Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist

Journal of Pharmacology and Experimental Therapeutics

Volumn 295, Issue 1, 2000, Pages 373-381

  Sarau, Henry M ^a   Griswold, Don E ^a   Bush, Brian ^a   Potts, William ^a   Sandhu, Punam ^a   Lundberg, Dave ^a   Foley, James J ^a   Schmidt, Dulcie B ^a   Webb, Edward F ^a   Martin, Lenox D ^a   Legos, Jeffrey J ^a   Whitmore, Robert G ^a   Barone, Frank C ^a   Medhurst, Andrew D ^a   Luttmann, Mark A ^a   Giardina, Giuseppe A M ^b   Hay, Douglas W P ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b SmithKline Beecham SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; CALCIUM ION; N (ALPHA ACETYLBENZYL) 3 METHYL 2 PHENYLQUINOLINE 4 CARBOXAMIDE; N (ALPHA ETHYLBENZYL) 3 METHYL 2 PHENYL 4 QUINOLINECARBOXAMIDE; N (ALPHA ETHYLBENZYL) 3 METHYL 2 PHENYLQUINOLINE 4 CARBOXYAMIDE; NEUROKININ 3 RECEPTOR; NEUROKININ 3 RECEPTOR ANTAGONIST; NEUROKININ B; NEUROKININ B [7 METHYLPHENYLALANINE]; OSANETANT; SB 221275; SB 222201; SB 227734; SENKTIDE; TACHYKININ RECEPTOR ANTAGONIST; TALNETANT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CALCIUM MOBILIZATION; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG INHIBITION; DRUG PENETRATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN; CALCIUM; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IRIS; MALE; MICE; MICE, INBRED BALB C; PEPTIDE FRAGMENTS; QUINOLINES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-3; SUBSTANCE P;

EID: 0033798643     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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