Association of UCP2 and UCP3 polymorphisms with heart rate variability in Japanese men

Journal of Hypertension

Volumn 27, Issue 2, 2009, Pages 305-313

  Matsunaga, Tetsuro ^a   Gu, Ning ^a   Yamazaki, Hanae ^a   Tsuda, Mariko ^a   Adachi, Tetsuya ^b   Yasuda, Koichiro ^c   Moritani, Toshio ^a   Tsuda, Kinsuke ^a   Nonaka, Masahiko ^a   Nishiyama, Tohru ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Dept of Respiratory Medicine Saiseikai Noe Hospital   (Japan)

Author keywords

Autonomic nervous system; Heart rate variability; Polymorphism; UCP2; UCP3

Indexed keywords

DNA; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; MITOCHONDRIAL UNCOUPLING PROTEIN 3;

ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CARDIOVASCULAR DISEASE; DIABETES MELLITUS; ENERGY METABOLISM; FAMILY HISTORY; FREQUENCY ANALYSIS; GENE; GENE DELETION; GENE INSERTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HEART RATE VARIABILITY; HETEROZYGOTE; HUMAN; HUMAN EXPERIMENT; HYPERTENSION; JAPAN; MALE; NORMAL HUMAN; OBESITY; PARASYMPATHETIC TONE; PRIORITY JOURNAL; SPECTROSCOPY; STANDING; SUPINE POSITION; SYMPATHETIC TONE; UCP2 GENE; UCP3 GENE; ADOLESCENT; ASIAN; AUTONOMIC NERVE; GENETICS; HEART RATE; INDEL MUTATION; PHYSIOLOGY; PROMOTER REGION;

ADOLESCENT; ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; AUTONOMIC PATHWAYS; HEART RATE; HUMANS; INDEL MUTATION; ION CHANNELS; JAPAN; MALE; MITOCHONDRIAL PROTEINS; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; YOUNG ADULT;

EID: 63849308886     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e32831ac967     Document Type: Article

References (65)

