Prominent and persistent extraneural infection in human PrP transgenic mice infected with variant CJD

PLoS ONE

Volumn 3, Issue 1, 2008, Pages

  Béringue, Vincent ^a   Le Dur, Annick ^a   Tixador, Philippe ^a   Reine, Fabienne ^a   Lepourry, Laurence ^b   Perret Llaudet, Armand ^c   Haik, Stéphane ^d,e   Vilotte, Jean Luc ^b   Fontés, Michel ^d   Laude, Hubert ^a  

^a INRA Institut National de la Recherche Agronomique   (France)

^b CEMAGREF   (France)

^c Groupement Hospitalier Est des Hôpitaux de Lyon   (France)

^d INSERM   (France)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

METHIONINE; PRION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CLINICAL FEATURE; CODON; CONTROLLED STUDY; DISEASE TRANSMISSION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; LYMPHATIC SYSTEM INFECTION; LYMPHOID TISSUE; MOUSE; NEUROPATHOLOGY; NONHUMAN; PERSISTENT INFECTION; PHENOTYPE; SPLEEN; TISSUE SPECIFICITY; TRANSGENIC MOUSE; VARIANT CREUTZFELDT JAKOB DISEASE; VARIANT CREUTZFELDT JAKOB DISEASE AGENT; VIRUS STRAIN; VIRUS TRANSMISSION; ANIMAL; CREUTZFELDT JAKOB DISEASE; PATHOLOGY; PRION DISEASE;

MUS; MUS MUSCULUS;

ANIMALS; CREUTZFELDT-JAKOB SYNDROME; HUMANS; MICE; MICE, TRANSGENIC; PRION DISEASES;

EID: 38949108662     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001419     Document Type: Article

References (38)

