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Volumn 46, Issue 8, 2009, Pages 1032-1041

Erythropoietin protects retinal pigment epithelial cells from oxidative damage

Author keywords

Apoptosis; Erythropoietin; Free radicals; Mitochondria; Oxidant stress

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; ERYTHROPOIETIN; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; INTERLEUKIN 1BETA; MALONALDEHYDE; PHOSPHATIDYLSERINE; PROTEIN KINASE B; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 63049096543     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.11.027     Document Type: Article
Times cited : (86)

References (73)
  • 1
    • 0038748022 scopus 로고    scopus 로고
    • The Bowman lecture: towards an understanding of age-related macular disease
    • Bird A.C. The Bowman lecture: towards an understanding of age-related macular disease. Eye 17 (2003) 457-466
    • (2003) Eye , vol.17 , pp. 457-466
    • Bird, A.C.1
  • 2
    • 0037211158 scopus 로고    scopus 로고
    • Common eye diseases of elderly people: identifying and treating causes of vision loss
    • Harvey P.T. Common eye diseases of elderly people: identifying and treating causes of vision loss. Gerontology 49 (2003) 1-11
    • (2003) Gerontology , vol.49 , pp. 1-11
    • Harvey, P.T.1
  • 3
    • 0033520636 scopus 로고    scopus 로고
    • Epidemiology of age-related macular degeneration
    • Hawkins B.S., Bird A., Klein R., and West S.K. Epidemiology of age-related macular degeneration. Mol. Vision 5 (1999) 26
    • (1999) Mol. Vision , vol.5 , pp. 26
    • Hawkins, B.S.1    Bird, A.2    Klein, R.3    West, S.K.4
  • 4
    • 0033795036 scopus 로고    scopus 로고
    • The role of oxidative stress in the pathogenesis of age-related macular degeneration
    • Beatty S., Koh H.H., Phil M., Henson D., and Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv. Ophthalmol. 45 (2000) 115-134
    • (2000) Surv. Ophthalmol. , vol.45 , pp. 115-134
    • Beatty, S.1    Koh, H.H.2    Phil, M.3    Henson, D.4    Boulton, M.5
  • 7
    • 0027930278 scopus 로고
    • Evaluation of oxidative processes in human pigment epithelial cells associated with retinal outer segment phagocytosis
    • Miceli M.V., Liles M.R., and Newsome D.A. Evaluation of oxidative processes in human pigment epithelial cells associated with retinal outer segment phagocytosis. Exp. Cell Res. 214 (1994) 242-249
    • (1994) Exp. Cell Res. , vol.214 , pp. 242-249
    • Miceli, M.V.1    Liles, M.R.2    Newsome, D.A.3
  • 9
    • 4644284867 scopus 로고    scopus 로고
    • Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis
    • Strunnikova N., Zhang C., Teichberg D., Cousins S.W., Baffi J., Becker K.G., and Csaky K.G. Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest. Ophthalmol. Visual Sci. 45 (2004) 3767-3777
    • (2004) Invest. Ophthalmol. Visual Sci. , vol.45 , pp. 3767-3777
    • Strunnikova, N.1    Zhang, C.2    Teichberg, D.3    Cousins, S.W.4    Baffi, J.5    Becker, K.G.6    Csaky, K.G.7
  • 10
    • 2942590471 scopus 로고    scopus 로고
    • Ceramide-induced apoptosis: role of catalase and hepatocyte growth factor
    • Kannan R., Jin M., Gamulescu M.A., and Hinton D.R. Ceramide-induced apoptosis: role of catalase and hepatocyte growth factor. Free Radic. Biol. Med. 37 (2004) 166-175
    • (2004) Free Radic. Biol. Med. , vol.37 , pp. 166-175
