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Volumn 30, Issue 2, 2004, Pages 75-88

Effects of chronic administration of D-003, a mixture of sugar cane wax high molecular acids, in beagle dogs

Author keywords

[No Author keywords available]

Indexed keywords

ALIPHATIC CARBOXYLIC ACID; COLLAGEN; D 003; KAOLIN; SACCHARUM OFFICINARUM EXTRACT; UNCLASSIFIED DRUG;

EID: 3142690967     PISSN: 03786501     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (11)

References (41)
  • 1
    • 0025959101 scopus 로고
    • An updated coronary risk profile. A statement for health professionals
    • Anderson K.M., Wilson P.W.F., Odell P.M., et al. An updated coronary risk profile. A statement for health professionals. Circulation, 83, 356, 1991.
    • (1991) Circulation , vol.83 , pp. 356
    • Anderson, K.M.1    Wilson, P.W.F.2    Odell, P.M.3
  • 2
    • 0021349709 scopus 로고
    • The Lipid Research Clinics Coronary Primary Prevention Trial results II. The relationship of reduction in the incidence of coronary heart disease to cholesterol lowering
    • Lipid Research Clinics Program. The Lipid Research Clinics Coronary Primary Prevention Trial results II. The relationship of reduction in the incidence of coronary heart disease to cholesterol lowering. JAMA, 251, 365, 1984.
    • (1984) JAMA , vol.251 , pp. 365
  • 3
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4,444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4,444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet, 344, 1383, 1994.
    • (1994) Lancet , vol.344 , pp. 1383
  • 4
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
    • Sacks F.M., Pfeffer M.A., Moy L.A., et al. for the Cholesterol and Recurrent Events Trial Investigators. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N. Engl. J. Med., 335, 1001, 1996.
    • (1996) N. Engl. J. Med. , vol.335 , pp. 1001
    • Sacks, F.M.1    Pfeffer, M.A.2    Moy, L.A.3
  • 5
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
    • Shepherd S., Cobbe S.M., Ford I., et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N. Engl. J. Med., 333, 1301, 1995.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1301
    • Shepherd, S.1    Cobbe, S.M.2    Ford, I.3
  • 6
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomized placebo-controlled trial
    • Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: A randomized placebo-controlled trial. Lancet, 360, 7, 2002.
    • (2002) Lancet , vol.360 , pp. 7
  • 7
    • 0028910696 scopus 로고
    • Role of thrombosis in atherosclerosis and its complications
    • Falk E., Fernández-Ortiz A. Role of thrombosis in atherosclerosis and its complications. Am. J. Cardiol., 75(6), 3B, 1995.
    • (1995) Am. J. Cardiol. , vol.75 , Issue.6
    • Falk, E.1    Fernández-Ortiz, A.2
  • 8
    • 0028120906 scopus 로고
    • Collaborative overview of randomized trials of antiplatelet therapy-1: Prevention of death, myocardial infarction and stroke by prolonged antiplatelet therapy in various categories of patients
    • Antiplatelet Trialists' Collaboration. Collaborative overview of randomized trials of antiplatelet therapy-1: Prevention of death, myocardial infarction and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ, 308, 81, 1994.
    • (1994) BMJ , vol.308 , pp. 81
  • 9
    • 0029838529 scopus 로고    scopus 로고
    • Antiplatelet therapy
    • Schafer A. Antiplatelet therapy. Am. J. Med., 101, 199, 1996.
    • (1996) Am. J. Med. , vol.101 , pp. 199
    • Schafer, A.1
  • 10
    • 3142718499 scopus 로고    scopus 로고
