Modified low molecular weight cyclic peptides as mimetics of BDNF with improved potency, proteolytic stability and transmembrane passage in vitro

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 7, 2009, Pages 2695-2702

  Fletcher, Jordan M ^a   Hughes, Richard A ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Agonist; Antagonist; BDNF; Neurotrophic factor; Neurotrophin; p75

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLOPEPTIDE; PENTAPEPTIDE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL SURVIVAL; CHICK; CONTROLLED STUDY; DRUG PENETRATION; DRUG POTENCY; DRUG STABILITY; HUMAN; HUMAN CELL; HYDROPHOBICITY; MEMBRANE MODEL; MEMBRANE PERMEABILITY; MOLECULAR WEIGHT; NERVE CELL; NONHUMAN; PROTEIN DEGRADATION; PROTEIN STABILITY;

AMINO ACID SEQUENCE; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CELLS, CULTURED; CHICK EMBRYO; DRUG STABILITY; NEURONS; PEPTIDES, CYCLIC; RECEPTOR, TRKB;

EID: 62949096175     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.02.053     Document Type: Article

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