    • Kannan, R.1    Jin, M.2    Gamulescu, M.A.3    Hinton, D.R.4
  • 12
    • 27244451344 scopus 로고    scopus 로고
    • SOD2 protects against oxidation-induced apoptosis in mouse retinal pigment epithelium: implications for age-related macular degeneration
    • Kasahara E., Lin L.R., Ho Y.S., and Reddy V.N. SOD2 protects against oxidation-induced apoptosis in mouse retinal pigment epithelium: implications for age-related macular degeneration. Invest. Ophthalmol. Visual Sci. 46 (2005) 3426-3434
    • (2005) Invest. Ophthalmol. Visual Sci. , vol.46 , pp. 3426-3434
    • Kasahara, E.1    Lin, L.R.2    Ho, Y.S.3    Reddy, V.N.4
  • 13
    • 0038107065 scopus 로고    scopus 로고
    • Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor
    • Zhang C., Baffi J., Cousins S.W., and Csaky K.G. Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor. J. Cell Sci. 116 (2003) 1915-1923
    • (2003) J. Cell Sci. , vol.116 , pp. 1915-1923
    • Zhang, C.1    Baffi, J.2    Cousins, S.W.3    Csaky, K.G.4
  • 14
    • 0034821283 scopus 로고    scopus 로고
    • Hydrogen peroxide stimulates apoptosis in cultured human retinal pigment epithelial cells
    • Jin G.F., Hurst J.S., and Godley B.F. Hydrogen peroxide stimulates apoptosis in cultured human retinal pigment epithelial cells. Curr. Eye Res. 22 (2001) 1.65-173
    • (2001) Curr. Eye Res. , vol.22
    • Jin, G.F.1    Hurst, J.S.2    Godley, B.F.3
  • 15
    • 0035040640 scopus 로고    scopus 로고
    • Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2
    • Sparrow J.R., and Cai B. Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2. Invest. Ophthalmol. Visual Sci. 42 (2001) 1356-1362
    • (2001) Invest. Ophthalmol. Visual Sci. , vol.42 , pp. 1356-1362
    • Sparrow, J.R.1    Cai, B.2
  • 17
    • 0036785896 scopus 로고    scopus 로고
    • Age-related changes in human RPE cell density and apoptosis proportion in situ
    • Del Priore L.V., Kuo Y.H., and Tezel T.H. Age-related changes in human RPE cell density and apoptosis proportion in situ. Invest. Ophthalmol. Visual Sci. 43 (2002) 3312-3318
    • (2002) Invest. Ophthalmol. Visual Sci. , vol.43 , pp. 3312-3318
    • Del Priore, L.V.1    Kuo, Y.H.2    Tezel, T.H.3
  • 18
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z., Dickens M., Raingeaud J., Davis R.J., and Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270 (1995) 1326-1331
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 19
    • 33750622313 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinases is essential for hydrogen peroxide-induced apoptosis in retinal pigment epithelial cells
    • Ho T.C., Yang Y.C., Cheng H.C., Wu A.C., Chen S.L., Chen H.K., and Tsao Y.P. Activation of mitogen-activated protein kinases is essential for hydrogen peroxide-induced apoptosis in retinal pigment epithelial cells. Apoptosis 11 (2006) 1899-1908
    • (2006) Apoptosis , vol.11 , pp. 1899-1908
    • Ho, T.C.1    Yang, Y.C.2    Cheng, H.C.3    Wu, A.C.4    Chen, S.L.5    Chen, H.K.6    Tsao, Y.P.7
  • 21
    • 0018776894 scopus 로고
    • Hydroperoxide metabolism in mammalian organs
    • Chance B., Sies H., and Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 59 (1979) 527-605
    • (1979) Physiol. Rev. , vol.59 , pp. 527-605
    • Chance, B.1    Sies, H.2    Boveris, A.3
  • 22
    • 0026587335 scopus 로고
    • Mitochondrial genetics: a paradigm for aging and degenerative diseases?
