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Volumn 29, Issue 8, 2004, Pages 773-786

D-003: Antiplatelet therapy treatment of lipoprotein disorders

Author keywords

[No Author keywords available]

Indexed keywords

1 DOTRIACONTANOIC ACID; 1 HENTRIACONTANOIC ACID; 1 HEPTACOSANOIC ACID; 1 HEXACOSANOIC ACID; 1 HEXATRIACONTANOIC ACID; 1 NONACOSANOIC ACID; 1 OCTACOSANOIC ACID; 1 TETRATRIACONTANOIC ACID; 1 TRIACONTANOIC ACID; 1 TRITRIACONTANOIC ACID; ACETYLSALICYLIC ACID; ALIPHATIC CARBOXYLIC ACID; CARBON TETRACHLORIDE; CHOLESTEROL; D 003; DICOUMAROL; DRUG METABOLIZING ENZYME; FLUINDOSTATIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENALINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; PARACETAMOL; PLANT EXTRACT; POLICOSANOL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 6344291874     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2004.029.08.828449     Document Type: Article
Times cited : (34)

References (93)
  • 1
    • 0031001720 scopus 로고    scopus 로고
    • Alternate projections of mortality and disability by cause 1990-2020. Global Burden Disease Study
    • Murray, C.J.L., López, A.D. Alternate projections of mortality and disability by cause 1990-2020. Global Burden Disease Study. Lancet 1997, 349: 1498-504.
    • (1997) Lancet , vol.349 , pp. 1498-1504
    • Murray, C.J.L.1    López, A.D.2
  • 3
    • 0030807192 scopus 로고    scopus 로고
    • The burden of the European Society of Cardiovascular Mortality and Morbidity in Europe Task Force of the European Society of Cardiovascular Mortality and Morbidity Statistics in Europe
    • Sans, S., Kesteloot, H., Kromhout, D. The burden of the European Society of Cardiovascular Mortality and Morbidity in Europe Task Force of the European Society of Cardiovascular Mortality and Morbidity Statistics in Europe. Eur Heart J 1997, 18: 1231-48.
    • (1997) Eur Heart J , vol.18 , pp. 1231-1248
    • Sans, S.1    Kesteloot, H.2    Kromhout, D.3
  • 4
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Expert Panel of Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA - J Am Med Assoc 2001, 285: 2486-97.
    • (2001) JAMA - J Am Med Assoc , vol.285 , pp. 2486-2497
  • 6
    • 0031939253 scopus 로고    scopus 로고
    • European and American recommendations for coronary heart disease prevention
    • Wood, D. European and American recommendations for coronary heart disease prevention. Eur Heart J 1998, 19(Suppl. A): A12-9.
    • (1998) Eur Heart J , vol.19 , Issue.SUPPL. A
    • Wood, D.1
  • 7
    • 0028910696 scopus 로고
    • Role of thrombosis in atherosclerosis and its complications
    • Falk, E., Fernández-Ortiz, A. Role of thrombosis in atherosclerosis and its complications. Am J Cardiol 1995, 75: 1B-7B.
    • (1995) Am J Cardiol , vol.75
    • Falk, E.1    Fernández-Ortiz, A.2
  • 8
    • 0031046435 scopus 로고    scopus 로고
    • Endothelial function: General considerations
    • Haller, H. Endothelial function: General considerations. Drugs 1997, 53(Suppl. 1): 1-10.
    • (1997) Drugs , vol.53 , Issue.SUPPL. 1 , pp. 1-10
    • Haller, H.1
  • 9
    • 0031265794 scopus 로고    scopus 로고
    • Biology of the endothelium
    • Luscher, T.F., Barton, M. Biology of the endothelium. Clin Cardiol 1997, 20(11, Suppl. 2): II-3-10.
    • (1997) Clin Cardiol , vol.20 , Issue.11 SUPPL. 2
    • Luscher, T.F.1    Barton, M.2
  • 10
    • 0031441704 scopus 로고    scopus 로고
    • Plaque disruption and coronary thrombosis: New insights into pathogenesis and prevention
    • Shah, P.K. Plaque disruption and coronary thrombosis: New insights into pathogenesis and prevention. Clin Cardiol 1997, 20(11, Suppl. 2): II-38-44.