1. Will RG, Ironside JW, Zeidler M, Cousens SN, Estibeiro K, et al. (1996) A new variant of Creutzfeldt-Jakob disease in the UK. Lancet 347: 921-925.
2. Prusiner SB (1997) Prion diseases and the BSE crisis. Science 278: 245-251.
3. Aguzzi A, Glatzel M (2006) Prion infections, blood and transfusions. Nat Clin Pract Neurol 2: 321-329.
4. Valleron AJ, Boelle PY, Will R, Cesbron JY (2001) Estimation of epidemic size and incubation time based on age characteristics of vCJD in the United Kingdom. Science 294: 1726-1728.
5. Clarke P, Ghani AC (2005) Projections of the future course of the primary vCJD epidemic in the UK: inclusion of subclinical infection and the possibility of wider genetic susceptibility. J R Soc Interface 2: 19-31.
6. Hilton DA, Ghani AC, Conyers L, Edwards P, McCardle L, et al. (2004) Prevalence of lymphoreticular prion protein accumulation in UK tissue samples. J Pathol 203: 733-739.
7. Ironside JW, Bishop MT, Connolly K, Hegazy D, Lowrie S, et al. (2006) Variant Greutzfeldt-Jakob disease: prion protein genotype analysis of positive appendix tissue samples from a retrospective prevalence study. Bmj 332: 1186-1188.
8. Hilton DA, Fathers E, Edwards P, Ironside JW, Zajicek J (1998) Prion immunoreactivity in appendix before clinical onset of variant Creutzfeldt-Jakob disease. Lancet 352: 703-704.
9. Hill AF, Butterworth RJ, Joiner S, Jackson G, Rossor MN, et al. (1999) Investigation of variant Creutzfeldt-Jakob disease and other'human prion diseases with tonsil biopsy samples. Lancet 353: 183-189.
10. Wadsworth JD, Joiner S, Hill AF, Campbell TA, Desbruslais M, et al. (2001) Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay. Lancet 358: 171-180.
11. Wadsworth JD Joiner S, Fox K, Linehan JM, Desbruslais M, et al. (2007) Prion infectivity in variant Creutzfeldt-Jakob disease rectum. Gut 56: 90-94.
12. Lasmezas CI, Fournier JG, Nouvel V, Boe H, Marce D, et al. (2001) Adaptablon of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-Jakob disease: implications for human health. Proc Natl Acad Sci U S A 98: 4142-4147.
13. Llewelyn CA; Hewitt PF, Knight RS, Amar K, Cousens S, et al. (2004) Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion. Lancet 363: 417-421.
14. Peden AH, Head MW, Ritchie DL, Bel1 JE, Ironside JW (2004) Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient. Lancet 364: 527-529.
15. Fourth case of transfusion-associated vCJD infection in die United Kingdom. Euro Surveill 12: E070118 070114.
16. Asante EA, LinehAn JM, Desbruslais M, Joiner S, Gowland I, et al. (2002) BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein. Fmbo J 21: 6358-6366.
17. Wadsworth JD, Asante EA, Desbruslais M, Linehan JM, Joiner S, et al. (2004) Human prion protein with valine 129 prevents expression of variant CJD phenotype. Science 306: 1793-1796.
18. Yull HM, Ritchie DI, Langeveld JP, van Zijderveld FG, Bruce ME, et al. (2006) Detection oftype 1 prion protein in variant creutzfeldt-jakob disease. Am J Pathol 168: 151-157.
19. Bishop MT, Hart P, Aitchison L, Baybutt HN, Plinston C, et al. (2006) Predicting susceptibility and incubation time of human-to-human transmission of vCJD. Lancet Neurol 5: 393-398.
20. Asano M, Mohri S, Ironside JW, Ito M, Tamaoki N, et al. (2006) vCJD prion acquires altered virulence through trans-species infection. Biochem Biophys Res Common 342: 293-299.
21. Szakal AK, Aydar Y, Balogh P, Tew JG (2002) Molecular interactions of FDCs with B cells in aging. Semin Immunol 14: 267-274.
22. Mabbott NA, MacPherson GG (2006) Prions and their lethal journey to the brain. Nat Rev Microbiol 4: 201-211.
23. Bruce ME, McCormell I, Will RG, Ironside JW (2001) Detection of variant Creutzfeldt-Jakob disease infectivity in extraneural tissues. Lancet 358: 208-209.
24. Korth C, Kaneko K, Groth D, Heye N, Telling G, et al. (2003) Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene. Proc Natl Acad Sci U S A 100; 478-4789.
25. Minor P, Newham J, Jones N, Bergeron C, Gregori L, et al. (2004) Standards for the assay of Creutzfeldt-Jakob disease specimens. J Gen Virol 85: 1777-1784.
26. Glatzel M, Ott PM, Linder T, Gebbers JO, Gmur A, et al. (2003) Human prion diseases: epidemiology and integrated risk assessment. Lancet Neurol 2: 757-763.
27. Collis SC, Kimberlin RH (1985) Long-term persistence of scrapie infection in mouse spleens in the absence of clinical disease. FEMS Microbiol Lett 29: 111-114.
28. Frosh A, Smith LC, Jackson CJ, Linehan JM, Brandner S, et al. (2004) Analysis of 2000 consecutive UK tonsillectomy specimens for disease-related prion protein. Lancet 364: 1260-1262.
29. Beringue V, Adjou KT, Lamoury F, Maignien T, Deslys JP, et al. (2000) Opposite effects of dextran sulfate 500, the polyene antibiotic MS-8209, and Congo red on accumulation of the protease-resistant isoform of PrP in the spleens of mice inoculated intraperitoneally with the scrapie agent. J Virol 74: 5432 5440.
30. Kitamoto T, Mohri S, Ironside JW, Miyoshi I, Tanaka T, et al. (2002) Follicular dendritic cell of the knock-in mouse provides a new bioassay for human prions. Biochem. Biophys; Res Commun 294: 280-286.
31. Le Dur A, Beringue V, Andreoletti O, Reine F, Lai TL, et al. (2005) A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes. Proc Natl Acad Sci U S A 102: 16031-16036.
32. Beringue V, Bencsik A, Le Dur A, Reine F, Lai TL, et al. (2006) Isolation from, Cattle of a Prion Strain Distinct from That Causing Bovine Spongiform Encephalopathy. PLoS Pathog 2: el12.
33. Beringue V, Mallinson G, Kaisar M, Tayebi M, Sattar Z, et al. (2003) Regional heterogeneity of cellular prion protein isoforms in the mouse brain. Brain 126: 2065-2073.
34. Feraudet C, Morel N, Simon S, Volland H, Frobert Y, et al. (2005) Screening of 145 anti-PrP monoclonal antibodies for their capacity to inhibit PrPSc replication in infected cells. J Biol Chem 280: 11247-11258.
35. Taraboulos A, Serban D, Prusiner SB (1990) Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells. J Cell Biol 110: 2117-2132.
36. Hauw JJ, Sazdovitch V, Laplanche JL, Peoc'h K, Kopp N, et al. (2000) Neuropathologic variants of sporadic Creutzfeldt-Jakob disease and codon 129 of PrP gene. Neurology 54: 1641-1646.
37. Schmidt ML, Robinson KA, Lee VM, Trujanowski JQ (1995) Chemical and immunological heterogeneity of fibrillar amyloid in plaques of Alzheimer's disease and Down's syndrome brains revealed by confocal microscopy. Am J Pathol, 147: 503-515.
38. Sun A, Nguyen XV, Bing G (2002) Comparative analysis of an improved thioflavin-s stain, Gallyas silver stain, and immunohistochemistry for neurofi-brillary tangle demonstration on the same sections. J Histochem Cytochem 50: 463-472.