    • Wallace D.C. Mitochondrial genetics: a paradigm for aging and degenerative diseases?. Science 256 (1992) 628-632
    • (1992) Science , vol.256 , pp. 628-632
    • Wallace, D.C.1
  • 23
    • 0037375044 scopus 로고    scopus 로고
    • Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration
    • Liang F.Q., and Godley B.F. Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration. Exp. Eye Res. 76 (2003) 397-403
    • (2003) Exp. Eye Res. , vol.76 , pp. 397-403
    • Liang, F.Q.1    Godley, B.F.2
  • 24
    • 3943071150 scopus 로고    scopus 로고
    • Cytochrome c-mediated apoptosis
    • Jiang X., and Wang X. Cytochrome c-mediated apoptosis. Annu. Rev. Biochem. 73 (2004) 87-106
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 87-106
    • Jiang, X.1    Wang, X.2
  • 25
    • 0034800655 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss
    • Age-Related Eye Disease Study Research Group
    • Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. Arch. Ophthalmol. 119 (2001) 1417-1436
    • (2001) Arch. Ophthalmol. , vol.119 , pp. 1417-1436
  • 26
    • 0031755934 scopus 로고    scopus 로고
    • Biology of erythropoietin
    • Lacombe C., and Mayeux P. Biology of erythropoietin. Haematologica 83 (1998) 724-732
    • (1998) Haematologica , vol.83 , pp. 724-732
    • Lacombe, C.1    Mayeux, P.2
  • 27
    • 34250655768 scopus 로고    scopus 로고
    • Antioxidant effect of erythropoietin on 1-methyl-4-phenylpyridinium-induced neurotoxicity in PC12 cells
    • Wu Y., Shang Y., Sun S., and Liu R. Antioxidant effect of erythropoietin on 1-methyl-4-phenylpyridinium-induced neurotoxicity in PC12 cells. Eur. J. Pharmacol. 564 (2007) 47-56
    • (2007) Eur. J. Pharmacol. , vol.564 , pp. 47-56
    • Wu, Y.1    Shang, Y.2    Sun, S.3    Liu, R.4
  • 28
    • 37349123107 scopus 로고    scopus 로고
    • Erythropoietin protects against doxorubicin-induced cardiomyopathy via a PI3K-dependent pathway
    • Kim K.H., Oudit G.Y., and Backx P.H. Erythropoietin protects against doxorubicin-induced cardiomyopathy via a PI3K-dependent pathway. J. Pharmacol. Exp. Ther. 324 (2008) 160-169
    • (2008) J. Pharmacol. Exp. Ther. , vol.324 , pp. 160-169
    • Kim, K.H.1    Oudit, G.Y.2    Backx, P.H.3
  • 30
    • 0035833541 scopus 로고    scopus 로고
    • Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades
    • Digicaylioglu M., and Lipton S.A. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature 412 (2001) 641-647
    • (2001) Nature , vol.412 , pp. 641-647
    • Digicaylioglu, M.1    Lipton, S.A.2
  • 32
    • 13244252517 scopus 로고    scopus 로고
    • Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2
    • Kilic U., Kilic E., Soliz J., Bassetti C.I., Gassmann M., and Hermann D.M. Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2. FASEB J. 19 (2005) 249-251
    • (2005) FASEB J. , vol.19 , pp. 249-251
    • Kilic, U.1    Kilic, E.2    Soliz, J.3    Bassetti, C.I.4    Gassmann, M.5    Hermann, D.M.6
  • 34
    • 31544460689 scopus 로고    scopus 로고
    • Intravitreal administration of erythropoietin and preservation of retinal ganglion cells in an experimental rat model of glaucoma
    • Tsai J.C., Wu L., Worgul B., Forbes M., and Cao J. Intravitreal administration of erythropoietin and preservation of retinal ganglion cells in an experimental rat model of glaucoma. Curr. Eye Res. 30 (2005) 1025-1031
    • (2005) Curr. Eye Res. , vol.30 , pp. 1025-1031