    • (1997) Clin Cardiol , vol.20 , Issue.11 SUPPL. 2
    • Shah, P.K.1
  • 11
    • 0021350001 scopus 로고
    • The Lipid Research Clinics Coronary Primary Prevention trial results. I. Reduction in the incidence of coronary heart disease
    • Lipid Research Clinics Program. The Lipid Research Clinics Coronary Primary Prevention trial results. I. Reduction in the incidence of coronary heart disease. JAMA - J Am Med Assoc 1984, 251: 351-64.
    • (1984) JAMA - J Am Med Assoc , vol.251 , pp. 351-364
  • 12
    • 0021349709 scopus 로고
    • The Lipid Research Clinics Coronary Primary Prevention trial results. II. The relationship of reduction in the incidence of coronary heart disease to cholesterol-lowering
    • Lipid Research Clinics Program. The Lipid Research Clinics Coronary Primary Prevention trial results. II. The relationship of reduction in the incidence of coronary heart disease to cholesterol-lowering. JAMA - J Am Med Assoc 1984, 251: 365-74.
    • (1984) JAMA - J Am Med Assoc , vol.251 , pp. 365-374
  • 13
    • 0023232216 scopus 로고
    • Helsinki Heart Study: Primary prevention with gemfibrozil in middle-aged men with dyslipidemia
    • Frick, M.H., Elo, O., Happa, K. et al. Helsinki Heart Study: Primary prevention with gemfibrozil in middle-aged men with dyslipidemia. New Engl J Med 1987, 317: 1237-45.
    • (1987) New Engl J Med , vol.317 , pp. 1237-1245
    • Frick, M.H.1    Elo, O.2    Happa, K.3
  • 14
    • 0025959101 scopus 로고
    • An updated coronary risk profile. A statement for health professionals
    • Anderson, K.M., Wilson, P.W.F., Odell, P.M. et al. An updated coronary risk profile. A statement for health professionals. Circulation 1991, 83: 356-62.
    • (1991) Circulation , vol.83 , pp. 356-362
    • Anderson, K.M.1    Wilson, P.W.F.2    Odell, P.M.3
  • 15
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4 444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4 444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet 1994, 344: 1383-9.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 16
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
    • Sacks, P.M., Pfeffer, M.A., Moyé, L.A. et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. New Engl J Med 1996, 335: 1001-9.
    • (1996) New Engl J Med , vol.335 , pp. 1001-1009
    • Sacks, P.M.1    Pfeffer, M.A.2    Moyé, L.A.3
  • 17
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events and deaths with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
    • The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. Prevention of cardiovascular events and deaths with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. New Engl J Med 1998, 339: 1349-57.
    • (1998) New Engl J Med , vol.339 , pp. 1349-1357
  • 19
    • 0032572086 scopus 로고    scopus 로고
    • Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: Results of AFCAPS/TexCAPS
    • Downs, J.R., Clearfield, M., Weiss, S. et al. for the AFCAPS/TexCAPS Research Group. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: Results of AFCAPS/TexCAPS. JAMA - J Am Med Assoc 1998, 279: 1615-22.
    • (1998) JAMA - J Am Med Assoc , vol.279 , pp. 1615-1622
    • Downs, J.R.1    Clearfield, M.2    Weiss, S.3
  • 20
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomized placebo-controlled trial
    • Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomized placebo-controlled trial. Lancet 2002, 360: 7-22.
    • (2002) Lancet , vol.360 , pp. 7-22
  • 21
    • 0037164314 scopus 로고    scopus 로고
    • Pravastatin in elderly individuals at risk of vascular disease (PROSPER): A randomized controlled study
    • Shepherd, J., Blauw, G.J., Murphy, M.B. et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): A randomized controlled study. Lancet 2002, 360: 1623-30.
    • (2002) Lancet , vol.360 , pp. 1623-1630
    • Shepherd, J.1    Blauw, G.J.2    Murphy, M.B.3
  • 22
    • 0027421996 scopus 로고
    • The rapid reduction in cardiac events with lipid-lowering therapy: Mechanisms and implications
    • Pearson, T.A., Marx, H.J. The rapid reduction in cardiac events with lipid-lowering therapy: Mechanisms and implications. Am J Cardiol 1993, 72: 1072-3.
