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Volumn 58, Issue 3, 2004, Pages 976-983

Combining EGFR inhibitors with radiation or chemotherapy: Will preclinical studies predict clinical results?

Author keywords

Angiogenesis; Apoptosis; Chemotherapy; EGFR; Radiation

Indexed keywords

CELLS; CHEMOTHERAPY; GROWTH KINETICS; SKIN; TOXICITY; TUMORS;

EID: 0842330212     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2003.09.097     Document Type: Conference Paper
Times cited : (71)

References (50)
  • 1
    • 0003336304 scopus 로고    scopus 로고
    • Final results from a phase II trial of ZD1839 ('Iressa') for patients with advanced non-small-cell lung cancer (IDEAL 1) [Abstract]
    • Fukuoka M, Yano S, Giaccone G, et al. Final results from a phase II trial of ZD1839 ('Iressa') for patients with advanced non-small-cell lung cancer (IDEAL 1) [Abstract]. Proc Am Soc Clin Oncol 2002; 21:298a.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 2
    • 0001303063 scopus 로고    scopus 로고
    • A phase II trial of ZD1839 (′Iressa') in advanced non-small cell lung cancer (NSCLC) patients who had failed platinum- and docetaxel-based regimens (IDEAL 2) [Abstract]
    • Kris MG, Natale RB, Herbst RS, et al. A phase II trial of ZD1839 (′Iressa') in advanced non-small cell lung cancer (NSCLC) patients who had failed platinum- and docetaxel-based regimens (IDEAL 2) [Abstract]. Proc Am Soc Clin Oncol 2002;21:292a.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3
  • 3
    • 0037674062 scopus 로고    scopus 로고
    • Phase II Trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Cohen E.E.W., Rosen F., Stadler W.M., et al. Phase II Trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol. 21:2003;1980-1987.
    • (2003) J Clin Oncol , vol.21 , pp. 1980-1987
    • Cohen, E.E.W.1    Rosen, F.2    Stadler, W.M.3
  • 4
    • 0029776415 scopus 로고    scopus 로고
    • 1 arrest in prostatic cancer cell line DU145
    • 1 arrest in prostatic cancer cell line DU145. Cancer Res. 56:1996;3666-3669.
    • (1996) Cancer Res , vol.56 , pp. 3666-3669
    • Peng, D.1    Fan, Z.2    Lu, Y.3
  • 5
    • 0033561522 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck
    • Huang S.-M., Bock J.M., Harari P.M. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res. 59:1999;1935-1940.
    • (1999) Cancer Res , vol.59 , pp. 1935-1940
    • Huang, S.-M.1    Bock, J.M.2    Harari, P.M.3
  • 6
    • 0029740759 scopus 로고    scopus 로고
    • Altered cell cycle distribution and cyclin-CDK protein expression in A431 epidermoid carcinoma cells treated with doxorubicin and a chimeric monoclonal antibody to epidermal growth factor receptor
    • Prewett M., Rockwell P., Rose C., et al. Altered cell cycle distribution and cyclin-CDK protein expression in A431 epidermoid carcinoma cells treated with doxorubicin and a chimeric monoclonal antibody to epidermal growth factor receptor. Mol Cell Differ. 4:1996;167-186.
    • (1996) Mol Cell Differ , vol.4 , pp. 167-186
    • Prewett, M.1    Rockwell, P.2    Rose, C.3
  • 7
    • 0035839317 scopus 로고    scopus 로고
    • EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells
    • Zhu X.F., Liu Z.C., Xie B.F., et al. EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells. Cancer Lett. 169:2001;27-32.
    • (2001) Cancer Lett , vol.169 , pp. 27-32
    • Zhu, X.F.1    Liu, Z.C.2    Xie, B.F.3
  • 8
    • 0035892346 scopus 로고    scopus 로고
    • ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression
    • Anderson N.G., Ahmad T., Chan K., et al. ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression. Int J Cancer. 94:2001;774-782.
    • (2001) Int J Cancer , vol.94 , pp. 774-782
    • Anderson, N.G.1    Ahmad, T.2    Chan, K.3
  • 9
    • 0035076065 scopus 로고    scopus 로고
    • Blockade of growth factor receptors in ductal carcinoma in situ inhibits epithelial proliferation
    • Chan K.C., Knox W.F., Gandhi A., et al. Blockade of growth factor receptors in ductal carcinoma in situ inhibits epithelial proliferation. Br J Surg. 88:2001;412-418.
