Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure-activity relationships of (N-methyl-piperazinyl)-containing derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 20, 2004, Pages 5133-5137

  Watkins, William J ^a,c   Lemoine, Rémy C ^a   Chong, Lee ^a   Cho, Aesop ^a   Renau, Thomas E ^a   Kuo, Bonnie ^a   Wong, Vickie ^a   Ludwikow, Maria ^a   Garizi, Negar ^a   Iqbal, Nadeem ^b   Barnard, John ^b   Jankowska, Renata ^b   Singh, Rajeshwar ^b   Madsen, Deidre ^a   Lolans, Karen ^a   Lomovskaya, Olga ^a   Oza, Uma ^a   Dudley, Michael N ^a  

^a Essential Therapeutics Inc   (United States)

^b NAEJA Pharmaceutical Inc   (Canada)

^c GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; FLUCONAZOLE; METHYL GROUP; PIPERAZINE DERIVATIVE; QUINAZOLINE DERIVATIVE;

ARTICLE; BACTERIAL STRAIN; CANDIDA ALBICANS; CANDIDA GLABRATA; CONTROLLED STUDY; DERIVATIZATION; DRUG POTENCY; DRUG SYNTHESIS; GENE OVEREXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTIFUNGAL AGENTS; CANDIDA; CANDIDA ALBICANS; CANDIDA GLABRATA; DRUG RESISTANCE, FUNGAL; DRUG SYNERGISM; FLUCONAZOLE; FUNGAL PROTEINS; HUMANS; MEMBRANE TRANSPORT MODULATORS; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; PIPERAZINES; QUINAZOLINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

CANDIDA; CANDIDA ALBICANS; CANDIDA GLABRATA;

EID: 4544265254     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.07.071     Document Type: Article

References (6)

1. Mistry, A.; Warren, M. S.; Blais, J.; Staley, A. L.; Galazzo, J. L.; Fuernkranz, H.; Chamberland, S.; Lee, M. D.; Watkins, W. J.; Lomovskaya, O.; Miller, G. H.; Sanglard, D. In 40th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, ON, September 2000, Abstract 1500
2. Lemoine, R.; Yang, J.; Staley, A.; Mathias, K.; Lolans, K.; Vijayam, U.; Shao, L.; Price, M. E.; Watkins, W. J.; Dudley, M. N. In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, December 2001, Abstract 2160
3. Lemoine, R. C.; Yang, J.; Lolans, K.; Oza, U.; Blais, J.; Staley, A.; Lee, M.; Lomovskaya, O.; Watkins, W. J. Bioorg. Med. Chem. Lett., submitted for publication
4. Lemoine, R. C.; Glinka, T. W.; Watkins, W. J.; Cho, A.; Yang, J.; Iqbal, N.; Singh, R.; Madsen, D.; Lolans, K.; Lomovskaya, O.; Oza, U.; Dudley, M. N. Bioorg. Med. Chem. Lett. 2004, 14, preceding paper in this issue. doi:10.1016/j.bmcl.2004.07.070
5. J. Clayden, P. Johnson, J.H. Pink, and M. Helliwell J. Org. Chem. 65 2000 7033
6. NCCLS. 1997. Reference method for broth dilution antifungal susceptibility testing of yeasts: approved standard. NCCLS document M27-A