Biology of erythropoietin

Haematologica

Volumn 83, Issue 8, 1998, Pages 724-732

  Lacombe, Catherine ^a,b   Mayeux, Patrick ^a  

^a Institut National de la Santé de la Recherche Médicale

^b Hôpital Cochin ^*  (France)

Author keywords

Differentiation; Erythropoietin; Erythropoietin receptor; Proliferation; Signal transduction

Indexed keywords

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; STAT1 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

COLONY FORMING UNIT E; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; HUMAN; HYPOXIA; KIDNEY; LIVER; NONHUMAN; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANOXIA; ERYTHROPOIESIS; ERYTHROPOIETIN; GENE EXPRESSION REGULATION; HUMANS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, ERYTHROPOIETIN; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031755934     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (129)

1. Jelkmann W, Metzen E. Erythropoietin in the control of red cell production. Ann Anat 1996; 178:391-403.
2. Wang GL, Semenza GL. Molecular basis of hypoxia-induced erythropoietin expression. Curr Opin Hematol 1996; 3:156-62.
3. Ratcliffe PJ. Molecular biology of erythropoietin [clinical conference]. Kidney Int 1993; 44:887-904.
4. Sawyer ST, Penta K. Erythropoietin cell biology. Hematol Oncol Clin North Am 1994; 8:895-911.
5. Porter DL, Goldberg MA. Physiology of erythropoietin production. Semin Hematol 1994; 31:112-21.
6. Fisher JW. Erythropoietin: physiologic and pharmacologic aspects. Proc Soc Exp Biol Med 1997; 216: 358-69.
7. Fried W. Erythropoietin. Annu Rev Nutr 1995; 15:353-77.
8. Lacombe C, Mayeux P. L'érythropoïétine. Médecine/sciences 1995; 11:947-55.
9. Damen JE, Krystal G. Early events in erythropoietin-induced signaling. Exp Hematol 1996; 24:1455-9.
10. Miyake T, Kung CK, Goldwasser E. Purification of human erythropoietin. J Biol Chem 1977; 252:5558-64.
11. Lin FK, Suggs S, Lin CH, et al. Cloning and expression of the human erythropoietin gene. Proc Natl Acad Sci USA 1985; 82:7580-4.
12. Jacobs K, Shoemaker C, Rudersdorf R, et al. Isolation and characterization of genomic cDNA clones of human erythropoietin. Nature 1985; 313:806-10.
13. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW. Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial. N Engl J Med 1987; 316:73-8.
14. Zanjani ED, Ascensao JL, McGlave PB, Banisadre M, Ash RC. Studies on the liver to kidney switch of erythropoietin production. J Clin Invest 1981; 67:1183-8.
15. Wintour EM, Butkus A, Earnest L, Pompolo S. The erythropoietin gene is expressed strongly in the mammalian mesonephric kidney. Blood 1996; 88:3349-53.
16. Jacobson LO, Goldwasser E, Fried W, Plzak L. Role of the kidney in erythropoiesis. Nature 1957; 179:633-4.
17. Beru N, McDonald J, Lacombe C, Goldwasser E. Expression of the erythropoietin gene. Mol Cell Biol 1986; 6:2571-5.
18. Bondurant MC, Koury MJ. Anemia induces accumulation of erythropoietin mRNA in the kidney and liver. Mol Cell Biol 1986; 6:2731-3.
19. Koury ST, Bondurant MC, Koury MJ. Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood 1988; 71:524-7.
20. Lacombe C, Da Silva JL, Bruneval P, et al. Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney. J Clin Invest 1988; 81:620-3.
21. Eckardt KU, Mollmann M, Neumann R, et al. Erythropoietin in polycystic kidneys. J Clin Invest 1989; 84:1160-6.
22. Bachmann S, Le Hir M, Eckardt KU. Co-localization of erythropoietin mRNA and ecto-5′-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin. J Histochem Cytochem 1993; 41:335-41.
23. Maxwell PH, Osmond MK, Pugh CW, et al. Identification of the renal erythropoietin-producing cells using transgenic mice. Kidney Int 1993; 44:1149-62.
24. Da Silva JL, Lacombe C, Bruneval P, et al. Tumor cells are the site of erythropoietin synthesis in human renal cancers associated with polycythemia. Blood 1990; 75:577-82.
25. Ratcliffe PJ, Jones RW, Phillips RE, Nicholls LG, Bell JI. Oxygen-dependent modulation of erythropoietin mRNA levels in isolated rat kidneys studied by RNase protection. J Exp Med 1990; 172:657-60.
