Metabolic detoxification: Implications for thresholds

Toxicologic Pathology

Volumn 28, Issue 3, 2000, Pages 382-387

  Oesch, Franz ^a   Herrero, María Elena ^a   Hengstler, Jan Georg ^a   Lohmann, Matthias ^a   Arand, Michael ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

DNA damage; Epoxide hydrolase; Epoxy compounds metabolism; Ester intermediate; Genotoxicity; V79 Chinese hamster lung fibroblasts; hydrolase fold

Indexed keywords

CARCINOGEN; EPOXIDE HYDROLASE; XENOBIOTIC AGENT;

ANIMAL CELL; CARCINOGENESIS; COMPLEX FORMATION; DETOXIFICATION; DNA DAMAGE; ENZYME KINETICS; ENZYME SUBSTRATE; GENOTOXICITY; HYDROLYSIS; LUNG FIBROBLAST; MAXIMUM ALLOWABLE CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; CARCINOGENS; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXIDE HYDROLASES; HUMANS; METABOLIC DETOXICATION, DRUG; MICROSOMES, LIVER; MUTAGENS; XENOBIOTICS;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0034084246     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262330002800305     Document Type: Review

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