    • (1993) Am J Cardiol , vol.72 , pp. 1072-1073
    • Pearson, T.A.1    Marx, H.J.2
  • 23
    • 0029737574 scopus 로고    scopus 로고
    • Non-lipid-related effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
    • Corsini, A., Bernini, F., Quarato, P. et al. Non-lipid-related effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Cardiology 1996, 87: 458-68.
    • (1996) Cardiology , vol.87 , pp. 458-468
    • Corsini, A.1    Bernini, F.2    Quarato, P.3
  • 24
    • 0029948598 scopus 로고    scopus 로고
    • Can the clinical efficacy of the HMG CoA reductase inhibitors be explained solely by their effects on LDL-cholesterol?
    • Graw, A. Can the clinical efficacy of the HMG CoA reductase inhibitors be explained solely by their effects on LDL-cholesterol? Atherosclerosis 1996, 125: 267-9.
    • (1996) Atherosclerosis , vol.125 , pp. 267-269
    • Graw, A.1
  • 25
    • 0030663693 scopus 로고    scopus 로고
    • Vascular effects of statins in stroke
    • Delanty, N., Vaughan, C.J. Vascular effects of statins in stroke. Stroke 1997, 28: 2315-20.
    • (1997) Stroke , vol.28 , pp. 2315-2320
    • Delanty, N.1    Vaughan, C.J.2
  • 26
    • 0034115496 scopus 로고    scopus 로고
    • Pleiotropic effects of statins in atherosclerosis and diabetes
    • Bellosta, S., Ferri, N., Arnaboldi, L. et al. Pleiotropic effects of statins in atherosclerosis and diabetes. Diabetes Care 2000, 23(Suppl. 2): B72-6.
    • (2000) Diabetes Care , vol.23 , Issue.SUPPL. 2
    • Bellosta, S.1    Ferri, N.2    Arnaboldi, L.3
  • 29
    • 0028962401 scopus 로고
    • Fibrates and statins in the treatment of hyperlipidaemia: An appraisal of their efficacy and safety
    • Shepherd, J. Fibrates and statins in the treatment of hyperlipidaemia: An appraisal of their efficacy and safety. Eur Heart J 1995, 16: 5-13.
    • (1995) Eur Heart J , vol.16 , pp. 5-13
    • Shepherd, J.1
  • 30
    • 0029828384 scopus 로고    scopus 로고
    • Choosing the right lipid-regulating agent
    • Farnier, J.A., Gotto, A.M. Choosing the right lipid-regulating agent. Drugs 1996, 52: 649-61.
    • (1996) Drugs , vol.52 , pp. 649-661
    • Farnier, J.A.1    Gotto, A.M.2
  • 31
    • 0035197395 scopus 로고    scopus 로고
    • Statin myopathies: Pathophysiologic and clinical perspectives
    • Baker, S.K., Tarnopolsky, M.A. Statin myopathies: Pathophysiologic and clinical perspectives. Clin Invest Med 2001, 24: 258-72.
    • (2001) Clin Invest Med , vol.24 , pp. 258-272
    • Baker, S.K.1    Tarnopolsky, M.A.2
  • 32
    • 0034887738 scopus 로고    scopus 로고
    • Lipid-lowering drugs and risk of myopathy: A population based follow-up study
    • Gaist, D., García, A., Huerta, C. et al. Lipid-lowering drugs and risk of myopathy: A population based follow-up study. Epidemiol 2001, 12: 565-9.
    • (2001) Epidemiol , vol.12 , pp. 565-569
    • Gaist, D.1    García, A.2    Huerta, C.3
  • 33
    • 0037036822 scopus 로고    scopus 로고
    • ACC/AHA/NHLBI clinical advisory on the use and safety of statins
    • Pasternak, R.C., Smith, S. Jr., Bairey-Merz, C.N. et al. ACC/AHA/NHLBI clinical advisory on the use and safety of statins. J Am Coll Cardiol 2002, 40: 567-72.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 567-572
    • Pasternak, R.C.1    Smith Jr., S.2    Bairey-Merz, C.N.3
  • 34
    • 0028120906 scopus 로고
    • Collaborative overview of randomized trials of antiplatelet therapy-I: Prevention of death, myocardial infarction and stroke by prolonged antiplatelet therapy in various categories of patients
    • Antiplatelet Trialists' Collaboration. Collaborative overview of randomized trials of antiplatelet therapy-I: Prevention of death, myocardial infarction and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ - Br Med J 1994, 308: 81-106.
