Practical guidelines for diagnosis and early management of drug-induced liver injury

World Journal of Gastroenterology

Volumn 14, Issue 44, 2008, Pages 6774-6785

  Tajiri, Kazuto ^a   Shimizu, Yukihiro ^b  

^a UNIVERSITY OF TOYAMA   (Japan)

^b KYOTO KATSURA HOSPITAL   (Japan)

Author keywords

Diagnosis; Drug induced liver injury; Guidelines; Management

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ATORVASTATIN; AZITHROMYCIN; BENTAZEPAM; BILIRUBIN; CAPTOPRIL; CARBAMAZEPINE; CLINDAMYCIN; CYCLOPHOSPHAMIDE; DICLOFENAC; EBROTIDINE; ERYTHROMYCIN; FENOFIBRATE; FLUTAMIDE; HALOTHANE; IBUPROFEN; ISONIAZID; NIMESULIDE; OXYCODONE; PARACETAMOL; PAROXETINE; STAVUDINE; TETRABAMATE; TICLOPIDINE; TROGLITAZONE; TROVAFLOXACIN; UNINDEXED DRUG; VALPROIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BLOOD ANALYSIS; DIAGNOSTIC PROCEDURE; DRUG WITHDRAWAL; EARLY INTERVENTION; HISTOPATHOLOGY; HUMAN; LIVER INJURY; MEDICAL DECISION MAKING; PRACTICE GUIDELINE; RATING SCALE; REVIEW; CHEMICALLY INDUCED DISORDER; DIFFERENTIAL DIAGNOSIS; DRUG EFFECT; EARLY DIAGNOSIS; HOSPITALIZATION; LIVER; LIVER DISEASE; LIVER FUNCTION TEST; PATHOLOGY; RISK FACTOR; TREATMENT OUTCOME;

DIAGNOSIS, DIFFERENTIAL; EARLY DIAGNOSIS; HUMANS; LIVER; LIVER DISEASES; LIVER FUNCTION TESTS; PRACTICE GUIDELINES AS TOPIC; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 64049090993     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.14.6774     Document Type: Review

References (111)

1. Hussaini SH, Farrington EA. Idiosyncratic drug-induced liver injury: an overview. Expert Opin Drug Saf 2007; 6: 673-684 (Pubitemid 351308279)
2. Norris W, Paredes AH, Lewis JH. Drug-induced liver injury in 2007. Curr Opin Gastroenterol 2008; 24: 287-297
3. Carey EJ, Vargas HE, Douglas DD, Balan V, Byrne TJ, Harrison ME, Rakela J. Inpatient admissions for druginduced liver injury: results from a single center. Dig Dis Sci 2008; 53: 1977-1982
4. Danan G, Benichou C. Causality assessment of adverse reactions to drugs - I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol 1993; 46: 1323-1330 (Pubitemid 23333873)
5. Bénichou C. Criteria of drug-induced liver disorders. Report of an international consensus meeting. J Hepatol 1990; 11: 272-276
6. Andrade RJ, Lucena MI, Kaplowitz N, García-Muncombining comma belowoz B, Borraz Y, Pachkoria K, García-Cortés M, Fernández MC, Pelaez G, Rodrigo L, Durán JA, Costa J, Planas R, Barriocanal A, Guarner C, Romero-Gomez M, Muncombining comma belowoz- Yagüe T, Salmerón J, Hidalgo R. Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry. Hepatology 2006; 44: 1581-1588
7. Meier Y, Cavallaro M, Roos M, Pauli-Magnus C, Folkers G, Meier PJ, Fattinger K. Incidence of drug-induced liver injury in medical inpatients. Eur J Clin Pharmacol 2005; 61: 135-143 (Pubitemid 40674746)
8. Arimone Y, Miremont-Salamé G, Haramburu F, Molimard M, Moore N, Fourrier-Réglat A, Bégaud B. Inter-expert agreement of seven criteria in causality assessment of adverse drug reactions. Br J Clin Pharmacol 2007; 64: 482-1288 (Pubitemid 47404316)
9. Björnsson E, Olsson R. Suspected drug-induced liver fatalities reported to the WHO database. Dig Liver Dis 2006; 38: 33-38 (Pubitemid 44356129)