    • González L., Marrero D., Laguna A., et al., inventors; Laboratorios Dalmer SA, assignee. Mixture of primary fatty acids of high molecular weight obtained from sugar cane wax and its pharmaceutical uses. Republic of South Africa patent 98-2744. December 30, 1998
    • González L., Marrero D., Laguna A., et al., inventors; Laboratorios Dalmer SA, assignee. Mixture of primary fatty acids of high molecular weight obtained from sugar cane wax and its pharmaceutical uses. Republic of South Africa patent 98-2744. December 30, 1998.
  • 11
    • 0033859508 scopus 로고    scopus 로고
    • Dose-dependent cholesterol-lowering effects of D-003 on normocholesterolemic rabbits
    • Gámez R., Mendoza S., Más R., et al. Dose-dependent cholesterol-lowering effects of D-003 on normocholesterolemic rabbits. Curr. Ther. Res. Clin. Exp., 61, 8, 2000.
    • (2000) Curr. Ther. Res. Clin. Exp. , vol.61 , pp. 8
    • Gámez, R.1    Mendoza, S.2    Más, R.3
  • 12
    • 0035057937 scopus 로고    scopus 로고
    • The effects of D-003 and policosanol on the lipid profile and endothelemia cells in normocholesterolemic rabbits: A head-to-head comparison
    • Mendoza S., Gámez R., Noa M., et al. The effects of D-003 and policosanol on the lipid profile and endothelemia cells in normocholesterolemic rabbits: A head-to-head comparison. Curr. Ther. Res., 62, 209, 2001.
    • (2001) Curr. Ther. Res. , vol.62 , pp. 209
    • Mendoza, S.1    Gámez, R.2    Noa, M.3
  • 13
    • 0034774858 scopus 로고    scopus 로고
    • Inhibition of cholesterol biosynthesis in cultured fibroblasts by D-003, a mixture of very long chain saturated fatty acids
    • Menéndez R., Más R., Amor A.M., et al. Inhibition of cholesterol biosynthesis in cultured fibroblasts by D-003, a mixture of very long chain saturated fatty acids. Pharmacol. Res., 44, 299, 2001.
    • (2001) Pharmacol. Res. , vol.44 , pp. 299
    • Menéndez, R.1    Más, R.2    Amor, A.M.3
  • 15
    • 0036661282 scopus 로고    scopus 로고
    • D-003, a potential antithrombotic compound isolated from sugar cane wax with effects on arachidonic acid metabolites
    • Molina V., Arruzazabala M.L., Carbajal D., Mas R. D-003, a potential antithrombotic compound isolated from sugar cane wax with effects on arachidonic acid metabolites. Prostaglandins Leukot. Essent. Fatty Acids, 67(1), 19, 2002.
    • (2002) Prostaglandins Leukot. Essent. Fatty Acids , vol.67 , Issue.1 , pp. 19
    • Molina, V.1    Arruzazabala, M.L.2    Carbajal, D.3    Mas, R.4
  • 16
    • 0038109797 scopus 로고    scopus 로고
    • Assessment of the effects of D-003, a new antiplatelet and hypocholesterolemic compound on healthy volunteers: A phase I clinical study
    • Castaño G., Mas R., Fernández L., et al. Assessment of the effects of D-003, a new antiplatelet and hypocholesterolemic compound on healthy volunteers: A phase I clinical study. Drugs R&D, 3, 337, 2002.
    • (2002) Drugs R&D , vol.3 , pp. 337
    • Castaño, G.1    Mas, R.2    Fernández, L.3
  • 17
    • 0037220697 scopus 로고    scopus 로고
    • Effects of D-003, a new compound purified from sugar cane wax, on platelet aggregation in healthy volunteers: A randomized, double-blinded clinical study
    • Arruzazabala M.L., Carbajal D., Mas R., et al. Effects of D-003, a new compound purified from sugar cane wax, on platelet aggregation in healthy volunteers: A randomized, double-blinded clinical study. Clin. Drug Invest., 23, 107, 2002.
    • (2002) Clin. Drug Invest. , vol.23 , pp. 107
    • Arruzazabala, M.L.1    Carbajal, D.2    Mas, R.3
  • 18
    • 0037236311 scopus 로고    scopus 로고
    • Effects of D-003 on lipid profile and lipid peroxidation in healthy volunteers
    • Castaño G., Menéndez R., Mas R., et al. Effects of D-003 on lipid profile and lipid peroxidation in healthy volunteers. Clin. Drug Invest., 23, 193, 2003.
