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Volumn 14, Issue 7-8, 2009, Pages 373-379

Molecular perspectives on the non-responder phenomenon

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BCR ABL PROTEIN; BOSUTINIB; CETUXIMAB; DASATINIB; ERLOTINIB; GEFITINIB; IMATINIB; INNO 404; N (5 CHLORO 1,3 BENZODIOXOL 4 YL) 7 [2 (4 METHYL 1 PIPERAZINYL)ETHOXY] 5 (TETRAHYDRO 2H PYRAN 4 YLOXY) 4 QUINAZOLINAMINE; NILOTINIB; PANITUMUMAB; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG;

EID: 62849123231     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2009.01.005     Document Type: Review
Times cited : (2)

References (67)
  • 1
    • 47249123315 scopus 로고    scopus 로고
    • Imatinib mesylate for the treatment of chronic myeloid leukemia
    • Soverini S., et al. Imatinib mesylate for the treatment of chronic myeloid leukemia. Exp. Rev. Anticancer Ther. 8 (2008) 853-864
    • (2008) Exp. Rev. Anticancer Ther. , vol.8 , pp. 853-864
    • Soverini, S.1
  • 2
    • 33846828641 scopus 로고    scopus 로고
    • The biology of chronic myelogenous leukemia: implications for imatinib therapy
    • Alvarez R.H., et al. The biology of chronic myelogenous leukemia: implications for imatinib therapy. Semin. Hematol. 44 Suppl. 1 (2007) S4-S14
    • (2007) Semin. Hematol. , vol.44 , Issue.SUPPL. 1
    • Alvarez, R.H.1
  • 3
    • 0345405480 scopus 로고    scopus 로고
    • Alpha1-acid glycoprotein expressed in the plasma of chronic myeloid leukemia patients does not mediate significant in vitro resistance to STI571
    • Jørgensen H.G., et al. Alpha1-acid glycoprotein expressed in the plasma of chronic myeloid leukemia patients does not mediate significant in vitro resistance to STI571. Blood 99 (2002) 713-715
    • (2002) Blood , vol.99 , pp. 713-715
    • Jørgensen, H.G.1
  • 4
    • 0142241268 scopus 로고    scopus 로고
    • Interaction of imatinib mesilate with human P-glycoprotein
    • Hamada A., et al. Interaction of imatinib mesilate with human P-glycoprotein. J. Pharmacol. Exp. Ther. 307 (2003) 824-828
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , pp. 824-828
    • Hamada, A.1
  • 5
    • 24344482346 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of imatinib
    • Peng B., et al. Clinical pharmacokinetics of imatinib. Clin. Pharmacokinet. 44 (2005) 879-894
    • (2005) Clin. Pharmacokinet. , vol.44 , pp. 879-894
    • Peng, B.1
  • 6
    • 0034254249 scopus 로고    scopus 로고
    • Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
    • Heinrich M.C., et al. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 96 (2000) 925-932
    • (2000) Blood , vol.96 , pp. 925-932
    • Heinrich, M.C.1
  • 7
    • 34147174980 scopus 로고    scopus 로고
    • Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia
    • Picard S., et al. Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia. Blood 109 (2007) 3496-3499
    • (2007) Blood , vol.109 , pp. 3496-3499
    • Picard, S.1
  • 8
    • 34548830783 scopus 로고    scopus 로고
    • Therapeutic drug monitoring in CML patients on imatinib
    • Blasdel C., et al. Therapeutic drug monitoring in CML patients on imatinib. Blood 110 (2007) 1699-1701
    • (2007) Blood , vol.110 , pp. 1699-1701
    • Blasdel, C.1
  • 9
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre M.E., et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293 (2001) 876-880
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1
  • 10
    • 0034665713 scopus 로고    scopus 로고
    • Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase
    • Schindler T., et al. Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase. Science 289 (2002) 1938-1942
    • (2002) Science , vol.289 , pp. 1938-1942
    • Schindler, T.1
  • 11
    • 0036769168 scopus 로고    scopus 로고
    • Imatinib: a selective tyrosine kinase inhibitor
    • Manley P.W., et al. Imatinib: a selective tyrosine kinase inhibitor. Eur. J. Cancer 38 (2002) S19-S27
    • (2002) Eur. J. Cancer , vol.38
    • Manley, P.W.1
  • 12
    • 0036682301 scopus 로고    scopus 로고
    • Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)
    • Nagar B., et al. Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res. 62 (2002) 4236-4243
    • (2002) Cancer Res. , vol.62 , pp. 4236-4243
    • Nagar, B.1
  • 13
    • 0036493544 scopus 로고    scopus 로고
    • Ph (+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation
    • Hofmann W.K., et al. Ph (+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation. Blood 99 (2002) 1860-1862
    • (2002) Blood , vol.99 , pp. 1860-1862
    • Hofmann, W.K.1
  • 14
    • 0036850514 scopus 로고    scopus 로고
    • Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
    • Hochhaus A., et al. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 16 (2002) 2190-2196
    • (2002) Leukemia , vol.16 , pp. 2190-2196
    • Hochhaus, A.1
  • 15
    • 0036682481 scopus 로고    scopus 로고
    • Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
    • Roche-Lestienne C., et al. Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood 100 (2002) 1014-1018
    • (2002) Blood , vol.100 , pp. 1014-1018
    • Roche-Lestienne, C.1
  • 16
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    • Branford S., et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 99 (2002) 3472-3475
    • (2002) Blood , vol.99 , pp. 3472-3475
    • Branford, S.1
  • 17
    • 1342287959 scopus 로고    scopus 로고
    • High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib
    • Al-Ali H.K., et al. High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib. Hematol. J. 5 (2002) 55-60
    • (2002) Hematol. J. , vol.5 , pp. 55-60
    • Al-Ali, H.K.1
  • 18
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah N.P., et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2 (2002) 117-125
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1
  • 19
    • 0036678472 scopus 로고    scopus 로고
    • Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the ABL kinase domain P-loop
    • Rourmiantsev S., et al. Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the ABL kinase domain P-loop. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 10700-10705
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 10700-10705
    • Rourmiantsev, S.1
  • 20
    • 0036682481 scopus 로고    scopus 로고
    • Several types of mutations of the ABL gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
    • Roche-Lestienne C., et al. Several types of mutations of the ABL gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood 100 (2002) 1014-1018
    • (2002) Blood , vol.100 , pp. 1014-1018
    • Roche-Lestienne, C.1
  • 21
    • 0034637599 scopus 로고    scopus 로고
    • The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells
    • Sattler M., et al. The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells. J. Biol. Chem. 275 (2000) 24273-24278
    • (2000) J. Biol. Chem. , vol.275 , pp. 24273-24278
    • Sattler, M.1
  • 22
    • 33745608455 scopus 로고    scopus 로고
    • BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance
    • Koptyra M., et al. BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance. Blood 108 (2006) 319-327
    • (2006) Blood , vol.108 , pp. 319-327
    • Koptyra, M.1
  • 23
    • 34547410311 scopus 로고    scopus 로고
    • Cellular responses to EGFR inhibitors and their relevance to cancer therapy
    • Dutta P.R., and Maity A. Cellular responses to EGFR inhibitors and their relevance to cancer therapy. Cancer Lett. 254 (2007) 165-177
    • (2007) Cancer Lett. , vol.254 , pp. 165-177
    • Dutta, P.R.1    Maity, A.2
  • 24
    • 43249117388 scopus 로고    scopus 로고
    • EGFR inhibitors as first-line therapy in advanced non-small cell lung cancer
    • Fong T., et al. EGFR inhibitors as first-line therapy in advanced non-small cell lung cancer. J. Thorac. Oncol. 3 (2008) 303-310
    • (2008) J. Thorac. Oncol. , vol.3 , pp. 303-310
    • Fong, T.1
  • 25
    • 23844490782 scopus 로고    scopus 로고
    • Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas
    • Taron M., et al. Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas. Clin. Cancer Res. 11 (2005) 5878-5885
    • (2005) Clin. Cancer Res. , vol.11 , pp. 5878-5885
    • Taron, M.1
  • 26
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
    • Paez J.G., et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304 (2004) 1497-1500
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1
  • 27
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
    • Cappuzzo F., et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J. Natl. Cancer Inst. 97 (2005) 643-655
    • (2005) J. Natl. Cancer Inst. , vol.97 , pp. 643-655
    • Cappuzzo, F.1
  • 28
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T.J., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350 (2004) 2129-2139