    • (2001) Br J Surg , vol.88 , pp. 412-418
    • Chan, K.C.1    Knox, W.F.2    Gandhi, A.3
  • 10
  • 11
    • 0036681995 scopus 로고    scopus 로고
    • Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa)
    • Huang S.-M., Li J., Armstrong E.A., et al. Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa). Cancer Res. 62:2002;4300-4306.
    • (2002) Cancer Res , vol.62 , pp. 4300-4306
    • Huang, S.-M.1    Li, J.2    Armstrong, E.A.3
  • 12
    • 0029670014 scopus 로고    scopus 로고
    • 1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody
    • 1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene. 12:1996;1397-1403.
    • (1996) Oncogene , vol.12 , pp. 1397-1403
    • Wu, X.1    Rubin, M.2    Fan, Z.3
  • 13
    • 0034084314 scopus 로고    scopus 로고
    • Modulation of radiation response following epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics and tumor angiogenesis
    • Huang S.-M., Harari P.M. Modulation of radiation response following epidermal growth factor receptor blockade in squamous cell carcinomas inhibition of damage repair, cell cycle kinetics and tumor angiogenesis . Clin Cancer Res. 6:2000;2166-2174.
    • (2000) Clin Cancer Res , vol.6 , pp. 2166-2174
    • Huang, S.-M.1    Harari, P.M.2
  • 14
    • 0031817827 scopus 로고    scopus 로고
    • EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5
    • Modjtahedi H., Affleck K., Stubberfield C., et al. EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5. Int J Oncol. 13:1998;335-342.
    • (1998) Int J Oncol , vol.13 , pp. 335-342
    • Modjtahedi, H.1    Affleck, K.2    Stubberfield, C.3
  • 15
    • 0028969852 scopus 로고
    • Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin
    • Wu X., Fan Z., Masui H., et al. Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. J Clin Invest. 95:1995;1897-1905.
    • (1995) J Clin Invest , vol.95 , pp. 1897-1905
    • Wu, X.1    Fan, Z.2    Masui, H.3
  • 16
    • 0034038282 scopus 로고    scopus 로고
    • Induction of apoptosis and activation of the caspase cascade by anti- EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity
    • Liu B., Fang M., Schmidt M., et al. Induction of apoptosis and activation of the caspase cascade by anti- EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. Br J Cancer. 82:2000;1991-1999.
    • (2000) Br J Cancer , vol.82 , pp. 1991-1999
    • Liu, B.1    Fang, M.2    Schmidt, M.3
  • 17
    • 0035927546 scopus 로고    scopus 로고
    • The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway
    • Liu B., Fan Z. The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway. Oncogene. 20:2001;3726-3734.
    • (2001) Oncogene , vol.20 , pp. 3726-3734
    • Liu, B.1    Fan, Z.2
  • 18
    • 0035879822 scopus 로고    scopus 로고
    • Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis, and cooperate with cytotoxic drugs in human cancer cell lines
    • Ciardiello F., Caputo R., Troiani T., et al. Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis, and cooperate with cytotoxic drugs in human cancer cell lines. Int J Cancer. 93:2001;172-178.
    • (2001) Int J Cancer , vol.93 , pp. 172-178
    • Ciardiello, F.1    Caputo, R.2    Troiani, T.3
  • 19
    • 0036096775 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by the antiepidermal growth factor receptor antibody ImClone C225 in androgen-independent prostate cancer growing orthotopically in nude mice
    • Karashima T., Sweeney P., Slaton J.W., et al. Inhibition of angiogenesis by the antiepidermal growth factor receptor antibody ImClone C225 in androgen-independent prostate cancer growing orthotopically in nude mice. Clin Cancer Res. 8:2002;1253-1264.
    • (2002) Clin Cancer Res , vol.8 , pp. 1253-1264
    • Karashima, T.1    Sweeney, P.2    Slaton, J.W.3
  • 20
    • 0036143027 scopus 로고    scopus 로고
    • Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast
    • Chan K.C., Knox W.F., Gee J.M., et al. Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast. Cancer Res. 62:2002;122-128.