    • (1994) BMJ - Br Med J , vol.308 , pp. 81-106
  • 37
    • 0029838529 scopus 로고    scopus 로고
    • Antiplatelet therapy
    • Schafer, A. Antiplatelet therapy. Am J Med 1996, 101: 199-209.
    • (1996) Am J Med , vol.101 , pp. 199-209
    • Schafer, A.1
  • 38
    • 0035124920 scopus 로고    scopus 로고
    • Platelet-active drugs: The relationships among dose, effectiveness, and side effects
    • Patrono, C., Coller, B., Dalen, J.E., FitzGerald, G.A., Fuster, V., Gent, M., Hirsch, J., Roth, G. Platelet-active drugs: The relationships among dose, effectiveness, and side effects. Chest 2001, 119(1, Suppl.): 39S-63S.
    • (2001) Chest , vol.119 , Issue.1 SUPPL.
    • Patrono, C.1    Coller, B.2    Dalen, J.E.3    FitzGerald, G.A.4    Fuster, V.5    Gent, M.6    Hirsch, J.7    Roth, G.8
  • 40
    • 0035196581 scopus 로고    scopus 로고
    • Aspirin for primary and secondary prophylaxis of cardiovascular disease
    • Hassan, M., Amonkar, M. Aspirin for primary and secondary prophylaxis of cardiovascular disease. Curr Ther Res 2001, 62: 676-90.
    • (2001) Curr Ther Res , vol.62 , pp. 676-690
    • Hassan, M.1    Amonkar, M.2
  • 41
    • 0024990144 scopus 로고
    • Ticlopidine. An updated review of its pharmacology and therapeutic use in platelet-dependent disorders
    • McTavish, D., Faulds, D., Goa, K.L Ticlopidine. An updated review of its pharmacology and therapeutic use in platelet-dependent disorders. Drugs 1990, 40: 238-59.
    • (1990) Drugs , vol.40 , pp. 238-259
    • McTavish, D.1    Faulds, D.2    Goa, K.L.3
  • 42
  • 43
    • 0030590746 scopus 로고    scopus 로고
    • A randomized, blinded, trial of Clopidogrel versus aspirin in patients at high risk of ischemic events (CAPRIE)
    • The CAPRIE Study Group. A randomized, blinded, trial of Clopidogrel versus aspirin in patients at high risk of ischemic events (CAPRIE). Lancet 1996, 348: 1329-39.
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 44
    • 0033748474 scopus 로고    scopus 로고
    • Assessment of antithrombotic agents using the platelet aggregation test
    • Tanemoto, K., Kanaoka, Y., Kuinose, M. Assessment of antithrombotic agents using the platelet aggregation test. Curr Ther Res 2000, 61: 798-806.
    • (2000) Curr Ther Res , vol.61 , pp. 798-806
    • Tanemoto, K.1    Kanaoka, Y.2    Kuinose, M.3
  • 49
    • 0035057937 scopus 로고    scopus 로고
    • The effects of D-003 and policosanol on the lipid profile and endothelemia cells in normocholesterolemic rabbits
    • Mendoza, S., Gámez, R., Noa, M., Más, R., Castaño, G., Mesa, R., Mesa, M., de Armas, M. The effects of D-003 and policosanol on the lipid profile and endothelemia cells in normocholesterolemic rabbits. Curr Ther Res 2001, 62: 209-20.
    • (2001) Curr Ther Res , vol.62 , pp. 209-220
    • Mendoza, S.1    Gámez, R.2    Noa, M.3    Más, R.4    Castaño, G.5    Mesa, R.6    Mesa, M.7    De Armas, M.8
  • 50
    • 0343081551 scopus 로고    scopus 로고
    • Policosanol
    • Mas, R. Policosanol. Drugs Fut 2000, 25: 569-86.