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2129-2139
    • Lynch, T.J.1
  • 29
    • 31544440171 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in needle biopsy/aspiration samples predict response to gefitinib therapy and survival of patients with advanced non-small cell lung cancer
    • Shih J.Y., et al. Epidermal growth factor receptor mutations in needle biopsy/aspiration samples predict response to gefitinib therapy and survival of patients with advanced non-small cell lung cancer. Int. J. Cancer 118 (2006) 963-969
    • (2006) Int. J. Cancer , vol.118 , pp. 963-969
    • Shih, J.Y.1
  • 30
    • 33845434121 scopus 로고    scopus 로고
    • A prospective phase II trial of erlotinib in advanced non-small cell lung cancer (NSCLC) patients (p) with mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR)
    • Paz-Ares L., et al. A prospective phase II trial of erlotinib in advanced non-small cell lung cancer (NSCLC) patients (p) with mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR). ASCO annual Meeting (2006)
    • (2006) ASCO annual Meeting
    • Paz-Ares, L.1
  • 31
    • 33746789922 scopus 로고    scopus 로고
    • Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations
    • Inoue A., et al. Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. J. Clin. Oncol. 24 (2006) 3340-3346
    • (2006) J. Clin. Oncol. , vol.24 , pp. 3340-3346
    • Inoue, A.1
  • 32
    • 33750205340 scopus 로고    scopus 로고
    • A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations
    • Asahina H., et al. A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations. Br. J. Cancer 95 (2006) 998-1004
    • (2006) Br. J. Cancer , vol.95 , pp. 998-1004
    • Asahina, H.1
  • 33
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W., et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2 (2005) e73
    • (2005) PLoS Med. , vol.2
    • Pao, W.1
  • 34
    • 45949083997 scopus 로고    scopus 로고
    • A polymorphism of EGFR extracellular domain is associated with progression free-survival in metastatic colorectal cancer patients receiving cetuximab-based treatment
    • Gonçalves A., et al. A polymorphism of EGFR extracellular domain is associated with progression free-survival in metastatic colorectal cancer patients receiving cetuximab-based treatment. BMC Cancer (2008) 169
    • (2008) BMC Cancer , pp. 169
    • Gonçalves, A.1
  • 35
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • Lièvre A., et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 66 (2006) 3992-3995
    • (2006) Cancer Res. , vol.66 , pp. 3992-3995
    • Lièvre, A.1
  • 36
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • Di Nicolantonio F., et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J. Clin. Oncol. 26 (2008) 5705-5712
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1
  • 37
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella R., et al. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 305 (2004) 1163-1167
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1
  • 38
    • 0036094196 scopus 로고    scopus 로고
    • Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation
    • Soria J.C., et al. Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation. Clin. Cancer Res. 8 (2002) 1178-1184
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1178-1184
    • Soria, J.C.1
  • 39
    • 33745615848 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib
    • Cappuzzo F., et al. Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib. Ann. Oncol. 17 (2006) 1120-1127
    • (2006) Ann. Oncol. , vol.17 , pp. 1120-1127
    • Cappuzzo, F.1
  • 40
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J., et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 20932-20937
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 20932-20937
    • Bean, J.1
  • 41
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman J.A., et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316 (2007) 1039-1043
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1
  • 42
    • 33746084112 scopus 로고    scopus 로고
    • Signaling via ErbB2 and ErbB3 associates with resistance and epidermal growth factor receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells
    • Erjala K., et al. Signaling via ErbB2 and ErbB3 associates with resistance and epidermal growth factor receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells. Clin. Cancer Res. 12 (2006) 4103-4111
