PIASy inhibits LRH-1-dependent CYP11A1 expression by competing for SRC-1 binding

Biochemical Journal

Volumn 419, Issue 1, 2009, Pages 201-209

  Hsieh, Hsiang Tsan ^a   Wang, Chih Hung ^a   Wu, Mei Ling ^a   Yang, Feng Ming ^a   Tai, Yu Chen ^a   Hu, Meng Chun ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Cholesterol side chain cleavage cytochrome P450 (CYP11A1); Liver receptor homologue 1 (LRH 1); Protein inhibitor of activated STAT (PIAS); Steroid receptor co activator 1 (SRC 1); Steroidogenesis; SUMOylation

Indexed keywords

ACTIVATION FUNCTIONS; BILE ACID; C-TERMINAL REGIONS; CHOLESTEROL METABOLISM; COACTIVATORS; HISTONE DEACETYLASE; IMMUNOPRECIPITATION; LIGASES; MOLECULAR MECHANISM; N-TERMINAL; NUCLEAR RECEPTORS; OVER-EXPRESSION; PROTEIN INHIBITOR OF ACTIVATED STAT (PIAS); PROTEIN INHIBITORS; SIGNAL TRANSDUCERS; SMALL UBIQUITIN-RELATED MODIFIERS; STEROID HORMONE; STEROID RECEPTOR CO-ACTIVATOR-1 (SRC-1); STEROID RECEPTORS; STEROIDOGENESIS; SUMO CONJUGATION; SUMOYLATION; TRANSACTIVATION; TRANSCRIPTIONAL REGULATION; TWO-HYBRID ANALYSIS;

CHOLESTEROL; ENZYMES; LIVER; MAMMALS; PROTEINS; TRANSCRIPTION;

CHEMICAL ACTIVATION;

CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); HISTONE DEACETYLASE; LIVER RECEPTOR HOMOLOG 1; PROTEIN INHIBITOR OF ACTIVATED STAT; PROTEIN INHIBITOR OF ACTIVATED STAT GAMMA; STEROID RECEPTOR COACTIVATOR 1; SUMO PROTEIN; UNCLASSIFIED DRUG; CELL RECEPTOR; DNA BINDING PROTEIN; HISTONE ACETYLTRANSFERASE; NR5A2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING COMPETITION; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVITY; GENE REPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; TRANSCRIPTION REGULATION; ANIMAL; CELL LINE; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOUSE; PROMOTER REGION; TWO HYBRID SYSTEM; WESTERN BLOTTING;

MAMMALIA;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DNA-BINDING PROTEINS; HISTONE ACETYLTRANSFERASES; HUMANS; IMMUNOPRECIPITATION; MICE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN INHIBITORS OF ACTIVATED STAT; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 62749200997     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20081402     Document Type: Article

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