    • Tsai, J.C.1    Wu, L.2    Worgul, B.3    Forbes, M.4    Cao, J.5
  • 35
    • 21544484345 scopus 로고    scopus 로고
    • Neuroprotective effects of erythropoietin on glutamate and nitric oxide toxicity in primary cultured retinal ganglion cells
    • Yamasaki M., Mishima H.K., Yamashita H., Kashiwagi K., Murata K., Minamoto A., and Inaba T. Neuroprotective effects of erythropoietin on glutamate and nitric oxide toxicity in primary cultured retinal ganglion cells. Brain Res. 1050 (2005) 15-26
    • (2005) Brain Res. , vol.1050 , pp. 15-26
    • Yamasaki, M.1    Mishima, H.K.2    Yamashita, H.3    Kashiwagi, K.4    Murata, K.5    Minamoto, A.6    Inaba, T.7
  • 36
    • 0037369477 scopus 로고    scopus 로고
    • Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8
    • Chong Z.Z., Lin S.H., Kang J.Q., and Maiese K. Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8. J. Neurosci. Res. 71 (2003) 659-669
    • (2003) J. Neurosci. Res. , vol.71 , pp. 659-669
    • Chong, Z.Z.1    Lin, S.H.2    Kang, J.Q.3    Maiese, K.4
  • 37
    • 48649089571 scopus 로고    scopus 로고
    • Expression of erythropoietin and its receptor in the human retina: a comparative study of diabetic and non-diabetic subjects
    • García-Ramírez M., Hernández C., and Simó R. Expression of erythropoietin and its receptor in the human retina: a comparative study of diabetic and non-diabetic subjects. Diabetes Care 31 (2008) 1189-1194
    • (2008) Diabetes Care , vol.31 , pp. 1189-1194
    • García-Ramírez, M.1    Hernández, C.2    Simó, R.3
  • 41
    • 1342289237 scopus 로고    scopus 로고
    • Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations
    • Tarpey M.M., Wink D.A., and Grisham M.B. Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286 (2004) R431-R444
    • (2004) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.286
    • Tarpey, M.M.1    Wink, D.A.2    Grisham, M.B.3
  • 44
    • 0036875316 scopus 로고    scopus 로고
    • The role of apoptosis in age-related macular degeneration
    • Dunaief J.L., Dentchev T., Ying G.S., and Milam A.H. The role of apoptosis in age-related macular degeneration. Arch. Ophthalmol. 120 (2002) 1435-1442
    • (2002) Arch. Ophthalmol. , vol.120 , pp. 1435-1442
    • Dunaief, J.L.1    Dentchev, T.2    Ying, G.S.3    Milam, A.H.4
  • 45
    • 0038708118 scopus 로고    scopus 로고
    • Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies
    • Ambati J., Ambati B.K., Yoo S.H., Lanchulev S., and Adamis A.P. Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv. Ophthalmol. 48 (2003) 257-293
    • (2003) Surv. Ophthalmol. , vol.48 , pp. 257-293
    • Ambati, J.1    Ambati, B.K.2    Yoo, S.H.3    Lanchulev, S.4    Adamis, A.P.5
  • 47
    • 0036349652 scopus 로고    scopus 로고
    • Bcl-2 overexpression increases survival in human retinal pigment epithelial cells exposed to HO
    • Godley B.F., Jin G.F., Guo Y.S., and Hurst J.S. Bcl-2 overexpression increases survival in human retinal pigment epithelial cells exposed to HO. Exp. Eye Res. 74 (2002) 663-669
    • (2002) Exp. Eye Res. , vol.74 , pp. 663-669
    • Godley, B.F.1    Jin, G.F.2    Guo, Y.S.3    Hurst, J.S.4
  • 48
  • 49
    • 0028988886 scopus 로고
    • 2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells
    • 2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells. Invest. Ophthalmol. Visual Sci. 36 (1995) 1271-1279