    • (2006) Clin. Cancer Res. , vol.12 , pp. 4103-4111
    • Erjala, K.1
  • 43
    • 47349125085 scopus 로고    scopus 로고
    • Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders
    • Cunha R.A., et al. Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders. Curr. Pharm. Des. 14 (2008) 1512-1524
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 1512-1524
    • Cunha, R.A.1
  • 44
    • 33645967176 scopus 로고    scopus 로고
    • Recognition and activation of ryanodine receptors by purines
    • Butanda-Ochoa A., et al. Recognition and activation of ryanodine receptors by purines. Curr. Med. Chem. 13 (2006) 647-657
    • (2006) Curr. Med. Chem. , vol.13 , pp. 647-657
    • Butanda-Ochoa, A.1
  • 45
    • 26844513636 scopus 로고    scopus 로고
    • The potential of caffeine for functional modification from cortical synapses to neuron networks in the brain
    • Yoshimura H. The potential of caffeine for functional modification from cortical synapses to neuron networks in the brain. Curr. Neuropharmacol. 3 (2005) 309-316
    • (2005) Curr. Neuropharmacol. , vol.3 , pp. 309-316
    • Yoshimura, H.1
  • 46
    • 38649116610 scopus 로고    scopus 로고
    • Caffeine inhibits UV-mediated NF-kappaB activation in A2058 melanoma cells: an ATM-PKCdelta-p38 MAPK-dependent mechanism
    • Ravi D., et al. Caffeine inhibits UV-mediated NF-kappaB activation in A2058 melanoma cells: an ATM-PKCdelta-p38 MAPK-dependent mechanism. Mol. Cell Biochem. 308 (2008) 193-200
    • (2008) Mol. Cell Biochem. , vol.308 , pp. 193-200
    • Ravi, D.1
  • 47
    • 34948875686 scopus 로고    scopus 로고
    • Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
    • Bantscheff M., et al. Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat. Biotechnol. 25 (2007) 1035-1044
    • (2007) Nat. Biotechnol. , vol.25 , pp. 1035-1044
    • Bantscheff, M.1
  • 48
    • 38049018155 scopus 로고    scopus 로고
    • A quantitative analysis of kinase inhibitor selectivity
    • Karaman M.W., et al. A quantitative analysis of kinase inhibitor selectivity. Nat. Biotechnol. 26 (2008) 127-132
    • (2008) Nat. Biotechnol. , vol.26 , pp. 127-132
    • Karaman, M.W.1
  • 49
    • 33745928129 scopus 로고    scopus 로고
    • Smoking history and epidermal growth factor receptor expression as predictors of survival benefit from erlotinib for patients with non-small-cell lung cancer in the National Cancer Institute of Canada Clinical Trials Group study BR.21
    • Clark G.M., et al. Smoking history and epidermal growth factor receptor expression as predictors of survival benefit from erlotinib for patients with non-small-cell lung cancer in the National Cancer Institute of Canada Clinical Trials Group study BR.21. Clin. Lung Cancer 7 (2006) 389-394
    • (2006) Clin. Lung Cancer , vol.7 , pp. 389-394
    • Clark, G.M.1
  • 50
    • 34248385777 scopus 로고    scopus 로고
    • Gefitinib (IRESSA) in patients of Asian origin with refractory advanced non-small cell lung cancer: subset analysis from the ISEL study
    • Chang A., et al. Gefitinib (IRESSA) in patients of Asian origin with refractory advanced non-small cell lung cancer: subset analysis from the ISEL study. J. Thorac. Oncol. 1 (2006) 847-855
    • (2006) J. Thorac. Oncol. , vol.1 , pp. 847-855
    • Chang, A.1
  • 51
    • 0036362221 scopus 로고    scopus 로고
    • Epidermal growth factor receptor dependence in human tumors: more than just expression?
    • Arteaga C.L. Epidermal growth factor receptor dependence in human tumors: more than just expression?. Oncologist 7 (2002) 31-39
    • (2002) Oncologist , vol.7 , pp. 31-39
    • Arteaga, C.L.1
  • 52
    • 0029074587 scopus 로고
    • Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
    • Miettinen P.J., et al. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376 (1995) 337-341
    • (1995) Nature , vol.376 , pp. 337-341
    • Miettinen, P.J.1
  • 53
    • 0028344729 scopus 로고
    • The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase
    • Luetteke N.C., et al. The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev. 8 (1994) 399-413
    • (1994) Genes Dev. , vol.8 , pp. 399-413
    • Luetteke, N.C.1
  • 54
    • 0842330212 scopus 로고    scopus 로고
    • Combining EGFR inhibitors with radiation or chemotherapy: will preclinical studies predict clinical results?
