Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 7, 2009, Pages 2925-2935

  Sechi, Mario ^a   Rizzi, Giuseppe ^a   Bacchi, Alessia ^b   Carcelli, Mauro ^b   Rogolino, Dominga ^b   Pala, Nicolino ^a   Sanchez, Tino W ^c   Taheri, Laleh ^c   Dayam, Raveendra ^c   Neamati, Nouri ^c  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

4 Hydroxy 2 oxo 1,2 dihydroquinoline 3 carboxylic acids; Drug design; HIV 1 integrase inhibitors; X ray crystallography

Indexed keywords

4 (4 FLUOROBENZYL) 4 HYDROXY 1 METHYL 2 OXO 1,2 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 4 [1 (4 FLUOROBENZYL) 2 PYRROLYL] 2,4 DIOXOBUTYRIC ACID; 4 HYDROXY 1 METHYL 2 OXO 6 PHENOXY 1,2 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 6 (4 FLUOROBENZYL) 4 HYDROXY 1 METHYL 2 OXO 1,2 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 6 (4 FLUOROBENZYL) 4 HYDROXY 2 OXO 1 PENTYL 1,2 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 6 BENZYL 4 HYDROXY 1 METHYL 2 OXO 1,2 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 6 METHOXY 1 METHYL 2 OXO 1,2 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; DIHYDROQUINOLINE 3 CARBOXYLIC ACID DERIVATIVE; ETHYL 4 HYDROXY 6 METHOXY 1 METHYL 2 OXO 1,2 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; ETHYL 6 (4 FLUOROBENZYL) 4 HYDROXY METHYL 2 OXO 1,2 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; ETHYL 6 BENZYL 4 HYDROXY 1 METHYL 2 OXO 1,2 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; INTEGRASE; INTEGRASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CARBOXYLIC ACIDS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR CONFORMATION; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 62949115722     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.088     Document Type: Article

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