MEN15596, a novel nonpeptide tachykinin NK2 receptor antagonist

European Journal of Pharmacology

Volumn 549, Issue 1-3, 2006, Pages 140-148

  Cialdai, Cecilia ^a   Tramontana, Manuela ^a   Patacchini, Riccardo ^a   Lecci, Alessandro ^a   Catalani, Claudio ^a   Catalioto, Rose Marie ^a   Meini, Stefania ^a   Valenti, Claudio ^a   Altamura, Maria ^a   Giuliani, Sandro ^a   Maggi, Carlo Alberto ^a  

^a Menarini Ricerche SpA   (Italy)

Author keywords

Bronchoconstriction; Colon contraction; Gastrointestinal disorders; Neurokinin A; NK2 receptor antagonist; Oral activity; Tachykinins

Indexed keywords

6 METHYLBENZO[B]THIOPHENE 2 CARBOXYLIC ACID [1 [2 PHENYL [[1 (TETRAHYDROPYRAN 4 YLMETHYL)PIPERIDIN 4 YLMETHYL]CARBAMOYL]ETHYLCARBAMOYL] CYCLOPENTYL]AMIDE; ION CHANNEL; MEN 15596; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR AGONIST; NEUROKININ 2 RECEPTOR; NEUROKININ 2 RECEPTOR AGONIST; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ 3 RECEPTOR; NEUROKININ 3 RECEPTOR AGONIST; NEUROKININ A; NEUROKININ A [8 BETA ALANINE]; NEUROKININ A DERIVATIVE; RECOMBINANT PROTEIN; SUBSTANCE P SULFONE [9 SERINE]; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ADULT; AGED; ANESTHESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BLADDER; BRONCHOSPASM; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ISOLATION; COLON; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG TARGETING; FEMALE; GUINEA PIG; HUMAN; ILEUM; INTESTINE CONTRACTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; SMOOTH MUSCLE FIBER;

AGED; ANIMALS; BINDING, COMPETITIVE; BRONCHOCONSTRICTION; CELL MEMBRANE; CHO CELLS; COLON; CRICETINAE; CRICETULUS; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUINEA PIGS; HUMANS; MALE; MICE; MIDDLE AGED; MUSCLE CONTRACTION; NEUROKININ A; PEPTIDE FRAGMENTS; RABBITS; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, NEUROKININ-2; SWINE; THIOPHENES; VASOCONSTRICTION;

EID: 33748978365     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.08.021     Document Type: Article

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