Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: Search for signals

Hepatology

Volumn 47, Issue 6, 2008, Pages 2003-2009

  Lammert, Craig ^a   Einarsson, Stefan ^b   Saha, Chandan ^c   Niklasson, Anna ^b   Bjornsson, Einar ^b   Chalasani, Naga ^c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMLODIPINE PLUS BENAZEPRIL; ANASTROZOLE; BENAZEPRIL; BENZATROPINE; BISOPROLOL; BUMETANIDE; CLONAZEPAM; COLCHICINE; DIAZEPAM; DONEPEZIL; DOXAZOSIN; ESZOPICLONE; GLIBENCLAMIDE; GLIMEPIRIDE; HYOSCYAMINE; INDAPAMIDE; LEVONORGESTREL; LORAZEPAM; METOLAZONE; OXYBUTYNIN; PRAMIPEXOLE; RAMIPRIL; RISEDRONIC ACID; ROSIGLITAZONE; TADALAFIL; TAMSULOSIN; TOLTERODINE; TRANDOLAPRIL; UNINDEXED DRUG; WARFARIN; DRUG;

ADULT; ADVERSE OUTCOME; AGED; ARTICLE; CONTROLLED STUDY; DRUG RESEARCH; FEMALE; HUMAN; JAUNDICE; LIVER FAILURE; LIVER INJURY; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SIDE EFFECT; STATISTICAL SIGNIFICANCE; UNITED STATES; CHEMICALLY INDUCED DISORDER; DATA BASE; DOSE RESPONSE; DRUG EFFECT; DRUG TOXICITY; INFORMATION PROCESSING; LIVER; LIVER DISEASE; ORAL DRUG ADMINISTRATION; PREVALENCE; PROGNOSIS; PROSPECTIVE STUDY; STATISTICAL MODEL; SWEDEN;

ADMINISTRATION, ORAL; DATA COLLECTION; DATABASES AS TOPIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOXICITY; HUMANS; LIVER; LIVER DISEASES; LIVER FAILURE; LOGISTIC MODELS; PHARMACEUTICAL PREPARATIONS; PREVALENCE; PROGNOSIS; PROSPECTIVE STUDIES; SWEDEN; UNITED STATES;

EID: 46249118651     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22272     Document Type: Article

References (19)

1. Watkins PB, Seeff LB. Drug-induced liver injury: summary of a single topic clinical research conference. HEPATOLOGY 2006;43:618-631.
2. Ostapowicz G, Fontana RJ, Schiodt FV, Larson A, Dvaern TJ, Han SH, et al. U.S. Acute Liver Failure Study Group: results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 2002;137:947-954.
3. Navarro VJ, Senior JR. Drug-related hepatotoxicity. N Engl J Med 2006;35:731-739.
4. Uetrecht J. Idiosyncratic drug reactions: current understanding. Annu Rev Pharmacol Toxicol 2007;47:513-539.
5. Chalasani N. Statins and hepatotoxicity: focus on statin usage in nonalcoholic fatty liver disease. HEPATOLOGY 2005;41:690-695.
6. Kenyon KW, Nappi JM. Bosentan for the treatment of pulmonary arterial hypertension. Ann Pharmacother 2003;37:1055-1062.
7. Top 200 Brand Drugs by Units in 2005. Available at: http://www. drugtopics.com/drugtopics/data/articlestandard//drugtopics/102006/311293/ article.pdf. Accessed November 2, 2007.
8. Top 200 Generic Drugs by Units in 2005. Available at: http://www.drugtopics.com/drugtopics/data/articlestandard//drugtopics/102006/ 311294/article.pdf. Accessed November 2, 2007.
9. DrugDex® System. Available at: http://www.micromedex.com/products/ drugdex/. Accessed November 2, 2007.
10. PubMed. Available at: http://www.ncbi.nlm.nih.gov/sites/entrez?holding= iusomlib. Accessed November 2, 2007.
11. Adverse Event Reporting System. Available at: http://www.fda.gov/cder/ aers/default.htm. Accessed on November 2, 2007.
12. Physician Desk Reference. Available at: http://www.pdr.net/login/Login. aspx. Accessed November 2, 2007.
13. Bjornsson E, Jerlstad P, Bergqvist A, Olsson R. Fulminant drug-induced hepatic failure leading to death or liver transplantation in Sweden. Scand J Gastroenterol 2005;40:1095-1101.
14. Bjornsson E, Olsson R. Outcome and prognostic markers in severe drug-induced liver disease. HEPATOLOGY 2005;42:481-489.
15. Benichou C. Criteria of drug induced liver disorders: report of an international consensus meeting. J Hepatol 1990;11:272-276.
16. Danan G, Benichou C. Causality assessment of adverse reactions to drugs - I: a novel method based on the conclusions of international consensus meeting. J Clin Epidemiol 1993;46:1323-1330.
17. Benichou C, Danan G, Flahault A. Causality assessment of adverse reactions to drugs - II: an original model for validation of drug causality assessment methods: case reports with positive rechallenge. J Clin Epidemiol 1993;46:1331-1336.
18. Russo MW, Galanko JA, Shrestha R, Fried MW, Watkins P. Liver transplantation for acute liver failure from drug induced liver injury in the United States. Liver Transpl 2004;10:1018-1023.
19. Gunawan BK, Kaplowitz N. Mechanisms of drug-induced liver disease. Clin Liver Dis 2007;11:459-475.