10. Andrade RJ, Lucena MI, Fernández MC, Pelaez G, Pachkoria K, García-Ruiz E, García-Muñoz B, González- Grande R, Pizarro A, Durán JA, Jiménez M, Rodrigo L, Romero-Gomez M, Navarro JM, Planas R, Costa J, Borras A, Soler A, Salmerón J, Martin-Vivaldi R. Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology 2005; 129: 512-521
11. Motola D, Vargiu A, Leone R, Cocci A, Salvo F, Ros B, Meneghelli I, Venegoni M, Cutroneo PM, Vaccheri A, Velo G, Montanaro N. Hepatic adverse drug reactions: a case/noncase study in Italy. Eur J Clin Pharmacol 2007; 63: 73-79 (Pubitemid 46025476)
12. Vuppalanchi R, Liangpunsakul S, Chalasani N. Etiology of new-onset jaundice: how often is it caused by idiosyncratic drug-induced liver injury in the United States? Am J Gastroenterol 2007; 102: 558-562; quiz 693 (Pubitemid 46328139)
13. Jinjuvadia K, Kwan W, Fontana RJ. Searching for a needle in a haystack: use of ICD-9-CM codes in drug-induced liver injury. Am J Gastroenterol 2007; 102: 2437-2443 (Pubitemid 47631775)
14. Hussaini SH, O'Brien CS, Despott EJ, Dalton HR. Antibiotic therapy: a major cause of drug-induced jaundice in southwest England. Eur J Gastroenterol Hepatol 2007; 19: 15-20
15. Bower WA, Johns M, Margolis HS, Williams IT, Bell BP. Population-based surveillance for acute liver failure. Am J Gastroenterol 2007; 102: 2459-2463 (Pubitemid 47631759)
16. Akhtar AJ, Shaheen M. Jaundice in African-American and Hispanic patients with AIDS. J Natl Med Assoc 2007; 99: 1381-1385 (Pubitemid 350308720)
17. Sgro C, Clinard F, Ouazir K, Chanay H, Allard C, Guilleminet C, Lenoir C, Lemoine A, Hillon P. Incidence of drug-induced hepatic injuries: a French population-based study. Hepatology 2002; 36: 451-455 (Pubitemid 34810366)
18. De Valle MB, Av Klinteberg V, Alem N, Olsson R, Björnsson E. Drug-induced liver injury in a Swedish University hospital out-patient hepatology clinic. Aliment Pharmacol Ther 2006; 24: 1187-1195 (Pubitemid 44427506)
19. Wai CT, Tan BH, Chan CL, Sutedja DS, Lee YM, Khor C, Lim SG. Drug-induced liver injury at an Asian center: a prospective study. Liver Int 2007; 27: 465-474 (Pubitemid 46534568)
20. Chitturi S, Farrell GC. Drug-induced liver disease. In: Schiff ER, Sorrell MF, Maddrey WC. Schiff's diseases of the liver. 9th ed. Tokyo: Lippincott Williams & Wilkins, 2003: 1059-1127
21. Danan G. Causality assessment of drug-induced liver injury. Hepatology Working Group. J Hepatol 1988; 7: 132-136 (Pubitemid 18244238)
22. Lucena MI, Andrade RJ, Fernández MC, Pachkoria K, Pelaez G, Durán JA, Villar M, Rodrigo L, Romero-Gomez M, Planas R, Barriocanal A, Costa J, Guarner C, Blanco S, Navarro JM, Pons F, Castiella A, Avila S. Determinants of the clinical expression of amoxicillin-clavulanate hepatotoxicity: a prospective series from Spain. Hepatology 2006; 44: 850-856 (Pubitemid 46489548)
23. Maddrey WC. Drug-induced hepatotoxicity: 2005. J Clin Gastroenterol 2005; 39: S83-S89
24. Russo MW, Galanko JA, Shrestha R, Fried MW, Watkins P. Liver transplantation for acute liver failure from drug induced liver injury in the United States. Liver Transpl 2004; 10: 1018-1023 (Pubitemid 39232756)
25. Andrade RJ, Lucena MI, Alonso A, García-Cortes M, García-Ruiz E, Benitez R, Fernández MC, Pelaez G, Romero M, Corpas R, Durán JA, Jiménez M, Rodrigo L, Nogueras F, Martín-Vivaldi R, Navarro JM, Salmerón J, de la Cuesta FS, Hidalgo R. HLA class II genotype influences the type of liver injury in drug-induced idiosyncratic liver disease. Hepatology 2004; 39: 1603-1612