    • (2000) Drugs Fut , vol.25 , pp. 569-586
    • Mas, R.1
  • 52
    • 0347316393 scopus 로고    scopus 로고
    • Effects of D-003, a mixture of long-chain aliphatic primary acids, fluvastatin and the combined therapy D-003 plus fluvastatin on the lipid profile of normocholesterolemic rabbits
    • Mendoza, S., Gamez, R., Mas, R., Goicochea, E. Effects of D-003, a mixture of long-chain aliphatic primary acids, fluvastatin and the combined therapy D-003 plus fluvastatin on the lipid profile of normocholesterolemic rabbits. Int J Tissue React 2003, 25: 81-9.
    • (2003) Int J Tissue React , vol.25 , pp. 81-89
    • Mendoza, S.1    Gamez, R.2    Mas, R.3    Goicochea, E.4
  • 53
    • 3142690967 scopus 로고    scopus 로고
    • Effects of chronic administration of D-003, a mixture of sugar cane wax high molecular weight acids, in beagle dogs
    • Gámez, R., Más, R., Noa, M., Menendez, R., Garcia, H., Gonzalez, J., Ferez, Y., Goicochea E. Effects of chronic administration of D-003, a mixture of sugar cane wax high molecular weight acids, in beagle dogs. Drugs Exp Clin Res 2004, 30: 75-88.
    • (2004) Drugs Exp Clin Res , vol.30 , pp. 75-88
    • Gámez, R.1    Más, R.2    Noa, M.3    Menendez, R.4    Garcia, H.5    Gonzalez, J.6    Ferez, Y.7    Goicochea, E.8
  • 54
    • 0034774858 scopus 로고    scopus 로고
    • Inhibition of cholesterol biosynthesis in cultured fibroblasts by D-003, a mixture of very long chain saturated fatty acids
    • Menéndez, R., Más, R., Amor, A.M., Rodeiros, I., Gonzalez, R.M., Alfonso, J.L. Inhibition of cholesterol biosynthesis in cultured fibroblasts by D-003, a mixture of very long chain saturated fatty acids. Pharmacol Res 2001, 44: 299-304.
    • (2001) Pharmacol Res , vol.44 , pp. 299-304
    • Menéndez, R.1    Más, R.2    Amor, A.M.3    Rodeiros, I.4    Gonzalez, R.M.5    Alfonso, J.L.6
  • 55
    • 0019983996 scopus 로고
    • The effects of mevinolin on serum cholesterol levels of rabbits with hypercholesterolemia
    • Kroon, P.A., Hand, K.M., Huff, J.W., Alberts, A.W. The effects of mevinolin on serum cholesterol levels of rabbits with hypercholesterolemia. Atherosclerosis 1982, 44: 41-8.
    • (1982) Atherosclerosis , vol.44 , pp. 41-48
    • Kroon, P.A.1    Hand, K.M.2    Huff, J.W.3    Alberts, A.W.4
  • 56
    • 0021071179 scopus 로고
    • Regulation of hepatic receptor-dependent degradation of LDL by mevinolin in rabbits with hypercholesterolaemia induced by a wheat starch-casein diet
    • Chao, Y.S., Kroon, P.A., Yamin, T.T. et al. Regulation of hepatic receptor-dependent degradation of LDL by mevinolin in rabbits with hypercholesterolaemia induced by a wheat starch-casein diet. Biochim Biophys Acta 1983, 754: 134-41.
    • (1983) Biochim Biophys Acta , vol.754 , pp. 134-141
    • Chao, Y.S.1    Kroon, P.A.2    Yamin, T.T.3
  • 57
    • 12144290538 scopus 로고    scopus 로고
    • Oral administration of D-003, a mixture of very long chain saturated fatty acids, prevents casein-induced endogenous hypercholesterolemia in rabbits
    • Menéndez, R., Más, R., Pérez, J., Gonzalez, R.M., Jimenez, S. Oral administration of D-003, a mixture of very long chain saturated fatty acids, prevents casein-induced endogenous hypercholesterolemia in rabbits. Can J Physiol Pharmacol 2004, 82: 22-9.
