Dendritic cell-mediated-immunization with xenogenic PrP and adenoviral vectors breaks tolerance and prolongs mice survival against experimental scrapie

PLoS ONE

Volumn 4, Issue 3, 2009, Pages

  Rosset, Martine Bruley ^a,b   Sacquin, Antoine ^a,b   Lecollinet, Sylvie ^c   Chaigneau, Thomas ^a,b   Adam, Micheline ^c   Crespeau, François ^c   Eloit, Marc ^c  

^a CENTRE DE RECHERCHE SAINT ANTOINE   (France)

^b HÔPITAL SAINT ANTOINE   (France)

^c ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; DENDRITIC CELL VACCINE; GAMMA INTERFERON; PRION PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNITY; BRAIN; CD3+ T LYMPHOCYTE; CELL BASED GENE THERAPY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOLYSIS; DRUG EFFICACY; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; LYMPHOCYTE COUNT; LYMPHOCYTIC INFILTRATION; MOUSE; MOUSE STRAIN; NONHUMAN; PROTEIN EXPRESSION; SCRAPIE; SCRAPIE AGENT; SPLEEN; SURVIVAL TIME; T LYMPHOCYTE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS INHIBITION; VIRUS REPLICATION; WILD TYPE; ADENOVIRUS; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; DENDRITIC CELL; GENE VECTOR; GENETICS; HUMAN; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE MUTANT; PATHOLOGY; PRION; SEQUENCE ALIGNMENT; SURVIVAL RATE; TRANSGENIC MOUSE;

ADENOVIRIDAE; MURINAE; MUS;

ADENOVIRIDAE; AMINO ACID SEQUENCE; ANIMALS; DENDRITIC CELLS; GENETIC VECTORS; HUMANS; IMMUNIZATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PRIONS; SCRAPIE; SEQUENCE ALIGNMENT; SURVIVAL RATE;

EID: 63349097762     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004917     Document Type: Article

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