26. Koury ST, Bondurant MC, Koury MJ, Semenza GL. Localization of cells producing erythropoietin in murine liver by in situ hybridization. Blood 1991; 77: 2497-503.
27. Maxwell PH, Ferguson DJ, Osmond MK, et al. Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells. Blood 1994; 84:1823-30.
28. Fandrey J, Bunn HF. In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction. Blood 1993; 81:617-23.
29. Tan CC, Eckardt KU, Ratcliffe PJ. Organ distribution of erythropoietin messenger RNA in normal and uremic rats. Kidney Int 1991; 40:69-76.
30. Masuda S, Okano M, Yamagishi K, Nagao M, Ueda M, Sasaki R. A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes. J Biol Chem 1994; 269:19488-93.
31. Digicaylioglu M, Bichet S, Marti HH, et al. Localization of specific erythropoietin binding sites in defined areas of the mouse brain. Proc Natl Acad Sci USA 1995; 92:3717-20.
32. Masuda S, Nagao M, Takahata K, et al. Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells. J Biol Chem 1993; 268:11208-16.
33. Morishita E, Masuda S, Nagao M, Yasuda Y, Sasaki R. Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 1997; 76:105-16.
34. Schuster SJ, Badiavas EV, Costa-Giomi P, Weinmann R, Erslev AJ, Caro J. Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure. Blood 1989; 73:13-6.
35. Semenza GL, Traystman MD, Gearhart JD, Antonarakis SE. Polycythemia in transgenic mice expressing the human erythropoietin gene. Proc Natl Acad Sci USA 1989; 86:2301-5.
36. Semenza GL, Koury ST, Nejfelt MK, Gearhart JD, Antonarakis SE. Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. Proc Natl Acad Sci USA 1991; 88:8725-9.
37. Semenza GL, Dureza RC, Traystman MD, Gearhart JD, Antonarakis SE. Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements. Mol Cell Biol 1990; 10:930-8.
38. Semenza GL, Nejfelt MK, Chi SM, Antonarakis SE. Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene. Proc Natl Acad Sci USA 1991; 88:5680-4.
39. Beck I, Ramirez S, Weinmann R, Caro J. Enhancer element at the 3′-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene. J Biol Chem 1991; 266:15563-6.
40. Blanchard KL, Acquaviva AM, Galson DL, Bunn HF. Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor, response elements. Mol Cell Biol 1992; 12:5373-85.
41. Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992; 12:5447-54.
42. Beck I, Weinmann R, Caro J. Characterization of hypoxia-responsive enhancer in the human erythropoietin gene shows presence of hypoxia-inducible 120-Kd nuclear DNA-binding protein in erythropoietin-producing and nonproducing cells. Blood 1993; 82: 704-11.
43. Wang GL, Semenza GL. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem 1993; 268:21513-8.
44. Pugh CW, Ebert BL, Ebrahim O, Ratcliffe PJ. Characterisation of functional domains within the mouse erythropoietin 3′ enhancer conveying oxygen-regulated responses in different cell lines. Biochim Biophys Acta 1994; 1217:297-306.
45. Galson DL, Tsuchiya T, Tendler DS, et al. The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1. Mol Cell Biol 1995; 15: 2135-44.
46. Arany Z, Huang LE, Eckner R, et al. An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 1996; 93:12969-73.
47. Huang LE, Ho V, Arany Z, et al. Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors. Kidney Int 1997; 51:548-52.
48. Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 1995; 270:1230-7.
49. 2 tension. Proc Natl Acad Sci USA 1995; 92:5510-4.
50. Hoffman EC, Reyes H, Chu FF, et al. Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 1991; 252:954-8.
51. Kallio PJ, Pongratz I, Gradin K, McGuire J, Poellinger L. Activation of hypoxia-inducible factor 1alpha: post-transcriptional regulation and conformational change by recruitment of the Arnt transcription factor. Proc Natl Acad Sci USA 1997; 94:5667-72.
52. Salceda S, Caro J. Hypoxia-inducible factor 1 alpha (HIF-1 alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 1997; 272:22642-7.
53. Maxwell PH, Pugh CW, Ratcliffe PJ. Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism. Proc Natl Acad Sci USA 1993; 90:2423-7.
54. Wang GL, Semenza GL. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA 1993; 90:4304-8.
