Activation-induced inhibition of interleukin 6-mediated T cell survival and signal transducer and activator of transcription 1 signaling

Journal of Experimental Medicine

Volumn 191, Issue 6, 2000, Pages 915-925

  Teague, T Kent ^a   Schaefer, Brian C ^b   Hildeman, David ^b   Bender, Jeremy ^a   Mitchell, Tom ^a   Kappler, John W ^b,c   Marrack, Philippa ^b,c  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Cytokine; Death; Memory; Signal transducer and activator of transcription 3; Survival

Indexed keywords

CYTOKINE; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 7; STAT1 PROTEIN; SUPERANTIGEN;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; IN VITRO STUDY; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; CARRIER PROTEINS; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DOWN-REGULATION; FEMALE; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INTERLEUKIN-6; INTERPHASE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; PHOSPHORYLATION; RECEPTORS, INTERLEUKIN-6; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; T-LYMPHOCYTE SUBSETS; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR AP-1;

EID: 0034689002     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.6.915     Document Type: Article

References (68)

1. The survival and turnover of mature and immature CD8 T cells
2. Life span of naive and memory T cells
3. Turnover of naive- and memory-phenotype T cells
4. T and B memory cells
5. The life span of naive α/β T cells in secondary lymphoid organs
6. Programmed cell death and extrathymic reduction of Vβ8+ CD4+ T cells in mice tolerant to Staphylococcus enterotoxin B
7. Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen
8. Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death
9. Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes
10. Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation
11. The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice
12. Induction of apoptosis in mature T cells by tumor necrosis factor
13. IL-2 addiction: Withdrawal of growth factor activates a suicide program in dependent T cells
14. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
15. Expression and involvement of c-los and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines
16. IL-6 rescues resting mouse T cells from apoptosis
17. IL-4 or IL-7 prevents the death of resting T cells: States probably not required for the effect of IL-4
18. Lipopolysaccharide interferes with the induction of peripheral T cell death
19. Cytokine-induced survival of activated T cells in vitro and in vivo
20. Reactive oxygen species regulate activation-induced T cell apoptosis
21. + T cells, but affect their long-term life span
22. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules
23. Costimulation of CD3/TcR complex with either integrin or nonintegrin ligands protects CD4+ allergen-specific T-cell clones from programmed cell death
24. Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division
25. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL
26. Differential effects of costimulator signals and interleukin-2 on T cell receptor-mediated cell death of resting and activated CD4+ murine splenic T cells
27. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis
28. Bystander virus infection prolongs activated T cell survival
29. A rapid method for the isolation of functional thymus-derived murine lymphocytes
30. The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression
31. Down-regulation of homing receptors after T cell activation
32. The surface phenotype of activated T lymphocytes
33. Twenty proteins containing a C-terminal SOCS box form five structural classes
34. SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase
35. A family of cytokine-inducible inhibitors of signalling
36. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3
37. Structure and function of a new STAT-induced STAT inhibitor
38. A new protein containing an SH2 domain that inhibits JAK kinases
39. + T cells
40. High and low affinity receptors for murine interleukin 6
41. Regulation of IL-6 signaling by p53: STAT3- and STAT5-masking in p53-Val135-containing human hepatoma Hep3B cell lines
42. Proteasomeand p53-dependent masking of signal transducer and activator of transcription (STAT) factors
43. Specific inhibition of Stat3 signal transduction by PIAS3
44. Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
45. The Janus protein tyrosine kinase family and its role in cytokine signaling
46. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
47. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
48. Transcriptional activation of the IL-6 response element in the junB promoter is mediated by multiple Stat family proteins
49. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130
50. Interleukin-6 signaling via four transcription factors binding palindromic enhancers of different genes
51. Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression
52. CD28 costimulation inhibits TCR-induced apoptosis during primary T cell response
53. Regulation of lymphocyte survival by the bcl-2 gene family
54. Signal transuction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily
55. STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase
56. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
57. Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3
58. Requirement of serine phosphorylation for formation of STAT-promoter complexes
59. Type I interferons keep activated T cells alive
60. Inhibition of Stat1-mediated gene activation by PIAS1
61. Accessory signals in murine cytolytic T cell responses. Dual requirement for IL-1 and IL-6
62. Role of IL-6, IL-2, and IL-4 in the in vitro induction of cytotoxic T cells
63. IL-6 enhances the generation of cytolytic T lymphocytes in the allogeneic mixed leucocyte reaction
64. Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro
65. Production of the cytokines interleukin 1 and 6 by murine brain microvessel endothelium and smooth muscle pericytes
66. The biology of interleukin-6
67. Production of interleukin-6 by human mast cells and basophilic cells
68. Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6)