    • (1995) Invest. Ophthalmol. Visual Sci. , vol.36 , pp. 1271-1279
    • Tate Jr., D.J.1    Miceli, M.V.2    Newsome, D.A.3
  • 50
    • 0033040503 scopus 로고    scopus 로고
    • Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells
    • Ballinger S.W., Van Houten B., Jin G.F., Conklin C.A., and Godley B.F. Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells. Exp. Eye Res. 68 (1999) 765-772
    • (1999) Exp. Eye Res. , vol.68 , pp. 765-772
    • Ballinger, S.W.1    Van Houten, B.2    Jin, G.F.3    Conklin, C.A.4    Godley, B.F.5
  • 52
    • 0035170082 scopus 로고    scopus 로고
    • Ceramide: a potential mediator of apoptosis in human retinal pigment epithelial cells
    • Barak A., Morse L.S., and Goldkorn T. Ceramide: a potential mediator of apoptosis in human retinal pigment epithelial cells. Invest. Ophthalmol. Visual Sci. 42 (2001) 247-254
    • (2001) Invest. Ophthalmol. Visual Sci. , vol.42 , pp. 247-254
    • Barak, A.1    Morse, L.S.2    Goldkorn, T.3
  • 53
    • 4143136302 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after single and multiple doses in healthy volunteers
    • Ramakrishnan R., Cheung W.K., Wacholtz M.C., Minton N., and Jusko W.J. Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after single and multiple doses in healthy volunteers. J. Clin. Pharmacol. 44 (2004) 991-1002
    • (2004) J. Clin. Pharmacol. , vol.44 , pp. 991-1002
    • Ramakrishnan, R.1    Cheung, W.K.2    Wacholtz, M.C.3    Minton, N.4    Jusko, W.J.5
  • 55
    • 0037016065 scopus 로고    scopus 로고
    • Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases
    • Chong Z.Z., Kang J.Q., and Maiese K. Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation 106 (2002) 2973-2979
    • (2002) Circulation , vol.106 , pp. 2973-2979
    • Chong, Z.Z.1    Kang, J.Q.2    Maiese, K.3
  • 57
    • 34248152673 scopus 로고    scopus 로고
    • The role of inflammation and infection in age-related macular degeneration
    • Barouch F.C., and Miller J.W. The role of inflammation and infection in age-related macular degeneration. Int. Ophthalmol. Clin. 47 (2007) 185-197
    • (2007) Int. Ophthalmol. Clin. , vol.47 , pp. 185-197
    • Barouch, F.C.1    Miller, J.W.2
  • 58
    • 0025357294 scopus 로고
    • In vivo angiogenic activity of interleukins
    • BenEzra D., Hemo I., and Maftzir G. In vivo angiogenic activity of interleukins. Arch. Ophthalmol. 108 (1990) 573-576
    • (1990) Arch. Ophthalmol. , vol.108 , pp. 573-576
    • BenEzra, D.1    Hemo, I.2    Maftzir, G.3
  • 59
    • 4444258865 scopus 로고    scopus 로고
    • Pathogenesis of age-related macular degeneration
    • Tezel T.H., Bora N.S., and Kaplan H.J. Pathogenesis of age-related macular degeneration. Trends Mol. Med. 10 (2004) 417-420
    • (2004) Trends Mol. Med. , vol.10 , pp. 417-420
    • Tezel, T.H.1    Bora, N.S.2    Kaplan, H.J.3
  • 60
    • 34548689373 scopus 로고    scopus 로고
    • Inhibitory effect on cerebral inflammatory agents that accompany traumatic brain injury in a rat model: a potential neuroprotective mechanism of recombinant human erythropoietin (rhEPO)
    • Chen G., Shi J.X., Hang C.H., Xie W., Liu J., and Liu X. Inhibitory effect on cerebral inflammatory agents that accompany traumatic brain injury in a rat model: a potential neuroprotective mechanism of recombinant human erythropoietin (rhEPO). Neurosci. Lett. 425 (2007) 177-182
    • (2007) Neurosci. Lett. , vol.425 , pp. 177-182