    • (2002) Cancer Res , vol.62 , pp. 122-128
    • Chan, K.C.1    Knox, W.F.2    Gee, J.M.3
  • 21
    • 0034068319 scopus 로고    scopus 로고
    • Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
    • Ciardiello F., Caputo R., Bianco R., et al. Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res. 6:2000;2053-2063.
    • (2000) Clin Cancer Res , vol.6 , pp. 2053-2063
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3
  • 22
    • 0034329308 scopus 로고    scopus 로고
    • Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers
    • Bonner J.A., Raisch K.P., Trummell H.Q., et al. Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers. J Clin Oncol. 18:2000;47S-53S.
    • (2000) J Clin Oncol , vol.18
    • Bonner, J.A.1    Raisch, K.P.2    Trummell, H.Q.3
  • 23
    • 18844473781 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms
    • Bruns C.J., Harbison M.T., Davis D.W., et al. Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. Clin Cancer Res. 6:2000;1936-1948.
    • (2000) Clin Cancer Res , vol.6 , pp. 1936-1948
    • Bruns, C.J.1    Harbison, M.T.2    Davis, D.W.3
  • 24
    • 0036094194 scopus 로고    scopus 로고
    • Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts
    • Prewett M.C., Hooper A.T., Bassi R., et al. Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts. Clin Cancer Res. 8:2002;994-1003.
    • (2002) Clin Cancer Res , vol.8 , pp. 994-1003
    • Prewett, M.C.1    Hooper, A.T.2    Bassi, R.3
  • 25
    • 0036733591 scopus 로고    scopus 로고
    • Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas
    • Baker C.H., Kedar D., McCarty M.F., et al. Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas. Am J Pathol. 161:2002;929-938.
    • (2002) Am J Pathol , vol.161 , pp. 929-938
    • Baker, C.H.1    Kedar, D.2    McCarty, M.F.3
  • 26
    • 0033049978 scopus 로고    scopus 로고
    • The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells
    • Contessa J.N., Reardon D.B., Todd D., et al. The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells. Clin Cancer Res. 5:1999;405-411.
    • (1999) Clin Cancer Res , vol.5 , pp. 405-411
    • Contessa, J.N.1    Reardon, D.B.2    Todd, D.3
  • 27
    • 0033966576 scopus 로고    scopus 로고
    • In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody
    • Milas L., Mason K., Hunter N., et al. In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody. Clin Cancer Res. 6:2000;701-708.
    • (2000) Clin Cancer Res , vol.6 , pp. 701-708
    • Milas, L.1    Mason, K.2    Hunter, N.3
  • 28
    • 0034565927 scopus 로고    scopus 로고
    • Radiosensitization of human breast cancer cells by a novel ErbB family receptor tyrosine kinase inhibitor
    • Rao G.S., Murray S., Ethier S.P. Radiosensitization of human breast cancer cells by a novel ErbB family receptor tyrosine kinase inhibitor. Int J Radiat Oncol Biol Phys. 48:2000;1519-1528.
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 1519-1528
    • Rao, G.S.1    Murray, S.2    Ethier, S.P.3
  • 29
    • 0033748391 scopus 로고    scopus 로고
    • Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase a antisense oligonucleotide
    • Bianco C., Bianco R., Tortora G., et al. Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide. Clin Cancer Res. 6:2000;4343-4350.
    • (2000) Clin Cancer Res , vol.6 , pp. 4343-4350
    • Bianco, C.1    Bianco, R.2    Tortora, G.3
  • 30
    • 0035479052 scopus 로고    scopus 로고
    • C225 antiepidermal growth factor receptor antibody enhances tumor radiocurability
    • Nasu S., Ang K.K., Fan Z., et al. C225 antiepidermal growth factor receptor antibody enhances tumor radiocurability. Int J Radiat Oncol Biol Phys. 51:2001;474-477.
    • (2001) Int J Radiat Oncol Biol Phys , vol.51 , pp. 474-477
    • Nasu, S.1    Ang, K.K.2    Fan, Z.3
  • 31
    • 0034899452 scopus 로고    scopus 로고
    • Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor receptor
    • Lammering G., Valerie K., Lin P.S., et al. Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor receptor. Clin Cancer Res. 7:2001;682-690.