26. Chessman D, Kostenko L, Lethborg T, Purcell AW, Williamson NA, Chen Z, Kjer-Nielsen L, Mifsud NA, Tait BD, Holdsworth R, Almeida CA, Nolan D, Macdonald WA, Archbold JK, Kellerher AD, Marriott D, Mallal S, Bharadwaj M, Rossjohn J, McCluskey J. Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity. Immunity 2008; 28: 822-832
27. Shapiro MA, Lewis JH. Causality assessment of drug-induced hepatotoxicity: promises and pitfalls. Clin Liver Dis 2007; 11: 477-505 (Pubitemid 47302343)
28. Huang YS, Su WJ, Huang YH, Chen CY, Chang FY, Lin HC, Lee SD. Genetic polymorphisms of manganese superoxide dismutase, NAD(P)H:quinone oxidoreductase, glutathione S-transferase M1 and T1, and the susceptibility to drug-induced liver injury. J Hepatol 2007; 47: 128-134
29. Huang YS, Chern HD, Su WJ, Wu JC, Chang SC, Chiang CH, Chang FY, Lee SD. Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis. Hepatology 2003; 37: 924-930
30. Lammert C, Einarsson S, Saha C, Niklasson A, Bjornsson E, Chalasani N. Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: search for signals. Hepatology 2008; 47: 2003-2009 (Pubitemid 351945567)
31. Lee BH, Koh WJ, Choi MS, Suh GY, Chung MP, Kim H, Kwon OJ. Inactive hepatitis B surface antigen carrier state and hepatotoxicity during antituberculosis chemotherapy. Chest 2005; 127: 1304-1311 (Pubitemid 46224295)
32. Núñez M. Hepatotoxicity of antiretrovirals: incidence, mechanisms and management. J Hepatol 2006; 44: S132-S139 (Pubitemid 43053889)
33. Tarantino G, Conca P, Basile V, Gentile A, Capone D, Polichetti G, Leo E. A prospective study of acute drug-induced liver injury in patients suffering from non-alcoholic fatty liver disease. Hepatol Res 2007; 37: 410-415 (Pubitemid 46915785)
34. Norris S. Drug- and toxin-induced liver disease. In: Bacon BR, O'Grady JG, Kinkhabwala M, Schilsky ML. Comprehensive clinical hepatology. 2nd ed. St. Louis: Mosby, 2006: 497-516
35. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239-245
36. García-Cortés M, Lucena MI, Pachkoria K, Borraz Y, Hidalgo R, Andrade RJ. Evaluation of naranjo adverse drug reactions probability scale in causality assessment of drug-induced liver injury. Aliment Pharmacol Ther 2008; 27: 780-789
37. Maria VA, Victorino RM. Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis. Hepatology 1997; 26: 664-669
38. Aithal GP, Rawlins MD, Day CP. Clinical diagnostic scale: a useful tool in the evaluation of suspected hepatotoxic adverse drug reactions. J Hepatol 2000; 33: 949-952
39. Lucena MI, Camargo R, Andrade RJ, Perez-Sanchez CJ, Sanchez De La Cuesta F. Comparison of two clinical scales for causality assessment in hepatotoxicity. Hepatology 2001; 33: 123-130 (Pubitemid 32016894)
40. Kaplowitz N. Causality assessment versus guilt-by-association in drug hepatotoxicity. Hepatology 2001; 33: 308-310 (Pubitemid 32016915)
41. Watanabe M, Shibuya A. Validity study of a new diagnostic scale for drug-induced liver injury in Japan-comparison with two previous scales. Hepatol Res 2004; 30: 148-154 (Pubitemid 39654745)
42. Grieco A, Miele L, Forgione A, Ragazzoni E, Vecchio FM, Gasbarrini G. Mild hepatitis at recommended doses of acetaminophen in patients with evidence of constitutionally enhanced cytochrome P450 system activity. J Clin Pharm Ther 2008; 33: 315-320 (Pubitemid 351629760)
