Adrenergic receptor polymorphisms and autonomic nervous system function in human obesity

Trends in Endocrinology and Metabolism

Volumn 17, Issue 7, 2006, Pages 269-275

  Yasuda, Koichiro ^a,b,c   Matsunaga, Tetsuro ^a   Adachi, Tetsuya ^a   Aoki, Norihiko ^b   Tsujimoto, Gozoh ^a   Tsuda, Kinsuke ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Tsunashimakai Kosei Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR; ALPHA 2B ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; CATECHOLAMINE; CELL SURFACE RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUCOSE; LIPID; UNCOUPLING PROTEIN 1;

ADRENERGIC SYSTEM; AUTONOMIC DYSFUNCTION; AUTONOMIC NERVOUS SYSTEM; AUTONOMIC NERVOUS SYSTEM FUNCTION; AUTOREGULATION; DISEASE ASSOCIATION; ENERGY METABOLISM; GENETIC POLYMORPHISM; GLUCOSE METABOLISM; HEART RATE VARIABILITY; HOMEOSTASIS; HUMAN; IN VITRO STUDY; LIPID METABOLISM; METABOLIC DISORDER; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; REVIEW;

ANIMALS; AUTONOMIC NERVOUS SYSTEM; GTP-BINDING PROTEINS; HUMANS; OBESITY; POLYMORPHISM, GENETIC; RECEPTORS, ADRENERGIC;

EID: 33747864781     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2006.07.001     Document Type: Review

References (69)

