Hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil

International Journal of Antimicrobial Agents

Volumn 26, Issue 2, 2005, Pages 176-178

  Wielgo Polanin, R ^a   Lagarce, L ^a   Gautron, E ^a   Diquet, B ^a   Laine Cessac P ^a  

^a ANGERS UNIVERSITY HOSPITAL   (France)

Author keywords

Chloroquine; Hepatotoxicity; Proguanil

Indexed keywords

CHLOROQUINE; CHLOROQUINE PLUS PROGUANIL; PROGUANIL;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; DRUG INDUCED DISEASE; FATIGUE; FECES ANALYSIS; FEMALE; GASTROINTESTINAL DISEASE; HOSPITAL ADMISSION; HUMAN; LABORATORY; LIVER TOXICITY; MALARIA; PATHOPHYSIOLOGY; PATIENT; PRIORITY JOURNAL; PYURIA; RISK FACTOR; SIDE EFFECT; VOMITING;

ADVERSE DRUG REACTION REPORTING SYSTEMS; ANTIMALARIALS; CHLOROGUANIDE; CHLOROQUINE; DRUG COMBINATIONS; DRUG INTERACTIONS; FEMALE; HUMANS; LIVER DISEASES; MALARIA, FALCIPARUM; MIDDLE AGED;

EID: 22544461618     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2005.04.019     Document Type: Article

References (13)

1. S.C. Sweetman Antimalarials S.C. Sweetman Martindale: the complete drug reference 33rd ed. 2002 The Pharmaceutical Press London, UK 428 448
2. G. Danan Causality assessment of drug-induced liver injury. Hepatology working group J Hepatol 7 1988 132 136
3. B. Bégaud, J.C. Evreux, J. Jouglard, and G. Lagier Unexpected or toxic drug reaction assessment (imputation). Actualization of the method used in France Thérapie 40 1985 111 118
4. W. Lee Drug-induced hepatotoxicity N Engl J Med 349 2003 474 485
5. E.E. Dass, and K.K. Shah Paracetamol and conventional antimalarial drugs induced hepatotoxicity and its protection by methionine in rats Indian J Exp Biol 38 2000 1138 1142
6. L. Pari, and P. Murugavel Protective effect of alpha-lipoic acid against chloroquine-induced hepatotoxicity in rats J Appl Toxicol 24 2004 21 26
7. J.J. Everdingen-Bongers, P. Janssen, M. Lammens, B.H. Stricker, and B. Bravenboer Granulomatous hepatitis attributed to the combination pyrimethamine-chloroquine Ned Tijdschr Geneeskd 140 1996 320 322
8. L.M. Oostweegel, J.H. Beijnen, and J.W. Mulder Hepatitis during chloroguanide prophylaxis Ann Pharmacother 32 1998 1023 1025
9. A.C. Liu Hepatotoxic reaction to chloroquine phosphate in a patient with previously unrecognized porphyria cutanea tarda West J Med 162 1995 548 551
10. A. Angles, H. Bagheri, and J.L. Montastruc Adverse drug reactions to antimalarial drugs. Analysis of spontaneous reports from the French Pharmacovigilance database (1996-2000) Presse Med 32 2003 106 113
11. D. Projean, B. Baune, and R. Farinotti In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalysing N-desethylchloroquine formation Drug Metab Dispos 31 2003 748 754
12. J.M. Hoskins, G.M. Shenfield, and A.S. Gross Relationship between proguanil metabolic ratio and CYP2C19 genotype in a Caucasian population Br J Clin Pharmacol 46 1998 499 504
13. A. Kaneko, Y. Bergqvist, G. Taleo, T. Kobayakawa, T. Ishizaki, and A. Bjorkman Proguanil disposition and toxicity in malaria patients from Vanuatu with high frequencies of CYP2C19 mutations Pharmacogenetics 9 1999 317 326