43. Zabala S, Calpe MJ, Pérez G, Lerín FJ, Mouronval L. Neutropenia, thrombocytopenia and hepatic injury associated with dexketoprofen trometamol therapy in a previously healthy 35-year-old woman. J Clin Pharm Ther 2008; 33: 79-81
44. Sánchez-Osorio M, Duarte-Rojo A, Martínez-Benítez B, Torre A, Uribe M. Anabolic-androgenic steroids and liver injury. Liver Int 2008; 28: 278-282
45. Elefsiniotis IS, Liatsos GD, Stamelakis D, Moulakakis A. Case report: mixed cholestatic/hepatocellular liver injury induced by the herbicide quizalofop-p-ethyl. Environ Health Perspect 2007; 115: 1479-1481 (Pubitemid 47618091)
46. Jakab SS, West AB, Meighan DM, Brown RS Jr, Hale WB. Mycophenolate mofetil for drug-induced vanishing bile duct syndrome. World J Gastroenterol 2007; 13: 6087-6089 (Pubitemid 350238281)
47. Kedzia A, Krysiak R, Madej A, Okopień B. [Is every case of muscle damage during hypolipemic therapy the side effect of this therapy? A case report] Pol Arch Med Wewn 2007; 117: 473-476
48. Markov M, Patel K, Raeesy A, Bant A, Van Thiel DH, Nadir A. Liver and pancreatic injury induced by antituberculous therapy. Dig Dis Sci 2007; 52: 3275-3281 (Pubitemid 47512489)
49. Wright TM, Vandenberg AM. Risperidone- and quetiapine-induced cholestasis. Ann Pharmacother 2007; 41: 1518-1523
50. Aygun C, Kocaman O, Gurbuz Y, Senturk O, Hulagu S. Clindamycin-induced acute cholestatic hepatitis. World J Gastroenterol 2007; 13: 5408-5410
51. Humayun F, Shehab TM, Tworek JA, Fontana RJ. A fatal case of bupropion (Zyban) hepatotoxicity with autoimmune features: Case report. J Med Case Reports 2007; 1: 88 (Pubitemid 351819195)
52. Miquel M, Soler A, Vaqué A, Ojanguren I, Costa J, Planas R. Suspected cross-hepatotoxicity of flutamide and cyproterone acetate. Liver Int 2007; 27: 1144-1147 (Pubitemid 47399450)
53. Kawakami T, Tanaka A, Negoro S, Morisawa Y, Mikami M, Hojo M, Yamamoto T, Uegaki S, Aiso M, Kawasaki T, Ishii T, Kuyama Y, Fukusato T, Takikawa H. Liver injury induced by levothyroxine in a patient with primary hypothyroidism. Intern Med 2007; 46: 1105-1108 (Pubitemid 47354467)
54. Brooks AJ, Begg EJ, Chapman BA, Fitzharris BM. Two cases of severe liver injury possibly related to 5-fluorouracil and calcium folinate. Intern Med J 2007; 37: 344-345
55. Aiba T, Takahashi T, Suzuki K, Okoshi S, Nomoto M, Uno K, Aoyagi Y. Liver injury induced by a Japanese herbal medicine, sairei-to (TJ-114, Bupleurum and Hoelen Combination, Chai-Ling-Tang) R1. J Gastroenterol Hepatol 2007; 22: 762-763 (Pubitemid 46608371)
56. Paredes AH, Lewis JH. Terbinafine-induced acute autoimmune hepatitis in the setting of hepatitis B virus infection. Ann Pharmacother 2007; 41: 880-884 (Pubitemid 46752668)
57. Liu Q, Tobias H, Petrovic LM. Drug-induced liver injury associated with ezetimibe therapy. Dig Dis Sci 2007; 52: 602-605 (Pubitemid 46202848)
58. Perveze Z, Johnson MW, Rubin RA, Sellers M, Zayas C, Jones JL, Cross R, Thomas K, Butler B, Shrestha R. Terbinafine-induced hepatic failure requiring liver transplantation. Liver Transpl 2007; 13: 162-164 (Pubitemid 46099987)
59. Buyse S, Vibert E, Sebagh M, Antonini T, Ichai P, Castaing D, Samuel D, Duclos-Vallée JC. Liver transplantation for fulminant hepatitis related to nevirapine therapy. Liver Transpl 2006; 12: 1880-1882 (Pubitemid 44911815)