1. Argyropoulos G, Harper ME. Uncoupling proteins and thermoregulation. J Appl Physiol 2002; 92:2187-2198.
2. Pecqueur C, Couplan E, Bouillaud F, Ricquier D. Genetic and physiological analysis of the role of uncoupling proteins in human energy homeostasis. J Mol Med 2001; 79:48-56.
3. Brand MD, Esteves TC. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab 2005; 2:85-93.
4. Krauss S, Zhang CY, Lowell BB. The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol 2005; 6:248-261.
5. Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning BS, Miroux B, et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 2000; 26:435-439.
6. Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, et al. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest 2003; 112:1831-1842.
7. Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, et al. Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem 2000; 275:16258-16266.
8. Horvath TL, Diano S, Barnstable C. Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector. Biochem Pharmacol 2003; 65:1917-1921.
9. Vincent AM, Olzmann JA, Brownlee M, Sivitz WI, Russell JW. Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death. Diabetes 2004; 53:726-734.
10. Danson EJ, Paterson DJ. Reactive oxygen species and autonomic regulation of cardiac excitability. J Cardiovasc Electrophysiol 2006; 17 (Suppl 1):S104-S112.
11. Lindley TE, Doobay MF, Sharma RV, Davisson RL. Superoxide is involved in the central nervous system activation and sympathoexcitation of myocardial infarction-induced heart failure. Circ Res 2004; 94:402-409.
12. Dalgaard LT, Pedersen O. Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and type II diabetes. Diabetologia 2001; 44:946-965.
13. Schonfeld-Warden NA, Warden CH. Physiological effects of variants in human uncoupling proteins: UCP2 influences body-mass index. Biochem Soc Trans 2001; 29:777-784.
14. Walder K, Norman RA, Hanson RL, Schrauwen P, Neverova M, Jenkinson CP, et al. Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima Indians. Hum Mol Genet 1998; 7:1431-1435.
15. Cassell PG, Neverova M, Janmohamed S, Uwakwe N, Qureshi A,McCarthy MI, et al. An uncoupling protein 2 gene variant is associated with a raised body mass index but not type II diabetes. Diabetologia 1999; 42:688-692.
16. Evans D, Minouchehr S, Hagemann G, Mann WA, Wendt D, Wolf A, et al. Frequency of and interaction between polymorphisms in the beta3- adrenergic receptor and in uncoupling proteins 1 and 2 and obesity in Germans. Int J Obes Relat Metab Disord 2000; 24:1239-1245.
17. Yanovski JA, Diament AL, Sovik KN, Nguyen TT, Li H, Sebring NG, et al. Associations between uncoupling protein 2, body composition, and resting energy expenditure in lean and obese African American, white, and Asian children. Am J Clin Nutr 2000; 71:1405-1420.
18. Schrauwen P, Xia J, Walder K, Snitker S, Ravussin E. A novel polymorphism in the proximal UCP3 promoter region: effect on skeletal muscle UCP3 mRNA expression and obesity in male nondiabetic Pima Indians. Int J Obes Relat Metab Disord 1999; 23:1242-1245.
19. La Rovere MT, Pinna GD, Maestri R, Mortara A, Capomolla S, FeboO, et al. Short-term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients. Circulation 2003; 107:565-570.
20. Liao D, Cai J, Barnes RW, Tyroler HA, Rautaharju P, Holme I, et al. Association of cardiac autonomic function and the development of hypertension: the ARIC study. Am J Hypertens 1996; 9:1147-1156.
21. Liao D, Cai J, Rosamond WD, Barnes RW, Hutchinson RG, Whitsel EA, et al. Cardiac autonomic function and incident coronary heart disease: a population-based case-cohort study. The ARIC Study. Atherosclerosis Risk in Communities Study. Am J Epidemiol 1997; 145:696-706.
22. Singh JP, Larson MG, Tsuji H, Evans JC, O'Donnell CJ, Levy D. Reduced heart rate variability and new-onset hypertension: insights into pathogenesis of hypertension: the Framingham Heart Study. Hypertension 1998; 32:293-297.
23. Brook RD, Julius S. Autonomic imbalance, hypertension, and cardiovascular risk. Am J Hypertens 2000; 13:112S-122S.
24. Pagani M, Malliani A. Interpreting oscillations of muscle sympathetic nerve activity and heart rate variability. J Hypertens 2000; 18:1709-1719.
25. Fagard RH, Pardaens K, Staessen JA. Relationships of heart rate and heart rate variability with conventional and ambulatory blood pressure in the population. J Hypertens 2001; 19:389-397.
26. Fagard RH, Stolarz K, Kuznetsova T, Seidlerova J, Tikhonoff V, Grodzicki T, et al. Sympathetic activity, assessed by power spectral analysis of heart rate variability, in white-coat, masked and sustained hypertension versus true normotension. J Hypertens 2007; 25:2280-2285.
27. Palatini P, Longo D, Zaetta V, Perkovic D, Garbelotto R, Pessina AC. Evolution of blood pressure and cholesterol in stage 1 hypertension: role of autonomic nervous system activity. J Hypertens 2006; 24: 1375-1381.
28. Piccirillo G, Nocco M, Lionetti M, Moise A, Naso C, Marigliano V, et al. Effects of sildenafil citrate (viagra) on cardiac repolarization and on autonomic control in subjects with chronic heart failure. Am Heart J 2002; 143:703-710.
29. Carpeggiani C, Emdin M, Bonaguidi F, Landi P, Michelassi C, Trivella MG, et al. Personality traits and heart rate variability predict long-term cardiac mortality after myocardial infarction. Eur Heart J 2005; 26: 1612-1617.
30. Ghuran A, Reid F, La Rovere MT, Schmidt G, Bigger JT Jr, Camm AJ, et al. Heart rate turbulence-based predictors of fatal and nonfatal cardiac arrest (The Autonomic Tone and Reflexes After Myocardial Infarction substudy). Am J Cardiol 2002; 89:184-190.
31. Vanoli E, Adamson PB, Foreman RD, Schwartz PJ. Prediction of unexpected sudden death among healthy dogs by a novel marker of autonomic neural activity. Heart Rhythm 2008; 5:300-305.
32. Wichterle D, Simek J, La Rovere MT, Schwartz PJ, Camm AJ, Malik M. Prevalent low-frequency oscillation of heart rate: novel predictor of mortality after myocardial infarction. Circulation 2004; 110:1183-1190.