55. Wenger RH, Gassmann M. Oxygen(es) and the hypoxia-inducible factor-1. Biol Chem 1997; 378:609-16.
56. Bunn HF, Poyton RO. Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 1996; 76:839-85.
57. Goldberg MA, Dunning SP, Bunn HF. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 1988; 242:1412-5.
58. D'Andrea AD, Zon LI. Erythropoietin receptor: subunit structure and activation. J Clin Invest 1990; 86: 681-7.
59. Mayeux P, Billat C, Jacquot R. The erythropoietin receptor of rat erythroid progenitor cell: Characterization and affinity cross-linkage. J Biol Chem 1987; 262:13985-90.
60. D'Andrea AD, Lodish HF, Wong GG. Expression cloning of the murine erythropoietin receptor. Cell 1989; 57:277-85.
61. Mayeux P, Lacombe C, Casadevall N, Chretien S, Dusanter I, Gisselbrecht S. Structure of the murine erythropoietin receptor complex. Characterization of the erythropoietin cross-linked proteins. J Biol Chem 1991; 266:23380-5.
62. Gobert S, Porteu F, Pallu S, et al. Tyrosine phosphorylation of the erythropoietin receptor: role for differentiation and mitogenic signal transduction. Blood 1995; 86:598-606.
63. Winkelmann JC, Ward J, Mayeux P, Lacombe C, Schimmenti L, Jenkins RB. A translocated erythropoietin receptor gene in a human erythroleukemia cell line (TF-1) expresses an abnormal transcript and a truncated protein. Blood 1995; 85:179-85.
64. Bazan JF. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 1990; 87:6934-8.
65. Hilton DJ, Watowich SS, Katz L, Lodish HF. Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor. J Biol Chem 1996; 271:4699-4708.
66. Philo JS, Aoki KH, Arakawa T, Nahri LO, Wen J. Dimerization of the extracellular domain of the erythropoietin (Epo) receptor by Epo: one high-affinity and one low-affinity interaction. Biochemistry 1996; 35:1681-91.
67. Boissel JP, Lee WR, Presnell SR, Cohen FE, Bunn HF. Erythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structure. J Biol Chem 1993; 268:15983-93.
68. Elliott S, Lorenzini T, Chang D, Barzilay J, Delorme E. Mapping of the active site of recombinant human erythropoietin. Blood 1997; 89:493-502.
69. Wen D, Boissel JP, Showers M, Ruch BC, Bunn HF. Erythropoietin structure-function relationships: Identification of functionally important domains. J Biol Chem 1994; 269:22839-46.
70. Caravella JA, Lyne PD, Richards WG. A partial model of the erythropoietin receptor complex. Proteins, structure, function. Genetics 1996; 24:394-401.
71. De Vos AM, Ultsch M, Kossiakoff AA. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 1992; 255: 306-12.
72. Li J-P, D'Andrea AD, Lodish HF, Baltimore D. Activation of cell growth by binding of friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor. Nature 1990; 343:762-4.
73. Casadevall N, Lacombe C, Muller O, Gisselbrecht S, Mayeux P. Multimeric structure of the membrane erythropoietin receptor of murine erythroleukemia cells (Friend cells): cross-linking of erythropoietin with the spleen focus-forming virus envelope protein. J Biol Chem 1991; 266:6952-6.
74. Yoshimura A, Longmore G, Lodish HF. Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity. Nature 1990; 348:647-9.
75. Longmore GD, Lodish HF. An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: a cytokine receptor superfamilly oncogene. Cell 1991; 67:1089-102.
76. Schneider H, Chaovapong W, Matthews DJ, et al. Homodimerization of the erythropoietin receptor by a divalent monoclonal antibody triggers cell proliferation and differentiation of erythroid precursors. Blood 1997; 89:473-82.
77. Livnah O, Stura EA, Johnson DL, et al. Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A. Science 1996; 273:464-71.
78. Wrighton NC, Farrell FX, Chang R, et al. Small peptides as potent mimetics of the protein hormone erythropoietin. Science 1996; 273:458-64.
79. Wrighton NC, Balasubramanian P, Barbone FP, et al. Increased potency of an erythropoietin peptide mimetic through covalent dimerization. Nature Biotechnol 1997; 15:1261-5.
80. Witthuhn B, Quelle FW, Silvennoinen O, et al. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following Epo stimulation. Cell 1993; 74:227-36.
