Contact allergens and irritants show discrete differences in the activation of human monocyte-derived dendritic cells: Consequences for in vitro detection of contact allergens

Archives of Toxicology

Volumn 79, Issue 1, 2005, Pages 37-46

  Straube, Frank ^a   Grenet, Olivier ^a   Bruegger, Peter ^a   Ulrich, Peter ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Activation marker; Contact allergen; Dose dependency; Monocyte derived dendritic cell (MoDC); Skin irritant

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; BENZALKONIUM CHLORIDE; CD86 ANTIGEN; CONTACT ALLERGEN; DODECYL SULFATE SODIUM; ENDOTOXIN; HLA DR ANTIGEN; IRRITANT AGENT; LIPOPOLYSACCHARIDE;

ARTICLE; CELL ACTIVATION; CELL CULTURE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CYTOTOXICITY; DENDRITIC CELL; DOSE RESPONSE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ALLERGENS; ANTIGENS, CD; ANTIGENS, CD86; CELL SURVIVAL; CELLS, CULTURED; DENDRITIC CELLS; DERMATITIS, ALLERGIC CONTACT; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HLA-DR ANTIGENS; HUMANS; INHIBITORY CONCENTRATION 50; IRRITANTS; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MONOCYTES;

EID: 12944321367     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-004-0606-8     Document Type: Article

References (20)

1. Aiba S, Terunuma A, Manome H, Tagami H (1997) Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules. Eur J Immunol 27:3031-3038
2. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K (2000) Immunobiology of dendritic cells. Annu Rev Immunol 18:767-811
3. Coutant KD, de Fraissinette AB, Cordier A, Ulrich P (1999) Modulation of the activity of human monocyte-derived dendritic cells by chemical haptens, a metal allergen, and a staphylococcal superantigen. Toxicol Sci 52:189-198
4. Dzionek A, Fuchs A, Schmidt P, Cremer S, Zysk M, Miltenyi S, Buck DW, Schmitz J (2000) BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol 165:6037-6046
5. European Pharmacopoeia (2002) 4th edn. Council of Europe, Strasbourg, France
6. McFadden JP, Basketter DA (2000) Contact allergy, irritancy and 'danger'. Contact Dermatitis 42:123-127
7. McLellan AD, Brocker EB, Kampgen E (2000) Dendritic cell activation by danger and antigen-specific T-cell signalling. Exp Dermatol 9:313-322
8. Poole S, Selkirk S, Rafferty B, Meager A, Thorpe R, Gearing AJ (1989) Assay of pyrogenic contamination in pharmaceuticals by cytokine release. Pharmeuropa, vol 1, special issue, pp 17-18
9. Romani N, Reider D, Heuer M, Ebner S, Kampgen E, Eibl B, Niederwieser D, Schuler G (1996) Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J Immunol Methods 196:137-151
10. Rougier N, Redziniak G, Mougin D, Schmitt D, Vincent C (2000) In vitro evaluation of the sensitization potential of weak contact allergens using Langerhans-like dendritic cells and autologous T cells. Toxicology 145:73-82
11. Ruedl C, Koebel P, Bachmann M, Hess M, Karjalainen K (2000) Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes. J Immunol 165:4910-4916
12. Ryan CA, Hulette BC, Gerberick GF (2001) Approaches for the development of cell-based in vitro methods for contact sensitization. Toxicol In Vitro 15:43-55
13. Sallusto F (2001) Origin and migratory properties of dendritic cells in the skin. Curr Opin Allergy Clin Immunol 1:441-448
14. Sauter B, Albert ML, Francisco L, Larsson M, Somersan S, Bhardwaj N (2000) Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med 191:423-434
15. Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271-296
16. Thurner B, Roder C, Dieckmann D, Heuer M, Kruse M, Glaser A, Keikavoussi P, Kampgen E, Bender A, Schuler G (1999) Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application. J Immunol Methods 223:1-15
17. + cells are capable of initiating delayed type hypersensitivity responses. J Invest Dermatol 94:267-272
18. Ulrich P, Streich J, Suter W (2001) Intralaboratory validation of alternative endpoints in the murine local lymph node assay for the identification of contact allergic potential: primary ear skin irritation and ear-draining lymph node hyperplasia induced by topical chemicals. Arch Toxicol 74:733-744
19. Verhasselt V, Buelens C, Willems F, De Groote D, Haeffner-Cavaillon N, Goldman M (1997) Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway. J Immunol 158:2919-2925
20. Weltzien HU, Moulon C, Martin S, Padovan E, Hartmann U, Kohler J (1996) T cell immune responses to haptens. Structural models for allergic and autoimmune reactions. Toxicology 107:141-151