60. Brncić N, Kraus I, Visković I, Mijandrusić- Sincić B, Vlahovic-Palcevski V. 3,4-methylenedioxymethamphetami ne (MDMA): an important cause of acute hepatitis. Med Sci Monit 2006; 12: CS107-CS109 (Pubitemid 44736934)
61. Topal F, Ozaslan E, Akbulut S, Küçükazman M, Yüksel O, Altiparmak E. Methylprednisolone-induced toxic hepatitis. Ann Pharmacother 2006; 40: 1868-1871
62. Cárdenas A, Restrepo JC, Sierra F, Correa G. Acute hepatitis due to shen-min: a herbal product derived from Polygonum multiflorum. J Clin Gastroenterol 2006; 40: 629-632 (Pubitemid 44259771)
63. Gasbarrini A, Rapaccini GL, Rutella S, Zocco MA, Tittoto P, Leone G, Pola P, Gasbarrini G, Di Campli C. Rescue therapy by portal infusion of autologous stem cells in a case of drug-induced hepatitis. Dig Liver Dis 2007; 39: 878-882 (Pubitemid 47215571)
64. Tobon GJ, Cañas C, Jaller JJ, Restrepo JC, Anaya JM. Serious liver disease induced by infliximab. Clin Rheumatol 2007; 26: 578-581 (Pubitemid 46359303)
65. Niemczyk M, Wyzgał J, Perkowska A, Porowski D, Paczek L. Sirolimus-associated hepatotoxicity in the kidney graft recipient. Transpl Int 2005; 18: 1302-1303 (Pubitemid 41726752)
66. Oikawa H, Maesawa C, Sato R, Oikawa K, Yamada H, Oriso S, Ono S, Yashima-Abo A, Kotani K, Suzuki K, Masuda T. Liver cirrhosis induced by long-term administration of a daily low dose of amiodarone: a case report. World J Gastroenterol 2005; 11: 5394-5397 (Pubitemid 41410315)
67. Wielgo-Polanin R, Lagarce L, Gautron E, Diquet B, Lainé- Cessac P. Hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil. Int J Antimicrob Agents 2005; 26: 176-178 (Pubitemid 41021972)
68. Miyakawa R, Ichida T, Yamagiwa S, Miyaji C, Watanabe H, Sato Y, Yokoyama H, Tsukada C, Ishimoto Y, Sugahara S, Yang XH, Abo T, Asakura H. Hepatic natural killer and natural killer T cells markedly decreased in two cases of drug-induced fulminant hepatic failure rescued by living donor liver transplantation. J Gastroenterol Hepatol 2005; 20: 1126-1130 (Pubitemid 40961243)
69. Chounta A, Zouridakis S, Ellinas C, Tsiodras S, Zoumpouli C, Kopanakis S, Giamarellou H. Cholestatic liver injury after glimepiride therapy. J Hepatol 2005; 42: 944-946 (Pubitemid 40693215)
70. Dobson JL, Angus PW, Jones R, Crowley P, Gow PJ. Flucloxacillin-induced aplastic anaemia and liver failure. Transpl Int 2005; 18: 487-489 (Pubitemid 41726887)
71. Köklü S, Köksal AS, Asil M, Kiyici H, Coban S, Arhan M. Probable sulbactam/ampicillin-associated prolonged cholestasis. Ann Pharmacother 2004; 38: 2055-2058
72. Arinzon Z, Alexander P, Berner Y. Hydrochlorothiazide induced hepato-cholestatic liver injury. Age Ageing 2004; 33: 509-510 (Pubitemid 39214285)
73. Kim TH, Kim BH, Kim YW, Yang DM, Han YS, Dong SH, Kim HJ, Chang YW, Lee JI, Chang R. Liver cirrhosis developed after ketoconazole-induced acute hepatic injury. J Gastroenterol Hepatol 2003; 18: 1426-1429 (Pubitemid 38045860)
74. Ozgür O, Hacihasanoǧlu A, Karti SS, Ovali E. Nimesulide-induced fulminant hepatitis. Turk J Gastroenterol 2003; 14: 208-210
75. Yeung E, Wong FS, Wanless IR, Shiota K, Guindi M, Joshi S, Gardiner G. Ramipril-associated hepatotoxicity. Arch Pathol Lab Med 2003; 127: 1493-1497
76. Robinson K, Lambiase L, Li J, Monteiro C, Schiff M. Fatal cholestatic liver failure associated with gemcitabine therapy. Dig Dis Sci 2003; 48: 1804-1808 (Pubitemid 37174737)