81. Hilton CJ, Berridge MV. Conserved region of the cytoplasmic domain is not essential for erythropoietin-dependent growth. Growth Factors 1995; 121:263-76.
82. Tilbrook PA, Ingley E, Williams JH, Hibbs ML, Klinken SP. Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells. EMBO J 1997; 16:1610-9.
83. Damen J, Mui ALF, Hughes P, Humphries KR, Krystal G. Erythropoietin-induced tyrosine phosphorylation in a high erythropoietin-receptor expressing lymphoid cell line. Blood 1992; 80:1923-32.
84. Dusanter-Fourt I, Casadevall N, Lacombe C, et al. Erythropoietin induces the tyrosine phosphorylation of its own receptor in human erythropoietin-responsive cells. J Biol Chem 1992; 267:10670-5.
85. Miura O, D'Andrea A, Kabat D, Ihle JN. Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis. Mol Cell Biol 1991; 11:4895-902.
86. Yoshimura A, Lodish HF. In vitro phosphorylation of the erythropoietin receptor and an associated protein, pp130. Mol Cell Biol 1992; 12:706-15.
87. Gobert S, Duprez V, Lacombe C, Gisselbrecht S, Mayeux P. Erythropoietin activates three forms of MAP kinase in UT7 erythroleukemia cells. Eur J Biochem 1995; 234:75-83.
88. Miura Y, Muira O, Ihle JN, Aoki N. Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor. J Biol Chem 1994; 269:29962-9.
89. Carroll MP, Spivak JL, McMahon M, Weich N, Rapp UR, May WS. Erythropoietin induces Raf-1 activation and Raf-1 is required for erythropoietin-mediated proliferation. J Biol Chem 1991; 266:14964-9.
90. Damen JE, Mui ALF, Puil L, Pawson T, Krystal G. Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor. Blood 1993; 81:3204-10.
91. He TC, Zhuang H, Jiang N, Waterfield MD, Wojchowski DM. Association of the p85 regulatory subunit of phosphatidylinositol 3-kinase with an essential erythropoietin receptor subdomain. Blood 1993; 82: 3530-8.
92. Mayeux P, Dusanter-Fourt I, Muller O, et al. Erythropoietin induces the association of phosphatidylinositol 3′ kinase with a tyrosine phosphorylated complex containing the erythropoietin receptor. Eur J Biochem 1993; 216:821-8.
93. Miura O, Nakamura N, Ihle JN, Aoki N. Erythropoietin-dependent Association of Phosphatidylinositol 3-Kinase with Tyrosine-phosphorylated Erythropoietin Receptor. J Biol Chem 1994; 269:614-20.
94. Verdier F, Chrétien S, Billat C, Gisselbrecht S, Lacombe C, Mayeux P. Erythropoietin induces the tyrosine phosphorylation of insulin receptor substrate-2: An alternate pathway for erythropoietin-induced phosphatidylinositol 3-kinase activation. J Biol Chem 1997; 272:26173-8.
95. Lioubin MN, Algate PA, Tsai S, Carlberg K, Aebersold R, Rohrschneider LR. p150 SHIP, a signal specific transduction molecule with inositol phosphate-5-phosphatase activity. Genes Develop 1996; 10:1084-95.
96. Damen JA, Liu L, Rosten P, et al. The 145-kDa protein induced to associate with Shc with multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase. Proc Natl Acad Sci USA 1996; 93:1689-93.
97. Franke TF, Kaplan DR, Cantley LC. PI3K: downstream AKTion blocks apoptosis. Cell 1997; 88:435-7.
98. del Peso L, Gonzalez-García M, Page C, Herrera R, Nunez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 1997; 278:687-9.
99. Ihle JN. Cytokine receptor signalling. Nature 1995; 377:591-4.
100. Gouilleux F, Pallard C, Dusanter-Fourt I, et al. Prolactin, growth hormone, erythropoietin and granulo cyte-macrophage colony stimulating factor induce MGF-STAT5 DNA binding activity. EMBO J 1995; 14: 2005-13.
101. Pallard C, Fabrice G, Martine C, Groner B, Gisselbrecht S, Dusanter-Fourt I. Interleukin-3, erythropoietin, and prolactin activate a STAT5 like factor in lymphoid cells. J Biol Chem 1995; 270:15942-5.
102. Wakao H, Harada N, Kitamura T, Mui ALF, Miyajima A. Interleukin 2 and erythropoietin activate STAT5/ MGF via distinct pathways. EMBOJ 1995; 14:2527-35.
103. Chin H, Nakamura N, Kamiyama R, Miyasaka N, Ihle JN, Miura O. Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3. Blood 1996; 88:4415-25.