    • (2004) Can J Physiol Pharmacol , vol.82 , pp. 22-29
    • Menéndez, R.1    Más, R.2    Pérez, J.3    Gonzalez, R.M.4    Jimenez, S.5
  • 59
    • 0036188392 scopus 로고    scopus 로고
    • Inhibition of rat lipoprotein lipid peroxidation by the oral administration of D-003, a mixture of very long chain saturated fatty acids
    • Menéndez, R., Mas, R., Amor, A.M., Ledon, N., Perez, J., Gonzalez, R.M., Rodeiro, I., Zayas, M., Jimenez, S. Inhibition of rat lipoprotein lipid peroxidation by the oral administration of D-003, a mixture of very long chain saturated fatty acids. Can J Physiol Pharmacol 2002, 80: 13-21.
    • (2002) Can J Physiol Pharmacol , vol.80 , pp. 13-21
    • Menéndez, R.1    Mas, R.2    Amor, A.M.3    Ledon, N.4    Perez, J.5    Gonzalez, R.M.6    Rodeiro, I.7    Zayas, M.8    Jimenez, S.9
  • 62
    • 3042712410 scopus 로고    scopus 로고
    • D-003 and warfarin on the bleeding time and venous thrombosis experimentally induced in rats
    • Arruzazabala, M.L., Molina, V., Carbajal, D., Mas, R. D-003 and warfarin on the bleeding time and venous thrombosis experimentally induced in rats. J Med Food 2004, 7: 260-3.
    • (2004) J Med Food , vol.7 , pp. 260-263
    • Arruzazabala, M.L.1    Molina, V.2    Carbajal, D.3    Mas, R.4
  • 65
    • 6344275439 scopus 로고    scopus 로고
    • Effects of D-003 on foam cells induced with carrageenan in experimental models
    • in press
    • Noa, M., Mas, R., Mendoza, N. et al. Effects of D-003 on foam cells induced with carrageenan in experimental models. Rev CNIC Cien Biol 2004, 36: in press.
    • (2004) Rev CNIC Cien Biol , vol.36
    • Noa, M.1    Mas, R.2    Mendoza, N.3
  • 70
    • 0346685839 scopus 로고    scopus 로고
    • Effect of D-003, a mixture of high molecular weight primary acids from sugar cane wax, on paracetamol-induced liver damage in rats
    • Mendoza, S., Noa, M., Mas, R., Mendoza, N. Effect of D-003, a mixture of high molecular weight primary acids from sugar cane wax, on paracetamol-induced liver damage in rats. Int J Tissue React 2003, 25: 91-8.
    • (2003) Int J Tissue React , vol.25 , pp. 91-98
    • Mendoza, S.1    Noa, M.2    Mas, R.3    Mendoza, N.4
  • 72
    • 13044283050 scopus 로고    scopus 로고
    • Alendronate mechanism of action: Geranylgeraniol, an intermediate of the mevalonate pathway, prevents inhibition of osteoclasts formation, bone resorption and kinase activation in vitro
    • Fisher, J.E., Rogers, M.J., Halasy, J.M., Luckman, S.P., Hugues, D.E., Masarachia, P.J., Wesolowski, G., Russell, R.G.G., Rodan, G.A., Reszka, A.A. Alendronate mechanism of action: Geranylgeraniol, an intermediate of the mevalonate pathway, prevents inhibition of osteoclasts formation, bone resorption and kinase activation in vitro. Proc Natl Acad Sci USA 1999, 96: 133-8.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 133-138
    • Fisher, J.E.1    Rogers, M.J.2    Halasy, J.M.3    Luckman, S.P.4    Hugues, D.E.5    Masarachia, P.J.6    Wesolowski, G.7    Russell, R.G.G.8    Rodan, G.A.9    Reszka, A.A.10
  • 73
    • 2342439784 scopus 로고    scopus 로고
    • Effects of D-003, a mixture of high molecular weight aliphatic acids from sugarcane wax, on bones of ovariectomized rats
    • Noa, M., Más, R., Mendoza, S., Gamez, R., Mendoza, N. Effects of D-003, a mixture of high molecular weight aliphatic acids from sugarcane wax, on bones of ovariectomized rats. Drugs Exp Clin Res 2004, 30: 35-41.