33. Kupper NH, Willemsen G, van den Berg M, de Boer D, Posthuma D, Boomsma DI, et al. Heritability of ambulatory heart rate variability. Circulation 2004; 110:2792-2796.
34. Matsunaga T, Yasuda K, Adachi T, Gu N, Yamamura T, Moritani T, et al. Association of beta-adrenoceptor polymorphisms with cardiac autonomic modulation in Japanese males. Am Heart J 2007; 154: 759-766.
35. Yasuda K, Matsunaga T, Adachi T, Aoki N, Tsujimoto G, Tsuda K. Adrenergic receptor polymorphisms and autonomic nervous system function in human obesity. Trends Endocrinol Metab 2006; 17: 269-275.
36. Otabe S, Clement K, Dina C, Pelloux V, Guy-Grand B, Froguel P, et al. A genetic variation in the 5' flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity. Diabetologia 2000; 43:245-249.
37. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 1996; 93:1043-1065.
38. Pumprla J, Howorka K, Groves D, Chester M, Nolan J. Functional assessment of heart rate variability: physiological basis and practical applications. Int J Cardiol 2002; 84:1-14.
39. Brown TE, Beightol LA, Koh J, Eckberg DL. Important influence of respiration on human R-R interval power spectra is largely ignored. J Appl Physiol 1993; 75:2310-2317.
40. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21:263-265.
41. Hamada T, Kotani K, Fujiwara S, Sano Y, Domichi M, Tsuzaki K, et al. The common -55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population. Metabolism 2008; 57:410-415.
42. Shiinoki T, Suehiro T, Ikeda Y, Inoue M, Nakamura T, Kumon Y, et al. Screening for variants of the uncoupling protein 2 gene in Japanese patients with noninsulin-dependent diabetes mellitus. Metabolism 1999; 48:581-584.
43. Mancia G, Bousquet P, Elghozi JL, Esler M, Grassi G, Julius S, et al. The sympathetic nervous system and the metabolic syndrome. J Hypertens 2007; 25:909-920.
44. Thayer JF, Lane RD. The role of vagal function in the risk for cardiovascular disease and mortality. Biol Psychol 2007; 74:224-242.
45. Lampert R, Ickovics JR, Viscoli CJ, Horwitz RI, Lee FA. Effects of propranolol on recovery of heart rate variability following acute myocardial infarction and relation to outcome in the Beta-Blocker Heart Attack Trial. Am J Cardiol 2003; 91:137-142.
46. Malfatto G, Facchini M, Branzi G, Riva B, Sala L, Perego GB. Long-term treatment with the beta-blocker carvedilol restores autonomic tone and responsiveness in patients with moderate heart failure. J Cardiovasc Pharmacol 2003; 42:125-131.
47. Ceriello A. Possible role of oxidative stress in the pathogenesis of hypertension. Diabetes Care 2008; Suppl 31:S181-S184.
48. Papaharalambus CA, Griendling KK. Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury. Trends Cardiovasc Med 2007; 17:48-54.
49. Pop-Busui R, Sima A, Stevens M. Diabetic neuropathy and oxidative stress. Diabetes Metab Res Rev 2006; 22:257-273.
50. Hang T, Jiang S, Wang C, Xie D, Ren H, Zhuge H. Apoptosis and expression of uncoupling protein-2 in pressure overload-induced left ventricular hypertrophy. Acta Cardiol 2007; 62:461-465.
51. McLeod CJ, Aziz A, Hoyt RF Jr, McCoy JP Jr, Sack MN. Uncoupling proteins 2 and 3 function in concert to augment tolerance to cardiac ischemia. J Biol Chem 2005; 280:33470-33476.
52. Puddu P, Puddu GM, Cravero E, De Pascalis S, Muscari A. The putative role of mitochondrial dysfunction in hypertension. Clin Exp Hypertens 2007; 29:427-434.
53. Teshima Y, Akao M, Jones SP, Marban E. Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circ Res 2003; 93:192-200.
54. Kim-Han JS, Dugan LL. Mitochondrial uncoupling proteins in the central nervous system. Antioxid Redox Signal 2005; 7:1173-1181.
55. Yoon Y, Park BL, Cha MH, Kim KS, Cheong HS, Choi YH, et al. Effects of genetic polymorphisms of UCP2 and UCP3 on very low calorie dietinduced body fat reduction in Korean female subjects. Biochem Biophys Res Commun 2007; 359:451-456.
56. Ji Q, Ikegami H, Fujisawa T, Kawabata Y, Ono M, Nishino M, et al. A common polymorphism of uncoupling protein 2 gene is associated with hypertension. J Hypertens 2004; 22:97-102.
57. Cheurfa N, Dubois-Laforgue D, Ferrarezi DA, Reis AF, Brenner GM, Bouche C, et al. The common -866G>A variant in the promoter of UCP2 is associated with decreased risk of coronary artery disease in type 2 diabetic men. Diabetes 2008; 57:1063-1068.
58. Stephens JW, Dhamrait SS, Mani AR, Acharya J, Moore K, Hurel SJ, et al. Interaction between the uncoupling protein 2-866G>A gene variant and cigarette smoking to increase oxidative stress in subjects with diabetes. Nutr Metab Cardiovasc Dis 2008; 18:7-14.
59. Liu YJ, Liu PY, Long J, Lu Y, Elze L, Recker RR, et al. Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian families. Physiol Genomics 2005; 22:197-203.
60. Halsall DJ, Luan J, Saker P, Huxtable S, Farooqi IS, Keogh J, et al. Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population. Int J Obes Relat Metab Disord 2001; 25:472-477.
61. Clapham JC, Arch JR, Chapman H, Haynes A, Lister C, Moore GB, et al. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 2000; 406:415-418.
62. Schrauwen P, Xia J, Bogardus C, Pratley RE, Ravussin E. Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians. Diabetes 1999; 48:146-149.
63. Berentzen T, Dalgaard LT, Petersen L, Pedersen O, Sorensen TI. Interactions between physical activity and variants of the genes encoding uncoupling proteins -2 and -3 in relation to body weight changes during a 10-year follow-up. Int J Obes (Lond) 2005; 29:93-99.
64. Hsu YH, Niu T, Song Y, Tinker L, Kuller LH, Liu S. Genetic variants in the UCP2-UCP3 gene cluster and risk of diabetes in the Women's Health Initiative Observational Study. Diabetes 2008; 57:1101-1107.
65. Harper ME, Bevilacqua L, Hagopian K, Weindruch R, Ramsey JJ. Ageing, oxidative stress, and mitochondrial uncoupling. Acta Physiol Scand 2004; 182:321-331.