77. Zaidi SA. Hepatitis associated with amoxicillin/clavulanic acid and/or ciprofloxacin. Am J Med Sci 2003; 325: 31-33
78. Khoo AL, Tham LS, Lee KH, Lim GK. Acute liver failure with concurrent bupropion and carbimazole therapy. Ann Pharmacother 2003; 37: 220-223 (Pubitemid 36172863)
79. Goetz M, Galle PR, Schwarting A. Non-fatal acute liver injury possibly related to high-dose ciprofloxacin. Eur J Clin Microbiol Infect Dis 2003; 22: 294-296 (Pubitemid 36760452)
80. Rulyak SJ, Saunders MD, Lee SD. Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease. J Clin Gastroenterol 2003; 36: 234-237 (Pubitemid 36232635)
81. Suyama T, Fujiwara H, Takenouchi K, Ito M. Drug eruption and liver injury caused by terfenadine and oxatomide. Eur J Dermatol 2002; 12: 385-386 (Pubitemid 34713111)
82. Pinto AG, Cummings OW, Chalasani N. Severe but reversible cholestatic liver injury after pioglitazone therapy. Ann Intern Med 2002; 137: 857 (Pubitemid 35334459)
83. Hayashi T, Takahashi T, Minami T, Akaike J, Kasahara K, Adachi M, Hinoda Y, Takahashi S, Hirayama T, Imai K. Fatal acute hepatic failure induced by danazol in a patient with endometriosis and aplastic anemia. J Gastroenterol 2001; 36: 783-786 (Pubitemid 33133505)
84. Karim A, Ahmed S, Rossoff LJ, Siddiqui RK, Steinberg HN. Possible levofloxacin-induced acute hepatocellular injury in a patient with chronic obstructive lung disease. Clin Infect Dis 2001; 33: 2088-2090 (Pubitemid 33152410)
85. Schattner A, Kozak N, Friedman J. Captopril-induced jaundice: report of 2 cases and a review of 13 additional reports in the literature. Am J Med Sci 2001; 322: 236-240 (Pubitemid 32973278)
86. Maeda K. Hepatocellular injury in a patient receiving pioglitazone. Ann Intern Med 2001; 135: 306 (Pubitemid 32799355)
87. Nachimuthu S, Volfinzon L, Gopal L. Acute hepatocellular and cholestatic injury in a patient taking celecoxib. Postgrad Med J 2001; 77: 548-550 (Pubitemid 32744061)
88. Merlani G, Fox M, Oehen HP, Cathomas G, Renner EL, Fattinger K, Schneemann M, Kullak-Ublick GA. Fatal hepatoxicity secondary to nimesulide. Eur J Clin Pharmacol 2001; 57: 321-326
89. García Cortés M, Andrade RJ, Lucena MI, Sánchez Martínez H, Fernández MC, Ferrer T, Martín-Vivaldi R, Peláez G, Suárez F, Romero-Gómez M, Montero JL, Fraga E, Camargo R, Alcántara R, Pizarro MA, García-Ruiz E, Rosemary- Gómez M. Flutamide-induced hepatotoxicity: report of a case series. Rev Esp Enferm Dig 2001; 93: 423-432 (Pubitemid 32757636)
90. Krebs S, Dormann H, Muth-Selbach U, Hahn EG, Brune K, Schneider HT. Risperidone-induced cholestatic hepatitis. Eur J Gastroenterol Hepatol 2001; 13: 67-69
91. Reinus JF, Persky S, Burkiewicz JS, Quan D, Bass NM, Davern TJ. Severe liver injury after treatment with the leukotriene receptor antagonist zafirlukast. Ann Intern Med 2000; 133: 964-968 (Pubitemid 32003512)
92. Li H, Heller DS, Leevy CB, Zierer KG, Klein KM. Troglitazone-induced fulminant hepatitis: report of a case with autopsy findings. J Diabetes Complications 2000; 14: 175-177
93. Miller KD, Cameron M, Wood LV, Dalakas MC, Kovacs JA. Lactic acidosis and hepatic steatosis associated with use of stavudine: report of four cases. Ann Intern Med 2000; 133: 192-196 (Pubitemid 30617057)