    • Harari P.M., and Huang S.M. Combining EGFR inhibitors with radiation or chemotherapy: will preclinical studies predict clinical results?. Int. J. Radiat. Oncol. Biol. Phys. 58 (2004) 976-983
    • (2004) Int. J. Radiat. Oncol. Biol. Phys. , vol.58 , pp. 976-983
    • Harari, P.M.1    Huang, S.M.2
  • 55
    • 0037446068 scopus 로고    scopus 로고
    • Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor (erbB1) and induce apoptosis in erbB1-overexpressing cells
    • Nagy P., et al. Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor (erbB1) and induce apoptosis in erbB1-overexpressing cells. Exp. Cell Res. 285 (2003) 39-49
    • (2003) Exp. Cell Res. , vol.285 , pp. 39-49
    • Nagy, P.1
  • 56
    • 42949176742 scopus 로고    scopus 로고
    • Survival of cancer cells is maintained by EGFR independent of its kinase activity
    • Weihua Z., et al. Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell. 13 (2008) 385-393
    • (2008) Cancer Cell. , vol.13 , pp. 385-393
    • Weihua, Z.1
  • 57
    • 62849085151 scopus 로고    scopus 로고
    • FDA's Critical Path Initiative website
    • FDA's Critical Path Initiative website. http://www.fda.gov/oc/initiatives/criticalpath/
  • 58
    • 11144333540 scopus 로고    scopus 로고
    • Absence of EGFR mutation in the kinase domain in common human cancers besides non-small cell lung cancer
    • Lee J.W., et al. Absence of EGFR mutation in the kinase domain in common human cancers besides non-small cell lung cancer. Int. J. Cancer 113 (2005) 510-511
    • (2005) Int. J. Cancer , vol.113 , pp. 510-511
    • Lee, J.W.1
  • 59
    • 33846475724 scopus 로고    scopus 로고
    • EGFR mutations in exons 18-21 in sporadic breast cancer
    • Generali D., et al. EGFR mutations in exons 18-21 in sporadic breast cancer. Ann. Oncol. 18 (2007) 203-205
    • (2007) Ann. Oncol. , vol.18 , pp. 203-205
    • Generali, D.1
  • 60
    • 24044520039 scopus 로고    scopus 로고
    • EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations
    • Bhargava R., et al. EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations. Mod. Pathol. 18 (2005) 1027-1033
    • (2005) Mod. Pathol. , vol.18 , pp. 1027-1033
    • Bhargava, R.1
  • 61
    • 19944422060 scopus 로고    scopus 로고
    • Somatic mutations of EGFR in colorectal cancers and glioblastomas
    • Barber T.D. Somatic mutations of EGFR in colorectal cancers and glioblastomas. N. Engl. J. Med. 351 (2004) 2883
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2883
    • Barber, T.D.1
  • 62
    • 23044511620 scopus 로고    scopus 로고
    • Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: a Gynecologic Oncology Group Study
    • Schilder R.J., et al. Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: a Gynecologic Oncology Group Study. Clin. Cancer Res. 11 (2005) 5539-5548
    • (2005) Clin. Cancer Res. , vol.11 , pp. 5539-5548
    • Schilder, R.J.1
  • 63
    • 28544443381 scopus 로고    scopus 로고
    • Epidermal growth factor receptor domain II, IV, and kinase domain mutations in human solid tumors
    • Sihto H., et al. Epidermal growth factor receptor domain II, IV, and kinase domain mutations in human solid tumors. J. Mol. Med. 83 (2005) 976-983
    • (2005) J. Mol. Med. , vol.83 , pp. 976-983
    • Sihto, H.1
  • 64
    • 33846220461 scopus 로고    scopus 로고
    • Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas
    • Kwak E.L., et al. Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas. Clin. Cancer Res. 12 Pt 1 (2006) 4283-4287
    • (2006) Clin. Cancer Res. , vol.12 , Issue.PART 1 , pp. 4283-4287
    • Kwak, E.L.1
  • 65
    • 27144523155 scopus 로고    scopus 로고
    • Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas
    • Gwak G.Y., et al. Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas. J. Cancer Res. Clin. Oncol. 131 (2005) 649-652
    • (2005) J. Cancer Res. Clin. Oncol. , vol.131 , pp. 649-652
    • Gwak, G.Y.1
  • 66
    • 33846609066 scopus 로고    scopus 로고
    • EGFR mutations and human papillomavirus in squamous cell carcinoma of tongue and tonsil
    • Na I.I., et al. EGFR mutations and human papillomavirus in squamous cell carcinoma of tongue and tonsil. Eur. J. Cancer 43 (2007) 520-526
    • (2007) Eur. J. Cancer , vol.43 , pp. 520-526
    • Na, I.I.1
  • 67
    • 29144520704 scopus 로고    scopus 로고
    • Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma
    • Loeffler-Ragg J., et al. Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma. Eur. J. Cancer 42 (2006) 109-111
    • (2006) Eur. J. Cancer , vol.42 , pp. 109-111
    • Loeffler-Ragg, J.1


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