    • Chen, G.1    Shi, J.X.2    Hang, C.H.3    Xie, W.4    Liu, J.5    Liu, X.6
  • 62
    • 0027769391 scopus 로고
    • Protection of retinal pigment epithelium from oxidative injury by glutathione and precursors
    • Sternberg Jr. P., Davidson P.C., and Jones D.P. Protection of retinal pigment epithelium from oxidative injury by glutathione and precursors. Invest. Ophthalmol. Visual Sci. 34 (1993) 3661-3668
    • (1993) Invest. Ophthalmol. Visual Sci. , vol.34 , pp. 3661-3668
    • Sternberg Jr., P.1    Davidson, P.C.2    Jones, D.P.3
  • 63
    • 46449117875 scopus 로고    scopus 로고
    • Effects of erythropoietin on blood-brain barrier disruption in focal cerebral ischemia
    • Chi O.Z., Hunter C., Liu X., and Weiss H.R. Effects of erythropoietin on blood-brain barrier disruption in focal cerebral ischemia. Pharmacology 82 (2008) 38-42
    • (2008) Pharmacology , vol.82 , pp. 38-42
    • Chi, O.Z.1    Hunter, C.2    Liu, X.3    Weiss, H.R.4
  • 64
    • 36048956106 scopus 로고    scopus 로고
    • Neuroprotection by erythropoietin administration after experimental traumatic brain injury
    • Grasso G., Sfacteria A., Meli F., Fodale V., Buemi M., and Iacopino D.G. Neuroprotection by erythropoietin administration after experimental traumatic brain injury. Brain. Res. 28 (2007) 99-105
    • (2007) Brain. Res. , vol.28 , pp. 99-105
    • Grasso, G.1    Sfacteria, A.2    Meli, F.3    Fodale, V.4    Buemi, M.5    Iacopino, D.G.6
  • 68
    • 1542328927 scopus 로고    scopus 로고
    • Structure, regulation and function of PKB/AKT-a major therapeutic target
    • Hanada M., Feng J., and Hemmings B.A. Structure, regulation and function of PKB/AKT-a major therapeutic target. Biochim. Biophys. Acta 1697 (2004) 3-16
    • (2004) Biochim. Biophys. Acta , vol.1697 , pp. 3-16
    • Hanada, M.1    Feng, J.2    Hemmings, B.A.3
  • 69
    • 33750584426 scopus 로고    scopus 로고
    • Sustained versus transient ERK1/2 signaling underlies the anti- and proapoptotic effects of oxidative stress in human RPE cells
    • Glotin A.L., Calipel A., Brossas J.Y., Faussat A.M., Tréton J., and Mascarelli F. Sustained versus transient ERK1/2 signaling underlies the anti- and proapoptotic effects of oxidative stress in human RPE cells. Invest. Ophthalmol. Visual Sci. 47 (2006) 4614-4623
    • (2006) Invest. Ophthalmol. Visual Sci. , vol.47 , pp. 4614-4623
    • Glotin, A.L.1    Calipel, A.2    Brossas, J.Y.3    Faussat, A.M.4    Tréton, J.5    Mascarelli, F.6
  • 71
    • 33644685057 scopus 로고    scopus 로고
    • Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion
    • Jin M., Yaung J., Kannan R., He S., Ryan S.J., and Hinton D.R. Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion. Invest. Ophthalmol. Visual Sci. 46 (2005) 4311-4319
    • (2005) Invest. Ophthalmol. Visual Sci. , vol.46 , pp. 4311-4319
    • Jin, M.1    Yaung, J.2    Kannan, R.3    He, S.4    Ryan, S.J.5    Hinton, D.R.6
  • 73
    • 0036238915 scopus 로고    scopus 로고
    • The role of apoptosis in the normal aging brain, skeletal muscle, and heart
    • Pollack M., Phaneuf S., Dirks A., and Leeuwenburgh C. The role of apoptosis in the normal aging brain, skeletal muscle, and heart. Ann. N. Y. Acad. Sci. 959 (2002) 93-107
    • (2002) Ann. N. Y. Acad. Sci. , vol.959 , pp. 93-107
    • Pollack, M.1    Phaneuf, S.2    Dirks, A.3    Leeuwenburgh, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.