    • (2001) Clin Cancer Res , vol.7 , pp. 682-690
    • Lammering, G.1    Valerie, K.2    Lin, P.S.3
  • 32
    • 0035918858 scopus 로고    scopus 로고
    • Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization
    • Lammering G., Hewit T.H., Hawkins W.T., et al. Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization. J Natl Cancer Inst. 93:2001;921-929.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 921-929
    • Lammering, G.1    Hewit, T.H.2    Hawkins, W.T.3
  • 33
    • 0036795061 scopus 로고    scopus 로고
    • Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa)
    • Bianco C., Tortora G., Bianco R., et al. Enhancement of antitumor activity of ionizing radiation by combined treatment with the selective epidermal growth factor receptor-tyrosine kinase inhibitor ZD1839 (Iressa). Clin Cancer Res. 8:2002;3250-3258.
    • (2002) Clin Cancer Res , vol.8 , pp. 3250-3258
    • Bianco, C.1    Tortora, G.2    Bianco, R.3
  • 34
    • 85047696958 scopus 로고    scopus 로고
    • ZD1839 (′Iressa'), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model
    • Williams K.J., Telfer B.A., Stratford I.J., et al. ZD1839 (′Iressa'), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model. Br J Cancer. 86:2002;1157-1161.
    • (2002) Br J Cancer , vol.86 , pp. 1157-1161
    • Williams, K.J.1    Telfer, B.A.2    Stratford, I.J.3
  • 35
    • 0036638329 scopus 로고    scopus 로고
    • Small-molecule tyrosine kinase inhibitors as radiosensitizers
    • Lawrence T.S., Nyati M.K. Small-molecule tyrosine kinase inhibitors as radiosensitizers. Semin Radiat Oncol. 12:2002;33-36.
    • (2002) Semin Radiat Oncol , vol.12 , pp. 33-36
    • Lawrence, T.S.1    Nyati, M.K.2
  • 36
    • 0037017877 scopus 로고    scopus 로고
    • Sequence-dependent effects of ZD1839 (′Iressa') in combination with cytotoxic treatment in human head and neck cancer
    • Magne N., Fischel J.L., Dubreuil A., et al. Sequence-dependent effects of ZD1839 (′Iressa') in combination with cytotoxic treatment in human head and neck cancer. Br J Cancer. 86:2002;819-827.
    • (2002) Br J Cancer , vol.86 , pp. 819-827
    • Magne, N.1    Fischel, J.L.2    Dubreuil, A.3
  • 37
    • 0031891006 scopus 로고    scopus 로고
    • Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells
    • Bandyopadhyay D., Mandal M., Adam L., et al. Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells. J Biol Chem. 273:1998;1568-1573.
    • (1998) J Biol Chem , vol.273 , pp. 1568-1573
    • Bandyopadhyay, D.1    Mandal, M.2    Adam, L.3
  • 38
    • 0034489914 scopus 로고    scopus 로고
    • Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase
    • Sirotnak F.M., Zakowski M.F., Miller V.A., et al. Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase. Clin Cancer Res. 6:2000;4885-4892.
    • (2000) Clin Cancer Res , vol.6 , pp. 4885-4892
    • Sirotnak, F.M.1    Zakowski, M.F.2    Miller, V.A.3
  • 39
    • 0032904485 scopus 로고    scopus 로고
    • Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225
    • Ciardiello F., Bianco R., Damiano V., et al. Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225. Clin Cancer Res. 5:1999;909-916.
    • (1999) Clin Cancer Res , vol.5 , pp. 909-916
    • Ciardiello, F.1    Bianco, R.2    Damiano, V.3
  • 40
    • 0036005846 scopus 로고    scopus 로고
    • ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, alone and in combination with radiation and chemotherapy as a new therapeutic strategy in non-small cell lung cancer
    • Raben D., Helfrich B.A., Chan D., et al. ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, alone and in combination with radiation and chemotherapy as a new therapeutic strategy in non-small cell lung cancer. Semin Oncol. 29:2002;37-46.
    • (2002) Semin Oncol , vol.29 , pp. 37-46
    • Raben, D.1    Helfrich, B.A.2    Chan, D.3
  • 41
    • 0032972944 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
    • Perrotte P., Matsumoto T., Inoue K., et al. Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin Cancer Res. 5:1999;257-264.
