PIASy-mediated repression of the Ets-1 is independent of its sumoylation

Biochemical and Biophysical Research Communications

Volumn 345, Issue 4, 2006, Pages 1536-1546

  Nishida, Tamotsu ^a   Terashima, Motoko ^a   Fukami, Kiyoko ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Ets; Ets 1; PIAS; PIASy; Repression; SUMO; SUMO 1; SUMO E3 ligase; Transcription

Indexed keywords

ARGININE; LYSINE; PROTEIN INHIBITOR OF ACTIVATED STAT; TRANSCRIPTION FACTOR ETS; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME SPECIFICITY; GENE OVEREXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MONKEY; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; TRANSACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; CELL LINE, TUMOR; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; COS CELLS; ENDOPEPTIDASES; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMMUNOBLOTTING; LUCIFERASES; MALE; MICE; MICROSCOPY, CONFOCAL; NUCLEAR MATRIX; PLASMIDS; PROTEIN INHIBITORS OF ACTIVATED STAT; PROTO-ONCOGENE PROTEIN C-ETS-1; SPODOPTERA; SUMO-1 PROTEIN; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 33744523786     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.05.065     Document Type: Article

References (37)

1. Graves B.J., and Petersen J.M. Specificity within the ets family of transcription factors. Adv. Cancer Res. 75 (1998) 1-55
2. Seth A., Ascione R., Fisher R.J., Mavrothalassitis G.J., Bhat N.K., and Papas T.S. The ets gene family. Cell Growth Differ. 3 (1992) 327-334
3. Janknecht R., and Nordheim A. Gene regulation by Ets proteins. Biochim. Biophys. Acta 1155 (1993) 346-356
4. Wasylyk B., Hahn S.L., and Giovane A. The Ets family of transcription factors. Eur. J. Biochem. 211 (1993) 7-18
5. Sharrocks A.D., Brown A.L., Ling Y., and Yates P.R. The ETS-domain transcription factor family. Int. J. Biochem. Cell Biol. 29 (1997) 1371-1387
6. Span P.N., Manders P., Heuvel J.J., Thomas C.M., Bosch R.R., Beex L.V., and Sweep C.G. Expression of the transcription factor Ets-1 is an independent prognostic marker for relapse-free survival in breast cancer. Oncogene 21 (2002) 8506-8509
7. Buggy Y., Maguire T.M., McGreal G., McDermott E., Hill A.D., O'Higgins N., and Duffy M.J. Overexpression of the Ets-1 transcription factor in human breast cancer. Br. J. Cancer 91 (2004) 1308-1315
8. Katayama S., Nakayama T., Ito M., Naito S., and Sekine I. Expression of the ets-1 proto-oncogene in human breast carcinoma: differential expression with histological grading and growth pattern. Histol. Histopathol. 20 (2005) 119-126
9. Sementchenko V.I., and Watson D.K. Ets target genes: past, present and future. Oncogene 19 (2000) 6533-6548
10. Dittmer J. The biology of the Ets1 proto-oncogene. Mol. Cancer 2 (2003) 29-49
11. Seidel J.J., and Graves B.J. An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors. Genes Dev. 16 (2002) 127-137
12. Cowley D.O., and Graves B.J. Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition. Genes Dev. 14 (2000) 366-376
13. Gill G. SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?. Genes Dev. 18 (2004) 2046-2059
14. Hay R.T. SUMO: a history of modification. Mol. Cell 18 (2005) 1-12
15. Verger A., Perdomo J., and Crossley M. Modification with SUMO. A role in transcriptional regulation. EMBO Rep. 4 (2003) 137-142
16. Hochstrasser M. SP-RING for SUMO: new functions bloom for a ubiquitin-like protein. Cell 107 (2001) 5-8
17. Johnson E.S., and Gupta A.A. An E3-like factor that promotes SUMO conjugation to the yeast septins. Cell 106 (2001) 735-744
18. Kahyo T., Nishida T., and Yasuda H. Involvement of PIAS1 in the sumoylation of tumor suppressor p53. Mol. Cell 8 (2001) 713-718
19. Takahashi Y., Kahyo T., Toh-E A., Yasuda H., and Kikuchi Y. Yeast Ull1/Siz1 is a novel SUMO1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme and substrates. J. Biol. Chem. 276 (2001) 48973-48977
20. Chung C.D., Liao J., Liu B., Rao X., Jay P., Berta P., and Shuai K. Specific inhibition of Stat3 signal transduction by PIAS3. Science 278 (1997) 1803-1805
21. Liu B., Liao J., Rao X., Kushner S.A., Chung C.D., Chang D.D., and Shuai K. Inhibition of Stat1-mediated gene activation by PIAS1. Proc. Natl. Acad. Sci. USA 95 (1998) 10626-10631
22. Kotaja N., Aittomäki S., Silvennoinen O., Palvimo J.J., and Jänne O.A. ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation. Mol. Endocrinol. 14 (2000) 1986-2000
23. Gross M., Liu B., Tan J., French F.S., Carey M., and Shuai K. Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells. Oncogene 20 (2001) 3880-3887
24. Yang S.H., Jaffray E., Hay R.T., and Sharrocks A.D. Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. Mol. Cell 12 (2003) 63-74
25. Salinas S., Briancon-Marjollet A., Bossis G., Lopez M.A., Piechaczyk M., Jariel-Encontre I., Debant A., and Hipskind R.A. SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1. J. Cell Biol. 165 (2004) 767-773
26. Chakrabarti S.R., Sood R., Nandi S., and Nucifora G. Posttranslational modification of TEL and TEL/AML1 by SUMO-1 and cell-cycle-dependent assembly into nuclear bodies. Proc. Natl. Acad. Sci. USA 97 (2000) 13281-13285
27. Wood L.D., Irvin B.J., Nucifora G., Luce K.S., and Hiebert S.W. Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor. Proc. Natl. Acad. Sci. USA 100 (2003) 3257-3262
28. Nishida T., and Yasuda H. PIAS1 and PIASxα function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription. J. Biol. Chem. 277 (2002) 41311-41317
29. Okuma T., Honda R., Ichikawa G., Tsumagari N., and Yasuda H. In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. Biochem. Biophys. Res. Commun. 254 (1999) 693-698
30. He D., Nickerson A.N., and Penman S. Core filaments of the nuclear matrix. J. Cell Biol. 110 (1990) 569-580
31. Hahn S.L., Wasylyk B., and Criqui-Filipe P. Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin-conjugating enzyme. Oncogene 15 (1997) 1489-1495
32. Iñiguez-Lluhí J.A., and Pearce D. A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy. Mol. Cell. Biol. 16 (2000) 6040-6050
33. Rodriguez M.S., Dargemont C., and Hay R.T. SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting. J. Biol. Chem. 276 (2001) 12654-12659
34. Sachdev S., Bruhn L., Sieber H., Pichler A., Melchior F., and Grosschedl R. PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes Dev. 15 (2001) 3088-3103
35. Dahle O., Andersen T.O., Nordgard O., Matre V., Del Sal G., and Gabrielsen O.S. Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner. Eur. J. Biochem. 270 (2003) 1338-1348
36. Macauley M.S., Errington W.J., Scharpf M., Mackereth C.D., Blaszczak A.G., Graves B.J., and McIntosh L.P. Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence. J. Biol. Chem. 281 (2006) 4164-4172
37. Long J., Matsuura I., He D., Wang G., Shuai K., and Liu F. Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT. Proc. Natl. Acad. Sci. USA 100 (2003) 9791-9796