Involvement of PIAS1 in the sumoylation of tumor suppressor p53

Molecular Cell

Volumn 8, Issue 3, 2001, Pages 713-718

  Kahyo, Tomoaki ^a   Nishida, Tamotsu ^a   Yasuda, Hideyo ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CYSTEINE; LIGASE; PROTEIN; PROTEIN P53; PROTEIN PIAS1; PROTEIN UBC9; SUMO 1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALYSIS; ENZYME REGULATION; IN VITRO STUDY; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STRUCTURE; TRANSCRIPTION REGULATION; TWO HYBRID SYSTEM; YEAST;

EID: 0034789730     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00349-5     Document Type: Article

References (32)

1. Specific inhibition of Stat3 signal transduction by PIAS3
2. The ubiquitin-proteasome pathway: The complexity & myriad functions of protein death
3. SUMO-1 modification of IκBα inhibits NF-κB activation
4. Identification of the enzyme required for activation of the small ubiquitin like protein SUMO-1
5. SUMO-1 modification of the acute promyelocytic leukaemia protein: PML implications for nuclear localization
6. MBP1: A novel mutant p53-specific protein partner with oncogenic properties
7. Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex
8. Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1
9. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
10. The ubiquitin system
11. Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
12. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumour suppressor p53
13. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
14. ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation
15. Modification of Ran GTPase-activating protein by the small ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type ubiquitin-conjugating enzyme homologue
16. p53, the cellular gatekeeper for growth and division
17. Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT1) (PIAS1) in cytokine-induced PIAS1-Stat1 interaction
18. Inhibition of Stat1-mediated gene activation by PIAS1
19. A transcriptional corepressor of Stat1 with an essential LXXLL signature motif
20. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
21. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
22. Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus
23. SUMO, ubiquitin's mysterious cousin
24. Arginine methylation of STAT1 modulates IFNα/β-induced transcription
25. In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2
26. The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3
27. SUMO-1 modification activates the transcriptional response of p53
28. RanBP2 associates with Ubc9p and a modified form of RanGAP1
29. DNA damage activates p53 through a phosphorylation-acetylation cascade
30. Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1
31. Modulation of STAT signaling by STAT-interacting proteins
32. Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7