    • (2004) Drugs Exp Clin Res , vol.30 , pp. 35-41
    • Noa, M.1    Más, R.2    Mendoza, S.3    Gamez, R.4    Mendoza, N.5
  • 74
    • 11844306539 scopus 로고    scopus 로고
    • Effects of D-003 on hepatic microsomal metabolizying enzymes
    • in press
    • Gámez, R., Rodeiro, I., González, J. et al. Effects of D-003 on hepatic microsomal metabolizying enzymes. J Med Food 2004, in press.
    • (2004) J Med Food
    • Gámez, R.1    Rodeiro, I.2    González, J.3
  • 75
    • 6344275816 scopus 로고    scopus 로고
    • Plasma levels of octacosanoic acid after endogenous dosing with D-003 to rabbits
    • in press
    • Menéndez, R., Marrero, D., Méndez, E. et al. Plasma levels of octacosanoic acid after endogenous dosing with D-003 to rabbits. Rev CNIC Cien Biol 2004, 36: in press.
    • (2004) Rev CNIC Cien Biol , vol.36
    • Menéndez, R.1    Marrero, D.2    Méndez, E.3
  • 76
    • 6344272897 scopus 로고    scopus 로고
    • Pharmacokinetic study of 3H-octacosanoic acid in male rats
    • in press
    • Menéndez, R., Mas, R., Pérez, Y. et al. Pharmacokinetic study of 3H-octacosanoic acid in male rats. Rev CNIC Cien Biol 2004, 36: in press.
    • (2004) Rev CNIC Cien Biol , vol.36
    • Menéndez, R.1    Mas, R.2    Pérez, Y.3
  • 77
    • 0027537570 scopus 로고
    • Biodistribution and metabolism of orally administered octacosanol in rats
    • Kabir, Y., Kimura, S. Biodistribution and metabolism of orally administered octacosanol in rats. Ann Nutr Metab 1993, 37: 33-8.
    • (1993) Ann Nutr Metab , vol.37 , pp. 33-38
    • Kabir, Y.1    Kimura, S.2
  • 78
    • 0034694778 scopus 로고    scopus 로고
    • Acute and subchronic oral toxicity of D-003 in rats
    • Gámez, R., Más, R., Noa, M. et al. Acute and subchronic oral toxicity of D-003 in rats. Toxicol Lett 2000, 118: 31-41.
    • (2000) Toxicol Lett , vol.118 , pp. 31-41
    • Gámez, R.1    Más, R.2    Noa, M.3
  • 79
    • 6344275817 scopus 로고    scopus 로고
    • Acute toxicology of D-003 in rabbits
    • in press
    • Gámez, R., Más, R., Noa, M. et al. Acute toxicology of D-003 in rabbits. Rev CNIC Cien Biol 2004, 36: in press.
    • (2004) Rev CNIC Cien Biol , vol.36
    • Gámez, R.1    Más, R.2    Noa, M.3
  • 80
    • 0036233230 scopus 로고    scopus 로고
    • Preliminary evaluation of the cytotoxic and genotoxic potential of D-003: Mixture of very long chain aliphatic acids
    • Gámez, R., Rodeiro, I., Fernández, I., Acosta, P. Preliminary evaluation of the cytotoxic and genotoxic potential of D-003: Mixture of very long chain aliphatic acids. Teratog Carcinog Mutag 2002, 22: 175-81.
    • (2002) Teratog Carcinog Mutag , vol.22 , pp. 175-181
    • Gámez, R.1    Rodeiro, I.2    Fernández, I.3    Acosta, P.4
  • 82
    • 6344269440 scopus 로고    scopus 로고
    • Study on the genotoxic effect of D-003 in SD rats using alkaline electrophoresis of individual cells in gel (pilot study)
    • González, J.E., Gámez, R., Rodeiro, I. et al. Study on the genotoxic effect of D-003 in SD rats using alkaline electrophoresis of individual cells in gel (pilot study). Rev CNIC Cien Biol 2004, 35: 125-7.
    • (2004) Rev CNIC Cien Biol , vol.35 , pp. 125-127
    • González, J.E.1    Gámez, R.2    Rodeiro, I.3
  • 85
    • 6344225695 scopus 로고    scopus 로고
    • Carcinogenesis study of D-003 in Sprague Dawley rats: Partial report of a 1-year study
    • in press
    • Gámez, R., Mas, R., Noa, M. et al. Carcinogenesis study of D-003 in Sprague Dawley rats: Partial report of a 1-year study. Rev CNIC Cien Biol 2004, 36: in press.
