J.J., et al. 2007. Redox modifier genes in amyotrophic lateral sclerosis in mice. J. Clin. Invest. 117:2913-2919.
15. Bedard, K., and Krause, K.H. 2007. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol. Rev. 87:245-313.
16. Walder, C.E., et al. 1997. Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase. Stroke. 28:2252-2258.
17. Wu, D.C., et al. 2003. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc. Natl. Acad. Sci. U. S. A. 100:6145-6150.
18. Gao, H.M., Liu, B., and Hong, J.S. 2003. Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J. Neurosci. 23:6181-6187.
19. Qin, B., et al. 2006. A key role for the microglial NADPH oxidase in APP-dependent killing of neurons. Neurobiol. Aging. 27:1577-1587.
20. Harraz, M.M., et al. 2008. SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. J. Clin. Invest. 118:659-670.
21. Sato, T., et al. 2005. Rapid disease progression correlates with instability of mutant SOD1 in familial ALS. Neurology. 65:1954-1957.
22. Subramaniam, J.R., et al. 2002. Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nat. Neurosci. 5:301-307.
23. Stolk, J., Hiltermann, T.J., Dijkman, J.H., and Verhoeven, A.J. 1994. Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am. J. Respir. Cell Mol. Biol. 11:95-102.