    • (1999) Clin Cancer Res , vol.5 , pp. 257-264
    • Perrotte, P.1    Matsumoto, T.2    Inoue, K.3
  • 42
    • 0034489116 scopus 로고    scopus 로고
    • Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma
    • Inoue K., Slaton J.W., Perrotte P., et al. Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma. Clin Cancer Res. 6:2000;4874-4884.
    • (2000) Clin Cancer Res , vol.6 , pp. 4874-4884
    • Inoue, K.1    Slaton, J.W.2    Perrotte, P.3
  • 43
    • 0036848820 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice
    • Kedar D., Baker C.H., Killion J.J., et al. Blockade of the epidermal growth factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice. Clin Cancer Res. 8:2002;3592-3600.
    • (2002) Clin Cancer Res , vol.8 , pp. 3592-3600
    • Kedar, D.1    Baker, C.H.2    Killion, J.J.3
  • 44
    • 0031039923 scopus 로고    scopus 로고
    • Transforming growth factor-alpha-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation
    • Gille J., Swerlick R.A., Caughman S.W. Transforming growth factor-alpha-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation. EMBO J. 16:1997;750-759.
    • (1997) EMBO J , vol.16 , pp. 750-759
    • Gille, J.1    Swerlick, R.A.2    Caughman, S.W.3
  • 45
    • 0035116241 scopus 로고    scopus 로고
    • Vascular endothelial growth factor family members are differentially regulated by c-erbB signaling in head and neck squamous carcinoma cells
    • O-Charoenrat P., Rhys-Evans P., Modjtahedi H., et al. Vascular endothelial growth factor family members are differentially regulated by c-erbB signaling in head and neck squamous carcinoma cells. Clin Exp Metastasis. 18:2000;155-161.
    • (2000) Clin Exp Metastasis , vol.18 , pp. 155-161
    • O-Charoenrat, P.1    Rhys-Evans, P.2    Modjtahedi, H.3
  • 46
    • 0034896362 scopus 로고    scopus 로고
    • Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor
    • Ciardiello F., Caputo R., Bianco R., et al. Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin Cancer Res. 7:2001;1459-1465.
    • (2001) Clin Cancer Res , vol.7 , pp. 1459-1465
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3
  • 47
    • 0036570203 scopus 로고    scopus 로고
    • ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase
    • Hirata A., Ogawa S., Kometani T., et al. ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase. Cancer Res. 62:2002;2554-2560.
    • (2002) Cancer Res , vol.62 , pp. 2554-2560
    • Hirata, A.1    Ogawa, S.2    Kometani, T.3
  • 48
    • 0345204078 scopus 로고    scopus 로고
    • Results of a multivariate analysis of prognostic factors of overall survival of patients with advanced non-small-cell lung cancer (NSCLC) treated with gefitinib (ZD1839) in combination with platinum-based chemotherapy (CT) in two large phase III trials (INTACT 1 and 2)
    • Giaccone G, Johnson D, Scagliotti GV, et al. Results of a multivariate analysis of prognostic factors of overall survival of patients with advanced non-small-cell lung cancer (NSCLC) treated with gefitinib (ZD1839) in combination with platinum-based chemotherapy (CT) in two large phase III trials (INTACT 1 and 2) [Abstract]. Proc Am Soc Clin Oncol 2003;22:627.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 627
    • Giaccone, G.1    Johnson, D.2    Scagliotti, G.V.3
  • 49
    • 0002806626 scopus 로고    scopus 로고
    • A phase III clinical trial of ZD1839 (′Iressa') in combination with gemcitabine and cisplatin in chemotherapy naive patients with advanced non-small-cell lung cancer (INTACT 1)
    • Giaccone G., Johnson D.H., Manegold C., et al. A phase III clinical trial of ZD1839 (′Iressa') in combination with gemcitabine and cisplatin in chemotherapy naive patients with advanced non-small-cell lung cancer (INTACT 1). Ann Oncol. 13:(Suppl. 5):2002;2-3.
    • (2002) Ann Oncol , vol.13 , Issue.SUPPL. 5 , pp. 2-3
    • Giaccone, G.1    Johnson, D.H.2    Manegold, C.3
  • 50
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • Mendelsohn J., Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene. 19:2000;6550-6565.
    • (2000) Oncogene , vol.19 , pp. 6550-6565
    • Mendelsohn, J.1    Baselga, J.2


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