94. Andrade RJ, Lucena MI, Aguilar J, Lazo MD, Camargo R, Moreno P, García-Escaño MD, Marquez A, Alcántara R, Alcáin G. Chronic liver injury related to use of bentazepam: an unusual instance of benzodiazepine hepatotoxicity. Dig Dis Sci 2000; 45: 1400-1404 (Pubitemid 30636517)
95. Al -Salman J, Arjomand H, Kemp DG, Mittal M. Hepatocellular injury in a patient receiving rosiglitazone. A case report. Ann Intern Med 2000; 132: 121-124 (Pubitemid 30044179)
96. Schattner A, Von der Walde J, Kozak N, Sokolovskaya N, Knobler H. Nitrofurantoin-induced immune-mediated lung and liver disease. Am J Med Sci 1999; 317: 336-340 (Pubitemid 30350428)
97. Van Steenbergen W, Peeters P, De Bondt J, Staessen D, Büscher H, Laporta T, Roskams T, Desmet V. Nimesulide-induced acute hepatitis: evidence from six cases. J Hepatol 1998; 29: 135-141 (Pubitemid 28307993)
98. Christe C, Stoller R, Vogt N. Omeprazole-induced hepatotoxicity? A case report. Pharmacoepidemiol Drug Saf 1998; 7 Suppl 1: S41-S44
99. Neuschwander-Tetri BA, Isley WL, Oki JC, Ramrakhiani S, Quiason SG, Phillips NJ, Brunt EM. Troglitazone-induced hepatic failure leading to liver transplantation. A case report. Ann Intern Med 1998; 129: 38-41 (Pubitemid 28304651)
100. Fujimoto Y, Ohhira M, Miyokawa N, Kitamori S, Kohgo Y. Acarbose-induced hepatic injury. Lancet 1998; 351: 340
101. Bauer TM, Bircher AJ. Drug-induced hepatocellular liver injury due to benzylpenicillin with evidence of lymphocyte sensitization. J Hepatol 1997; 26: 429-432
102. Mallat A, Zafrani ES, Met reau JM, Dhumeaux D. Terbinafine-induced prolonged cholestasis with reduction of interlobular bile ducts. Dig Dis Sci 1997; 42: 1486-1488 (Pubitemid 27339368)
103. Takikawa H, Takamori Y, Kumagi T, Onji M, Watanabe M, Shibuya A, Hisamochi A, Kumashiro R, Ito T, Mitsumoto Y, Nakamura A, Sakaguchi T. Assessment of 287 Japanese cases of drug induced liver injury by the diagnostic scale of the International Consensus Meeting. Hepatol Res 2003; 27: 192-195 (Pubitemid 37407666)
104. Usui K, Oda Y, Kubota R, Negishi K, Uno K, Tsunematsu S, Kumagai N, Komiyama T. Clinical application of the leukocyte migration test and new diagnostic criteria for identifying causative agents in patients with drug-induced liver injury. Hepatogastroenterology 2007; 54: 1752-1757 (Pubitemid 350068471)
105. Murata H, Shimizu Y, Okada K, Higuchi K, Watanabe A. Detection and analysis of intracytoplasmic cytokines in peripheral blood mononuclear cells in patients with drug-induced liver injury. J Hepatol 2003; 38: 573-582 (Pubitemid 36560641)
106. Scheuer PJ, Lefkowitch JH. Drug and toxins. In: Scheuer PJ, Lefkowitch JH. Liver biopsy interpretation. 7th ed. Philadelphia: Elsevier Saunders, 2006: 125-144
107. Lee WM. Drug-induced hepatotoxicity. N Engl J Med 1995; 333: 1118-1127
108. Kaplowitz N, DeLeve LD. Drug-induced liver disease, 1st ed. New York: Informa Healthcare, 2003: 227-242
109. Zimmerman HJ. Hepatotoxicity: The adverse effects of drugs and other chemicals on the liver. 2nd ed. Philadelphia: Lippincott Williams & Wilkins, 1999: 428-433
110. Vuppalanchi R, Teal E, Chalasani N. Patients with elevated baseline liver enzymes do not have higher frequency of hepatotoxicity from lovastatin than those with normal baseline liver enzymes. Am J Med Sci 2005; 329: 62-65 (Pubitemid 40250595)
111. Bleibel W, Kim S, D'Silva K, Lemmer ER. Drug-induced liver injury: review article. Dig Dis Sci 2007; 52: 2463-2471 (Pubitemid 47373878)