    • (2004) Rev CNIC Cien Biol , vol.36
    • Gámez, R.1    Mas, R.2    Noa, M.3
  • 86
    • 0028865605 scopus 로고
    • The international validation study of the acute toxic Class method (oral)
    • Schlede, E., Mischke, U., Diener, W., Kayser, D. The international validation study of the acute toxic Class method (oral). Arch Toxicol 1995, 69: 659-70.
    • (1995) Arch Toxicol , vol.69 , pp. 659-670
    • Schlede, E.1    Mischke, U.2    Diener, W.3    Kayser, D.4
  • 87
    • 0038109797 scopus 로고    scopus 로고
    • Assessment of the effects of D-003, a new antiplatelet and hypocholesterolemic compound on healthy volunteers: A phase I clinical study
    • Castaño, G., Mas, R., Fernãndez, L. et al. Assessment of the effects of D-003, a new antiplatelet and hypocholesterolemic compound on healthy volunteers: A phase I clinical study. Drugs R&D 2002, 3: 337-48.
    • (2002) Drugs R&D , vol.3 , pp. 337-348
    • Castaño, G.1    Mas, R.2    Fernãndez, L.3
  • 88
    • 0037220697 scopus 로고    scopus 로고
    • Effects of D-003, a new compound purified from sugar cane wax, on platelet aggregation in healthy volunteers: A randomized, double-blinded clinical study
    • Arruzazabala, M.L., Carbajal, D., Mas, R., Molina, V., Castãno, G., Gãmez, R. Effects of D-003, a new compound purified from sugar cane wax, on platelet aggregation in healthy volunteers: A randomized, double-blinded clinical study. Clin Drug Invest 2003, 23: 107-18.
    • (2003) Clin Drug Invest , vol.23 , pp. 107-118
    • Arruzazabala, M.L.1    Carbajal, D.2    Mas, R.3    Molina, V.4    Castãno, G.5    Gãmez, R.6
  • 90
    • 6344272389 scopus 로고    scopus 로고
    • Effects of one month treatment with D-003, a mixture of very long chain fatty acids purified from sugar cane wax, on platelet aggregation in healthy volunteers: A double-blinded, placebo-controlled clinical trial
    • in press
    • Arruzazabala, M.L., Molina, V., Carbajal, D. et al. Effects of one month treatment with D-003, a mixture of very long chain fatty acids purified from sugar cane wax, on platelet aggregation in healthy volunteers: A double-blinded, placebo-controlled clinical trial. Rev CNIC Cien Biol 2004, 36: in press.
    • (2004) Rev CNIC Cien Biol , vol.36
    • Arruzazabala, M.L.1    Molina, V.2    Carbajal, D.3
  • 91
    • 6344275545 scopus 로고    scopus 로고
    • A randomised, double-blinded clinical study of the effects of policosanoic (D-003), a new substance purified from sugar cane wax, on platelet aggregation and plasma levels of arachidonic acid metabolites in healthy volunteers
    • in press
    • Arruzazabala, M.L., Molina, V., Carbajal, D. et al. A randomised, double-blinded clinical study of the effects of policosanoic (D-003), a new substance purified from sugar cane wax, on platelet aggregation and plasma levels of arachidonic acid metabolites in healthy volunteers. Int J Pharmacol Clin Res 2004, in press.
    • (2004) Int J Pharmacol Clin Res
    • Arruzazabala, M.L.1    Molina, V.2    Carbajal, D.3
  • 92
    • 0346101506 scopus 로고    scopus 로고
    • Effects of D-003 (5-40 mg/day) on lipid profile of patients with type II hypercholesterolemia: A phase II clinical study
    • Castaño, G., Mas, R., Fernández, L. et al. Effects of D-003 (5-40 mg/day) on lipid profile of patients with type II hypercholesterolemia: A phase II clinical study. Clin Drug Invest 2003, 23: 789-802.
    • (2003) Clin Drug Invest , vol.23 , pp. 789-802
    • Castaño, G.1    Mas, R.2    Fernández, L.3


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