1. Lafontan M. Fat cells: afferent and efferent messages define new approaches to treat obesity. Annu. Rev. Pharmacol. Toxicol. 45 (2005) 119-146
2. Snitker S., et al. The sympathetic nervous system and obesity: role in aetiology and treatment. Obes. Rev. 1 (2000) 5-15
3. van Baak M.A. The peripheral sympathetic nervous system in human obesity. Obes. Rev. 2 (2001) 3-14
4. Poehlman E.T., et al. Sympathetic nervous system activity, body fatness, and body fat distribution in younger and older males. J. Appl. Physiol. 78 (1995) 802-806
5. Scherrer U., et al. Body fat and sympathetic nerve activity in healthy subjects. Circulation 89 (1994) 2634-2640
6. Seals D.R., and Bell C. Chronic sympathetic activation: consequence and cause of age-associated obesity?. Diabetes 53 (2004) 276-284
7. Bachman E.S., et al. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science 297 (2002) 843-845
8. Jimenez M., et al. Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting. FEBS Lett. 530 (2002) 37-40
9. Anon. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93 (1996) 1043-1065
10. Akselrod S., et al. Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science 213 (1981) 220-222
11. Pumprla J., et al. Functional assessment of heart rate variability: physiological basis and practical applications. Int. J. Cardiol. 84 (2002) 1-14
12. Piccirillo G., et al. Power spectral analysis of heart rate variability in obese subjects: evidence of decreased cardiac sympathetic responsiveness. Int. J. Obes. Relat. Metab. Disord. 20 (1996) 825-829
13. Laederach-Hofmann K., et al. Autonomic cardiovascular regulation in obesity. J. Endocrinol. 164 (2000) 59-66
14. Matsumoto T., et al. Autonomic responsiveness to acute cold exposure in obese and non-obese young women. Int. J. Obes. Relat. Metab. Disord. 23 (1999) 793-800
15. Karason K., et al. Heart rate variability in obesity and the effect of weight loss. Am. J. Cardiol. 83 (1999) 1242-1247
16. Lowell B.B., and Bachman E.S. Beta-adrenergic receptors, diet-induced thermogenesis, and obesity. J. Biol. Chem. 278 (2003) 29385-29388
17. Rohrer D.K. Physiological consequences of beta-adrenergic receptor disruption. J. Mol. Med. 76 (1998) 764-772
18. Clement K., et al. Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N. Engl. J. Med. 333 (1995) 352-354
19. Walston J., et al. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N. Engl. J. Med. 333 (1995) 343-347
20. Widen E., et al. Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. N. Engl. J. Med. 333 (1995) 348-351
21. Hoffstedt J., et al. Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function. Diabetes 48 (1999) 203-205
22. Leineweber K., et al. Beta-adrenoceptor polymorphisms. Naunyn Schmiedebergs Arch. Pharmacol. 369 (2004) 1-22
23. Arner P., and Hoffstedt J. Adrenoceptor genes in human obesity. J. Intern. Med. 245 (1999) 667-672
24. Kurokawa N., et al. Association of BMI with the beta3-adrenergic receptor gene polymorphism in Japanese: meta-analysis. Obes. Res. 9 (2001) 741-745
25. Zhan S., and Ho S.C. Meta-analysis of the association of the Trp64Arg polymorphism in the beta3 adrenergic receptor with insulin resistance. Obes. Res. 13 (2005) 1709-1719
26. Sakane N., et al. Beta 3-adrenergic-receptor polymorphism: a genetic marker for visceral fat obesity and the insulin resistance syndrome. Diabetologia 40 (1997) 200-204
27. Strazzullo P., et al. Relationship of the Trp64Arg polymorphism of the beta3-adrenoceptor gene to central adiposity and high blood pressure: interaction with age. Cross-sectional and longitudinal findings of the Olivetti Prospective Heart Study. J. Hypertens. 19 (2001) 399-406
28. Sipilainen R., et al. Polymorphism of the beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns. Diabetes 46 (1997) 77-80
29. Yoshida T., et al. Mutation of beta 3-adrenergic-receptor gene and response to treatment of obesity. Lancet 346 (1995) 1433-1434
30. Shihara N., et al. The association between Trp64Arg polymorphism of the beta3-adrenergic receptor and autonomic nervous system activity. J. Clin. Endocrinol. Metab. 84 (1999) 1623-1627
31. Shiwaku K., et al. Difficulty in losing weight by behavioral intervention for women with Trp64Arg polymorphism of the beta3-adrenergic receptor gene. Int. J. Obes. Relat. Metab. Disord. 27 (2003) 1028-1036
32. Romijn J.A., and Fliers E. Sympathetic and parasympathetic innervation of adipose tissue: metabolic implications. Curr. Opin. Clin. Nutr. Metab. Care 8 (2005) 440-444
33. Dalgaard L.T., and Pedersen O. Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and type II diabetes. Diabetologia 44 (2001) 946-965
34. Inokuma K., et al. Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue. Diabetes 54 (2005) 1385-1391
35. Yang X., et al. Reduced expression of FOXC2 and brown adipogenic genes in human subjects with insulin resistance. Obes. Res. 11 (2003) 1182-1191
36. Klein J., et al. Insulin and the beta3-adrenoceptor differentially regulate uncoupling protein-1 expression. Mol. Endocrinol. 14 (2000) 764-773
37. Esterbauer H., et al. Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus. J. Lipid Res. 39 (1998) 834-844