    • (2003) Clin. Drug Invest. , vol.23 , pp. 193
    • Castaño, G.1    Menéndez, R.2    Mas, R.3
  • 19
    • 0024972452 scopus 로고
    • Animal safety and toxicology of simvastatin and related hydroxy-methylglutaryl coenzyme A reductase inhibitors
    • Gerson R., MacDonald J., Alberts W., et al. Animal safety and toxicology of simvastatin and related hydroxy-methylglutaryl coenzyme A reductase inhibitors. Am. J. Med., 87 (Suppl. 4a), 28, 1989.
    • (1989) Am. J. Med. , vol.87 , Issue.SUPPL. 4A , pp. 28
    • Gerson, R.1    MacDonald, J.2    Alberts, W.3
  • 20
    • 0031826626 scopus 로고    scopus 로고
    • Lipid-lowering drugs in the management of hyperlipidaemia
    • Bhatnagar D. Lipid-lowering drugs in the management of hyperlipidaemia. Pharmacol. Ther., 79, 205, 1998.
    • (1998) Pharmacol. Ther. , vol.79 , pp. 205
    • Bhatnagar, D.1
  • 21
    • 0029880822 scopus 로고    scopus 로고
    • Gastrointestinal hemorrhage after acute stroke
    • Davenport R.J., Dennis M.S., Warlow C.P. Gastrointestinal hemorrhage after acute stroke. Stroke, 27, 421, 1996.
    • (1996) Stroke , vol.27 , pp. 421
    • Davenport, R.J.1    Dennis, M.S.2    Warlow, C.P.3
  • 23
    • 0034694778 scopus 로고    scopus 로고
    • Acute and subchronic oral toxicity of D-003 in rats
    • Gámez R., Más R., Noa M., et al. Acute and subchronic oral toxicity of D-003 in rats. Toxicol. Letts., 118, 31, 2000.
    • (2000) Toxicol. Letts. , vol.118 , pp. 31
    • Gámez, R.1    Más, R.2    Noa, M.3
  • 24
    • 0034901550 scopus 로고    scopus 로고
    • In vivo genotoxic evaluation of D-003, a mixture of very long-chain aliphatic acids
    • Gámez R., González J.E., Rodeiro I., et al. In vivo genotoxic evaluation of D-003, a mixture of very long-chain aliphatic acids. J. Med. Food, 4, 85, 2001.
    • (2001) J. Med. Food , vol.4 , pp. 85
    • Gámez, R.1    González, J.E.2    Rodeiro, I.3
  • 25
    • 0002262269 scopus 로고    scopus 로고
    • A preliminary evaluation of the cytotoxic and genotoxic potential of D-003, a mixture of very long chain fatty acids
    • Gámez R., Rodeiro I., Fernández I. A preliminary evaluation of the cytotoxic and genotoxic potential of D-003, a mixture of very long chain fatty acids. Teratogen. Carcinogen. Mutagen., 21, 85, 2001.
    • (2001) Teratogen. Carcinogen. Mutagen. , vol.21 , pp. 85
    • Gámez, R.1    Rodeiro, I.2    Fernández, I.3
  • 26
    • 0038641218 scopus 로고    scopus 로고
    • Six-month toxicity study of oral administration of D-003 in Sprague Dawley rats
    • Gámez R., Mas R., Noa M., et al. Six-month toxicity study of oral administration of D-003 in Sprague Dawley rats. Drugs R&D, 3, 375, 2002.
    • (2002) Drugs R&D , vol.3 , pp. 375
    • Gámez, R.1    Mas, R.2    Noa, M.3
  • 28
    • 0031771526 scopus 로고    scopus 로고
    • Rodent quarantine programs: Purpose, principles and practice
    • Rehg J.E., Toth L.A. Rodent quarantine programs: Purpose, principles and practice. Lab. An. Sci., 48, 438, 1998.
    • (1998) Lab. An. Sci. , vol.48 , pp. 438
    • Rehg, J.E.1    Toth, L.A.2
  • 30
    • 0025004154 scopus 로고
    • An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program
    • Chhabra R.S., Huff J.E., Schwetz B.S., Selkirk J. An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program. Environ. Health Persp., 86, 313, 1990.
    • (1990) Environ. Health Persp. , vol.86 , pp. 313
    • Chhabra, R.S.1    Huff, J.E.2    Schwetz, B.S.3    Selkirk, J.4
  • 31
    • 3142747877 scopus 로고    scopus 로고
    • United States Environmental Protection Agency, prevention, pesticides and toxic substances (7101), EPA 712C-96-210
