Characterization of species-related differences in the pharmacology of tachykinin NK receptors 1, 2 and 3

Biochemical Pharmacology

Volumn 77, Issue 9, 2009, Pages 1522-1530

  Leffler, Agnes ^a   Ahlstedt, Ingela ^a   Engberg, Susanna ^a   Svensson, Arne ^a   Billger, Martin ^a   Öberg, Lisa ^a   Bjursell, Magnus K ^a   Lindström, Erik ^a   von Mentzer, Bengt ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Aprepitant; Chemistry; NK receptors; NK receptor function; NK receptor sequences; Saredutant; Species difference; Talnetant

Indexed keywords

2 [1 IMINO 2 (2 METHOXYPHENYL)ETHYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 ONE; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; AMINO ACID; APREPITANT; CALCIUM ION; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NEUROKININ 3 RECEPTOR; OSANETANT; RHODOPSIN; SAREDUTANT; TACHYKININ RECEPTOR ANTAGONIST; TALNETANT; UNCLASSIFIED DRUG; ZD 6021;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; CHO CELL; CODING; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOG; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; GERBIL; HUMAN; IC 50; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CALCIUM; CHO CELLS; CRICETINAE; CRICETULUS; DOGS; GERBILLINAE; GUINEA PIGS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MORPHOLINES; RATS; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; RECEPTORS, NEUROKININ-3; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; TRANSFECTION;

EID: 63349107260     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.01.020     Document Type: Article

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