Acute and oral subchronic toxicity of D-003 in rats

Toxicology Letters

Volumn 118, Issue 1-2, 2000, Pages 31-41

  Gámez, Rafael ^a   Mas, Rosa ^a   Noa, Miriam ^a   Menéndez, Roberto ^a   Alemán, Celia ^a   Acosta, Pilar ^a   García, Haydee ^a   Hernández, Caridad ^a   Amor, Ana ^a   Pérez, Johany ^a   Goicochea, Eddy ^a  

^a NATL CENTER FOR SCIENTIFIC RESEARCH   (Cuba)

Author keywords

Antiplatelet drugs; Cholesterol lowering drugs; D 003; Higher aliphatic primary acids

Indexed keywords

ANTITHROMBOCYTIC AGENT; D 003; HYPOCHOLESTEROLEMIC AGENT; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CHRONIC TOXICITY; CLINICAL OBSERVATION; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME INHIBITION; FEMALE; FOOD INTAKE; HISTOPATHOLOGY; LD 50; MALE; MOUTH LESION; NONHUMAN; ORGAN WEIGHT; PATHOGENESIS; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION INHIBITION; WEIGHT GAIN;

ADMINISTRATION, ORAL; ANIMALS; ANTICHOLESTEREMIC AGENTS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS; FEMALE; LETHAL DOSE 50; MALE; PLATELET AGGREGATION INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR;

ANIMALIA; ARUNDINARIA; RATTUS NORVEGICUS; SACCHARUM OFFICINARUM; UNCLASSIFIED ORGANISMS;

EID: 0034694778     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(00)00260-5     Document Type: Article

References (66)

1. Toxicología aguda del Ateromixol (PPG) en roedores
2. Acute, subchronic and chronic toxicity of policosanol in rats
3. A 12 month study of policosanol oral toxicity in Sprague Dawley rats
4. Carcinogenicity of policosanol in Sprague Dawley rats: A 24 months study
5. Carcinogenicity of policosanol in mice: A 18 months study
6. Reference database of the main physiological parameters in Sprague Dawley rats from 6 to 32 months
7. Effect of policosanol in lowering-cholesterol levels in patients with type II hypercholesterolemia
8. Effects of policosanol on platelet aggregation in rats
9. Effect of policosanol on cerebral ischemia in mongolian gerbils: Role of prostacyclin and thromboxane A2
10. Cholesterol-lowering effects of policosanol on normocholesterolaemic rabbits
11. Comparative study of policosanol, aspirin and the combination of policosanol-aspirin on platelet aggregation in healthy volunteers
12. Effect of policosanol on platelet aggregation in type II hypercholesterolemic patients
13. Effects of policosanol on atherosclerotic lesions in rabbits with exogenous hypercholesterolemia
14. Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis
15. A two years study on the efficacy and tolerability of policosanol in patients with hypercholesterolemia type II
16. Interaction policosanol-warfarin on bleeding time and thrombosis in rats
17. Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy volunteers
18. One-year study of the efficacy and safety of policosanol (5 mg twice daily) in the treatment of type II hypercholesterolemia
19. Open study of the efficacy, safety and tolerability of policosanol in patients with high global coronary risk
20. An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program
21. Effect of policosanol on patients with non-insulin-dependent diabetes mellitus (NIDDM) and hypercholesterolemia
22. Gastrointestinal hemorrage after acute stroke
23. Antithrombotic treatment in acute ischemia stroke
24. Estudio genotoxico del Ateromixol (PPG) un nuevo medicamento hipolipemiante
25. Dose-dependent cholesterol-lowering effects of D-003 on normocholesterolemic rabbits
26. Animal safety and toxicology of simvastatin and related hydroxy-methylglutaryl coenzyme A reductase inhibitors
27. HMG-CoA reductase inhibitors for treatment of hypercholesterolemia
28. Effects of policosanol on serum lipids and lipoproteins in healthy volunteers
29. Biodistribution and metabolism of orally administered octacosanol to rats
30. Precision in data acquisition and reporting of organ weights in rats and mice
31. Preclinical safety evaluation of lovastatin
32. Clinical pathology references ranges of laboratory animals
33. Policosanol inhibits cholesterol biosynthesis and enhances LDL processing in cultured human fibroblasts
34. Effect of policosanol on the hepatic cholesterol biosynthesis of normocholesterolemic rats
35. Cholesterol-lowering effects of policosanol on rabbits with hypercholesterolemia induced by a wheat starch-casein diet
36. Inhibition of cholesterol biosynthesis in cultured fibroblasts by D-003, a mixture of very long chain saturated fatty acids
37. Toxicity of policosanol in beagle dogs: One-year study
38. Antiplatelet and antithrombotic effect of D-003
39. Removal of blood from laboratory mammals and birds
40. Treatment of hypercholesterolemia in NIDDM with policosanol
41. One year efficacy and safety of policosanol in patients with type II hypercholesterolemia
42. Rodent quarantine programs: Purpose, principles and practice
43. Policosanol: A study of its genotoxicity and teratogenecity in rodents
44. Effects of cyclic starvation-feeding and splectomy on the development of hemosiderosis in rats livers
45. Efectos del policosanol sobre las enzimas microsomales hepáticas en ratas Sprague Dawley
46. Teratogenic and reproductive studies of policosanol in the rats and rabbits
47. Evaluation of peri- and post-natal toxicity of policosanol in rats
48. Effects of policosanol chronically administered in male monkeys (Maccaca arctoides)
49. Multigeneration reproduction study of policosanol in rats
50. The international validation study of the acute toxic class method (oral)
51. Effect of policosanol on platelet aggregation in healthy volunteers
52. Preclinical safety evaluation of cerivastatin, a novel HMG-CoA reductase inhibitor
53. Red cell and plasma cholinesterase activities in microsamples of human and animal blood determined simultaneously by modified acetylthiocoline-DTNB procedure
54. Simvastatin: The clinical profile
55. Morphological and histochemical characteristics of pigments in aging F 344 rats
56. Reference range database for serum chemistry and haematology values in laboratory animals