    • EPA: Health effects test guidelines. OPPTS 870.4100, Chronic toxicity. United States Environmental Protection Agency, prevention, pesticides and toxic substances (7101), EPA 712C-96-210, 1996.
    • (1996) EPA: Health Effects Test Guidelines. OPPTS 870.4100, Chronic Toxicity
  • 32
    • 0027528531 scopus 로고
    • Removal of blood from laboratory mammals and birds
    • Morton B., Abbot D., Barclay R., et al. Removal of blood from laboratory mammals and birds. Lab. Animals, 27, 1, 1993.
    • (1993) Lab. Animals , vol.27 , pp. 1
    • Morton, B.1    Abbot, D.2    Barclay, R.3
  • 33
    • 0014791552 scopus 로고
    • Red cell and plasma cholinesterase activities in microsamples of human and animal blood determined simultaneously by modified acetylthiocoline-DTNB procedure
    • Voss G., Sachsse K. Red cell and plasma cholinesterase activities in microsamples of human and animal blood determined simultaneously by modified acetylthiocoline-DTNB procedure. Toxicol. Appl. Pharmacol., 16, 764, 1970.
    • (1970) Toxicol. Appl. Pharmacol. , vol.16 , pp. 764
    • Voss, G.1    Sachsse, K.2
  • 34
    • 0346367328 scopus 로고
    • Aggregation of blood platelets by adenosine diphosphate and its reversal
    • Born G.V.R. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature, 194, 927, 1962.
    • (1962) Nature , vol.194 , pp. 927
    • Born, G.V.R.1
  • 35
    • 0001621039 scopus 로고
    • Histopathology in safety evaluation
    • Anderson, D. (Ed.). BIBRA, Surrey
    • Evans L.G., Butler W.H. Histopathology in safety evaluation. In: "Experimental Toxicology. The Basic Issues." Anderson, D. (Ed.). BIBRA, Surrey, 1993, pp. 119-129.
    • (1993) Experimental Toxicology. The Basic Issues , pp. 119-129
    • Evans, L.G.1    Butler, W.H.2
  • 36
    • 0022540388 scopus 로고
    • Reference range database for serum chemistry and haematology values in laboratory animals
    • Wolford S.T., Schoer R.A., Gohs F.X., Gallo P.P. Reference range database for serum chemistry and haematology values in laboratory animals. J. Toxicol. Environ. Health, 18, 161, 1986.
    • (1986) J. Toxicol. Environ. Health , vol.18 , pp. 161
    • Wolford, S.T.1    Schoer, R.A.2    Gohs, F.X.3    Gallo, P.P.4
  • 37
    • 0027620863 scopus 로고
    • Clinical pathology references ranges of laboratory animals
    • Matsuzawa T., Nomura M., Unno T. Clinical pathology references ranges of laboratory animals. J. Vet. Med. Sci., 55, 351, 1993.
    • (1993) J. Vet. Med. Sci. , vol.55 , pp. 351
    • Matsuzawa, T.1    Nomura, M.2    Unno, T.3
  • 39
    • 0028144949 scopus 로고
    • Toxicity of policosanol in beagle dogs: One-year study
    • Mesa A.R., Más R., Noa M., et al. Toxicity of policosanol in beagle dogs: One-year study. Toxicol. Lett., 73, 81, 1994.
    • (1994) Toxicol. Lett. , vol.73 , pp. 81
    • Mesa, A.R.1    Más, R.2    Noa, M.3
  • 40
    • 0028033806 scopus 로고
    • Carcinogenicity of policosanol in Sprague Dawley rats: A 24-month study
    • Alemán C.L., Mas R., Noa M., et al. Carcinogenicity of policosanol in Sprague Dawley rats: A 24-month study. Teratog. Carcinog. Mutagen, 14, 239, 1994.
    • (1994) Teratog. Carcinog. Mutagen. , vol.14 , pp. 239
    • Alemán, C.L.1    Mas, R.2    Noa, M.3
  • 41
    • 0028174497 scopus 로고
    • Teratogenic and reproductive studies of policosanol in the rat and rabbit
    • Rodriguez M., García H. Teratogenic and reproductive studies of policosanol in the rat and rabbit. Teratog. Carcinog. Mutagen., 14, 107, 1994.
    • (1994) Teratog. Carcinog. Mutagen. , vol.14 , pp. 107
    • Rodriguez, M.1    García, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.