Liver injury induced by levothyroxine in a patient with primary hypothyroidism

Internal Medicine

Volumn 46, Issue 14, 2007, Pages 1105-1108

  Kawakami, Tomotaka ^a   Tanaka, Atsushi ^a   Negoro, Shinichiro ^a   Morisawa, Yoshihiko ^a   Mikami, Masaki ^a   Hojo, Makoto ^a   Yamamoto, Takatsugu ^a   Uegaki, Satoko ^a   Aiso, Mitsuhiko ^a   Kawasaki, Takahiro ^a   Ishii, Taro ^a   Kuyama, Yasushi ^a   Fukusato, Toshio ^a   Takikawa, Hajime ^a  

^a TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Drug induced liver injury; Levothyroxine

Indexed keywords

LEVOTHYROXINE; LIOTHYRONINE; THYROGLOBULIN ANTIBODY; THYROID PEROXIDASE ANTIBODY; THYROTROPIN; THYROXINE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIGENICITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD ANALYSIS; CASE REPORT; CELL INFILTRATION; DRUG DOSE INCREASE; DRUG SUBSTITUTION; DRUG TOLERABILITY; DRUG WITHDRAWAL; EOSINOPHIL; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; HYPOTHYROIDISM; IMMUNE SYSTEM; JAUNDICE; LIVER BIOPSY; LIVER CELL DAMAGE; LIVER INJURY; LIVER NECROSIS; LYMPHOCYTE TRANSFORMATION TEST; MALE; SIDE EFFECT; TREATMENT DURATION;

HUMANS; HYPOTHYROIDISM; LIVER DISEASES; MALE; MIDDLE AGED; THYROXINE; TREATMENT OUTCOME; TRIIODOTHYRONINE;

EID: 34548430621     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.46.0086     Document Type: Article

References (10)

1. Larsen P, Davies T. Hypothyroidism and thyroiditis. in: Williams Textbook of Endocrinology Larsen P, Kronenberg H, Melmed S, Polonsky K, Eds. Saunders, Philadelphia 2003: 331-373.
2. Mandel S, Brent G, Larsen P. Levothyroxine therapy in patients with thyroid disease. Ann Intern Med 119: 492-502, 1993.
3. Toft A. Thyroxine therapy. N Engl J Med 331: 174-180, 1994.
4. Inui A, Ishikawa K, Mizuno N, Oimomi M, Baba S. Case of Hashimoto's disease with thyroxine induced allergic hepatitis. Nippon Naika Gakkai Zasshi 72: 1407-1413, 1983 (in Japanese, abstract in English).
5. Shibata H, Hayakawa H, Hirukawa M, Tadokoro K, Ogata E. Hypersensitivity caused by synthetic thyroid hormones in a hypothyroid patient with Hashimoto's thyroiditis. Arch Intern Med 146: 1624-1625, 1986.
6. Ohmori M, Harada K, Tsuruoka S, Sugimoto K, Kobayashi E, Fujimura A. Levothyroxine-induced liver dysfunction in a primary hypothyroid patient. Endocr J 46: 579-583, 1999.
7. Takikawa H, Onji M. A proposal of the diagnostic scale of drug-induced liver injury. Hepatol Res 32: 250-251, 2005.
8. Maria V, Pinto L, Victorino R. Lymphocyte reactivity to exvivo drug antigens in drug-induced hepatitis. J Hepatol 21: 151-158, 1994.
9. Maria V, Victorino R. Diagnostic value of specific T cell reactivity to drugs in 95 cases of drug induced liver injury. Gut 41: 534-540, 1997.
10. Matsuno M, Sohmiya M, Nishiki M, Ohguni S, Kato Y. A case of chronic thyroiditis associated with drug eruption induced by levothyroxine sodium (Thyradin S). Folia Endocrinol 73: 617-622, 1997 (in Japanese, abstract in English).