38. Heilbronn L.K., et al. Association of -3826 G variant in uncoupling protein-1 with increased BMI in overweight Australian women. Diabetologia 43 (2000) 242-244
39. Clement K., et al. Additive effect of A → G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity. Int. J. Obes. Relat. Metab. Disord. 20 (1996) 1062-1066
40. Sivenius K., et al. Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on long-term body weight change in Finnish type 2 diabetic and non-diabetic control subjects. Int. J. Obes. Relat. Metab. Disord. 24 (2000) 514-519
41. Kogure A., et al. Synergic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on weight loss in obese Japanese. Diabetologia 41 (1998) 1399
42. Valve R., et al. Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns. Diabetologia 41 (1998) 357-361
43. Shihara N., et al. Synergistic effect of polymorphisms of uncoupling protein 1 and beta3-adrenergic receptor genes on autonomic nervous system activity. Int. J. Obes. Relat. Metab. Disord. 25 (2001) 761-766
44. Fleisher L.A., et al. Thermoregulation and heart rate variability. Clin. Sci. (Lond.) 90 (1996) 97-103
45. Valet P., et al. Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity. J. Biol. Chem. 275 (2000) 34797-34802
46. Flordellis C., et al. Clinical and pharmacological significance of alpha2-adrenoceptor polymorphisms in cardiovascular diseases. Int. J. Cardiol. 97 (2004) 367-372
47. Garenc C., et al. The alpha 2-adrenergic receptor gene and body fat content and distribution: the HERITAGE Family Study. Mol. Med. 8 (2002) 88-94
48. Oppert J.M., et al. DNA polymorphisms in the alpha 2- and beta 2-adrenoceptor genes and regional fat distribution in humans: association and linkage studies. Obes. Res. 3 (1995) 249-255
49. Rosmond R., et al. A C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels. J. Intern. Med. 251 (2002) 252-257
50. Ukkola O., et al. Interactions among the alpha2-, beta2-, and beta3-adrenergic receptor genes and obesity-related phenotypes in the Quebec Family Study. Metabolism 49 (2000) 1063-1070
51. Heinonen P., et al. Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects. J. Clin. Endocrinol. Metab. 84 (1999) 2429-2433
52. Small K.M., et al. Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. J. Biol. Chem. 276 (2001) 4917-4922
53. Philipp M., et al. Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283 (2002) R287-R295
54. Sivenius K., et al. Effect of a three-amino acid deletion in the alpha2B-adrenergic receptor gene on long-term body weight change in Finnish non-diabetic and type 2 diabetic subjects. Int. J. Obes. Relat. Metab. Disord. 25 (2001) 1609-1614
55. Dionne I.J., et al. Identification of an interactive effect of beta3- and alpha2b-adrenoceptor gene polymorphisms on fat mass in Caucasian women. Diabetes 50 (2001) 91-95
56. Suzuki N., et al. Alpha(2B)-adrenergic receptor deletion polymorphism associates with autonomic nervous system activity in young healthy Japanese. J. Clin. Endocrinol. Metab. 88 (2003) 1184-1187
57. Sivenius K., et al. A deletion in the alpha2B-adrenergic receptor gene and autonomic nervous function in central obesity. Obes. Res. 11 (2003) 962-970
58. Dionne I.J., et al. Association between obesity and a polymorphism in the beta(1)-adrenoceptor gene (Gly389Arg ADRB1) in Caucasian women. Int. J. Obes. Relat. Metab. Disord. 26 (2002) 633-639
59. Linne Y., et al. Beta1-adrenoceptor gene polymorphism predicts long-term changes in body weight. Int. J. Obes. (Lond). 29 (2005) 458-462
60. Large V., et al. Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function. J. Clin. Invest. 100 (1997) 3005-3013
61. Hellstrom L., et al. The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females. J. Intern. Med. 245 (1999) 253-259
62. Ishiyama-Shigemoto S., et al. Association of polymorphisms in the beta2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus. Diabetologia 42 (1999) 98-101
63. Meirhaeghe A., et al. Impact of polymorphisms of the human beta2-adrenoceptor gene on obesity in a French population. Int. J. Obes. Relat. Metab. Disord. 24 (2000) 382-387
64. Garenc C., et al. Effects of beta2-adrenergic receptor gene variants on adiposity: the HERITAGE Family Study. Obes. Res. 11 (2003) 612-618
65. Pereira A.C., et al. Beta2 adrenoceptor functional gene variants, obesity, and blood pressure level interactions in the general population. Hypertension 42 (2003) 685-692
66. Oomen J.M., et al. beta2-adrenergic receptor polymorphisms and salbutamol-stimulated energy expenditure. J. Clin. Endocrinol. Metab. 90 (2005) 2301-2307
67. Weinstein L.S., et al. Genetic diseases associated with heterotrimeric G proteins. Trends Pharmacol. Sci. 27 (2006) 260-266
68. Matsunaga T., et al. Association of C825T polymorphism of G protein beta3 subunit with the autonomic nervous system in young healthy Japanese individuals. Am. J. Hypertens. 18 (2005) 523-529
69. Yasuda K., et al. T393C polymorphism of GNAS1 associated with the autonomic nervous system in young, healthy Japanese subjects. Clin. Exp. Pharmacol. Physiol. 31 (2004) 597-601