104. Damen JE, Wakao H, Miyajima A, et al. Tyrosine 343 in the erythropoietin-receptor positively regulates erythropoietin-induced cell proliferation and STAT5 activation. EMBO J 1995; 14:5557-68.
105. Gobert S, Chrétien S, Gouilleux F, et al. Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation. EMBO J 1996; 15:2434-41.
106. Klingmuller U, Bergelson S, Hsiao JG, Lodish HC. Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5. Proc Natl Acad Sci USA 1996; 93:8324-8.
107. Quelle FW, Wang D, Nosaka T, et al. Erythropoietin induces the activation of STAT5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol Cell Biol 1996; 16:1622-31.
108. Chrétien S, Varlet P, Verdier F, et al. Erythropoietin-induced differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activation. EMBO J 1996:4174-81.
109. Iwatsuki K, Endo T, Misawa H, et al. STAT5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line. J Biol Chem 1997; 272:8149-52.
110. Wakao H, Chida D, Damen JE, Krystal G, Miyajima A. A possible involvement of Stat5 in erythropoietin-induced hemoglobin synthesis. Biochem Biophys Res Commun 1997; 234:198-205.
111. Tauchi T, Damen JE, Toyama K, Feng GS, Broxmeyer HE, Krystal G. Tyrosine 426 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation and promotes mitogenesis. Blood 1996; 87:4495-501.
112. Klingmuller U, Lorenz U, Cantley LC, Neel BC, Lodish HC. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 1995; 80:729-38.
113. De La Chapelle A, Traskelin A, Juvonen E. Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis. Proc Natl Acad Sci USA 1993; 90:4495-9.
114. Krosl J, Damen J, Krystal G, Humphries RK. Interleukin-3 (IL-3) inhibits erythropoietin-induced differentiation in Ba/F3 cells via the IL-3 receptor alpha subunit. J Biol Chem 1996; 271:27432-7.
115. Wu H, Klingmuller U, Acurio A, Hsiao JG, Lodish HF. Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation. Proc Natl Acad Sci USA 1997; 94:1806-10.
116. Klingmuller U, Wu H, Hsiao JG, et al. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci USA 1997; 94:3016-21.
117. Longmore GD, You Y, Molden J, et al. Redundant and selective roles for erythropoietin receptor tyrosines in erythropoiesis in vivo. Blood 1998; 91:870-878.
118. Wu H, Klingmuller U, Besmer P, Lodish HF. Interaction of the erythropoietin and stem-cell-factor receptors. Nature 1995; 377:242-6.
119. Jacobs-Helber SM, Penta K, Sun Z, Lawson A, Sawyer ST. Distinct signaling from stem cell factor and erythropoietin in HCD57 cells. J Biol Chem 1997; 272: 6850-3.
120. Kieran MW, Perkins AC, Orkin SH, Zon LI. Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci USA 1996; 93:9126-31.
121. Lin C-S, Lim SK, D'Agati V, Costantini F. Differential effects of an erythropoietin receptor gene disruption on primitive and definitive eythropoiesis. Genes Develop 1996; 10:154-64.
122. Wu H, Liu X, Jaenisch R, Lodish HF. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 1995; 83:59-67.
123. Koury MJ, Bondurant MC. Erythropoietin retards DNA breakdown and prevents programmed cell death in erythroid progenitor cells. Science 1990; 248:378-80.
124. Socolovsky M, Dusanter-Fourt I, Lodish HF. The prolactin receptor and severely truncated erythropoietin receptors support differentiation of erythroid progenitors. J Biol Chem 1997; 272:14009-12.
125. Silva M, Grillot D, Benito A, Richard C, Nunez G, Fernandez-Luna JL. Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2. Blood 1996; 88:1576-82.
126. Faquin WC, Schneider TJ, Goldberg MA. Effect of inflammatory cytokines on hypoxia-induced erythropoietin production. Blood 1992; 79:1987-94.
127. Means RT, Jr., Krantz SB. Progress in understanding the pathogenesis of the anemia of chronic disease. Blood 1992; 80:1639-47.
128. Taniguchi S, Dai CH, Price JO, Krantz SB. Interferon gamma downregulates stem cell factor and erythropoietin receptors but not insulin-like growth factor-I receptors in human erythroid colony-forming cells. Blood 1997; 90:2244-52.
129. Dai C-H, Price JO, Brunner T, Krantz SB. Fas ligand is present in human erythroid colony-forming cells and interacts with Fas indiced by Interferon g to produce erythroid cell apoptosis. Blood 1998; 91:2135-1242.